Content

The liver is a unique organ that performs a protective function, cleanses the blood of toxins, toxins and other chemical elements that are harmful to the human body. At the same time, it is capable of self-healing, but sometimes, for various reasons, its own protective potential is not enough for it. Then modern pharmacology suggests using hepatoprotectors. Take these medicines according to the instructions and only on the advice of a doctor.

What are Liver Recovery Pills

Hepatoprotectors are an extensive class of medications that have a stimulating effect on liver cells, help restore its structure and functionality. These drugs are available in the form of tablets, pills or dragees. They help maintain the integrity of hepatocytes, improve the excretion of harmful substances, improve the outflow of bile and restore the absorption of vitamins by the body.

Groups

There are a lot of different hepatoprotectors today. Each of these drugs is generally responsible for one function - restoring the organ's performance and minimizing the damage caused to it, but in fact they can differ somewhat from each other. According to the active active substance, all preparations for liver restoration can conditionally be divided into several classes:

• Phospholipids are substances obtained by special processing of soybeans. Their action is to improve the state of cell walls at the lipid level, increase enzymatic activity, and increase the likelihood of a response to α-interferon. Phospholipid-based liver recovery pills include: Essentiale N, Essentiale Forte N, Essliver Forte, Phosfonciale, Gepagard, Phosphogliv, Rezalyut.
• Derivatives of amino acids. The active components of the preparations are involved in the production of phospholipids and the processes of assimilation of biologically active substances, reduce the level of ammonia, start the processes of self-healing of gland cells and purification. Medications with amino acids: Hepa-Merz (Ornithine aspartate), Heptral, Heptor.
• Medicines of animal origin. The composition includes hydrolyzed pork liver. Known medicines: Sirepar, Progepar, Hepatosan.
• Medicines with the addition of medicinal plants. They are used for organ damage by toxins, poisons or medicines, for cholecystitis, hepatitis, cholelithiasis and for preventive purposes. These include products based on milk thistle (Legalon, Karsil, Gepabene, Silimar), artichoke (Tsinariks, Hofitol), pumpkin seed oil (Tykveol, Peponen), elecampane or burdock root, volodushka herb, agrimony, corn stigmas.
• Homeopathic remedies. Drugs help eliminate numerous symptoms, improve the functionality of the organ, and are used to cleanse it. Best pills: Hepel, Galstena, May celandine and milk thistle.
• dietary supplements. Biologically active food supplements help to better absorb vitamins, cleanse the liver, and restore its structure. Popular supplements: Hepatamine, Hepatotransit, Artichoke extract, Hepatotransit, Milona 10, Ovesol, Dipana, Hepatrin.
• Bile acids. Medicines have a hypoglycemic and choleretic effect, lower cholesterol levels, increase the secretion of gastric juice, and affect immunological reactions. Popular tablets: Ursosan, Urdox, Livodex, Ursodez, Ursofalk, Ursoliv.

Indications for use

It is possible to be treated with hepatoprotectors only after consulting a doctor. They are prescribed for the following diagnoses:

• Alcoholic hepatitis, which increases the risk of developing cirrhosis. To achieve success with drug treatment, it is necessary that the patient completely refuses to drink alcohol.
• Fatty hepatitis - provided that it is not a consequence of alcoholism - the growth of fat cells. Often people with type 2 diabetes or obesity suffer from this disease.
• Hepatitis of viral etiology - primary treatment is carried out with antiviral drugs. Hepatoprotectors are prescribed only when the first course of therapy has not brought the desired result.
• Toxic hepatitis or primary biliary cirrhosis - hepatoprotectors are prescribed as the basis for the complex treatment of the disease and subject to diet.

Hepatoprotectors for the liver

In addition to restoring the cell walls of an organ, good hepatoprotectors should regulate intracellular metabolism, stimulate the outflow of bile, remove toxins and toxins, prevent further spread of infection, and stop the inflammatory process. To achieve good results, you must follow a diet, give up bad habits, and lead an active lifestyle. The following medicines have proven themselves well: Heptral, Essentiale, Liv 52, Osalmid and some others.

FanDetox

A biologically active supplement for the restoration of the liver gland is produced by the Korean company Coral Club in the form of a powder in individual foil bags weighing 4.5 grams each. The product contains only natural ingredients:

• glucose;
• persimmon fruit extract;
• extract of Chinese wolfberry;
• soy sprouts;
• Japanese mandarin peel extract;
• buckwheat seeds;
• taurine;
• citric acid;
• stevia glycoside;
• ascorbic acid.

FanDetox is prescribed to protect the body from the pathological effects of alcohol, drugs, and poor-quality food on it. Before taking the contents of the sachet must be dissolved with half a glass of warm water. The drink is drunk 2 times a day after meals for a month. No side effects were recorded during the treatment, but FanDetox is categorically contraindicated:

• during lactation;
• patients with bowel disorders;
• during pregnancy;
• with individual intolerance to the components;
• with disorders of carbohydrate metabolism.

Tablets for the restoration of hepatic function are available in cardboard boxes of 20 pieces. The drug has hepatoprotective, detoxifying, neuroprotective properties, pronounced antidepressant activity, activates the regenerating functions of the hepatic gland. Heptral contains:

• ademetionine (the main active ingredient);
• talc;
• magnesium stearate;
• polysorbate;
• silica;
• sodium glycolate;
• simethicone;
• purified water.

Heptral is prescribed by physicians after the diagnosis and the following diagnoses:

• intrahepatic cholestasis against the background of fatty degradation, alcoholic hepatosis, viral or drug-induced hepatitis, toxic or drug-induced liver damage;
• chronic hepatitis of various origins;
• fibrosis;
• cirrhosis;
• severe intoxication with drugs, alcohol, food;
• depression.

Heptral must be taken in the morning. The daily dosage is 800-1600 mg, the course of treatment is determined individually. The drug should be abandoned for genetic metabolic disorders, patients under 18 years of age, people with bipolar disorder. While taking Heptral, undesirable effects may occur:

• within the nervous system - dizziness, migraine, paresthesia, insomnia. confusion;
• cardiovascular system - phlebitis of superficial veins, heart rhythm disturbance, hot flashes;
• digestion - bloating, dry mouth, diarrhea, dyspepsia, flatulence, colic, gastrointestinal bleeding, nausea with vomiting;
• musculoskeletal system - muscle spasms, arthralgia;
• others - swelling of the larynx, allergies, fever, flu-like symptoms, sweating, urinary tract infections.

Essentiale forte

These are brown capsules. The active component of Essentiale forte - essential phospholipids - starts regeneration processes, normalizes metabolism and stops the replacement of healthy hepatocytes with connective tissue. Auxiliary components are:

• gelatin;
• purified water;
• ethanol 96%;
• α-tocopherol;
• castor oil;
• soybean oil;
• titanium dioxide;
• sodium lauryl sulfate.

Tablets are prescribed for recovery from toxicosis in pregnant women, chronic hepatitis, fatty liver degradation, cirrhosis, as an adjuvant therapy for psoriasis, and radiation syndrome. Essentiale forte should be taken with meals 2 capsules 2-3 times a day. The duration of treatment is 3 months, if necessary, can be repeated. Essentiale is well tolerated by the body, only occasionally causing stool upset. Essentiale has no serious contraindications.

Liv 52

This is a combined medicine to restore the functionality of the hepatic gland. The composition of Liv 52 consists entirely of vegetable raw materials:

• caper powder and common chicory;
• iron oxide;
• black nightshade;
• terminalia arjuna;
• cassia western;
• common yarrow;
• Gallic tamarix;
• eclipta white;
• medicinal fumes;
• Ceylon pig;
• medicinal emblic;
• seed radish.

Liv 52 has antitoxic, choleretic, anti-inflammatory, hepatoprotective effects. The components of the composition restore intracellular processes and protein synthesis. Due to such positive properties, a homeopathic remedy is prescribed for:

• different types of hepatitis (drug, toxic, viral);
• cholecystitis;
• fatty hepatosis;
• violations of the outflow of bile;
• fibrosis;
• biliary dyskinesia;
• cholangitis;
• for the prevention of alcohol abuse.

Liv 52 is available without a prescription. Adults need to take 2-3 tablets up to three times a day, children - 1 tablet 2-3 times a day. The duration of drug therapy is determined by the doctor. The drug is well tolerated by patients, only sometimes causing allergic reactions or dyspepsia. Liv 52 is prescribed with caution to patients with acute inflammation of the gastrointestinal tract (gastrointestinal tract).

The drug to restore the functionality of the liver is produced in capsules of 30 pieces or dragees of 80-180 pieces. The active component of the capsules is a dry extract of milk thistle fruits, dragees - silymarin. The pharmacodynamics and pharmacokinetics of the drug have not been fully studied, but it is known that the drug has a membrane-stabilizing effect and an antioxidant effect, and is able to improve blood microcirculation.

Karsil is used to prevent liver damage with prolonged use of alcohol or drugs. As part of complex therapy, capsules are prescribed for:

• chronic hepatitis of non-viral nature;
• cirrhosis;
• steatosis of alcoholic or non-alcoholic etiology;
• recovery of the body after acute hepatitis;
• toxic cell damage.

Karsil rarely causes adverse reactions. Contraindicated in case of hypersensitivity to components from the composition, lactase deficiency, celiac disease. The dosage depends on the form of release:

• capsules - for severe lesions, take 1 piece 3 times a day, for pathologies of moderate severity - 2 times a day;
• dragee - 1 or 2 pieces 3 times a day;
• the duration of drug treatment is 90 days.

Ovesol

The drug is one of the natural dietary supplements. Ovesol contains natural components that have anti-inflammatory, detoxifying, restorative effects - this is an extract of sowing oats, turmeric, immortelle flowers, peppermint. Bioadditive carefully "washes" the liver, reduces stagnation of bile, reduces the chance of cholelithiasis.

Tablets can cause allergies, are contraindicated in people with hypersensitivity to one or more components. With caution, Ovesol is prescribed to patients with bending of the gallbladder or cholelithiasis. According to the instructions, it is necessary to take dietary supplements for 20 days twice a day, 1 tablet. The course must be repeated 3-4 times a year.

Phosphogliv

This combined medicine is able to stabilize the membranes of liver cells, protect the organ from negative effects, and relieve inflammation. Phosphogliv is available in the form of gelatin capsules of 50 pieces with several active ingredients - phospholipids and sodium glycyrrhizinate. Auxiliary substances are:

• microcrystalline cellulose;
• sodium carbonate;
• calcium stearate;
• talc;
• silica;
• aerosil;
• titanium dioxide.

