"Fenspiride": instructions for use, indications, side effects. Medicinal reference book geotar Fenspiride action

Fenspiride is a modern pharmacological agent, the use of which contributes to the removal. Has anti-inflammatory action. Refers to bronchodilators and is used in the treatment of bronchial asthma and inflammation of the respiratory tract.

Release form

The drug Fenspiride is available in film-coated tablets and as a syrup. Tablets are packaged in a carton of 30, 20 or 10 pieces. This medicine is sold in jars containing from 10 to 100 tablets (depending on the packaging format).

The syrup is available in plastic bottles containing 150 ml of medication. Instructions are attached to the medicine in any form.

The composition of the drug

One tablet contains 80 mg fenspiride hydrochloride. This is the active ingredient. The auxiliary components are:

• dihydrate calcium phosphate;
• hypromellose;
• povidone K25;
• colloidal silicon dioxide;
• magnesium stearate.

1 ml of syrup contains 2 mg of the active substance. Auxiliary components included in this release form:

• concentrated hydrochloric acid;
• methyl parahydroxybenzoate;
• glycerol;
• sugar;
• potassium sorbate;
• propyl parahydroxybenzoate;
• flavoring.

Mechanism of drug action

The drug Fenspiride reduces the production of biological substances that are actively involved in the development of inflammation and bronchospasm. The main property is associated with antagonism with bradykinin, serotonin, histamine (H-1 receptors). It blocks α-adrenergic receptors, which, when stimulated, provoke an increase in the secretion of bronchial glands. It has an antispasmodic papaverine-like effect.

The instructions for use indicate that Fenspiride does not have an antibacterial effect and cannot replace an antibiotic in cases where there are indications for its use.

Means Fenspiride is characterized by rather slow absorption when it enters the gastrointestinal tract. Only 6 hours after ingestion, the maximum concentration is reached. The half-life is 12 hours. About 90% of the substance is excreted through the kidneys, another 10% through the intestines.

Indications for the use of Fenspiride

The drug Fenspiride is prescribed for diseases indicated in the instructions:

• asthma;
• bronchitis (acute and chronic);
• tonsillitis;
• sinusitis (acute and chronic);
• pharyngitis, nasopharyngitis (chronic and acute);
• rhinitis;
• tracheitis;
• laryngitis.

This medicine is used as directed for respiratory symptoms caused by influenza, whooping cough or measles. It is a tool for maintenance therapy of complicated and isolated bronchial asthma.

Dosage of the drug

The drug Fenspiride is intended for oral use. The dosage depends on the dosage form and the age of the patient.

Before using the drug, consult your doctor

Fenspiride tablets are prescribed for adult patients. The standard dose is 1 tablet 2 times a day. This is indicated in the instructions. With a complex course of the disease, the doctor may prescribe a third daily intake to enhance the effect. The duration of the course is determined by the doctor, taking into account the type and degree of the disease.

Syrup

Fenspiride syrup is prescribed for both adults and children. Adults are recommended to take about 80 mg of the active substance. This dose corresponds to 50-90 mg of syrup.

When prescribing Fenspiride to children, the dosage is calculated according to the instructions depending on the weight of the child: per 1 kg of weight = 4 mg of syrup. Small children who weigh up to 10 kg are given 10–20 mg of liquid Fenspiride per day. It's 2, 3 or 4 teaspoons. The daily dose for older children is 30 to 60 mg syrup.

For convenience, dilution of the liquid agent in milk or juice is allowed. Toddlers add medicine to a bottle with a drink or baby food.

Application features

Fenspiride has an anti-bronchoconstrictor effect and does not replace antibiotics. If the disease requires antibiotic therapy, it must be started immediately.

To date, there is no reliable data confirming or denying the fact that the components of Fenspiride are excreted in breast milk. Therefore, this medicine is not recommended for lactating women.

