The effectiveness of dioxidine in the treatment of sinusitis. In what cases should Dioxidin be used and can it be used without a doctor's prescription? Release form and composition

In this article, you can read the instructions for using the drug Dioxidine. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Dioxidin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Dioxidine analogues in the presence of existing structural analogues. Use for the treatment of wounds and ulcers, sinusitis and boils, as well as inhalation in adults, children, as well as during pregnancy and lactation.

Dioxidine- a broad-spectrum antibacterial drug from the group of quinoxaline derivatives, has chemotherapeutic activity in infections caused by Proteus vulgaris, dysentery bacillus, Klebsiella, Pseudomonas aeruginosa, salmonella, staphylococci, streptococci, pathogenic anaerobes (including pathogens of gas gangrene), acts on strains of bacteria resistant to other chemotherapy drugs, including antibiotics.

The development of drug resistance in bacteria is possible. When administered intravenously, it is characterized by a small therapeutic breadth, and therefore it is necessary to strictly adhere to the recommended doses. Treatment of burn and purulent-necrotic wounds promotes faster cleansing of the wound surface, stimulates reparative regeneration and marginal epithelization, and favorably affects the course of the wound process.

Pharmacokinetics

When applied topically, it is partially absorbed from the wound or burn surface, excreted by the kidneys.

Indications

• purulent bacterial infections caused by sensitive microflora with the ineffectiveness of other chemotherapeutic agents or their poor tolerance.

Outdoor use

• superficial and deep wounds of various localization;
• long-term non-healing wounds and trophic ulcers;
• phlegmon of soft tissues;
• infected burns;
• purulent wounds in osteomyelitis.

Intracavitary administration

• purulent processes in the chest and abdominal cavity;
• with purulent pleurisy, pleural empyema, lung abscesses, peritonitis, cystitis, wounds with deep purulent cavities (soft tissue abscesses, phlegmon of the pelvic tissue, postoperative wounds of the urinary and biliary tract, purulent mastitis).

Release forms

Solution in ampoules for inhalation and local, as well as intracavitary use (in the nose) 5 mg / ml and 1%.

Ointment for external use 5%.

Solution for intravenous administration 0.5%.

Instructions for use and schemes of use

Dioxidin is prescribed in a hospital setting. Applied externally, intracavitary.

Dioxidine 1% solution cannot be used for intravenous administration, due to the instability of the solution when stored at low temperatures.

Outdoor use

Apply 0.1-1% Dioxidine solutions. To obtain 0.1-0.2% solutions, ampoule solutions of the drug are diluted to the desired concentration with sterile isotonic sodium chloride solution or water for injection.

For the treatment of superficial infected purulent wounds, napkins moistened with a 0.5-1% solution of dioxidine are applied to the wound. Deep wounds after treatment are loosely packed with swabs moistened with a 1% solution of dioxidine, and in the presence of a drainage tube, from 20 to 100 ml of a 0.5% solution of the drug is injected into the cavity.

For the treatment of deep purulent wounds in osteomyelitis (wounds of the hand, foot), 0.5-1% solutions of the drug are used in the form of baths or a special treatment of the wound with a solution of the drug is carried out for 15-20 minutes (introduction of the solution into the wound for this period) followed by bandaging with 1% dioxidine solution.

Dioxidine in the form of 0.1-0.5% solutions can be used to prevent infection after surgery. According to the indications (patients with osteomyelitis) and with good tolerance, treatment can be carried out daily for 1.5-2 months.

Intracavitary administration

Depending on its size, 10-50 ml of a 1% dioxidine solution is injected into the purulent cavity per day. A solution of dioxidine is injected into the cavity through a catheter, drainage tube or syringe.

The maximum daily dose for injection into the cavity is 70 ml of a 1% solution.

The drug is injected into the cavity usually 1 time per day. According to the indications, it is possible to administer a daily dose in two divided doses. With good tolerance and indications, the drug can be administered daily for 3 weeks or more. If necessary, after 1-1.5 months, repeated courses are carried out.

Side effect

• headache;
• chills;
• rising temperatures;
• dyspeptic disorders;
• convulsive muscle contractions;
• allergic reactions;
• photosensitizing effect (the appearance of pigmented spots on the body when exposed to sunlight);
• peri-wound dermatitis (for external use).

Contraindications

• adrenal insufficiency (including history);
• pregnancy;
• lactation period;
• childhood;
• hypersensitivity to dioxidine.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

special instructions

Dioxidine is prescribed only for adults. Before starting the course of treatment, a drug tolerance test is carried out, for which 10 ml of a 1% solution is injected into the cavity. In the absence of side effects (dizziness, chills, fever) within 3-6 hours, a course of treatment is started.

Dioxidine is prescribed only for severe forms of infectious diseases or with the ineffectiveness of other antibacterial drugs, incl. cephalosporins of 2-4 generations, fluoroquinolones, carbapenems.

In chronic renal failure, the dose is reduced.

When age spots appear, the duration of a single dose is increased to 1.5-2 hours, the dose is reduced, antihistamines are prescribed, or Dioxidin is canceled.

In the event of precipitation of Dioxidine crystals in ampoules with a solution during storage (at a temperature below 15 ° C), they are dissolved by heating the ampoules in a boiling water bath with shaking until the crystals are completely dissolved (clear solution). If, when cooled to 36-38 ° C, the crystals do not fall out again, the drug is ready for use.

Dioxidin's analogues

Structural analogues for the active substance:

• Hydroxymethylquinoxylindioxide;
• Dioxysept;
• Dichinoxide;
• Urotravenol.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Dioxidine is one of the varieties of antibacterial drugs with a large amount of positive qualities, which belongs to the pharmaceutical group of quinoxaline. Kills harmful bacteria and destroys unnecessary microorganisms. Certain bacteria are susceptible to the drug: streptococcus, Escherichia coli and anaerobic flora. For the correct use of the drug, read the instructions for use and do not violate it.

Dioxidine is widely used for certain unnatural health conditions:

• Effective treatment by means of acute inflammatory processes that occur due to harmful microflora.
• The drug is taken during sinusitis, lung disease and severe meningitis.
• Cystitis is being treated.
• They take medicine when complex acute infectious diseases appear - it is prescribed when peritonitis and sepsis occur.
• The effectiveness of the ointment is manifested during infection processes that affect the skin: burns, injuries, wounds, soft tissue abscesses.
• The drug is prescribed for washing inside the mouth with dental pathology.
• The medicine in ampoules is used for inhalation, as nasal and ear drops.

This drug is considered a reserve, due to the high toxicity. It is prescribed only in those situations when taking other antibacterial drugs does not bring the desired result.

Contraindications of the drug

The instructions for dioxidin contain important specific restrictions on prescribing it:

• High susceptibility and inability to tolerate dioxidine components.
• Its use is prohibited for small children who have not yet reached the age of seven.
• It is not recommended to use Dioxidin for women in the position and during the time when she is a nursing mother.
• The tool is harmful to use for problems with the adrenal glands.

Dioxidine is prescribed with great care for kidney failure.

Instructions for use

Dioxidine in an ampoule

It is made for intracavitary use. It is prescribed in an ampoule if the treatment takes place in a hospital. There are several types of drug release - one percent and half percent. A one percent preparation is used infrequently, as a rule, it is diluted with water for injections to obtain a specific solution.

Dioxidine nasal drops (for children)

Children's drops are instilled into the nasal passages for children with the appearance of acute purulent rhinitis and sinusitis. The drug does not have a special form for instilling into the nose. In order to make dioxidine in ampoules, it is diluted with a special solution until the desired remedy is obtained. For children, dioxidine nasal drops are prescribed from one to two drops, no more, and adults are prescribed three drops twice a day. In the process of instillation, the head must be thrown back so that the drops get deeper into the nasal passages.

If you have opened an ampoule of a medicinal product, then the duration of the drug in order to drip your nose does not last more than a day. The longest treatment time is seven days, but most often experts prescribe three to four days.

Use of the drug in the ears

Dioxidine is required to drip into the ears in case of severe development of ear inflammation, otitis media, when other antibacterial agents do not help. At the beginning of the procedure, the ears must be cleaned of sulfur with cotton swabs. A remedy for children with inflammation is required to drip both into the ears and into the nasal passages a couple of times a day. It does not negatively affect hearing, does not have ototoxic properties.

Dioxidine, use for inhalation method

The tool is also used for inhalation. This method well cures a strong cough in a child. It is necessary to do inhalations with a special preparation, preferably using a nebulizer - this is a specific apparatus into which any agent is immersed. We must not forget that this drug is very strong, because the inhalation method is carried out only after it is prescribed by a specialist who examines the child and decides that he definitely needs to take a drug with great toxicity.