Capsules are taken orally during meals, without chewing. Recommended dosage - 2 pcs. three times a day. The duration of rehabilitation therapy can be up to 6 months. Phosphogliv often provokes allergic reactions, rarely causes hypertension, swelling of soft tissues. From the use of tablets to restore the liver must be abandoned:

• people with hypersensitivity to the composition;
• pregnant women;
• nursing mothers;
• patients with antiphospholipid syndrome;
• children under 12 years of age.

Gepabene

Combined agents restore bile secretion, relieve spasm of the gallbladder, and have hepatoprotective properties. One capsule contains many active ingredients - dry extract of fume, protopin, milk thistle fruit, silymarin. Excipients:

• magnesium stearate;
• microcrystalline cellulose;
• silica;
• corn starch;
• macrogol;
• gelatin;
• povidone.

The drug should be taken orally during meals. To restore the functionality of the hepatic gland, doctors prescribe 1 capsule 3 times a day. Duration is selected individually. Gepabene can rarely provoke an allergic reaction or cause a laxative effect. It is contraindicated:

• adolescents who have not reached the age of majority;
• patients with active forms of biliary tract diseases;
• with increased sensitivity of the patient to the composition of the drug.

The drug is produced in the form of capsules with the active ingredient - ursodeoxycholic acid. Ursofalk reduces the tendency to form stones in the bile ducts, helps to dissolve cholesterol plaques. The auxiliary components are:

• magnesium stearate;
• colloidal silicon dioxide;
• corn starch;
• gelatin;
• titanium dioxide;
• completed.

Ursofalk must be taken at bedtime in accordance with weight: 2 capsules for patients weighing up to 60 kg, 3 for patients weighing up to 80 kg, 4 pieces for patients weighing up to 100 kg. The duration of therapy is 6-12 months. Ursofalk is not recommended by the manufacturer for patients with acute inflammatory diseases of the gallbladder, blockage of the ducts. Ursofalk is able to provoke the appearance of:

• nausea;
• pain in the abdomen or right hypochondrium;
• diarrhea;
• increased activity of hepatic transaminases;
• allergic reactions.

Galstena

A homeopathic remedy with a mild hepatoprotective, antispasmodic, anti-inflammatory and choleretic effect is available in the form of tablets. The main active ingredients are extracts of milk thistle, medicinal dandelion, large celandine, phosphorus, sodium sulfate. Galstena is prescribed to restore the organ, with diseases of the gallbladder or pancreas.

Galstena can rarely provoke the appearance of increased salivation. The drug is not prescribed for alcohol dependence, hypersensitivity to the components. The drug is taken half an hour or an hour before meals in dosages depending on the diagnosis and age of the patient:

• With hepatitis, hepatosis or pancreatitis: children under 12 years of age are prescribed ½, adults - 1 tablet. The duration of therapy before recovery is 3 months, the frequency of use is 3 times / day.
• In chronic cholecystitis, cholelithiasis: children - ½ tab., adults - 1 tablet. The frequency of admission is 3 times / day, the duration of therapy is 1 month.

Hofitol

The choleretic agent has the ability to increase diuresis, has a pronounced hepatoprotective effect, reduces blood azotemia, and intensively removes urea. Hofitol refers to homeopathic remedies. It contains only one active ingredient - an extract of fresh leaves of the field artichoke. Hofitol is available in the form of tablets of 60 pieces per pack.

Adults are prescribed 2-3 tablets. 3 times a day before meals, children from 6 years old - 1-2 tab. The course of drug therapy is 3 months. Hofitol is well tolerated by patients, but can rarely cause minor allergic reactions or diarrhea. From taking pills to restore the liver will have to be abandoned when:

• acute diseases of the biliary or urinary tract;
• the presence of kidney stones;
• obstruction of the bile ducts.

tsikvalon

It is a synthetic drug developed on the basis of a single active ingredient - tsikvalon. The medicine is produced in the form of tablets for liver restoration with anti-inflammatory properties. Tsikvalon:

1. stimulates the secretion of bile;
2. reduces the severity of inflammatory processes;
3. relieves pain in diseases of the gallbladder;
4. prevents bloating;
5. eliminates fermentation in the intestines, normalizes stool.

Tsikvalon is prescribed for cholecystitis, cholangitis, cholelithiasis in dosages per gram 3-4 times a day. The course of treatment is 3-4 weeks (if necessary, it can be repeated in a month). Tsikvalon is contraindicated in case of blockage of the bile ducts. Tablets are well tolerated by patients and only occasionally can provoke a feeling of heaviness or a bitter taste in the mouth.

The phospholipid preparation has hepatoprotective properties, stabilizes cell membranes, activates tissue regeneration processes, inhibits collagen synthesis, and reduces cholesterol levels. The composition of tablets for liver restoration Rezalut Pro:

• phospholipids from soy lecithin;
• glycerol mono- or dialconate;
• soybean oil;
• α-tocopherol;
• gelatin.

Tablets should be taken 2 pieces 3 times a day before meals. The terms of rehabilitation therapy are selected for each patient individually. Rezalut pro is not prescribed to patients with antiphospholipid syndrome. With prolonged use, the drug provokes side effects from the systems:

• digestion - diarrhea, nausea, stomach discomfort;
• hematopoiesis - violation of the menstrual cycle in women, petechial rash;
• allergic reactions - urticaria.

Osalmid

The choleretic agent stimulates the formation and outflow of bile, has analgesic and anti-inflammatory properties, and normalizes the level of bilirubin. Osalmid is available in white or almost white powder, soluble in water. Take the drug inside 250-500 mg 3 times a day for up to 20 days. Osalmid can very rarely provoke diarrhea or allergies. Reception of the powder is contraindicated in:

• hypersensitivity;
• acute inflammation of the liver gland;
• dystrophic processes of soft tissues.

How to choose liver recovery pills

The list of hepatoprotectors offered by pharmaceutical companies is very wide, so it is often difficult for a patient to choose the best medicine. The fundamental factors are often the reviews of other patients, the price of the medicine, the proven effectiveness, but for liver diseases it is important to follow only one rule - the choice of medications should be made only by a doctor. Otherwise, the situation may worsen.

After alcohol

Drug treatment after severe alcohol intoxication is possible only after the patient completely refuses further use of alcoholic beverages. Homeopathic medicines, herbal remedies based on milk thistle, burdock root, and elecampane are considered the safest pharmaceutical products. They have a minimum of side effects and are used as a food supplement. Gepabene, Heptral, restorative Dipana, HepatoTransit, Tykveol have cleansing properties.

Hepatoprotectors for children

The list of drugs that are allowed for a child is not very large. Treatment of liver diseases in childhood must necessarily take place under the supervision of an experienced pediatrician or attending physician. Appointments:

1. From the age of one year it is allowed to use Galstena, Hepel.
2. Children who have reached the age of three may be prescribed Essentiale Forte, Antral.
3. After five years, Karsil, Gepabene, Ursosan are allowed.

With cirrhosis of the liver

Hepatotropic drugs will not allow the liver to collapse, restore its functionality as much as possible, and prevent the replacement of healthy cells with fibrous tissue in cirrhosis. At the initial stage of the disease, patients are prescribed a special diet and taking vitamin complexes. If the disease has entered the active phase, the treatment is supplemented with essential phospholipids, herbal medicines with milk thistle or artichoke - these are Karsil, Lipolyic acid, Phosphogliv.

With hepatitis

Hepatoprotectors are often prescribed as adjuvant therapy for hepatitis, but the main treatment is carried out with special antiviral agents. Preparations for the liver help restore its functionality, protect against the damaging effects of exogenous or endogenous factors, and accelerate the regeneration of its cells. Hepatitis is often prescribed:

• Ursoliv;
• Hofitol;
• Gepabene;
• Essentiale.

From fatty liver

Treatment of fatty hepatosis necessarily includes dieting, taking vitamin complexes and drugs with an antifibrotic effect:

• drugs with flavonoids - milk thistle tablets, Karsil, Silibor, Gepabene, Liv 52;
• hepatoprotectors with active ingredients of animal origin - Sirepar, Hepatostan;
• drugs with phospholipids - Essentiale, Essliver;
• preparations based on urodeoxycholic acid - Ursohol.

Hepatoprotectors while taking antibiotics

To prevent drug intoxication, drugs are prescribed to restore hepatic functionality with a minimum of contraindications and side effects. These are inexpensive hepatoprotectors with a strong cleansing function - Liv 52, Ovesol, Gepabene, Essentiale. To enhance the effect of these drugs, the doctor may prescribe Allochol, Essliver, HeptraLight.

Price

Most hepatoprotectors are available without a doctor's prescription. They can be bought at any pharmacy or ordered through an online store. The cost of the medicine will depend on its volume, manufacturer, pharmacy pricing and your region of residence. The average price of tablets for liver restoration in Moscow.

The largest organ of the human body, the liver performs a number of vital functions, including those that ensure the perfect functioning of other organs and systems. It is the state of the liver that largely determines how we feel, and therefore there is nothing surprising in the general desire to support the organ, to help it in hard work. To do this, consumers resort to a variety of methods and measures: from very dubious and categorically rejected by official medicine methods of “cleansing” the liver using dubious pills to officially approved and widely used drugs of the group hepatoprotectors.

It should also be recognized that the liver is indeed susceptible to a number of diseases. It is very vulnerable to infection, suffers from the accumulation of toxins in the bloodstream, and is damaged by some strong drugs and alcohol. Therefore, it is not surprising that hepatoprotectors, drugs designed to protect liver cells, are so popular. However, it should immediately be noted that the drugs of this pharmacological group are not recognized in all countries of the world. Moreover, the group of hepatoprotectors in the West does not exist as such. But in the CIS countries, many "protectors of the liver" go to the TOP of sales.

So what are the properties of hepatoprotectors actually? What are these medicines that many doctors do not recognize as medicines? How do they work, and do they work at all? For these and many other questions about hepatoprotectors in tablets and ampoules, we will try to find questions in our article. And we will start with a description of the pathological conditions in which drugs are prescribed for the treatment of the liver.

Liver in danger

“Something is playing tricks on my liver ...” This alarming remark sounds quite often. Almost every adult person from time to time, especially after a heavy dinner or a big feast, has heaviness in the right hypochondrium and nausea. It is these signs that may indicate the development of one of the most common chronic liver diseases, fatty hepatosis, or steatosis. So what is hepatic steatosis? This is a non-inflammatory disease in which liver cells, hepatocytes change, degenerating into adipose tissue.