In the course of an experimental study of this drug on animals, undesirable changes in the development of the fetus were revealed. The effect of Fenspiride on human intrauterine development has not yet been determined by research. This medicine is currently contraindicated for pregnant women.

Contraindications for use

Fenspiride tablets are contraindicated in children under 14 years of age. In any form, the drug is contraindicated in case of allergy to the main active substance. And also in the instructions it is written that the drug is forbidden to be used during pregnancy and lactation.

Side effects

As side effects when taking Fenspiride, nausea, indigestion, and vomiting sometimes occur. In special cases, the work of the cardiovascular system is disrupted, which provokes tachycardia. Some patients develop drowsiness or vice versa - nervous overexcitation. Allergic reactions are also possible. They can occur in the form of a rash, pigmentation, swelling of the face or extremities, erythema. Taking Fenspiride, in addition to other side effects, may be accompanied by fatigue and drowsiness.

When taking syrup, urticaria sometimes occurs as a side effect. The occurrence of negative side effects, regardless of whether they are indicated in the instructions for use or not, means that the drug should be stopped immediately. To select an analogue medicine, you should consult a doctor.

Interaction with other pharmaceuticals

Since Fenspiride has a sedative effect, it is better to cancel other drugs in this category when taking it. If this is not possible, the increased sedative effect of the drug group should be taken into account, and driving vehicles and other activities requiring increased concentration of attention should not be planned.

drug overdose

Overdose is accompanied by such phenomena as vomiting, sinus tachycardia, drowsiness or agitation. To eliminate the consequences of an overdose, gastric lavage and drug maintenance of vital body functions are necessary. ECG monitoring is carried out to control the patient's condition.

Drug analogues

Fenspiride itself, produced by various manufacturers, is sold under other names - Amispirone, Sinuspal, Bronchomax, Inspiron,. There are other drugs for relieving bronchial spasm and treating infections in the mucous membrane of the respiratory organs, the active ingredient in which is fenspiride.

A remedy with a bronchodilator effect that eliminates mucosal edema and inflammation. Produced in tablet form by a Russian manufacturer.

The instructions for use of this drug indicate that it is anti-inflammatory and bronchodilator. Suitable for relieving swelling and inflammation of the bronchial glands. It is an antihistamine drug with antispasmodic myotropic activity.

Prolonged action tablets. According to the instructions, the use of this remedy helps with inflammatory diseases of the respiratory tract and bronchial asthma in combination with other pharmaceuticals.

Bronchicum

If Fenspiride was not effective enough in eliminating the inflammatory disease, it can be replaced with a stronger one. This medicine costs more, but acts more actively. Produced in the form of pastilles. Manufacturer - Germany.

A well-known and proven drug for the treatment of inflammation of the respiratory tract. Available in tablets and as a syrup. It has an expectorant and mucolytic effect. The active substance is Ambroxol, produced in Russia.

Flavored syrup for the treatment of acute and chronic diseases of the respiratory organs. The instructions for use indicate that its use is allowed to relieve inflammation in young children.

This medicine is sold in the form of granules intended for suspension immediately before use. The cooking method is described in the instructions. Fluifort is indicated for the treatment of various diseases of the respiratory organs, accompanied by too much mucus secretion.

Tablets with mucolytic, expectorant and bronchodilator action. The instructions list such indications for use - bronchial asthma, tuberculosis, pneumoconiosis, whooping cough, pneumonia, bronchitis.

Formula: C15H20N2O2, chemical name: 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro-decan-2-one (as hydrochloride).
Pharmacological group: intermediates / histaminergics / histaminolytics / H1-antihistamines.
Pharmachologic effect: anti-asthma, bronchodilator, antihistamine, anti-inflammatory.