The use of the drug helps to disinfect the nasal passages and sinuses, destroys pathogenic bacteria in the pharynx and bronchi. If you prescribe inhalations with this drug in time, you can very quickly get rid of a runny nose, a strong cough.

The drug for inhalation is required to be used when severe bronchitis occurs, which cannot be treated with other antibiotics. During treatment with the drug, a half-percentage agent in ampoules should be used. Dioxidine must be diluted with a hypertonic solution, in a ratio of one to two. The duration of the procedure is three to four minutes, 2 times a day.

Ointment!#22#

Dioxidin in the form of a five percent ointment is required for external use. The most important advantage of dioxidine ointment is that it does not have an irritating effect on the skin, has an activating effect on tissue regeneration and has an excellent effect on the wound process. The instructions for using the ointment say that with prolonged use, microorganisms may develop addiction to this remedy.

Use of dioxidine during!#29#

Most often, the drug in ampoules is used to treat infections that form in the sinuses. The medicine during sinusitis is required to be applied by making inhalations. An effective way to treat sinusitis is to instill the medicine into the nasal passages, two to three drops twice a day.

In order to cure sinusitis, complex drops are used, which contain dioxidine, and other drugs. Drip this medicine one drop into the nose four to five times a day. Complex drops with dioxidine for the nose should be ordered only in the pharmacy network according to the prescription prescribed by the pediatrician.

Application of the solution!#26#

A solution of this drug is used to treat purulent wounds. With a large lesion, a half-percent solution is used, which is not suitable for prolonged use. In the process of wound healing, the use of a 0.1% solution of the drug is required in order to treat the damaged skin or start using a five percent cream.

Replacement drugs!#22#

In our pharmacy chains, there is a chance to find a similar medicine for dioxidine, it is Dioxycol ointment. There is also a similar dioxidine remedy, which is produced in tablets, it is called quinoxidine, but during its use obvious side effects on the gastrointestinal tract were noticed.

Drug evaluation

Evaluation of people who were prescribed dioxidine is extremely ambivalent. The remedy has a great effect, especially in case of purulent septic diseases. But, as assessments show, a large number of negative results are noticed during its application. Dioxidine is a toxic drug, so it belongs to the reserve. Dioxidine is treated in rare situations. In no case should the drug be given to children who have not reached the age of seven, and should not be instilled into the nose.

Wounds on the surface of the skin can cause us great trouble. Most often this happens due to the fact that foreign bodies, for example, various microorganisms, get into them, and an inflammatory process begins, the main symptom of which is the presence of pus in the wound. Special preparations will help us get rid of it. for local use with antibacterial effect. Dioxidin ointment also belongs to such means, the instructions for use of which, as well as reviews about this drug, we will consider in this article.

Composition and principle of action of the drug

In general, Dioxidin has different forms of release, except for the ointment, packed in tubes of various volumes from 25 to 100 mg and cardboard boxes (you can see what the packaging looks like in the photo), there is also a one percent solution for intracavitary and external use, and 0.5- percentage solution for intracavitary, intravenous and local use.

But the main active substance in all forms of the drug one - hydroxymethylquinoxaline dioxide. Its content in the ointment is 5%. And the excipients in the composition of the ointment, as stated in the instructions for use, are:

• polyethylene oxide 1500,
• polyethylene oxide 400,
• paraoxybenzoic acid propyl ester,
• nipagin.

The main active ingredient of this drug belongs to the group of quinoxaline derivatives and it shows activity against many types of bacteria. This substance damages the cell walls of microorganisms, which ultimately leads to their death. Most often, Dioxidin is used to treat various purulent diseases of both internal organs and the outer surface.

And here is the list of indications for the use of the ointment, indicated in the instructions. This is:

Dioxidine solution for intravenous and intracavitary administration is used to treat purulent meningitis, purulent pleurisy, peritonitis, cystitis, gallbladder empyema. But these are not all diseases for which Dioxidin is prescribed in any form. In the reviews you can read about the successful use of this drug in the treatment of sinusitis, purulent rhinitis, purulent otitis media. It is also used for inhalation with a nebulizer in the treatment of cough associated with bronchitis and other respiratory diseases.

Contraindications and side effects

This drug, in any form, cannot be applied in cases, if there:

• hypersensitivity to the components of this drug,
• adrenal insufficiency, including a history of this disease,
• pregnancy,
• breastfeeding period,
• age up to 18 years.

With existing renal insufficiency, the drug should be used with caution.

Using the ointment as directed in the instructions for use, and confirm the reviews about this drug, gives a minimal set of side effects, dermatitis near the wound and itching at the site of application of the remedy. The use of the solution may lead to other side effects, such as:

• chills,
• headache,
• elevated body temperature,
• nausea, vomiting, diarrhea,
• allergic reactions,
• the appearance of pigmented spots on the skin from exposure to UV rays,
• muscle cramps, manifested by twitching.

It is possible to avoid such reactions to taking the drug, as noted in the reviews of medical workers, if you follow the instructions for use and the recommendations of the attending physician.

How to apply the remedy

As for the use of the ointment, it is quite simple, it is applied to the infected area once a day with a thin layer. Typically, this course of treatment lasts up to 3 weeks.

The solution is administered, depending on the disease either intravenously or intracavitary using cotton swabs, napkins, catheters or a drainage tube. For the treatment of sinusitis and otitis, a dropper is used, and for inhalation in the treatment of cough from bronchitis and other respiratory diseases, a nebulizer.

Dosing is important the drug indicated in the instructions and prescribed by the doctor. After all, overdose is also the most common cause of possible side effects, as stated in the reviews. In addition, it can lead to the development of acute adrenal insufficiency. In this case, the drug should be stopped and seek help from a doctor who will prescribe the appropriate treatment.

Dioxidin ointment, price and analogues

A lot of positive reviews about this drug end with the words that the only thing that does not suit them is price of funds. On average in Russia, the price of an ointment is from 350 to 400 rubles. Ampoules with a solution of 0.5% can be purchased at the same average price. A one percent solution will cost more. The price of a package with these ampoules can be on average from 350 to 750 rubles. It depends on the number of ampoules in the package and the manufacturer. In general, the prices for any medicines also depend on the region and the pharmacy chain where the drug is purchased.

Dioxidin also has analogues, some of them are cheaper, but there are also the same price category, and the drugs are more expensive. Here is a list of some of them:

• Dioxysept,
• dichinoxide,
• Urotravenol,
• Hydroxymethylquinoxylindioxide.

But it is not recommended to replace the drug with an analogue without consulting a doctor. No matter what positive reviews you read about him or heard from your friends. After all, what suits someone may be you are contraindicated. Also, be sure to read the instructions for using the analogue.

The drug dioxidine in the form of an ointment

It is usually used in a hospital setting for the treatment of septic conditions, as it is a reserve antibacterial drug. Its effectiveness is combined with high toxicity, therefore, a remedy is prescribed only if there is no result of treatment with other, less toxic antibiotics.

On this page you will find all the information about Dioxidin: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Dioxidin in ampoules. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibacterial drug, a derivative of quinoxaline.

Terms of dispensing from pharmacies

Released by prescription.

How much does Dioxidine cost? The average price in pharmacies is at the level of 300 rubles.

Release form and composition

Dioxidin has several forms of release:

• ointment 5%;
• Dioxidine solution (0.5%) for intravenous injection;
• Dioxidine in ampoules for inhalation (5 mg) and intracavitary use (1%).

Dioxidine 1% solution is available in 10 ml glass ampoules. 1 ml of a clear, colorless solution contains 10 mg of the active ingredient dissolved in water for injection.

Dioxidin 5 mg for inhalation is produced in 10 and 20 ml ampoules. In each milliliter of the drug in water for injection, 5 mg of hydroxymethylquinoxaline dioxide is dissolved. Ampoules containing a solution for injection and inhalation are placed 10 pieces in cardboard boxes.

Pharmacological effect

Dioxidine is a synthetic bactericidal agent that is used in the treatment of purulent and infectious pathologies. Usually the drug is applied externally, however, if necessary, intracavitary lavage and intravenous administration are allowed.

Dioxidine has a detrimental effect on pathogenic cells by inhibiting the formation of DNA, while not affecting the production of RNA and protein. Also, the main active substance destroys the microbiological structure (shell and nucleotides, which play an important role in the formation of intracellular energy).

The drug is widely used in medicine due to its effective suppression of pathogenic flora in anoxic conditions.

Indications for use

According to the instructions, Dioxidin is indicated for use in bacterial infections that are sensitive to the active ingredient of the drug.

External use of Dioxidin is advisable in the following cases:

1. infected burns;
2. Phlegmon of soft tissues;
3. Deep or superficial wounds on the body;
4. Trophic ulcers and long-term non-healing wounds;
5. Purulent wounds in osteomyelitis.