As a rule, steatosis develops as a result of overeating, overweight, poor nutrition with an excess load of fatty foods. Another common cause of fatty hepatosis is the abuse of alcohol, and the likelihood of developing the disease is not always directly proportional to the doses of alcohol. It happens that even the periodic intake of a small amount of alcohol leads to liver steatosis. In addition, the disease can also develop while taking medications that adversely affect the liver.

Much less common cholestatic hepatosis, in which the formation and outflow of bile is disturbed, as a result of which bile pigment accumulates in hepatocytes. Its cause may be the negative impact of toxins or stress on the liver, for example, during pregnancy. With cholestasis, there is a pronounced itching of the skin, darkening of the color of urine and discoloration of feces, as well as biochemical parameters of the blood.

Speaking of common liver diseases, one cannot fail to mention inflammation of the liver, hepatitis. It can develop both as a result of intoxication with alcohol, drugs or poisons, and against the background of a viral infection. The most common are hepatitis B (about 350 million people a year), hepatitis A (more than 100 million) and hepatitis C (140 million patients a year). Hepatitis C has the most aggressive course, which, if left untreated, is complicated by liver cancer in a large number of cases. Hepatitis D and E viruses are also known. It has been proven that infection with hepatitis B and C is the main cause of liver cancer. All about chronic hepatitis.

Principles of treatment of liver diseases

The tactics of treating liver pathologies is based on two main approaches:

1. The so-called etiotropic therapy, which is aimed at the cause of the disease. A good example of such treatment is the fight against the virus in viral hepatitis. However, it should be noted that not all viral hepatitis need elimination therapy. So, with hepatitis A, it is not needed - the virus dies on its own. But with hepatitis, which are transmitted through blood and sexual contact, antiviral treatment is really necessary.
2. Pathogenetic therapy, implying influence on various stages of the pathogenic process.

To protect the liver, drugs of various pharmacological groups can be prescribed, including:

• vitamins, amino acids and other means that improve metabolism;
• drugs that increase the detoxification capabilities of the liver (for example, adsorbents);
• drugs that stimulate the formation and excretion of bile (choleretic);
• antiviral drugs;
• means that stimulate the immune response (immunomodulators). Play an important role in the complex therapy of hepatitis C;
• painkillers and anti-inflammatory drugs (NSAIDs);
• antioxidants that bind free radicals and thus prevent organ damage;
• hepatoprotectors, which differ in structure, origin, and mechanism of action.

Classification of hepatoprotectors

There is no universal classification of hepatoprotectors today - among specialists, even domestic ones, there are quite serious disagreements about which drugs of which list to refer to them. However, they can be conditionally divided into at least five pharmacological groups:

1. Herbal preparations that contain milk thistle flavonoids. These include Gepabene, Karsil, Silibor and others.
2. Other herbal remedies, which include Hofitol, Liv-52.
3. Hepatoprotectors of animal origin, in particular, Sirepar.
4. Products containing essential phospholipids. The most famous drug of this group is Essentiale.
5. Drugs belonging to different pharmacological groups.

It should be noted that, although the classification and the very concept of hepatoprotectors in the world today do not exist, scientists still came to a common denominator on the question of what should be the ideal, best drug that restores the liver. Basic requirements for it:

• high bioavailability;
• the ability to bind toxins, free radicals;
• anti-inflammatory action;
• stimulation of self-healing of the liver;
• high security profile.

Unfortunately, despite the rather impressive list of modern hepatoprotectors that Russian pharmacies are full of, none of them meets the above requirements.

In world modern medicine, it is believed that drugs that can "start" the process of liver regeneration simply do not exist. And why start if the liver itself is perfectly restored, it is enough to create appropriate conditions for it, reducing the load of fatty foods and toxins to a minimum.

About liver regeneration

This section is more intended for those who like to "clean" the liver, which is "clogged" with toxins and other waste products, using tablets. Many of our compatriots are sincerely sure that over the years of work for the benefit of our body, the liver “wears out” and requires a restart - cleaning. For this, hepatoprotectors are used, which also have a choleretic effect, thermal procedures and folk remedies, such as vegetable oil with lemon juice. Some especially zealous citizens after the procedures find strange-looking calculi in the feces, which they sincerely regard as “stones, slags and compressed waste” that left the long-suffering organ under the influence of effective hepatoprotective drugs and other active measures. In fact, these stones are formed due to the processing of oil and lemon juice, acting as home-grown "cleaners". “Well, what about the liver? the reader will ask, “doesn’t it need to be restored?” Of course not!

The liver is the only organ with a truly remarkable ability to regenerate. It is known that only 25% of the initial mass of the liver can recover to its full normal size.

The restoration of the organ occurs due to replication, that is, the reproduction of liver cells, hepatocytes, as well as bile epithelial and some other cells. Thus, the liver regenerates its own damaged tissue, thereby preventing its damage. But let's get back to the drugs, which, in fact, should stimulate the regeneration of the liver and help it "repair itself", and we will try to dwell on the most famous of them.

Milk thistle flavonoids

And let's start with popular herbal remedies containing milk thistle flavonoids, which include Karsil, Karsil forte, Legalon, Silimar, Silymarin and Silibinin.

Milk thistle is a plant widely distributed in the Mediterranean and the Middle East. Milk thistle fruits have medicinal properties, containing flavonoid compounds, in particular, silymarin - it is he who presumably has a hepatoprotective effect.

Mechanism of action

Silymarins contained in milk thistle fruits interact with free radicals formed in the liver and stop their destructive effect. In addition, in damaged liver cells, they stimulate the synthesis of various proteins and phospholipids - components of the cell membrane that ensure the functioning of cells (in this case, hepatocytes). Silymarin also accelerates the regeneration of liver cells and prevents the penetration of certain toxic substances into them.

It is believed that silymarin preparations help improve the condition of liver diseases, normalize laboratory parameters, and even increase the survival rate of patients with cirrhosis.

When are they assigned?

Indications for the use of Karsil and other hepatoprotectors based on silymarin are toxic liver damage (due to exposure to alcohol, various poisons and drugs), chronic hepatitis, fatty liver, cirrhosis.

Advantages

The positive aspects of medicines based on milk thistle extract include their safety: they have practically no contraindications, and side effects during their use are extremely rare.

A review of research data on the effectiveness of milk thistle preparations in alcoholic hepatitis, hepatitis B and C showed that they do not have a significant effect on the course of these diseases and the state of the liver, and, moreover, mortality.

Despite the fact that some studies have demonstrated the possible positive effect of silymarin in liver damage from industrial toxins, Western medicine is extremely reserved about its use.

Other herbal preparations

The possibilities of herbal medicine in protecting the liver with milk thistle extract, of course, are not exhausted, and on the domestic market there are a number of herbal preparations that are in great demand, based on other natural extracts.

These include:

1. Preparations based on artichoke extract - Hofitol, Cholebil, Artichoke extract
2. Combined herbal preparations - Gepabene, Sibektan, Gepafor, Dipana, Liv-52.

Let's get to know them better.

Hepatoprotective drugs based on artichoke

The medicinal properties of the field artichoke are due to the content in its leaves of a chemical compound called cynarin. The highest concentrations of cynarin are found in fresh, unprocessed foliage, and significantly lower concentrations are found in dry plant materials.

Mechanism of action

Presumably, artichoke extract exhibits a choleretic effect, stimulating the production and secretion of bile by the liver, in addition, artichoke preparations are attributed to a hypolipidemic effect - they help reduce the level of "bad" cholesterol in the blood.

When are they assigned?

According to the instructions for use of hepatoprotective drugs Hofitol and other artichoke-based drugs, they are used in conditions associated with impaired bile formation, in particular, heaviness in the epigastric region, flatulence, nausea, and belching.

In practice, the range of prescriptions for these drugs is much wider. So, Hofitol is often used in obstetrics to reduce the severity of toxicosis during pregnancy, as well as to maintain the liver in hepatitis, fatty liver hepatosis, atherosclerosis, cirrhosis of the liver, chronic intoxication, obesity, chronic renal failure. In addition, Hofitol is prescribed for such a highly controversial disease that does not exist in most developed countries of the world, such as.

Advantages

Of course, as is the case with many other herbal hepatoprotectors, products based on artichoke extract are highly safe. They are prescribed for children, pregnant and lactating women, which, of course, is an exhaustive evidence of their excellent tolerance.

NB! Since Hofitol and other hepatoprotectors containing artichoke extract stimulate the formation of bile, they are categorically contraindicated in case of. Therefore, before taking these funds, you should make sure that there are no stones in the biliary tract! In addition, artichoke extract is not recommended for use in acute diseases of the kidneys, liver, biliary tract and urinary system.

Effectiveness in terms of evidence-based medicine

While we see many indications in artichoke formulations covering the widest range of hepatobiliary system diseases and even hyperlipidemia (increased blood cholesterol levels), clinical studies have not confirmed almost any of the claimed effects of these herbal hepatoprotectors. To date, there is not a single comprehensive medical evidence demonstrating the positive effect of preparations containing artichoke extract on blood cholesterol levels and bile formation. In Western medicine, the artichoke is not used at all.

Combined herbal remedies for liver diseases

Gepabene is one of the leaders among choleretic and hepatoprotective drugs. It contains two active components:

• milk thistle extract;
• fume extract officinalis.

The first active substance, as we have already said, exhibits a hepatoprostatic effect in acute and chronic intoxication conditions. The second component, fume extract, works due to the content of fumarin alkaloid in it, which has a choleretic effect and reduces spasm of the bile ducts, which facilitates the flow of bile from the liver into the intestines.

Indications for the appointment of Gepabene are chronic liver damage of various origins and dyskinesia of the excretory tract. The drug should not be used in acute diseases of the liver and biliary system (acute cholecystitis, acute hepatitis), as well as in children under 18 years of age due to the lack of tests on this category of patients.

Sibektan is a complex combined herbal preparation of domestic development. It contains extracts of tansy, milk thistle, St. John's wort, birch. It protects liver cells, cell membranes of hepatocytes, exhibits antioxidant and choleretic effects. A contraindication to the use of these tablets is cholelithiasis, and indications are various chronic lesions of the liver and biliary tract.

The composition of another Russian drug, Gepafor, along with milk thistle extract, includes bifidus and lactobacilli, designed to restore the intestinal flora and thereby normalize bowel function.

Deepana, Liv-52- the means of production of Indian pharmaceutical companies, containing many plant components used in Ayurvedic medicine. Both drugs, according to the instructions for use, have a hepatoprotective effect, restoring liver function, stimulate the regeneration of its cells, exhibit a choleretic effect, and protect the organ from the action of toxins.