Pharmacological properties

Fenspiride blocks H1-histamine receptors and is an antagonist of inflammatory mediators (histamine, serotonin, bradykinin), has an antispasmodic papaverine-like effect. Fenspiride in high doses reduces the formation of pro-inflammatory agents (tumor necrosis factor alpha, cytokines, free radicals, arachidonic acid metabolites), some of which have a bronchoconstrictive effect. Fenspiride is well absorbed in the gastrointestinal tract, the maximum concentration is reached after 2.3 hours when taking syrup and 6 hours when taking tablets; the half-life of fenspiride is 12 hours. Excreted by the intestines (10%) and kidneys (90%). In experimental studies, the risk of manifestation of teratogenic effects (development of the "cleft palate") was found.

Indications

Rhinopharyngitis, rhinotracheobronchitis, laryngitis, sinusitis, otitis media, bronchospastic syndrome, chronic bronchitis with respiratory failure, bronchial asthma (supportive treatment), respiratory disorders in whooping cough, measles, influenza.

Method of application of fenspiride and dose

Fenspiride is taken orally. Adults, before meals: 2-3 times a day for 80 mg or 3 times a day for 45-90 ml of syrup. Children (only in the form of syrup) - weighing up to 10 kg - 10-20 ml per day (can be added to a bottle with food), weighing more than 10 kg - 30-60 ml daily, before meals.
Sunset Yellow S, which is used as a dye in the syrup, can cause allergic reactions, including bronchospasm (especially in people who are hypersensitive to aspirin).

Contraindications for use

Hypersensitivity, for tablets under 14 years of age.

Application restrictions

Breastfeeding, pregnancy.

Use during pregnancy and lactation

Taking fenspiride during pregnancy is possible if the expected effects of treatment are higher than the possible risk to the fetus. During lactation, the use of fenspiride is not recommended.

Side effects of fenspiride

Nervous system: agitation, drowsiness;
circulatory system: tachycardia (rarely);
digestive system: nausea, abdominal pain, dyspepsia, vomiting;
allergic reactions (very rare): Quincke's edema, erythema, rash, fixed erythema pigmentosa, urticaria (due to the presence of parahydroxybenzoate in the composition of the syrup).

Interaction of fenspiride with other substances

No data.

Overdose

With an overdose of fenspiride, agitation or drowsiness, sinus tachycardia, nausea, and vomiting appear. Necessary: ​​gastric lavage, ECG monitoring, maintenance of vital functions.

We have selected real reviews about the drug Fenspiride, which are published by our users. Most often, the review is written by the mothers of young patients, but they also describe a personal history of using the medication on themselves.

Indications for use

Rhinopharyngitis, laryngitis, otitis media, sinusitis, rhinotracheobronchitis, bronchitis, maintenance therapy of isolated and complicated bronchial asthma, respiratory symptoms in measles, whooping cough, influenza.

Discussion of the drug Fenspiride in the records of mothers

Also bronchoconstrictor activity. Pharmacokinetics After taking the tablets inside, Cmax is reached after 6 hours, after taking the syrup - after 2.3 ± 2.5 hours. T1 / 2 is 12 hours. 90% of fenspiride is excreted from the body by the kidneys, 10% through the intestines. laryngitis; - otitis and sinusitis; - rhinotracheobronchitis; - bronchitis; - maintenance therapy of isolated and complicated bronchial asthma; - respiratory phenomena with measles, whooping cough, influenza (for syrup). If necessary, daily d...

Children from 0 to 2 years (body weight up to 10 kg): 2 to 4 teaspoons of syrup per day (or 10 to 20 ml), can be added to a feeding bottle (1 teaspoon contains 10 mg fenspiride hydrochloride and 3 g sucrose).

Sano with 0. Dosage and administration. For adults, the drug is prescribed 80 mg (1 tab.) 2-3 times / day or 3-6 tablespoons (45-90 ml) of syrup per day. 1 tablespoon contains 30 mg of fenspiride hydrochloride and 9 g of sucrose. Erespal in the form of tablets is not intended for the treatment of children under 14 years of age. For the use of the drug in children under 14 years of age, Erespal is recommended in the form of a syrup. For children and adolescents under the age of 14 years, the drug is prescribed at the rate of 4 mg / kg of body weight / day. Children aged 0 to 2 years (body weight up to 10 kg) - 2-4 teaspoons of syrup (10-20 ml) / day, can be added to a feeding bottle (1 teaspoon contains 10 mg fenspiride hydrochloride and 3 g sucrose ...