Intracavitary administration of Dioxidin is indicated in the following cases:

1. Peritonitis;
2. Abscesses;
3. Purulent pleurisy;
4. Purulent processes in the abdominal or chest cavity;
5. Wounds of the biliary and urinary tract;
6. Pleural empyema;
7. Wounds and phlegmon with the presence of deep purulent cavities (phlegmon of the pelvic tissue, soft tissue abscesses, purulent mastitis, postoperative wounds of the biliary and urinary tract).

Contraindications

Dioxidine is contraindicated in:

• individual intolerance to the drug;
• dysfunction of the adrenal glands;
• pregnancy and lactation;
• under the age of 12.

Use during pregnancy and lactation

The effect of hydroxymethylquinoxylindioxide on the body has been studied in the course of many years of research. As a result, its mutagenic and teratogenic effects were reliably established.

Women at any stage of pregnancy should not be prescribed this drug, and not only intravenously or in the body cavity. Even local use in the form of ointments, compresses or nasal drops ensures the penetration of the active substance into the bloodstream through the mucous membranes and skin. For the same reason, treatment with Dioxidin during lactation is excluded (usually a temporary transition to pumping and artificial feeding is recommended).

Instructions for use

The instructions for use indicate that Dioxidine is most often used in stationary conditions. A 1% solution of the drug is usually not used for intravenous injection (due to the instability of the drug when stored at low temperatures). Apply 0.1-1% solutions, for which the drug is diluted with water for injection or sodium chloride solution.

External use of Dioxidin:

1. For the prevention of infections after surgery, Dioxidin is used in the form of a 0.1-0.5% solution.
2. In the treatment of superficial infected purulent wounds, napkins soaked in a 0.5-1% Dioxidin solution are applied to the wound. When treating deep wounds, they are loosely plugged with swabs pre-moistened in a 1% solution. In the presence of a drainage tube, a 0.5% solution is injected into the cavity, from 20 to 100 ml.
3. For the treatment of deep purulent wounds in osteomyelitis - in the form of baths with a 0.5-1% solution. Less commonly, a special treatment of the wound is carried out by introducing the drug for a minute, then a bandage is applied with a 1% solution of Dioxidine. With good tolerability of the drug, treatment can be carried out daily for 1.5-2 months.

For intracavitary administration, a catheter, syringe or drainage tube is used. A 1% solution of the drug is injected into the purulent cavity, the dose depends on the size of the cavity, usually ml per day. Usually the drug is administered 1 time per day. The maximum daily dose is 70 ml. Treatment can be continued for three weeks or more if indicated and well tolerated.

Instructions for use Dioxidin in the nose

Dioxidine solution is used in the presence of complicated inflammatory processes of the nasal cavity, in particular for the treatment of sinusitis, sinusitis, frontal sinusitis and other pathologies. The nasal cavity is washed with a solution of Dioxidine 2-3 times a day, using a syringe for convenience.

The drug has an excellent therapeutic effect in complicated sinusitis, when other drugs, including antibiotics, are ineffective. The pierced maxillary sinuses are washed with a solution of the drug 2-3 times a day, after which, if necessary, gauze turundas moistened with a solution are inserted into the nasal cavity.

Dioxin in the ear

Otitis media is usually treated with antibiotics and vasoconstrictor drugs. However, in cases where they are not effective, Dioxidin becomes the drug of choice, a feature of which is its effectiveness against anaerobic bacteria.

Before instillation of the medicine, it is recommended to clean the ear canal from sulfur using a cotton swab moistened with a 3% hydrogen peroxide solution or special cotton swabs (for convenience, the auricle is slightly pulled back). If the ear is very dirty, the peroxide swab is left in it for about 5 minutes.

1. In case of purulent otitis, which is often accompanied by perforation of the eardrum and the release of pus, all purulent contents are first removed from the ear canal before instillation.
2. With otitis, Dioxidin should be administered simultaneously into the nose and into the ear canal. The solution effectively sanitizes the nasal cavity and stops the inflammatory process in it, and since the nose is connected to the ear by the Eustachian tube, the removal of the inflammatory process in the nose has a beneficial effect on the situation as a whole.

The dose and frequency of instillations are selected individually in each case and exclusively by the attending physician.

Dioxidine ointment

It is used to treat purulent wounds, trophic ulcers, phlegmon, osteomyelitis wounds, pustular skin rashes. Apply a thin layer to the surface of the skin, tampons with ointment are injected into purulent wounds. The daily dose for adults should not be more than 2.5 g. The duration of the drug is 3 weeks.

Inhalation with a nebulizer

Today, the nebulizer is popular in the treatment of coughs and runny noses. However, not all owners of a useful device know which solutions are suitable for inhalation and which are not. What doctors say about the use of Dioxidine in nebulizers and inhalers.

The solution can be used at home, but under strict control of the Dioxidin dosage. Inhalations are prescribed for lung abscesses, pleural empyema, severe inflammation of the bronchi. Dioxidin for sinusitis, frontal sinusitis, is rarely prescribed - with a protracted course of the disease and the appearance of resistance (immunity) to other (weaker) drugs.

The concentrated solution is not poured into the nebulizer, it is diluted with saline. How to breed Dioxidin correctly?

• ampoules with a 1% solution are diluted in a ratio of 1:4;
• ampoules with a 0.5% solution are diluted in a ratio of 1:2.

One inhalation will require 3 ml. Leftovers can be stored in the refrigerator for up to 12 hours. The only moment, before inhalation, Dioxidine should be removed from the refrigerator so that it warms up naturally. The solution must not be heated!

Side effects

Dioxidine with intracavitary administration can cause:

• dyspeptic disorders;
• convulsive muscle contractions;
• allergic reactions;
• headache;
• chills;
• rising temperatures;
• photosensitizing effect (the appearance of pigmented spots on the body when exposed to sunlight);
• peri-wound dermatitis (for external use).

When applied externally, Dioxidin can provoke peri-wound dermatitis.

Overdose

Symptoms in case of overdose include both excessive symptoms from the list of side effects and acute insufficiency of the function of the adrenal cortex:

1. To cope with the difficulty in the synthesis of corticosteroids (stress hormones), therapy must be stopped.
2. Against other manifestations of an overdose, therapeutic methods are selected - symptomatic treatment.

Hormone replacement therapy is allowed - in the form of doses of glucocorticosteroids determined by the doctor (normally up to 1 mg per kilogram of the patient's weight).

special instructions

1. The drug is prescribed only with the ineffectiveness of other antibacterial drugs, including fluoroquinolones, cephalosporins II-IV generations, carbapenems.
2. Before starting the use of Dioxidin, it is imperative to conduct a study on the tolerability of the drug. To do this, a small volume (10 ml) of a 1% solution is injected into the cavity and the patient's condition is monitored for 3-6 hours. If during this time there are no side effects (chills, fever, dizziness), the drug can be used for course treatment.
3. If age spots occur, the duration of a single dose is increased to 1.5-2 hours, the dose is reduced, dioxidine is canceled, or antihistamines are prescribed.

Reviews

We have selected some reviews of people about the drug Dioxidin:

1. Elena. I usually use dioxidine solution to treat my child's persistent runny nose. I mix it in equal parts with aloe extract and drip twice a day. The tool is cheap and very effective. Does not dry out the mucous membrane and does not cause discomfort.
2. Anna. One day in early spring I had a congestion in the auricle. I tried to treat folk methods, but the disease only worsened. The otallarinologist prescribed dioxidine drops. At the same time, the doctor assured that the drug has absolutely no side effects. Having dripped the maximum dose of the drug into the auricle, I felt a burning sensation. After that, I read the instructions, and found a large number of side effects. For treatment, I reduced the dose and quickly cured the inflammation of the ear canal. I recommend this drug to everyone, but before using it, carefully read the instructions.
3. Tanya. Dioxidine is a very good medicine. I only use it for mixed drops, for the nose. With a runny nose that I can’t cure for more than a week or two, this is an indispensable remedy! An ENT doctor prescribed me, he said that even sinusitis is treated with mixed drops, patients do not have to pierce their sinuses. Here is the recipe: Dioxidin 1% - 5 ml, Mezaton - 2 ml, Dexamethasone - 2 ml = mix everything in 10 cc. syringe, and 2 drops to drip, 3 times a day. The nose breathes and the runny nose passes very quickly. The price is affordable, even very much and in all pharmacies you can find this drug.
4. Sasha. For furunculosis, I was prescribed Dioxidin in ampoules, which I laid on gauze folded in several layers, which I dipped into the printed ampoule of the solution to the place where the boil broke through. Surgeons said that this medicine is an antibiotic and sucks out pus well. In principle, for his own money, he did his front of work and the wounds were cleared of pus quickly, faster than before, when they simply changed the bandages or applied Ichthyol ointment.