Effectiveness in terms of evidence-based medicine

A certain evidence base has been accumulated in relation to some herbal hepatoprotective drugs, in particular, Gepabene and Liv-52. The first one was mostly studied in Russian studies, the second - including Western ones. Evidence of the beneficial effects of these hepatoprotectors on liver function has been obtained, but many Western experts do not consider them exhaustive. This opinion is also confirmed by the data of some studies demonstrating the lack of effectiveness of Liv-52 in alcoholic hepatitis.

NB! Liv-52 is associated with a scandalous study in which patients with alcoholic hepatitis participated. It showed that the survival rate in the group of patients treated with Liv-52 was 12% lower than in the group of patients taking dummy tablets (74% compared to 86%). Of the 23 deaths in the Liv-52 group, 22 were associated with acute liver failure. The results of this work have become a good reason for the immediate withdrawal of funds from the US market.

Thus, the effectiveness of combined herbal hepatoprotectors in terms of evidence-based medicine remains extremely doubtful. And yet, in domestic practice, drugs of this group are widely used and are very popular.

Hepatoprotectors of animal origin

In Russia, only two hepatoprotectors of animal origin are registered - Sirepar and Hepatosan.

Sirepar contains a liver extract hydrolyzate enriched with vitamin B12. According to the manufacturer, the drug helps to restore liver tissue and has a detoxifying effect. It is administered only intravenously or intramuscularly, there is no oral form. At the same time, Sirepar is categorically contraindicated in acute liver diseases and is used only in the remission stage for chronic hepatitis and other pathologies.

The composition of the second hepatoprotector, Hepatosan, includes dried donor pig liver cells. It is assumed that they are biologically compatible with the macromolecules of the human body. According to the manufacturer, Hepatosan has a hepatoprotective and detoxifying effect, and also exhibits adsorbing properties and stabilizes cell membranes. Indications for the appointment of Hepatosan are cirrhosis, hepatitis, liver failure, liver damage by drugs and alcohol, and so on.

Effectiveness in terms of evidence-based medicine

There is no evidence that animal products have any beneficial effect on liver function. But they definitely carry a potential danger. First of all, these funds should not be used categorically in the acute period of the disease, since this can lead to the activation of the pathological process.

NB! it is important to take into account the allergenicity of hepatoprotectors of animal origin. To exclude hypersensitivity reactions, an allergenic test should be performed before starting treatment to make sure that the drug does not cause allergies.

In addition, some experts believe that the use of bovine liver hydrolysates increases the risk of contracting a prion infection, which is associated with the deadly Creutzfeldt-Jakob disease.

Rich and Famous: Essential Phospholipids

Phospholipids are an important component of every cell membrane, ensuring its integrity and function. The body's need for them increases sharply with increased loads and damage to some organs, in particular, the liver. At the same time, a defect is formed in the wall of hepatocytes, liver cells, which can be filled with preparations containing essential phospholipids.

A number of hepatoprotectors with this active substance are registered on the modern market:

• Essentiale forte N;
• Rezalut Pro;
• Essliver;
• Phosfonciale;
• Phosphogliv;
• Brenziale forte;
• Livolife forte;
• Antraliv;
• Livenziale and others.

All of them are of natural origin: essential phospholipids are obtained from soybeans by processing their oil.

Mechanism of action

The properties of essential phospholipids are due to their similarity with phospholipids in the human body. They are easily integrated into the cell membrane, providing a complex therapeutic effect. Hepatoprotectors of this group stimulate the recovery of liver cells and protect them from the action of toxins, including alcohol, chemicals, aggressive drugs, and so on. According to some reports, essential phospholipids also help reduce the level of "bad" cholesterol and, as a result, reduce the risk of atherosclerosis. In addition, their use helps prevent the formation of cholesterol stones in the gallbladder.

When are they assigned?

Hepatoprotectors containing essential phospholipids are used for various liver diseases both in the acute period and in remission. Among the indications for their use are acute and chronic hepatitis, fatty degeneration of the liver, regardless of its origin, alcoholic lesions, cirrhosis, poisoning, including drugs, disruption of the liver in other pathologies.

It should be borne in mind that the effectiveness of treatment with essential phospholipids largely depends on the duration of the course: according to the instructions for use, these hepatoprotectors are prescribed in high doses (600 mg up to three times a day) for at least three months. If necessary, the course of therapy is repeated and extended up to several years of continuous use.

NB! Clinicians believe that parenteral therapy with essential phospholipids shows the best results. So, Essentiale forte N and its generics are prescribed intravenously by stream, after diluting the drug with the patient's blood in a ratio of 1:1.

Effectiveness in terms of evidence-based medicine

Over the years, essential phospholipids and their effectiveness have been studied in many clinical studies. Nevertheless, the conclusions of experts regarding the appropriateness of their appointment remain ambiguous.

However, on the other hand, neither Essentiale, nor any other drug containing essential phospholipids, is included in the pharmacopoeia of the developed countries of the world. In the US and some European countries, they can be purchased as dietary supplements and nothing more.

In official international protocols for the management of patients with liver diseases, essential phospholipids, respectively, are also not included. The position of Western colleagues is supported by some domestic doctors. Thus, the formulary committee of the Russian Academy of Sciences included Essentiale in the list of drugs with unproven efficacy.

Unfortunately, today the situation with the means of this series remains controversial: studies demonstrating their effectiveness, as a rule, do not meet the requirements of evidence-based medicine and are not perceived by specialists as evidence that the drug really works.

And at the same time, Essentiale and its cheaper analogues remain the most prescribed hepatoprotectors, which are very popular among both doctors and consumers, and occupy a leading position in the top sales of drugs.

Hepatoprotectors of different pharmacological groups

All other drugs are difficult to systematize on any common basis, so they are considered separately.

Heptral

Heptral, a drug from the Italian company Abbot, as well as its generics (Heptor, Ademetionine) contain an amino acid, a methionine derivative, ademetionine.

Mechanism of action

Presumably, the drug has a complex effect on the body.

1. Prevents bile stasis by stimulating phospholipids in liver cells and thereby improving their function.
2. Binds free radicals, preventing oxidative damage to the liver, as well as toxins.
3. Stimulates liver regeneration.
4. It has an antidepressant effect, including with prolonged depression, resistant to the action of amitriptyline.

In patients with cholestasis (impaired bile excretion, accompanied by the release of bile acids into the blood and painful itching), ademetionine reduces the severity of itching and helps to normalize liver parameters, including the concentration of direct bilirubin, alkaline phosphatase activity, and so on. At the same time, according to the instructions for use, the hepatoprotective effect of Heptral persists for three months after the end of treatment.

When are they assigned?

Heptral or its analogues are used for liver damage of various origins, including toxic, alcoholic, viral, drug, liver failure. An important indication of the drug is intrahepatic cholestasis.

Due to its antidepressant properties, Heptral is used to treat withdrawal symptoms in alcoholism and drug addiction, especially in patients with liver damage.

NB! The bioavailability of the oral form of hepatoprotectors containing ademetionine is low. Therefore, most clinicians prefer intravenous injections of Heptral, which have a more pronounced effect.

Effectiveness in terms of evidence-based medicine

The situation with the evidence base of Heptral somewhat resembles that of essential phospholipids. And in this case, several studies have demonstrated the positive effects of the drug in relation to the liver. And in the same way, neither Heptral nor any other drug containing ademetionine is registered in the United States and most European countries (with the exception of Italy, where it is produced). But it is successfully sold in pharmacies in Malaysia, India, Bulgaria, Argentina, Georgia, Ukraine, Mexico and the Czech Republic. And yes, it is registered as a veterinary drug in Australia and New Zealand.

Thus, the Western world did not accept Heptral and did not introduce it into the standards for the treatment of liver diseases, based, again, on the lack of reliable clinical studies confirming its effectiveness. And this is against the backdrop of the widespread popularity of the drug in Russia and other CIS countries, where ademetionine is used both for the treatment of outpatients and in hospitals.

Hepa-Merz is an original drug containing a complex compound L-ornithine-L-aspartate. In the body, it quickly turns into two independent active substances - ornithine and aspartate. Hepatoprotectors of this group are produced in the form of granules for the preparation of a solution for oral administration, as well as ampoules for intramuscular and intravenous injections. Along with Hepa-Merz, its analogues Ornitsetil, Larnamin and Ornilatex are registered in the Russian Federation.

Mechanism of action

The drug works due to the ability of the amino acids formed during its dissolution to reduce the concentration of ammonia in the blood plasma, to normalize the acid-base composition of the body, thus providing a detoxifying effect. In addition, Hepa-Merz helps to reduce pain and dyspeptic syndrome in case of poisoning, as well as normalize the mass of the case (for example, with).

When are they assigned?

Hepatoprotectors containing this active substance are prescribed for acute and chronic liver pathologies, in which the content of ammonia in the blood increases. Among the indications for Hepa-Merz is also fatty degeneration of the liver of various origins.

Effectiveness in terms of evidence-based medicine

The situation with the evidence in the case of Hepa-Merz and his analogues is just as vague as with our previous heroes. On the one hand, several studies have demonstrated its effectiveness in cirrhosis of the liver, accompanied by an increase in the concentration of ammonia in the blood. On the other hand, the results of the use of this hepatoprotector in hepatitis, alcoholic liver damage and other pathologies remain very doubtful. And again, in Western medicine, a hepatoprotector, which includes L-ornithine-L-aspartate, does not exist.

Homeopathic remedies and dietary supplements

The mechanism of action of drugs with a "hepatoprotective effect", belonging to this category, remains extremely vague. Homeopathic medicines have an effect that is so inexplicable from the point of view of medicine that homeopaths themselves often cannot explain it.

With regard to dietary supplements, the situation could theoretically be more transparent, but their composition is not subject to pharmacological control. What they contain, in what dosages - a mystery behind seven seals.

From the point of view of evidence-based medicine, homeopathy is a big soap bubble. A lot of large studies testify to the complete failure of homeopathic medicines. There is no need to talk about dietary supplements at all, because even their composition is unreliable.

Consumers who choose to support the liver with homeopathic hepatoprotectors (Hepel, Galstena, etc.) or supplements should understand that they are playing roulette. If they are lucky, as lucky, for example, those who experience a placebo effect, they may feel relief. If you're not lucky, they won't feel it. But we must not lose sight of the likelihood that the effect may be negative, because no one has canceled allergic reactions or side effects (especially in the case of dietary supplements that have a dubious composition).