I believe it! / when buying medicines, there are a couple of pharmacies where it’s definitely cheaper, but in order to save money, I don’t buy as, for example, you were prescribed Erespal, I’m looking for the active substance, in this case, fenspiride and, as a rule, the same but different pharmaceutical manufacturers differ in price at times! and they have the same manufacturing formula! it’s understandable, they have a percentage of this / but this was not allowed before, they wrote in la ...

Here is the instruction for children aged 0 to 2 years (body weight up to 10 kg) - 2-4 teaspoons of syrup (10-20 ml) / day, can be added to a feeding bottle (1 teaspoon contains 10 mg fenspiride hydrochloride and 3 g sucrose). Children aged 2 to 16 years (body weight over 10 kg) - 2-4 tablespoons of syrup (30-60 ml) / day.

...))) she prescribed him to us, but together with the same viferon, since the horse cannot replace him in any way. Then, in general, the doctor said that if it comes to that, then you can take a cheap analogue of erespal - fenspiride, it's the same, only it has age limits up to 14 years, so you should think about whether erespal is possible for small children.

a hoarse voice is laryngitis, I usually prescribe fenspiride (erespal) for laryngitis. If there is no temperature, then in principle you don’t need to bother much, drink more, especially chamomile tea works wonders. with regard to angina - if the temperature does not exceed 37, then this can be done ... But of course I'm not entirely supportive ...

Etam Piracetam syrup, tab. Cinnarizine Cinnarizine tab. Paracetamol Paracetamol syrup, tablets, suppositories Sorbents Diosmectide Smecta powder Antitussives and expectorants Fenspiride hydrochloride Erespal suspension Ambrogescal Ambroxal syrup Neuroprotectors Holantenic acid Pantogam, pantocalcin tab. Actovegin Actovegin 2.0 amp. Cerebrolysin Cerebrolysin 1.0 amp. Nose drops Oxymetazoline Nazol spray, drops Oxymetazoline Nazivin drops Vitamins Colecalciferol Vitamin Dz Bon Oral solution Thiamine bromide Vitamin B1 injection solution Pyridoxine g/chl Vitamin B6 injection solution Cyanocobalamin Vitamin B12 injection solution Eye drops and ma...

of antibiotics, we were prescribed amoxicillin suspension. Erespal can be taken with an antibiotic, an excerpt from the annotation "Special instructions: Treatment with fenspiride does not replace antibiotic therapy and cannot serve as a reason for postponing the adequate prescription of antibacterial drugs."

To be treated with normal medicines, even if they say "under the supervision of a doctor and if the benefit to the mother outweighs the harm to the fetus", and not folk remedies (for the future). Both fenspiride (erespal) and carbocysteine ​​(fluditec) are allowed, and antibiotics can be prescribed by a therapist if there is no result from mucolytics. Can you find out if the therapist is in the LCD? We have it. Try to avoid contact with a large number of people (public transport, shops), since immunity decreases during pregnancy - the amount of blood and fluid in the body increases dramatically, and therefore the cough becomes attached and it is more difficult to get rid of it than in ordinary life, and unfortunately the quality of the blood n...

Yeksin, etc. Release form: oral tablets, syrups, effervescent tablets, powders. Dosages depend on the age and weight of the patient. Separately, I would like to highlight the drug Erespal (fenspiride). It has both expectorant and anti-inflammatory effects. Available in tablet and syrup form. Treatment for at least 10 days. Can be assigned even...