Analogues

What analogues of Dioxidine can be found in pharmacies?

1. Dioxysept. It is identical to Dioxidin in all respects: action, method of application, indications, side effects.
2. Dioxycol. Available in the form of an ointment. In addition to Dioxidin, it contains Trimecaine, Methyluracil, Polyethylene oxide. It is well tolerated, practically does not cause side effects.
3. Urotravenol. Consists of Dioxidin, Glycine and water. Supplied in sterile 10 liter containers. Used in hospitals for intracavitary administration.
4. quinoxidine. In fact, this drug is a tablet form of Dioxidin. It is prescribed for multiresistant urinary tract infections. It is characterized by a high frequency of side effects from the digestive system.

Before using analogues, consult your doctor.

Storage conditions and shelf life

On average, the drug has a long (3 years) shelf life, less often - 24 months. Any form (ointment, ampoules) is released only by prescription. Storage conditions:

• in a safe place out of the reach of children;
• at a temperature of degrees;
• in a dry place protected from light.

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2 comments

Dioxidine is the best and most effective antimicrobial agent in the history of medicine. Quickly inactivates almost all pathogenic microorganisms known to science, including some protozoa, moreover, without side effects. At observance of the recommended dosages at local, intracavitary application does not cause any toxic effects.

It is especially effective for the treatment of bacterial infections of the respiratory tract in immunocompromised individuals, by instillation into the nose, inhalation of a 1% solution using a pocket inhaler and washing the maxillary sinuses. Efficiency has been proven many times personally on me and many others. Dioxidine is a Russian miracle that has almost no analogues abroad. Thanks to the developers and Soviet science.

I suffer from chronic sinusitis, often exacerbations, especially against the background of severe colds. In the polyclinic, the ENT doctor advised, in addition to traditional antibiotics in tablets, to use the antibacterial agent Dioxidin by instilling it directly into the nose.

First you need to clear the nose (if it is clogged) with any vasoconstrictor (Xylen, Rinostop, Nazivin, etc.), then take an ampoule of 1% solution and drip 2 drops into each nostril 3 times a day.

You can use a syringe or pipette for this. Sometimes there may be temporary slight discomfort - burning in the nose or tingling, but this is not for long. I can say for sure - it helps 100%.

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Dioxidin - instructions for use

general information

The advantages and disadvantages of the drug depend on its structure, physical and biochemical characteristics. Dioxidine is a derivative of quinoxaline di-N-oxide. Derivatives of this substance have an antibacterial effect. They are characterized by increased reactive properties, and also easily enter into redox reactions. These characteristics determine the features of antibacterial activity and a number of other biochemical properties of the above substances, incl. toxicity. Quinoxaline di-N-oxide derivatives have been actively studied since the early 20th century. In Western countries, a number of drugs have been developed based on these compounds, which have high antibacterial activity and a wide range of bactericidal action (Quindoxin, Temadox, etc.). These drugs have found application only in veterinary practice - in the treatment and prevention of Salmonella infections and other pathogenic bacteria.

Composition and form of release

Dioxidine solution 0.5% for intravenous, intracavitary and external use, 0.01 and 0.02 liters in ampoules of 10 pieces per pack.

Dioxidin ointment for topical use 5% at 0.025, 0.03, 0.05, 0.06 or 0.1 kg in a jar or tube.

Pharmacological properties

Indications

Dioxidine is used as a systemic drug (intravenously) when other antimicrobial agents are ineffective. It is used in the treatment of severe forms of bacterial infection caused by microorganisms that are insensitive to other antibacterial drugs. Treatment is carried out exclusively in a hospital, under the strict supervision of a doctor. Since the drug is toxic, regular examinations and tests for vital signs are necessary.

• sepsis (including burns);
• purulent meningitis, accumulation of pus in the brain;
• spreading purulent-inflammatory processes;
• prevention of infection during heart surgery (vascular prosthesis, coronary bypass grafting).

Dioxidine is used externally and intracavitary in the form of a solution or ointment for purulent-infectious processes. It is actively used in surgery, urology and dentistry. Perhaps the introduction of the solution into the bronchi.

• purulent pleurisy;
• abscess pneumonia;
• inflammation of the peritoneum;
• suppuration of the gallbladder;
• purulent cystitis;
• infected deep wounds: suppuration of soft tissues, surgical wounds, purulent chest, etc.;
• prevention of infection after catheterization of the urethra.

Dioxidin is applied externally in the following situations:

• shallow festering wounds;
• infected burn surfaces;
• trophic ulcers in a neglected state;
• festering wounds with osteomyelitis;
• pustular skin pathologies.

Method of application and dosage

Dioxidine is administered intravenously only under medical supervision. The introduction of the drug without a dropper is contraindicated. Prior to infusion, a tolerance test should be performed. In severe sepsis, a 0.5% solution is poured, mixed with a 5% glucose solution or with a 0.9% sodium salt solution to a dicosidin concentration of 0.1-0.2%. The maximum dose of the drug is 0.3 g, the maximum daily dose is 0.6 g.

A solution of the drug is poured into the cavity through drainage, a catheter or a syringe - 0.01-0.05 liters of a one percent solution. The maximum dose of the drug is 0.5 g, the maximum daily dose is 0.7 g.

On the surface of the wound, cleaned of pus and dead tissue, swabs soaked in a one percent solution of the drug are fixed. Tampons are changed daily or every other day, depending on the condition of the damaged surface and the rate of healing. Deep wounds are treated with a 0.5% solution of the drug. With prolonged treatment of wounds, 0.1-0.2% dioxidine solutions are used. The maximum dose of the drug is 2.5 g. The duration of the course is no more than 20 days.

The ointment is applied in a thin layer directly to the surface of the wound or burn, previously cleaned of pus and dead tissue. Tampons lubricated with ointment are introduced into the purulent cavities. For one dressing, up to 30 g of ointment is needed. Dressings with ointment are replaced daily or every other day, depending on the condition of the damaged surface and the rate of healing. The maximum amount of ointment used per day is 0.1 kg. The duration of the course is determined by the severity of the disease, the effectiveness of treatment and the tolerability of the drug. With normal tolerance, treatment lasts days. If necessary, the course can be repeated in a day.

Contraindications and side effects

Despite the obvious positive effect of the drug in the treatment of purulent-microbial pathologies, the high toxicity of dioxidine determined it as a reserve drug, especially for intravenous infusions.

The frequency of manifestation of the above symptoms depended both on the dose and on the individual tolerability of the drug, and was registered on average in 8-10% of patients. Subject to the correct dosage and administration of the drug through a dropper, side effects developed much less frequently, or did not develop at all. Clinical practice has shown the feasibility of using dioxidine in patients with intolerance (including allergies) to antibiotics. Particular attention should be paid to spasms of the striated muscles. The factors and pathogenesis of the development of this symptom are still unknown, however, there are versions that its development may be due to an increase in the number of free radicals in the patient's body, or the effect of the drug on the adrenal glands. An important advantage of dioxide is the absence of toxic effects on the kidneys, liver and hearing organs.

Clinical Trials

Analogues

Storage conditions

Shelf life - 24 months.

The drug is issued in pharmacies only by prescription.

Reviews

Two years ago, at the beginning of winter, my ear was blocked. The whole day to feel as if the ear is clogged with cotton, the feeling is not pleasant. This went on for a week, there were no signs of recovery. I turned to my otolaryngologist, she suggested dioxidine drops. I asked about the side effects - the doctor said that this is a completely safe medicine, recommended even for children. Mom approved this appointment, mentioning that earlier otitis in children was treated only with dioxidine.

Having heeded the recommendations, I bought one ampoule and dripped a sore ear with it. In less than five minutes, I regretted it - a severe pain appeared in my ear, I just closed my eyes, waiting for it to pass. But the pain didn't subside. An hour later, I decided to try a folk recipe - to be treated with onion juice. The husband chopped the onion, squeezed the juice out of it - I moistened a cotton swab in it and inserted it into my ear (I wet the inside of the swab with juice, and left the outside dry, because onion juice irritates the mucous membrane). Within minutes, the pain was completely gone.

After recovering from the pain, I decided to learn more about Dioxidine. It turned out that the medicine is quite dangerous and not at all harmless. And on medical forums, doctors themselves confirm that dioxidine is a toxic drug, so it can only be used as a last resort, and it is generally contraindicated for children.

I decided to enlighten my otolaryngologist, but she was only surprised and shrugged. As a result, she prescribed me another drug - otipax. I bought a bottle, dripped for 7 or 8 days, but my ear never let go. As a result, disappointed in medical preparations, I returned to the folk method with onion juice.

Literally on the first day of treatment, pus began to drain, and in large quantities. After 3-4 days, the congestion disappeared, and so far everything is in order with the ear.