UDCA - a white crow among hepatoprotectors

And finally, the time has come to talk about the drug, which occupies a special place among hepatoprotectors. We will make a reservation right away so as not to torment the reader - special from the positive side.

Ursodeoxycholic acid is a bile acid that is produced in small amounts in the human body. The drug was first obtained from bear bile, but today it is obtained synthetically.

In domestic pharmacies, this hepatoprotector is represented by a galaxy of trade names, including:

• Ursofalk, the most expensive, original drug
• Urososan
• Ursodez
• Livodex
• Urdox
• Ursoliv
• Grinterol
• Holudekasan
• Ursodex and others.

Mechanism of action

Ursodeoxycholic acid (UDCA) exhibits a complex immunomodulatory, hepatoprotective, choleretic effect. In addition, it reduces the level of cholesterol in the blood and prevents the stagnation of bile.

The properties of the hepatoprotector are due to its ability to stabilize the membranes of liver cells and protect the hepatocytes themselves. It inhibits the absorption of cholesterol in the intestine, as a result of which its content in bile decreases, and also increases the solubility of cholesterol. This quality allows UDCA preparations not only to protect the liver, but also to help dissolve existing cholesterol stones in the gallbladder and bile ducts and prevent the formation of new ones.

When is it appointed?

Hepatoprotectors containing ursodeoxycholic acid are used for cholelithiasis (only in the case of confirmed cholesterol stones, which is observed in 80-90% of cases), as well as acute and chronic hepatitis, toxic liver damage, regardless of the type of toxic substance that provoked the disease, alcohol disease liver, biliary dyskinesia. In addition, ursodeoxycholic acid is used as part of combination therapy for cystic fibrosis.

Hepatoprotective drugs UDCA are also used for cholestasis, including in pregnant women - their safety profile allows them to be prescribed to the most vulnerable categories of consumers, including young children.

Effectiveness in terms of evidence-based medicine

Hepatoprotectors containing UDCA are almost the only representatives of this pharmacological group that have no disagreements with evidence-based medicine. Numerous studies indicate that this medicine really works effectively with liver damage of various origins, intrahepatic cholestasis, alcoholic cirrhosis (improving the prognosis of the disease), steatosis and other liver pathologies.

And no less strong evidence that hepatoprotectors based on UDCA are really effective is their worldwide recognition. The funds of this group are registered and widely used in developed countries of the world, including Switzerland, Italy, France, Japan, Germany and others. True, it is worth noting that he is included in the group of choleretics that contribute to the dissolution of gallstones, and not hepatoprotectors. But in the end, this aspect does not affect the result.

Thus, if you look for an answer to a question that often arises among consumers - what kind of hepatoprotector is the most powerful, most effective, and in general the most-most - the answer will be unambiguous: the one that has proven effectiveness, beyond doubt even with the most skeptical attitude. And only one active substance meets this requirement - ursodeoxycholic acid.

“But what about the rest of the hepatoprotectors? - the reader will doubt, - after all, the doctor said (it is written in the article, they said on TV) that their effectiveness has also been proven? Yes, indeed, such situations do occur. And that's why.

Clinical Research: Not All That Glitters Is Gold

As we wrap up our talk about modern hepatoprotectors, we'll dot the i's on a question that confuses many consumers (and, unfortunately, even doctors) and gives them false ideas about the effectiveness of these drugs.

The fact is that the results of various studies of drugs are not always reliable. To exclude the possibility of obtaining false data, the work must be carried out in accordance with certain requirements formulated in the basic principles of evidence-based medicine. So, the most reliable studies are those in which participants are divided into several groups taking the study drug and pacifiers or other means of comparison (randomized trial). No patient should know what he is receiving - a drug or a placebo (blind study), but it is better if even the doctor does not know about it (double-blind study). An important condition for reliability is the inclusion of a large number of participants in the work - in large works we are talking about thousands of volunteers. And this is not all the requirements for modern research.

Such experiments require both time and huge material costs. In addition, no pharmaceutical company will conduct them if there are serious doubts about the results, because the goal of the work is to confirm the effectiveness, register the drug in the maximum number of markets, increase sales and maximize profits.

To get out of the situation and present at least some “evidence of effectiveness”, drug companies with dubious effectiveness resort to a trick: they initiate studies with almost obviously positive results. These experiments are carried out at best with a few dozen patients, and the requirements of evidence-based medicine are being reshaped in their own way. The obtained data, which satisfies the interests of the manufacturer, is used to promote the drug - they sound in advertising, decorate booklets and confuse consumers.

Alas, such a situation in the CIS countries is the rule rather than the exception. And therefore, in the choice of over-the-counter drugs, the law of a cruel market must apply: not all that glitters is gold. Especially when it comes to hepatoprotectors.

Updated: 03/23/2020

The liver is the largest gland. Takes part in digestion and neutralization of harmful substances. Responsible for the production of bilirubin, cholesterol, enzymes and hormones. Capable of storing blood and glucose. Any violations in the work of the body are manifested by poor health.

Typical signs of failure are bloating, pain, and poor digestion. Harmful food, poor environmental conditions, and an unhealthy lifestyle can harm the liver. If you need treatment or want to take preventive measures, check out the ranking of the best drugs for the liver. You will get the opinion of buyers and experienced professionals. Be sure to consult your doctor before taking.

Essential phospholipids

Pharmaceutical companies offer several medicines containing polyunsaturated (essential) fatty acids. The components have metabolic and hepatoprotective properties. They are used to treat liver diseases.

Designed to restore the structure of the body with hepatitis, fatty degeneration and cirrhosis. Manufacturers also claim that phospholipids have additional properties: they improve metabolism, reduce the likelihood of developing atherosclerosis, improve skin condition, and help after irradiation.

Advantages

• Preparations for liver restoration are well tolerated by patients.
• Reduce the likelihood of disease recurrence.
• Help as a complex drug in the treatment of hepatitis C.
• Easily digestible.
• Assign even during pregnancy.
• Reduce liver costs.
• Improve enzymatic activity and physicochemical parameters of bile.

disadvantages

• Pain may occur after intravenous injection.
• They do not restore liver cells, but only cell walls.
• For maximum results, the course of treatment should be at least 6 months.
• It should not be taken concomitantly with preparations containing vitamin B.
• They can activate the inflammatory process.
• High price.

Rating of the best essential phospholipids

Hepatoprotector. A complex of vitamins, amino acids, essential phospholipids and plant extracts that protect and support liver cells, as well as help restore already damaged liver structure (including after hepatitis).

Helps the body as a whole in the fight against harmful factors (alcohol, heavy metals, poisoning, malnutrition, etc.) and diseases.

Capsules (90 pcs.).

• Provides 4-component complex protection of the liver
• Helps gently cleanse the liver of toxins
• Protects the liver from adverse factors
• Promotes natural regeneration of liver cells
• Improves metabolism and restores liver function
• The components of the formulation are well studied and have a favorable safety profile.

• Not available for sale in all regions
• Contraindications: pregnancy, lactation, individual intolerance to the components.

Hepatoprotective, antiviral agent with a combined composition. Contains simultaneously two active active components - phospholipids and glycyrrhizic acid.

Has a regenerative effect. Restores the functions and structure of membranes.

It also has cytoprotective properties. Normalizes protein and lipid metabolism.

Produced in capsules for oral use. The best effect is achieved when taking the drug during meals.

It is prescribed for viral hepatitis (both chronic and acute forms), toxic damage and cirrhosis of the liver. As an auxiliary component, it can be used in the treatment of neurodermatitis, intoxication, psoriasis, eczema.

• Prevents loss of enzymes.
• Stimulates the work of the liver.
• Promotes the formation of connective tissue.
• Reduces the risk of cirrhosis and fibrosis.
• Well tolerated by the body.
• Contains herbal ingredients.
• Cheaper than analogues.
• Increases the protective function of the body.
• Eliminates pain in the right hypochondrium.
• Small capsules.

• There are side effects.
• Raises blood pressure.
• duration of treatment.

Dietary supplement helps to fill the body's need for vitamin E and essential phospholipids. Thus, the state of the antioxidant system improves, the functionality of the liver is normalized.

Metabolism is optimized. The drug protects cell membranes from oxidation.

Supports the functioning of the nervous system. Also, "Gepagard" is prescribed for low body resistance to toxins.

To achieve a therapeutic effect, it is necessary to take the drug two capsules with meals. During the day you need to drink dietary supplements 2 times.

The course of treatment is one month.

• Accelerates cell regeneration.
• Improves metabolism.
• Normalizes the work of the digestive tract.
• Improves memory.
• Normalizes the conduction of impulses.
• Safe composition.
• Affordable price.
• Easy to accept.

• A small number of capsules in one package.

One of the most effective hepatoprotectors. Has a combined effect.

Contains essential phospholipids and milk thistle. One capsule of the drug contains seventy milligrams of silimar and one hundred to two hundred milligrams of lipoid.

It also contains additional ingredients. In one package - 30 capsules of a light orange hue.

Normalizes the exchange of proteins, phospholipids and lipids. Helps digest food and activates the production of enzymes.

Stabilizes cell membranes. Protects cells from destruction.

Accelerates the regeneration and excretion of bile. Prevents the formation of connective tissue.

• Removes toxins from the body.
• Has antioxidant properties.
• There are practically no contraindications and side effects.
• Protects tissues from toxic damage.
• Restores the structure and functions of the liver.

• During the day you need to take about 6 capsules.
• The high cost of the drug.

The drug was created to prevent acute liver diseases. It also stops the progression of existing chronic ailments.

Helps to lead a full-fledged lifestyle in chronic hepatitis and cirrhosis. Regulates carbohydrate and fat balance.

Has a detoxifying effect. Like other hepatoprotectors, it is prescribed in combination to eliminate organ damage.

Contains fat metabolism products and B vitamins, including pyridoxine hydrochloride, riboflavin, cyanocobalamin, thiamine mononitrate. Helps the body cope with heavy foods - broths, mayonnaise, fatty and fried foods, cakes with cream and alcohol.

• Helps to remove toxins and slags.
• Affordable price compared to foreign counterparts.
• Improves blood counts. Proven by ALT test results.
• Supports the body during a diet.
• Can be taken by children.
• Helps within a few days after the first application.

• Fragile capsules.
• Not produced in ampoules.
• There are contraindications.
• May cause side effects.
• To consolidate the result, you need to take several months.

The drugs are designed for the prevention and treatment of the liver. Can change the cellular structure of an organ.