Yes, it does not contain any antibiotic, have you even read the composition? The active substance is fenspiride hydrochloride, one of its effects on the mechanism of cough is the suppression of beta-adrenergic receptors (in this case, it reduces bronchial secretion, and therefore reduces the amount of sputum), but the stimulation of these receptors in medicine is much more important for cardiology, this is a whole group of drugs, for the development of which even the Nobel Prize was awarded in the eighties of the last century. So the whole "side effect" is due to this, the dose just needs to be adjusted. Help me...

The second time I consulted with a good Laura and were treated for a week, the third time in general in 4 days I recovered, as they quickly realized it. As for drugs: it is worth replacing Erespal with fenspiride (only in the form of syrup), if you weigh up to 10 kg, then 2–4 teaspoons of syrup (10–20 ml) per day. Protorgol for miramistin, suprastin for finestil in drops, viferon only in candles, and give lazolvan with pure syrup (inhalations are certainly effective, but the syrup itself has an excellent effect) ... Do not get sick ...

The instructions say about erespal: aged 0 to 2 years (body weight up to 10 kg) - 2-4 teaspoons of syrup (10-20 ml) / day, can be added to a bottle with food (1 teaspoon contains 10 mg fenspiride hydrochloride and 3 g of sucrose). Mtvgthfnehs no thank god. Just a cough!

Xin etc. Release form: oral tablets, syrups, effervescent tablets, powders. Dosages depend on the age and weight of the patient. Separately, I want to highlight the drug Erespal (fenspiride). It has both expectorant and anti-inflammatory effects. Available in tablet and syrup form. Treatment for at least 10 days. It can be prescribed even to children under 1 year old. The presence of shortness of breath in bronchitis is a direct indication for the use of bronchodilator drugs. They are available in tablets (eufillin, teopec, teotard) and inhalation forms (aerosol for inhalation: berodual, berotek, salbutamol). It is possible to use combined drugs for the treatment of bronchitis.

• fenspiride

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Release form:

Release form, description and composition

Film-coated tablets light yellow, round, biconvex; on a cross section - a kernel of white or almost white color.

Excipients: calcium hydrophosphate dihydrate - 104.5 mg, hypromellose - 100 mg, crospovidone - 12.8 mg, colloidal silicon dioxide - 0.5 mg, magnesium stearate - 2.2 mg.

Shell composition: Opadry II yellow 85F32771 (polyvinyl alcohol 35 - 49%, talc - 9.8 - 25%, macrogol 3350 7.35 - 35.2%, titanium dioxide and iron oxide yellow - 15.15 - 30%)

10 pieces. - cellular contour packings (3) - packs of cardboard.
15 pcs. - cellular contour packings (2) - packs of cardboard.
30 pcs. - polyethylene terephthalate bottles (1) - cardboard packs.

Pharmacotherapeutic group:

• intermediates

Pharmacological properties:

Pharmacodynamics

Means with bronchodilator and anti-inflammatory action. Reduces manifestations of bronchospasm and inflammation in the airways. The mechanism of action is associated with antagonistic activity against histamine H 1 receptors and with myotropic antispasmodic activity. Reduces the production of a number of biologically active substances involved in the development of inflammation and contributing to an increase in bronchial tone (including cytokines, TNFα, arachidonic acid derivatives, free radicals).

Pharmacokinetics

Well absorbed from the gastrointestinal tract. Cmax is achieved 6 hours after administration and after 12 hours it decreases by 3 times. It is excreted mainly by the kidneys (90%), through the intestines - 10%. T 1/2 - 12 hours

Indications for use:

Rhinopharyngitis, laryngitis, otitis media, sinusitis, rhinotracheobronchitis, bronchitis, maintenance therapy of isolated and complicated bronchial asthma, respiratory symptoms in measles, whooping cough, influenza.

Regarding diseases:

• Bronchitis
• Flu
• Whooping cough
• Laryngitis
• Otitis
• Sinusitis

Contraindications:

Hypersensitivity to fenspiride, pregnancy, lactation, children under 18 years of age (for tablets), children under 2 years of age (for syrup).