This is how I learned a lesson for life - now, first of all, I try to be treated with folk methods and natural remedies, and I try to avoid medicines unless absolutely necessary ..

A year ago, my daughter fell ill with sinusitis - at first they wanted to recover themselves, but still decided to consult a pediatrician. The pediatrician offered a choice of nasal drops Dioxidin or Protargol. Protargol was not sold in our city, so I bought an ampoule of dioxidine. I diluted it with water (50 to 50) and began to drip to my daughter. By that time, I also had purulent discharge from the nose, so my daughter and I began to drip this solution together. However, neither I nor the child did not improve. I decided to give it up, and started rinsing my nose with salt water for myself and my daughter. After this procedure, Derinat was instilled. It took us only 5 days to fully recover.

Later I read on the Internet that dioxidine is contraindicated for children in any form, even in the form of nasal drops. I don’t understand what our pediatrician was guided by when she prescribed him ...

Read more:

Reviews

and without side effects. At observance of the recommended dosages at local, intracavitary application does not cause any toxic effects. It is especially effective for the treatment of bacterial infections of the respiratory tract in immunocompromised individuals, by instillation into the nose, inhalation of a 1% solution using a pocket inhaler and washing the maxillary sinuses. Efficiency has been proven many times personally on me and many others. Dioxidine is a Russian miracle that has almost no analogues abroad. Thanks to the developers and Soviet science.

Yes, take the instructions for ANY honey. drug (at least analgin, aspirin) and you will read a bunch of contraindications and possible reactions of the body to it. This does not mean that you will have all this, just the manufacturer reports the possibility of such reactions. A person has purulent rhinitis, and on some forum he is recommended to replace dioxidine with nazivin and pinosol! Rave!

If you know everything yourself - do not go to the doctors.

There is no limit to human stupidity!

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DIOXIDINE analogues

We kindly ask you not to make a decision to replace DIOXIDIN on your own, only on the instructions and with the permission of a doctor.

(157 offers from 157 to 452 UAH)

ALGOFIN-FORTE

GIVALEX

TIBERAL

SEBIDIN

VIJAYSAR

PROALOR

ACNESTOP

TSIPROLET

respiratory infections: exacerbation of chronic bronchitis, pneumonia, bronchopneumonia, lung abscess, empyema, infectious pleurisy, infected bronchiectasis, pulmonary infections in patients with fibrocystic changes in the lungs;

Infections of the genitourinary system: prostatitis, chronic and acute pyelonephritis, cystitis, epididymitis;

ENT infections: otitis media, sinusitis, mastoiditis;

Gynecological infections: adnexitis, salpingitis, oophoritis, endometritis, pelvic abscess, pelvioperitonitis, infected ulcer;

gonorrhea, including rectal, urethral and pharyngeal localization of gonococcal lesions, including cases caused by resistant gonococci;

infections of the abdominal organs: cholecystitis, peritonitis, intra-abdominal abscesses, cholangitis, gallbladder empyema;

Infections of joints and bones: purulent arthritis, chronic and acute osteomyelitis;

Infectious diseases of the gastrointestinal tract: typhoid fever, bacterial diarrhea;

common severe infectious diseases: bacteremia, septicemia and infections in immunocompromised patients;

Infections of soft tissues and skin: infected wound, cellulitis, burns, abscess.

AMOXIL-K

Infections of ENT organs, incl. recurrent tonsillitis, sinusitis, otitis media.

Infections of the lower respiratory tract, incl. exacerbation of chronic bronchitis, lobar and bronchopneumonia.

Infections of the urinary system, incl. cystitis, urethritis, pyelonephritis, female genital infections and gonorrhea.

Skin and soft tissue infections.

Osteoarticular infections, incl. osteomyelitis.

Other infections, incl. intra-abdominal sepsis.

Prevention of infectious complications during surgical interventions, in most cases during surgical interventions on the gastrointestinal tract, pelvic organs, head and neck, heart, kidneys, joint replacement and bile duct surgery.

Infections caused by amoxicillin-sensitive microorganisms are effectively treated with Amoxil - K, given the content of amoxicillin in it. Mixed infections that are caused by amoxicillin-insensitive microorganisms in combination with amoxicillin-sensitive microorganisms - beta-lactamase producers - can be treated with Amoxil - K.

CLAVAM

inflammation of the sinus sinuses of the bacterial nature of an acute course,

acute inflammation of the middle ear,

chronic bronchitis in the acute stage,

community-acquired form of pneumonia,

cystitis of bacterial etiology of various forms of severity,

infectious and inflammatory disease of the renal pelvis (pyelonephritis),

infectious pathologies of the skin and soft tissues, such as cellulitis, animal bites, severe dentoalveolar abscesses with widespread cellulitis,

infectious lesions of the musculoskeletal system (for example, osteomyelitis).

erythromycin

LOSTERIN

ZINERIT

ORNIDAZOL

DIFFERIN

TRINEFRON

Chronic non-communicable diseases of the kidneys (glomerulonephritis, interstitial nephritis).

Prevention of the formation of urinary stones, including after their removal.

BAZIRON AS

OFLOKSIN

Infections that are sensitive to ofloxacin:

Diseases of the lower respiratory tract;

Infectious and inflammatory lesions of the ENT organs (except for tonsillitis);

Infections of bones, joints and soft tissues;

Infectious diseases of the abdominal cavity, small pelvis and kidneys;

Prostatitis, gonorrhea, chlamydia;

Respiratory infections on the background of tuberculosis, pulmonary fibrosis;

Concomitant infections with AIDS;

Shigellosis and salmonellosis.

TRIMISTINE

The drug can also be prescribed to patients with discoid lupus erythematosus and skin lymphoma.

VIFERON

GATIFLOXACIN

Treatment of infectious and inflammatory processes caused by microorganisms sensitive to the drug, such as: - respiratory tract infections (including acute bronchitis, exacerbation of chronic bronchitis, acute sinusitis, community-acquired pneumonia);

- infections of the kidneys and urinary system (including complicated urinary tract infections, acute pyelonephritis, uncomplicated urinary tract infections (cystitis);

- uncomplicated infections of the skin and soft tissues;

- uncomplicated urethral gonorrhea in men;

- endocervical and rectal gonorrhea in women.

CHLOROPHILLIN-03

Inside Chlorophyllin-03 is used to treat staphylococcal lesions of the digestive tract.

In the form of inhalations, Chlorophyllin-03 is used for bronchitis, pneumonia, lung abscesses.

Chlorophyllin-03 gives a pronounced effect when applied against antibiotic-resistant bacterial flora.

ORVAGIL

TRICHO-PIN

Protozoal infections: trichomoniasis, extraintestinal amoebiasis, including amoebic liver abscess, intestinal amoebiasis (amebic dysentery), giardiasis.

Anaerobic bacterial infections (gynecological, including bacterial vaginosis, as well as abdominal infections, infections of the central nervous system, bacteremia, sepsis, endocarditis, bone, joint, skin and soft tissue infections, periodontal infections, respiratory tract infections) caused by Bacteroides spp. , Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp. and other anaerobes sensitive to metronidazole (for adults and children).

Treatment of Helicobacter pylori infections in duodenal ulcers or stomach ulcers in combination with bismuth preparations and an antibiotic, such as amoxicillin.

Treatment of enterocolitis caused by Clostridium difficile.

Prophylactic appointment before surgery on the gastrointestinal tract and reproductive organs.

TRICHOBROL

Trichomonas vaginitis and urethritis in women, Trichomonas urethritis in men, giardiasis, amoebic dysentery; anaerobic infections caused by microorganisms sensitive to the drug.

Combination therapy for severe mixed aerobic anaerobic infections.

Prevention of anaerobic infection during surgical interventions (especially on the abdominal organs, urinary tract).

In combination with amoxicillin: chronic gastritis in the acute phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.

Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Dioxidin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Dioxidine analogues in the presence of existing structural analogues. Use for the treatment of wounds and ulcers, sinusitis and boils, as well as inhalation in adults, children, as well as during pregnancy and lactation.

Dioxidin is a broad-spectrum antibacterial drug from the group of quinoxaline derivatives, has chemotherapeutic activity in infections caused by Proteus vulgaris, dysentery bacillus, Klebsiella, Pseudomonas aeruginosa, salmonella, staphylococci, streptococci, pathogenic anaerobes (including pathogens of gas gangrene), acts strains of bacteria resistant to other chemotherapy drugs, including antibiotics.

The development of drug resistance in bacteria is possible. When administered intravenously, it is characterized by a small therapeutic breadth, and therefore it is necessary to strictly adhere to the recommended doses. Treatment of burn and purulent-necrotic wounds promotes faster cleansing of the wound surface, stimulates reparative regeneration and marginal epithelization, and favorably affects the course of the wound process.