Improve the density of membranes and restore their functionality. Able to relieve severe symptoms of the disease in a short time, improve well-being.

The composition includes linoleic and linolenic acid. One pack contains 30 capsules.

Each of which contains 6 milligrams of thiamine, 3 thousand milligrams of essential phospholipids and 6 milligrams of riboflavin.

In addition to these active substances, there are also auxiliary components. .

• Contains no vitamins. The therapeutic effect is provided by hepatoprotectors.
• Unlike classic multivitamin complexes, the drug can be taken without harm to health for a long time.
• Has a detoxifying effect.
• Stops cirrhosis of the liver.
• Safe composition.
• Slows down the inflammatory process and reduces the degree of tissue necrosis.
• Improves the general condition of the digestive tract and well-being in general.
• Released without a prescription.
• You can buy at any pharmacy.
• Suitable for treatment during pregnancy.

• For a stable and long-term effect, you need to take the drug from 3 to 12 months.
• Not prescribed for children.
• Contraindicated in case of individual intolerance to phosphatidylcholine.

Rating of the best solutions of low molecular weight sugars

The drug is designed to comprehensively support liver function. Geptrong has an antioxidant effect, it contains low molecular weight sugars obtained from a natural beekeeping product - honey.

Active components protect the organ, reduce the cell permeability of its tissues. This hepatoprotector is indicated for use in people suffering from liver damage of various origins: alcoholic, drug and other toxic.

• works as an antioxidant
• allowed for pregnant women
• can be taken at any severity of the problem
• reduces the intensity of inflammation
• completely decomposes into water and carbon dioxide
• well tolerated, no pain at injection sites

• Only injectable form
• Not suitable for people allergic to bee stings, honey and other derivatives

The main purpose of the drug is to restore the working capacity of the liver, for which it is an antispasmodic and choleretic agent. Its effect is noticeable even with serious pathologies, such as cirrhosis of the liver.

In addition, heptral has a sedative and antidepressant effect on the patient, which is necessary in the acute phase of the disease. Also, the drug is effective in certain pathologies of the brain.

The action of the drug is associated with its accumulation in the body. Therefore, a quick effect that occurs immediately after taking it is not worth waiting for.

• Indications for use:
• Cholangitis (infectious inflammation of the bile ducts).
• Fatty degeneration of the liver.
• Cirrhosis of the liver.
• chronic hepatitis.
• Withdrawal syndrome, including alcohol.

• May cause headaches, dizziness, confusion.
• Possible side effects - increased sweating, rash, itching, allergic reactions
• May cause muscle spasms and joint pain.

The drug has a hepatoprotective effect, accelerates the transition of anaerobic processes to aerobic ones. Its intake improves the energy supply of hepatocytes, restores the activity of antioxidant defense enzymes, and increases the resistance of hepatocyte membranes to lipid peroxidation.

• Indications for use:
• Alcoholic hepatitis
• Toxic hepatitis
• medicinal hepatitis.
• Functional disorders of the liver associated with its acute or chronic diseases

• Possible metabolic disorders associated with the activation of aerobic processes (
• Unpleasant sensations during the administration of the drug
• Allergic reactions (rash, pruritus) are possible.
• Nausea, headache, dizziness are possible.

Preparations for the liver of plant origin

According to experts, the best herbal medicines contain milk thistle. These include Karsil, Legalon, Silimar, Gepabene, Sibektan. The main active ingredient of such drugs is silymarin. It combines three compounds - silidianin, silicristin and silibinin.

It has antioxidant and membrane stabilizing properties. Counteracts liver stress (oxidative). It has an immunomodulatory effect. Protects the body from alcohol disease. With prolonged use - about six months, the number of cytotoxic lymphocytes and the production of gamma globulin decreases. Minimizes the susceptibility of cells to toxic substances.

Advantages

• Natural composition.
• Promote cell regeneration.
• Stimulates protein synthesis.
• They have a choleretic effect.
• Increase the secretion of bile acids.
• Eliminate spasm of the biliary tract.
• Can be used for prevention.
• They have a strong antioxidant effect.

disadvantages

• Manufacturers, in addition to milk thistle, may use other, less safe ingredients.
• The course of treatment, as a rule, is at least 3 months.
• The effectiveness of drugs during the treatment of acute hepatitis or alcohol abuse has not been clinically proven.

Rating of the best drugs for the liver of plant origin

The composition of the drug includes extracts of St. John's wort, common tansy and milk thistle. Helps in the treatment of alcoholic fatty liver disease, alcoholic liver disease, alcoholic cirrhosis of the liver, chronic type of cholecystitis and chronic persistent hepatitis.

It has hepatoprotective, membrane-stabilizing, antioxidant and choleretic effects. Has a mild effect.

Doctors also prescribe the drug in combination with others to restore liver cell membranes and have a better antioxidant effect. "Sibektan" also additionally has a tonic property.

Relieves depression, improves the functioning of the digestive tract. Clinically proven anti-inflammatory and antibacterial properties.

For maximum effectiveness, take on an empty stomach half an hour before a meal. The daily dose should not exceed 800 milligrams.

The standard course of treatment is 20 weeks. According to the doctor's decision, it will need to be repeated after 2 or 3 weeks.

• It has a complex effect. May help with peptic ulcer, gastritis or kidney disease.
• Does not cause overdose.
• Safe composition.
• Various release forms.

• During the day you need to take a lot of pills. You have to get used to the new regime.
• There are contraindications.
• Not prescribed for under 18s.

The drug contains herbal ingredients. It has antitoxic and hepatoprotective properties.

Designed for the treatment of cirrhosis of the liver, toxic damage to the organ, as well as for recovery from hepatitis. Assign as a prophylaxis for intoxication in a chronic form.

With prolonged use of medications and alcohol abuse. The medicine should be taken before meals, half an hour.

The standard dosage includes one or two liver repair tablets three times a day. The course of therapy, depending on the severity of the disease, is 25-30 days.

To prevent a recurrence of a chronic disease, a repeated course of treatment with an interval of one to three months will be required.

• Contains ingredients of plant origin.
• It has antitoxic and hepatoprotective effects.
• Slows down the penetration of toxins into cells.
• Stimulates regeneration.
• Fast effective action.
• Affordable price.
• Relieves pain.
• Can be used in combination with other drugs.

Complex preparation with plant components. Contains an extract of fumes, fruits of milk thistle.

Has a choleretic effect. It also normalizes the amount of its production and reduces the tone of the sphincter.

It has a hepatoprotective effect. Protects liver cells from alcohol and toxins.

Stimulates hepatocyte recovery and protein synthesis. Suitable for the treatment of liver diseases at various stages - acute and chronic.

For maximum effect, take after meals. The standard dosage for adults is one capsule three times a day.

To relieve severe pain, the doctor may prescribe an additional dose before bedtime. The product is produced in hard capsules.

The package contains thirty pieces.

• Natural composition.
• Fast effect.
• Removes severe pain.
• Improves the work of the digestive tract.
• Removes heaviness.
• Affordable price.
• After application, constant nausea disappears.

• You can not take with individual intolerance to one of the active ingredients.
• Do not prescribe for acute inflammatory processes of the liver and biliary tract.
• Caution should be taken during pregnancy and breastfeeding.
• Inconvenient release form - large capsules.
• Laxative effect.

Refers to herbal medicines. Assign for diseases of the gastrointestinal tract and severe pathological conditions of the liver.

The composition includes flavonoid isomeric compounds. Produced in the form of dragees, capsules and suspensions.

The main active ingredient is isolated from milk thistle. The drug has a hepatoprotective and antitoxic effect.

Normalizes physical and chemical indicators. Slows down the penetration of toxic components into the liver cells.

Accelerates the regeneration of body cells. It is prescribed for lesions with several medicines - Paracetamol, antidepressants, antibiotics, after anesthesia, immunosuppressants and psychotropics.

• Relieves skin itching, vomiting.
• Eliminates heaviness in the right hypochondrium.
• Restores appetite.
• Improves general condition.
• According to the results of the analyzes, bilirubin, transaminases, and alkaline phosphatase activity decrease.
• Contains natural ingredients.

• High price.
• May cause diarrhea.
• Contains dyes.

The drugs belong to hepatoprotectors from the group - herbal preparations. Silymarin is used as the main active ingredient.

It is obtained from milk thistle fruit. Produced by the Bulgarian company Sopharma.

The drug with the prefix "forte" has a high concentration of the active ingredient. They produce a classic drug in the form of a brown dragee.

In one package - 80 pieces. Carsil Forte contains 30 capsules of gelatin structure.

Has a specific smell. It is prescribed for toxic liver damage as a result of long-term treatment, for chronic and alcoholic intoxications, cirrhosis, steatosis, for recovery from acute hepatitis.

• Has a stabilizing effect.
• Normalizes fat metabolism.
• Stimulates the production of phospholipids.
• Protects liver cells from the negative effects of toxins.
• Restores hepatocytes.
• It slows down the fatty degeneration of the organ and the development of fibrosis.
• Has an antioxidant effect.
• Normalizes blood microcirculation.
• Improves general condition, including increases appetite.

Liver tablets - bile acids

Ursodeoxycholic acid (UDCA) is the only acid of its kind that does not harm the human body. Refers to the means of bile acids. Assign for the treatment of diseases of the liver and biliary tract, cholelithiasis (not complicated type).

It should not be taken with an increased calcium content of gallstones. It has hypoglycemic properties. Increases gastric and pancreatic secretion. Can change the immune response of the liver. You can not take the drug without a doctor's prescription. There are very serious contraindications.

Advantages

• Reduces the number of eosinophils.
• In combination with other drugs, it will help dissolve cholesterol formations in the gallbladder.
• It will help with toxic, alcoholic liver damage.
• Can be used by pregnant women to treat hepatopathy.
• One of the most effective means for the treatment of sclerosing cholangitis (primary type) and biliary cirrhosis.
• Assign the most vulnerable category of patients - in adolescence, pregnancy. And also for the treatment of hemophilia, substance abuse and drug addiction.

disadvantages

• There are many drugs with unconfirmed quality.
• They can harm with inflammation of the gallbladder, intestines, disruption of the kidneys, pancreas, liver.
• Often there is an individual intolerance.

Rating of the best bile acid drugs for the treatment of the liver

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Hepatoprotector with choleretic, choleretic, hypocholesterolemic, and immunomodulatory effects. Increases the protection of liver cells from bile acids.

Changes their structure. Improves the production and excretion of bile.

Destroys gallstones and protects the liver from the harmful effects of alcohol. Ursodeoxycholic acid in the composition of the drug prevents cholestatic liver disease.

Produced in the form of gelatin capsules of a milky shade. The number of capsules, as well as the duration of administration, depends on the disease and body weight.

It is prescribed for biliary cirrhosis at the stage of compensation of the primary type, with biliary reflux gastritis, medium and small cholesterol stones. Intended for oral use.

• Reduces the production of cholesterol.
• Minimizes the lithogenicity of bile.
• Breaks down cholesterol stones.
• Replaces toxic bile acids with non-toxic ones.
• Improves the secretion of liver cells.
• Improves immunoregulatory processes in the body.
• Copes with stagnant bile.

• The drug is not prescribed to children.
• For long-term use, significant costs will be required.
• Causes side effects - nausea, vomiting, constipation, diarrhea.

An effective hepatoprotective drug with a choleretic effect. Reduces the concentration of cholesterol in the blood, its further absorption in the intestine.

Promotes the formation and secretion of bile. Enhances pancreatic and gastric secretion.

It has hypoglycemic properties. When administered enterally, it partially or completely dissolves cholesterol stones.

Promotes the removal of organic compounds from gallstones. It has an immunomodulatory effect.

The main active ingredient is ursodeoxycholic acid. Dosage and duration of treatment depends on the disease.

To dissolve gallstones, you will need to take Ursodez at the rate of ten milligrams of the active ingredient per kilogram of body weight. The best time to use is before bed.

Capsules should not be chewed. It is important to drink a small amount of water.

• It can be taken for a long time - up to 24 months.
• It is very easy to evaluate the effectiveness of the drug using ultrasound diagnostics or radiography.
• Effective treatment.
• It has a complex effect.
• Convenient release form.
• Small capsule size.
• The minimum number of side effects.

The hepatoprotector is produced in the form of white gelatin capsules. Packaged in plastic bottles or blisters.

It has a choleretic effect. Does not allow the formation of stones.

Displays existing gems. Effectively affects the composition of bile, the work of the pancreas and stomach.

Activates the functions of liver cells. Increases the protective functions of the body.

Absorbed in the small intestine. The maximum concentration is observed in the blood two hours after ingestion.

It then binds to plasma proteins. As a result of prolonged intake, it turns into a basic bile acid.

It is located in the blood serum.

• Decreased secretion of cholesterol.
• Toxins are removed from the body faster.
• Improves the work of the pancreas and stomach.
• Increased lipase activity.
• The level of sugar in the blood drops.
• Convenient packaging.
• Works effectively. The dynamics can be tracked by the results of the analyzes.
• Affordable price.

• It is forbidden to take the drug with calcified stones, obstruction of the bile ducts, acute inflammatory processes, hepatic colic, with a weight of less than 34 kg.
• Causes nausea, vomiting, pain, diarrhea or constipation.
• Can calcify gallstones.
• Exacerbates psoriasis.
• Leads to hair loss from the scalp.

Contains ursodeoxycholic acid. Assign in the treatment of diseases of the digestive tract.

The main active ingredient reduces the synthesis of cholesterol. Due to this, an increase in the concentration in the intestine occurs.

The drug has a particularly effective effect when the disease is not running. Doctors recommend taking the medicine in the evening.

It is enough to drink the capsules with plenty of water. In the first days of admission, you need to control the level of liver enzymes.

• The drug replaces harmful bile acids (with toxins) with non-toxic UDCA.
• Stimulates the protective functions of the body.
• Improves the secretory properties of liver cells.
• "Ursosan" is quickly broken down and excreted from the body.
• Painlessly dissolves stones.
• Relieves gastritis.
• Wide spectrum of action.
• Safe composition.
• Eliminates colic in the right hypochondrium.
• Reduces cholesterol levels.
• Helps with jaundice in newborns.

• Do not prescribe if the diameter of the stones exceeds 15 mm.
• May not help with biliary cirrhosis of the primary type, even with prolonged use - from 6 to 24 months.
• There are contraindications. You can not take with inflammation of the gallbladder and gallstones in acute form, colic, and obstruction.
• Causes side effects.
• Be wary appoint with hepatitis and cirrhosis of the liver.
• As a standard, the drug is allowed to be given to children from 5 years of age. But the age threshold can be changed at the discretion of the doctor.
• Exceeding the dosage indicated in the instructions causes a disorder. You need to stop the drug and consult a doctor. It is necessary to restore the water-salt balance in the body.

Has a choleretic effect. Breaks down cholesterol stones.

Prevents the growth of connective tissue after damage to liver cells. Contains ursodeoxycholic acid.

The substance forms micelles of a mixed type. Protects membranes from damage.

Increases the content of bile acids. Which, in turn, contributes to the dissolution of cholesterol gallstones.

Enhances the secretion of the pancreas and stomach. It also has an immunological effect.

Regulates the number of immune cells. Suspends fibrosis in primary biliary cirrhosis, cystic fibrosis, and alcoholic liver disease.

Reduces the likelihood of varicose veins in the esophagus. As a result of research, the effectiveness of "Ursofalk" in delaying the development of tumor tissues has been proven.

Therefore, it is prescribed in combination with other drugs for the treatment of colon cancer. Produced in the form of a suspension and capsules.

• There are no age restrictions.
• Reduces bilirubin. They are prescribed even for newborns.
• Can be used in combination with other drugs and herbal decoctions.
• Dissolves gallstones.
• Eliminates the bend of the gallbladder.
• Has a choleretic effect.
• Eliminates allergic reaction.
• Can be used during pregnancy. Prescribed for hypatosis.
• Relieves nausea and itching.

Tablets for the liver of animal origin

There are only a few such drugs. They are usually not prescribed as a prophylaxis. Suitable for the treatment of liver diseases for several reasons - hepatitis, cirrhosis, fatty liver, toxic and drug-induced hepatitis. Depending on the preparation, porcine liver cells, hydrolysed bovine liver, cyanocobalamin, amino acids, segments of liver growth factors and low molecular weight metabolites are used for production. Pharmaceutical companies also produce drugs with a combined effect.

Advantages

• Able to restore the structure of cells.
• Improve blood flow.
• Change the functional indicators of the liver.
• After taking, as a rule, diuresis increases.
• Can be used in combination with other drugs for the treatment of cirrhosis, chronic hepatitis, radiation sickness, fatty degeneration, drug intoxication.

disadvantages

• There is no official confirmation of the clinical safety and efficacy of drugs.
• With extreme caution, you need to take the medicine in the acute stage of hepatitis. There is a possibility of aggravation of the inflammatory, immunopathological, cytological syndrome.
• Causes a severe allergic reaction. Before starting treatment, you need to check for hypersensitivity to the components of the drug.
• Bovine liver hydrolysates can cause prion infection. The latter, in turn, causes Creutzfeldt-Jakob disease (a dangerous neurodegenerative disease).
• It is not recommended to take as a preventive measure.

Rating of the best preparations for the liver of animal origin

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The drug contains both plant and animal components. The effectiveness of the treatment of the pathological condition of the hepatobiliary system has been proven.

The composition includes crushed nettle leaves, garlic powder, dry bile, activated charcoal. Components regulate metabolic processes in the intestinal wall.

Suppress the development of helminths. Promote absorption of vitamins A, D, E, K.

Has a detoxifying effect. Stimulates emulsification of lipids in the gastrointestinal tract.

Accelerates metabolism. Removes them from the body.

Helps reduce flatulence and the growth of pathogenic microorganisms. The duration of treatment, as well as the dosage depends on the disease.

• Improves the secretory function of liver cells.
• Stimulates the synthesis of bile acids.
• Accelerates the movement of bile through the biliary tract.
• Eliminates atonic constipation.
• Prevents infection.
• Reduces inflammation.
• The film coating of the drug protects the properties of Allochol.
• Can be combined with other medicines.

• There are contraindications.
• May cause side effects such as diarrhea. Clinical cases of an allergic reaction are also known.
• Exceeding the prescribed amount of the drug leads to an overdose.
• Can not be taken simultaneously with "Cholestyramine", aluminum hydroxide and "Cholestipol"

The drug is designed to protect liver tissue. It also contributes to the restoration of damaged functional and structural elements of the body.

Normalizes hepatic blood flow. Increases urination.

Improves liver function. It is prescribed for chronic hepatitis, hepatocardial syndrome, cirrhosis of the liver, toxic hepatitis, toxicosis of pregnant women, kwashiorkor and other disorders.

There are several forms of release. Dragees are suitable for oral use.

Also produced in the form of a solution for intravenous, intramuscular injections.

• Fast action.
• Effectively restores the liver.
• Created on a biological basis.
• Helps with viral hepatitis.
• Helps with depletion of the body.

Liver bioregulator improves its functions. Restores after a course of treatment, poisoning or under the influence of other negative factors.

Released in the form of tablets. In one package - 40 pieces.

Assign as a prevention and treatment of polyetiological diseases and other liver damage. Eliminates the consequences of toxic, infectious, metabolic, involutional and other influences.

The drug relieves chronic and acute liver failure. It has a hepatotropic property.

The composition includes nucleoproteins and proteins from cattle. Enhances reparative processes in liver cells.

Restores their work. The functional corrective and hepatoprotective effect of the drug has been clinically confirmed.

Assign depending on the complexity of the disease. The standard course of treatment is 10 to 14 days.

Repeat therapy may be required after 3 or 6 months.

• It is forbidden to take with individual intolerance to the drug, during pregnancy and breastfeeding.
• May cause an allergic reaction.

It has a detoxifying and hepatoprotective effect. It has an effect at two stages - in the intestines and during metabolism.

The drug is able to absorb harmful components from the intestines and restore liver cells. The composition includes essential phospholipids, amino acids, vitamins, cytochromes, trace elements, mesenchymal enzymes.

"Hepatosan" prevents the absorption of toxins and metabolic products from the large intestine. It also strengthens the walls of liver cells.

It is prescribed for the treatment of cirrhosis of the liver, poisoning with mushrooms, alcohol or drugs, chronic and acute form of liver failure, cholelithiasis. The capsules are for oral use.

Dosage and duration of treatment depends on the complexity and type of disease.

• Supports the liver, pancreas, gastrointestinal tract.
• Fast effect.
• Easy to accept.
• Can be combined with other drugs, for example, Enterosan.
• Available in almost all pharmacies.

• There are side effects.
• You can take the drug during pregnancy only under the supervision of a doctor.
• Causes allergies.

The hepatoprotective drug has a detoxifying property. Restores the liver parenchyma, changes the synthesis of methionine and choline.