When applied topically, it is partially absorbed from the wound or burn surface, excreted by the kidneys.

• purulent bacterial infections caused by sensitive microflora with the ineffectiveness of other chemotherapeutic agents or their poor tolerance.

• superficial and deep wounds of various localization;
• long-term non-healing wounds and trophic ulcers;
• phlegmon of soft tissues;
• infected burns;
• purulent wounds in osteomyelitis.

• purulent processes in the chest and abdominal cavity;
• with purulent pleurisy, pleural empyema, lung abscesses, peritonitis, cystitis, wounds with deep purulent cavities (soft tissue abscesses, phlegmon of the pelvic tissue, postoperative wounds of the urinary and biliary tract, purulent mastitis).

Solution in ampoules for inhalation and local, as well as intracavitary use (in the nose) 5 mg / ml and 1%.

Ointment for external use 5%.

Solution for intravenous administration 0.5%.

Instructions for use and schemes of use

Dioxidin is prescribed in a hospital setting. Applied externally, intracavitary.

Dioxidine 1% solution cannot be used for intravenous administration, due to the instability of the solution when stored at low temperatures.

Apply 0.1-1% Dioxidine solutions. To obtain 0.1-0.2% solutions, ampoule solutions of the drug are diluted to the desired concentration with sterile isotonic sodium chloride solution or water for injection.

For the treatment of superficial infected purulent wounds, napkins moistened with a 0.5-1% solution of dioxidine are applied to the wound. Deep wounds after treatment are loosely packed with swabs moistened with a 1% solution of dioxidine, and in the presence of a drainage tube, from 20 to 100 ml of a 0.5% solution of the drug is injected into the cavity.

For the treatment of deep purulent wounds in osteomyelitis (wounds of the hand, foot), 0.5-1% solutions of the drug are used in the form of baths or a special treatment of the wound with a solution of the drug is carried out for a minute (introduction of the solution into the wound for this period) followed by bandaging with a 1% solution of dioxidine .

Dioxidine in the form of 0.1-0.5% solutions can be used to prevent infection after surgery. According to the indications (patients with osteomyelitis) and with good tolerance, treatment can be carried out daily for 1.5-2 months.

In the purulent cavity, depending on its size, 1% dioxidine solution is injected ml per day. A solution of dioxidine is injected into the cavity through a catheter, drainage tube or syringe.

The maximum daily dose for injection into the cavity is 70 ml of a 1% solution.

The drug is injected into the cavity usually 1 time per day. According to the indications, it is possible to administer a daily dose in two divided doses. With good tolerance and indications, the drug can be administered daily for 3 weeks or more. If necessary, after 1-1.5 months, repeated courses are carried out.

• headache;
• chills;
• rising temperatures;
• dyspeptic disorders;
• convulsive muscle contractions;
• allergic reactions;
• photosensitizing effect (the appearance of pigmented spots on the body when exposed to sunlight);
• peri-wound dermatitis (for external use).

• adrenal insufficiency (including history);
• pregnancy;
• lactation period;
• childhood;
• hypersensitivity to dioxidine.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

Dioxidine is prescribed only for adults. Before starting the course of treatment, a drug tolerance test is carried out, for which 10 ml of a 1% solution is injected into the cavity. In the absence of side effects (dizziness, chills, fever) within 3-6 hours, a course of treatment is started.

Dioxidine is prescribed only for severe forms of infectious diseases or with the ineffectiveness of other antibacterial drugs, incl. cephalosporins of 2-4 generations, fluoroquinolones, carbapenems.

In chronic renal failure, the dose is reduced.

When age spots appear, the duration of a single dose is increased to 1.5-2 hours, the dose is reduced, antihistamines are prescribed, or Dioxidin is canceled.

In the event of precipitation of Dioxidine crystals in ampoules with a solution during storage (at a temperature below 15 ° C), they are dissolved by heating the ampoules in a boiling water bath with shaking until the crystals are completely dissolved (clear solution). If, when cooled to 36-38 ° C, the crystals do not fall out again, the drug is ready for use.

Dioxidin's analogues

Structural analogues for the active substance:

Dioxidine: instructions, price and analogues

Dioxidine is a synthetic antibacterial drug with a wide range of uses.

The active ingredient of Dioxidine is hydroxymethylquinoxylindioxide.

The considered antibacterial drug has proven itself in the fight against such pathogenic (pathogenic) bacteria:

• streptococci;
• staphylococci;
• sticks of klebsiella and dysentery;
• pathogenic anaerobes;
• Pseudomonas aeruginosa;
• salmonella.

The manufacturer of Dioxidin is the Russian pharmaceutical company OJSC NIZHFARM.

This antibacterial agent is sold in pharmacies by prescription from the attending physician.

Instructions for use Dioksidina recommends storing it in a dark and dry place, protected from direct sunlight. Children should not have access to the medicine. The recommended storage temperature should not exceed 20 degrees Celsius.

If the storage conditions are observed, the expiration date declared by the manufacturer of Dioxidine is 3 years from the date of issue, which must be indicated on the package.

It is forbidden to use this antibacterial medicine after its expiration date.

Release form and price

Currently, manufacturers produce it in two dosage forms:

The solution is poured into glass ampoules. Each package of this medicine contains 10 medicine ampoules.

Also, the solution is available in bottles equipped with a dropper cap. This package appeared not by chance, with its help it is very convenient to instill Dioxidin into the nose.

The ointment is available in special tubes (tubes) with a volume of 25, 30, 50 and 100 grams.

Prices for the drug in question can vary significantly depending on where you buy it.

Indications for use and pharmacological properties

The annotation of the medicinal product contains an extensive and detailed list of diseases and pathological conditions in which it is used.

An antibacterial drug is used to treat in cases of:

• pyoderma (infectious skin lesions);
• burns, ulcers and wounds;
• purulent meningitis;
• purulent pleurisy;
• inflammation of the gallbladder;
• peritonitis;
• cystitis;
• sepsis.

The use of Dioxidin for various wounds and other skin disorders is caused by their infection, as well as the difficulty and duration of healing.

In otolaryngology, it is used in the complex therapy of sinusitis (sinusitis, frontal sinusitis, ethmoiditis and sphenoiditis), otitis and bacterial rhinitis. In particular, Dioxidin with sinusitis is used for especially severe and advanced forms of the disease.

For more information, you can get by reading the article "Rinsing the nose with sinusitis."

The pharmacological action of Dioxidine is due to the fact that its active substance, hydroxymethylquinoxylindioxide, is capable of extremely effectively destroying the structure of pathogenic bacteria. This quickly causes their death.

Depending on the form of release and the specific indication for use, the antibacterial drug in question is used:

• for intracavitary therapy;
• intravenously (injections);
• intranasally (drops in the nose);
• locally (in the treatment of wounds).

Therapeutic and therapeutic course of intravenous and intracavitary administration of Dioxidin is always set by the attending physician on an individual basis.

In the treatment of difficult-to-heal wounds with Dioxidine, the most commonly practiced method is the local application of napkins moistened with a medicinal solution to the wound.

Such procedures are usually prescribed by the attending physician for daily use. Sometimes they are prescribed with a frequency of once every two days.

The average duration of such treatment is 2-3 weeks.

In the treatment of otitis media, before instilling the required number of drops of the drug, the ear canals should be thoroughly cleaned of earwax with the help of hydrogen peroxide (3%). These procedures are carried out using turundas or cotton swabs.

In the treatment of otitis media, the drug is simultaneously injected into the ears and nasal passages.

The required dosage and frequency of taking the drug is determined by the attending physician.

When treating sinusitis and rhinitis, doctors often dilute the drug with saline or water for injection. It is used as nasal drops.

Dioxidine for sinusitis (rhinitis), according to the requirements of the instructions, can only be used to treat adult patients. In such cases, 2-10 drops of the solution should be instilled 3-5 times a day into each nasal passage.

However, doctors often prescribe this antibacterial drug to children. The dosage is also individual. On average, it is 1-2 drops in each nasal passage 2-3 times a day. In addition, washing the nasal cavity with a solution of this drug shows high efficiency.

Dioxidin with a runny nose (sinusitis) is used no longer than 5-7 days.

When treating with ointment, it should be applied daily in a thin layer directly to the wound. The average duration of the treatment and therapeutic course is 15-20 days.

Inhalations

Inhalations with Dioxidine are prescribed by doctors for diseases of the respiratory system and ENT organs.

Such inhalations can be prescribed for both children and adult patients. It is forbidden to self-medicate and carry out similar procedures without the appointment of a doctor. Possible side effects.

When preparing a solution for inhalation, the recommended proportions must be strictly observed. When using a 1% solution of the drug, it should be diluted with 4 parts of saline. If you have a 0.5% solution, you will need 2 parts of saline.

Inhalations are carried out 1-2 times a day. For each procedure, an average of 3.5 ml of Dioxidin is spent.

Contraindications, overdose and side effects

The use of Dioxidin is contraindicated in case of hypersensitivity and individual intolerance to its components. In addition, officially it cannot be used to treat children.

Taking Dioxidine sometimes causes negative side effects. These include:

• allergic reactions;
• increase in body temperature;
• muscle cramps;
• headaches;
• nausea, diarrhea and vomiting;
• chills.

During pregnancy and lactation

Dioxidin during pregnancy and lactation is categorically contraindicated for admission.

Analogues

Currently, many antibacterial drugs are being produced, which in their action are analogues of Dioxidin. Here is just a short list:

Remember, only a qualified doctor can choose from a large number of analogues the optimal drug in each specific situation.

Efficiency and reviews

On the Internet, you can find a huge amount of a wide variety of reviews about Dioxidine. Most of them are positive.

However, often in their reviews people complain about the rather high cost of the medicine.

Many copies have been broken around the question: “Can children be treated with it?”. In this matter, not a review, but a recommendation from the attending physician should be at the forefront.

Dear reader, if you have already used Dioxidin, please leave a review about it on our website. Your opinion and experience will help other people choose an antibacterial drug.

I successfully use dioxidine in complex therapy with other drugs in the treatment of sinusitis. I did not find any side effects, I instill half a pipette into each nostril of a 1% solution 3 times a day. I apply after vasoconstrictors and washing with Dolphin. I wish everyone good health!!

All materials are for informational purposes only.

Please consult your doctor before using the information you have received.

Questions and suggestions:

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Dioxidin - instructions for use, composition, indications, analogues and reviews

Dioxidine belongs to the group of antibacterial drugs that are obtained synthetically. The negative effect of the drug Dioxidin is explained by the negative effect of hydroxymethylquinoxaline dioxide on bacterial cells, which ends in their death.

Composition and form of release

The manufacturer produces the drug in the form of several dosage forms:

• 1% solution for intracavitary and external use.
• 0.5% solution for the same purposes.
• Ointment Dioxidin 5%.

The composition of the medicine in the form of an ointment

1 gram of ointment contains 50 mg main active ingredient, and also as complementary substances contain:

• Polyethylene oxide 400.
• Polyethylene oxide 1500.
• Nipagin.
• Propyl ester of paraoxybenzoic acid.

The composition of Dioxidine in the form of a solution

The solution for use is available in 10 ml ampoules, 10 ampoules are packed in a box. The ointment is packaged in tubes of programs.

The composition of 1 ml of solution for external or internal use includes main active ingredient: hydroxymethylquinoxaline dioxide in the amount of 10 mg, as well as water for injection - 1 ml. If the drug is 0.5%, then active ingredient contains two times less, that is, 5 mg.

Dioxidine instructions for use in various dosage forms

Scheme for the use of Dioxidin in solution

With intravenous administration, Dioxidin should be administered by drip. Before this, Dioxidin must be diluted with 5% dissolved dextrose or 0.9% sodium chloride to obtain a concentration of 0.1%. The introduction of no more than 0.6 grams per day is allowed, and for one injection - 0.3 grams. If the drug is used externally, then plug deep wounds or irrigate the damaged area with a 1% solution.

The cavity administration of the drug allows the use of 20 to 100 ml of a 0.5% solution of the drug. Treatment of deep purulent wounds, for example, in osteomyelitis, involves the use of a 1% Dioxidin solution in the form of baths. Therapy of superficial infected purulent wounds allows you to apply a napkin moistened with a 1% solution of the drug to the affected area. Such a procedure must be performed every day or every other day, this is determined by the doctor, taking into account the condition of the wound and the patient. 2.5 grams of the drug can be used per day. Treatment can last up to 21 days.

Patients suffering from osteomyelitis can be treated for up to 1.5-2 months if the drug is well tolerated. With intracavitary therapy, from 10 to 50 ml of a 1% solution of the drug Dioxidin is administered daily orally once, in some cases the daily rate is allowed to be divided into 2 injections. According to the instructions, the course of therapy lasts 3 weeks, if necessary, then after 1-1.5 it can be repeated.

The use of Dioxidine for the treatment of ear diseases

Most often, when a diagnosis is made - otitis, the doctor prescribes antibiotics and vasoconstrictor drugs. But they are not always effective, so in this case, Dioxidin comes to the rescue, which has proven its effectiveness against anaerobic bacteria.

Scheme for the use of Dioxidin in the treatment of ear pathologies

Before instilling Dioxidin into the ear canal, it is necessary to free it from accumulated sulfur with 3% hydrogen peroxide. If there is purulent otitis media, then before using the remedy, all accumulated purulent discharge must be removed from the passage. With otitis media, Dioxidin should be administered simultaneously into the ear and nose. The solution sanitizes the nasal cavity well and relieves the inflammatory process, and since the nasal cavity is connected with the inner ear, this procedure has a positive effect on the entire treatment process.

The dosage and scheme of application is selected in each case, taking into account individual characteristics, age and severity of the disease.

The use of Dioxidin in the treatment of rhinitis

The need to use a solution of Dioxidine for instillation into the nose most often appears in some forms of rhinitis or sinusitis. If the patient is an adult, Dioxidine must be diluted with a solution of sodium chloride, hydrocortisone or water for injection before instillation. The dose for an adult is from 2 drops to the third part of the pipette. The procedure is carried out 3-5 times a day. The exact dosage and frequency of administration is determined by the doctor.

Therapy should last no more than a week, if during this time there is no improvement, then you will have to undergo an additional examination.

The use of Dioxidin in the form of an ointment

Scheme for the use of Dioxidin in the form of an ointment

The ointment is usually applied to damaged areas of the skin. It is necessary to apply so that the drug layer is thin. Enough once a day. The course of therapy is usually about three weeks.

Indications, contraindications and side effects of Dioxidin

Given the pharmacokinetics of the drug, Dioxidin has a fairly large list of indications.

Indications for the use of Dioxidin

• septic conditions.
• Purulent-inflammatory lesions of the brain.
• Purulent pleurisy.
• Peritonitis.
• Cystitis.
• Acute purulent inflammation of the gallbladder.
• To prevent the development of infections after catheterization of the bladder.
• For the treatment of burns and trophic ulcers.
• Soft tissue abscesses.
• postoperative wounds.
• Purulent mastitis.
• Infectious lesions provoked by the activity of streptococci or staphylococci.

The dosage and treatment regimen for any disease is prescribed by the doctor in accordance with the instructions.

Contraindications for the use of the drug Dioxidin

• If there is hypersensitivity to the components of the drug.
• In the presence of adrenal insufficiency, even in history.
• During pregnancy.
• Contraindicated in women during breastfeeding.
• For the treatment of children.
• Great care must be taken when prescribing the drug to patients with renal insufficiency.

Side effects when using

If the drug is prescribed without taking into account contraindications or the individual characteristics of the patient are not taken into account, then the following side effects are possible.

Side effects on the use of the drug:

• With intracavitary administration, a headache is possible.
• Chills.
• Nausea, vomiting and indigestion.
• Slight increase in body temperature.
• Convulsive twitching of the muscles.
• The appearance of pigmented spots on the body under the influence of ultraviolet rays.
• allergic manifestations.
• With topical use, dermatitis, itching is possible.

When the first adverse reactions appear, it is imperative to inform the doctor in order to adjust the dose or cancel the drug.

Therapeutic effect of Dioxidine

The use of the agent is quite active against the following microorganisms:

• Friedlander sticks.
• Pseudomonas aeruginosa.
• The causative agents of bacillary dysentery.
• Salmonella.
• coli.
• Staphylococcus.
• Streptococcus.

The use of the drug differs from other similar drugs in that it destroys even those microorganisms that are not susceptible to the effects of strong antibacterial agents. If the drug is used to treat wounds after burns, purulent-necrotic wounds, then the healing process will go much faster. Numerous experimental studies have established that Dioxidine has:

The drug penetrates well into all cells and organs, with prolonged use does not accumulate in the body.

Interaction of Dioxidin with other drugs

This drug has not been found to have a negative combination with other drugs. The only clarification is that for patients who are hypersensitive to hydroxymethylquinoxaline dioxide, Dioxidine is prescribed in combination with antihistamines or calcium preparations.

The use of Dioxidine for the treatment of children

In pediatric practice, it is not customary to prescribe Dioxidin for the treatment of children under 18 years of age. This is due to the toxic effect of the main active ingredient of the drug. But there are cases when the benefits of the use outweigh all the risks, in this situation the doctor turns a blind eye to such a restriction. It is only necessary to take into account that the therapy of children in case of urgent need with Dioxidine should be carried out in a hospital under the supervision of a doctor.

In children, the remedy is most often used to fight ENT diseases, such as purulent rhinitis or sinusitis. It is advisable to use a 0.5% Dioxidine solution. The solution and ointment can also be used to treat wounds, esp. If the damage is deep enough. Dioxidine therapy should not be carried out for a long time in children. As you improve, you can switch to the use of a 0.1% solution, followed by its cancellation.

The use of Dioxidin during pregnancy

If you study the pharmacological properties of the drug, it becomes clear that it is strictly forbidden to use it during the period of bearing a child. The drug can provoke violations of embryogenesis and adversely affect the formation of the fetal nervous system.

You can not use Dioxidin during breastfeeding, as it is able to penetrate into breast milk, and then into the baby's body.

Special instructions for the use of Dioxidine

Doctors prescribe Dioxidin therapy most often when other antimicrobials do not have the desired effect. For patients with chronic renal insufficiency, the dosage should be carefully calculated. To prevent allergic reactions, therapy is combined with taking antihistamines. If side effects occur during treatment, the dose should be reduced. In serious situations, some side effects are a signal to stop the drug.

If age spots appear on the skin, then the dosage of the agent should be reduced, and the duration of administration should be increased. Also add the intake of antiallergic drugs. During storage of Dioxidin ampoules with a solution at a temperature below 15 degrees, crystals may appear in them. In this case, the ampoules must be heated in a water bath until they are completely dissolved. Dioxidine solution for use must be completely transparent.

The drug affects the attention and concentration of a person. Therefore, during treatment, it is worth refraining from driving a car, performing dangerous and requiring high concentration, types of work.

Dioxidine analogues include the following drugs:

• Galenophyllipt.
• The analogue of the remedy is Zyvox.
• Kirin.
• Kubitsin.
• Monural.
• Nitroxoline.
• An analogue of Dioxidine is Urofosfabol.
• Fosfomycin.
• Zenix.
• Amizolid.
• Analog means - Dioksikol.
• quinoxidine and others.

If you decide to replace the original with an analogue, then this issue should be discussed with your doctor.

The price of the drug in pharmacies

Check out the price of Dioxidin in 2018 and cheap analogues >>> The cost of Dioxidin in different pharmacies can vary significantly. This is due to the use of cheaper components in the drug, and the pricing policy of the pharmacy chain. But the important thing is that the difference in price between foreign and Russian counterparts remains virtually unchanged.

On the MedMoon.ru website, drugs are classified both alphabetically and by their effect on the body. We publish only the most relevant and new medicines. Instructions for use Dioxidin is regularly updated at the request of manufacturers.

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DIOXIDINE analogues

We kindly ask you not to make a decision to replace DIOXIDIN on your own, only on the instructions and with the permission of a doctor.

(6 offers from 190 to 212 UAH)

Price update date: 16 hours 58 minutes ago

ALGOFIN-FORTE

GIVALEX

TIBERAL

SEBIDIN

VIJAYSAR

PROALOR

ACNESTOP

TSIPROLET

respiratory infections: exacerbation of chronic bronchitis, pneumonia, bronchopneumonia, lung abscess, empyema, infectious pleurisy, infected bronchiectasis, pulmonary infections in patients with fibrocystic changes in the lungs;

Infections of the genitourinary system: prostatitis, chronic and acute pyelonephritis, cystitis, epididymitis;

ENT infections: otitis media, sinusitis, mastoiditis;

Gynecological infections: adnexitis, salpingitis, oophoritis, endometritis, pelvic abscess, pelvioperitonitis, infected ulcer;

gonorrhea, including rectal, urethral and pharyngeal localization of gonococcal lesions, including cases caused by resistant gonococci;

infections of the abdominal organs: cholecystitis, peritonitis, intra-abdominal abscesses, cholangitis, gallbladder empyema;

Infections of joints and bones: purulent arthritis, chronic and acute osteomyelitis;

Infectious diseases of the gastrointestinal tract: typhoid fever, bacterial diarrhea;

common severe infectious diseases: bacteremia, septicemia and infections in immunocompromised patients;

Infections of soft tissues and skin: infected wound, cellulitis, burns, abscess.

AMOXIL-K

Infections of ENT organs, incl. recurrent tonsillitis, sinusitis, otitis media.

Infections of the lower respiratory tract, incl. exacerbation of chronic bronchitis, lobar and bronchopneumonia.

Infections of the urinary system, incl. cystitis, urethritis, pyelonephritis, female genital infections and gonorrhea.

Skin and soft tissue infections.

Osteoarticular infections, incl. osteomyelitis.

Other infections, incl. intra-abdominal sepsis.

Prevention of infectious complications during surgical interventions, in most cases during surgical interventions on the gastrointestinal tract, pelvic organs, head and neck, heart, kidneys, joint replacement and bile duct surgery.

Infections caused by amoxicillin-sensitive microorganisms are effectively treated with Amoxil - K, given the content of amoxicillin in it. Mixed infections that are caused by amoxicillin-insensitive microorganisms in combination with amoxicillin-sensitive microorganisms - beta-lactamase producers - can be treated with Amoxil - K.

CLAVAM

inflammation of the sinus sinuses of the bacterial nature of an acute course,

acute inflammation of the middle ear,

chronic bronchitis in the acute stage,

community-acquired form of pneumonia,

cystitis of bacterial etiology of various forms of severity,

infectious and inflammatory disease of the renal pelvis (pyelonephritis),

infectious pathologies of the skin and soft tissues, such as cellulitis, animal bites, severe dentoalveolar abscesses with widespread cellulitis,

infectious lesions of the musculoskeletal system (for example, osteomyelitis).

erythromycin

LOSTERIN

ZINERIT

ORNIDAZOL

DIFFERIN

TRINEFRON

Chronic non-communicable diseases of the kidneys (glomerulonephritis, interstitial nephritis).

Prevention of the formation of urinary stones, including after their removal.

BAZIRON AS

OFLOKSIN

Infections that are sensitive to ofloxacin:

Diseases of the lower respiratory tract;

Infectious and inflammatory lesions of the ENT organs (except for tonsillitis);

Infections of bones, joints and soft tissues;

Infectious diseases of the abdominal cavity, small pelvis and kidneys;

Prostatitis, gonorrhea, chlamydia;

Respiratory infections on the background of tuberculosis, pulmonary fibrosis;

Concomitant infections with AIDS;

Shigellosis and salmonellosis.

TRIMISTINE

The drug can also be prescribed to patients with discoid lupus erythematosus and skin lymphoma.

VIFERON

GATIFLOXACIN

Treatment of infectious and inflammatory processes caused by microorganisms sensitive to the drug, such as: - respiratory tract infections (including acute bronchitis, exacerbation of chronic bronchitis, acute sinusitis, community-acquired pneumonia);

- infections of the kidneys and urinary system (including complicated urinary tract infections, acute pyelonephritis, uncomplicated urinary tract infections (cystitis);

- uncomplicated infections of the skin and soft tissues;

- uncomplicated urethral gonorrhea in men;

- endocervical and rectal gonorrhea in women.

CHLOROPHILLIN-03

Inside Chlorophyllin-03 is used to treat staphylococcal lesions of the digestive tract.

In the form of inhalations, Chlorophyllin-03 is used for bronchitis, pneumonia, lung abscesses.

Chlorophyllin-03 gives a pronounced effect when applied against antibiotic-resistant bacterial flora.

ORVAGIL

TRICHO-PIN

Protozoal infections: trichomoniasis, extraintestinal amoebiasis, including amoebic liver abscess, intestinal amoebiasis (amebic dysentery), giardiasis.

Anaerobic bacterial infections (gynecological, including bacterial vaginosis, as well as abdominal infections, infections of the central nervous system, bacteremia, sepsis, endocarditis, bone, joint, skin and soft tissue infections, periodontal infections, respiratory tract infections) caused by Bacteroides spp. , Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp. and other anaerobes sensitive to metronidazole (for adults and children).

Treatment of Helicobacter pylori infections in duodenal ulcers or stomach ulcers in combination with bismuth preparations and an antibiotic, such as amoxicillin.

Treatment of enterocolitis caused by Clostridium difficile.

Prophylactic appointment before surgery on the gastrointestinal tract and reproductive organs.

TRICHOBROL

Trichomonas vaginitis and urethritis in women, Trichomonas urethritis in men, giardiasis, amoebic dysentery; anaerobic infections caused by microorganisms sensitive to the drug.

Combination therapy for severe mixed aerobic anaerobic infections.

Prevention of anaerobic infection during surgical interventions (especially on the abdominal organs, urinary tract).

In combination with amoxicillin: chronic gastritis in the acute phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.