Prevents grease filtration. Contains vitamin B12.

The component ensures the normal maturation of red blood cells, and also contributes to better hematopoiesis. It also contains amino acids, fatty acids, carbohydrates.

Released in the form of a solution for injection. Suitable for intravenous and intramuscular slow administration.

It is necessary to mix the drug with blood or sodium chloride (0.9%). Before treatment, it is important to check the body's reaction to possible hypersensitivity.

findings

The liver is one of the most vulnerable organs. Suffering from malnutrition, alcohol abuse and a sedentary lifestyle. Also, various inflammatory processes can harm the body. There are several types of drugs for the treatment and restoration of the body. Before use, be sure to consult a specialist. As a rule, in such cases, an appropriate diagnosis is prescribed. You can also clarify information about medicines on the websites of pharmacies in the section - "Preparations for the liver."

Hepatoprotectors: a complete list of drugs with proven efficacy and price (inexpensive and expensive drugs)

Hepatoprotectors - These are medicines used mainly in relation to patients of the older age category who have liver problems. Due to the fact that this gland performs cleansing functions, any damage to it can lead to poisoning of the whole organism.

Over time, a change in peptic activity occurs in the human stomach and intestines for the worse. This feature leaves an imprint on the metabolism and begins a more intense flow of withering of the human body. The main task of such drugs is to increase the viability of the population.

At the moment, there are about two hundred products of this category on the drug market, which have their own beneficial and harmful properties for an individual organism. The use of such medicinal products is permitted only on the prescription of a doctor.

To resuscitate the activity of the liver, it is necessary to make significant efforts in the treatment with the use of drugs of various functionalities. Pharmacological groups of the following types are suitable for treatment:

• Biologically active additives that have immune stimulating properties and saturate the body with biologically active substances;
• Medications that are involved in the elimination;
• Means to alleviate pain in the affected organ;
• Medicines that help drain bile and liquefy stones from cholesterol;
• Means of regeneration of liver elements.

Medicine for the liver is determined in patients under the following circumstances:

• If the patient has hepatitis resulting from the abuse of alcoholic beverages, and the disease is at risk of developing into. For effective therapy, the patient is also recommended to stop drinking alcohol. Only by observing this condition, the medicine for the liver will assist in the regeneration of damaged elements of the liver.
• If hepatitis has a bacterial infectious origin and has received a protracted nature of the outcome. Such drugs are especially recommended if the infection has acquired the form C, A or B;
• If the patient for a long period of time used therapeutic agents that caused a disruption in the functioning of the elements of the liver. Medicines that protect the organ from the situation will protect its cells from the influence of harmful circumstances;
• If a patient has hepatosis of liver cells from overeating fatty foods. Deviation is fixed in patients leading a calm life deprived of physical exercise or sick. In the treatment of such cases, the recommended preparations for the liver must be combined with sports and diet.

List of hepatoprotectors with proven effectiveness

The list of drugs with proven effectiveness includes the basic pharmacological category of drugs that promote the rapid regeneration of certain parts of the organ. The liver remedies listed below have delicate and specific uses. Before choosing the right medicine, you should definitely get a detailed consultation with your doctor.

• Rezalut Pro (Price 1500-1800 rubles)

​ The drug compensates for the organic component of the hepatic gland in order to reduce the destructive effect of pathogenic circumstances. A distinctive degree of usefulness of the drug shows the symptoms of the hypothesis, with any modification of hepatitis, with frequent use of alcohol.

• Heptral (Price 1622-1950 rubles)

It is a compound medical substance. In addition to the basic properties, it also differs in that it is in some way a depressant. Ademetionine is the reactive component of the drug, which promotes the reparative functions of the body subject to damage. Doctors prescribe Heptral with an acute form cholestasis and at the withdrawal stage.

Ademetionine is an amino acid that is involved in the generation of phospholipids. Heptral is a remedy with proven medicinal properties exclusively in three countries: Italy, Germany and Russia. In other countries, medical institutions consider Heptral as a dietary supplement with suspicious drug functions. Doctors recognize the drug's effectiveness only when administered venously. With aggravating forms, Heptral tablets are not used.

With rapidly developing cirrhosis, one of the types of hepatitis, a long-term form of renal dysfunction, Hepatosan can serve as a very effective remedy. Hepatosan looks like a yellow tablet that helps with poisoning by toxic and harmful substances.

• Phosphogliv (Price 523-600 rubles)

Also refers to the active drug substance. The main therapeutic property of the drug is its positive effect on the damaged part of the body.

The content of the amino acid ornithine aspartate in Hepa-Merz lowers the ammonia content in the human body and is used to support the functioning of the hepatic gland and in the thinning of the fatty layer of its cells. Hepa-Merz is recommended for use, but it is expensive. The effectiveness of Hepa-Merz has been proven in laboratory and clinical studies.

Affordable and effective drugs for the liver

For a certain category of citizens, the main factor is that the medicine should be inexpensive and efficient. Often, inexpensive funds, despite their cost, have instant post-appointment actions. These medicines include:

• Hofitol (Price 360-750 rubles)

Hofitol with artichoke extract has a beneficial effect on. Its specialists in medical practice are advised to use it as an auxiliary supplement to the main therapy.

• Liv.52 (Price 363-520 rubles)

Doctors recognized Liv.52 as a compound therapeutic substance with beneficial effects for the liver. It reduces the concentration of bile and has a restorative effect.

• Allochol (Price 12-59 rubles)

A drug called Allochol is included in the list of drugs with proven effectiveness , since it provides a decrease in the amount of bile, it removes the waste of its activity in its natural form.

Means suitable for the treatment of both the pancreas and the liver

Since it is these organs of the human body that have a direct relationship, it makes sense to carry out their complex therapy. To prevent severe symptoms, medical practitioners recommend the following low-cost medicines:

• No-shpa (Price 70-480 rubles)

No-shpa is a medicine for short-term and liver.

• Festal (Costs 200-670 rubles)

It is a drug in capsule form, which is recommended for enlargement of the filtering organ and pancreas. Festal represents one of the most effective ways in the fight against.

• Lohelan (Cost RUB 500)

It is a brown substance in powder form based on herbal extracts.

Anticirrhosis and antihepatitis drugs

Both cirrhosis and hepatitis have long-term forms that are difficult to treat. Similar diseases also include thinning of the fatty tissues of the liver, since it is not subject to a final cure and is characterized by periodic repetitions of symptoms. Health care professionals recommend prompt prevention of symptoms of these diseases when detected. Below is a list of effective medical products for which have a quick therapeutic effect:

• Livolin Forte (It costs 454 rubles)

It is an accelerator of fat metabolism, therefore it is an effective way to combat fatty hepatosis and excess fat in the liver.

• Essentiale Forte (Price 660-1598 rubles)

Another drug that has proven itself in the fight against cirrhosis and hepatitis has become Essentiale Forte. It has a mild effect and is involved in the normalization of the activity of cells susceptible to damage by toxic substances. It is produced both in liquid form in ampoules and in the form of tablets. Take it three times a day, 2 capsules. With a severe course of the disease, the number of ampoules increases to four.

Preparations for the liver of new modifications

It's no secret that the more modern the drugs, the more effective they are. With hepatic dysfunction, auxiliary use of therapeutic agents is necessary so that the regeneration of the elements of a vital organ occurs at an accelerated pace. Global pharmacological companies are constantly improving the drug list, and their prices are presented for categories of citizens with different income levels. Now there are a great many manufacturers of drugs in new forms on the market. The following list contains tools that have proven themselves from the best side:

• Hepa-Merz (Price 772-2796 rubles)

One of these medicines on a natural granular herbal basis is Hepa-Merz. It has a high price and high performance.

• Hepatosan (Price 300-550 rubles)

Hepatosan is a fermented representative of a new generation of medicinal substances. It is produced on the basis of elements of the porcine liver gland. Hepatosan copes with almost all forms of damage, except for those that were obtained by infection.

• Sirepar (Costs 150-250 rubles.)

Sirepar can be considered similar to the previous medicine in terms of medicinal properties. Sirepar is a domestic development.

Combined medicines for the gallbladder and liver

In cases where the patient is simultaneously observed, in order to avoid complications with the liver, doctors recommend that you first drink a course of funds to dissolve cholesterol formations. This approach will contribute to the accelerated flow of the process of regeneration of liver elements. Safe drugs in this category include:

• Ursosan (Costs 200-1500 rubles)

A means of diluting bile, as well as dissolving cholesterol formations of large dimensions.

• Exhol (cost 161-1520 rubles)

Exhol proved to be a highly productive tool for the elimination of cholesterol formations. It is also effective in alcoholic.

Liver diseases are one of the common causes of disability and mortality in all countries, despite their economic development and climatic conditions. Every year, about 1 million people fall ill with liver diseases, among which the majority are young, able-bodied people.

Experts note that the development of new drugs, vaccination and modern diagnostic methods do not give a positive trend: people continue to get hepatitis, cirrhosis, cancer, which is associated with many factors: alcoholism, unbalanced nutrition, poor ecology, chronic diseases.

To alleviate the condition of the victims and prevent the destruction of hepatocytes, many drugs have been developed, in particular, hepatoprotectors. Together with dietary nutrition and basic therapy, they normalize the basic functions of the liver, help restore its structure, and protect against the toxic effects of harmful compounds.

Any disease that affects the liver causes a serious disorder in almost all body systems, since the organ performs a number of important functions, in particular, the liver:

• responsible for protein, carbohydrate, lipid, pigment metabolism;
• neutralizes the harmful effects of toxins and drugs;
• stores vitamins and minerals;
• produces cholesterol and lipids;
• regulates blood clotting;
• responsible for the production of bile acids and their transportation to the gallbladder;
• stimulates the work of the intestines;
• synthesizes and inactivates some hormones, including sex hormones;
• produces enzymes;
• is a repository of blood.

Nature, endowing the liver with so many functions, took care of its integrity. This is the only organ that can recover even after partial removal. But the body cannot always cope with some factors on its own, namely, with:

• obesity;
• alcohol;
• medicines;
• genetic factors;
• drug use;
• bad ecology;
• diabetes mellitus;
• hypodynamia;
• improper nutrition.

Although the liver is able to recover, prolonged unbearable loads sooner or later disrupt its activity. Hepatoprotectors are designed to protect the liver from such factors. They, of course, will not replace basic therapy, but will complement the effect of prescribed drugs and can improve the function of liver cells.

With liver pathologies (hepatitis, hepatosis, fibrosis, cirrhosis, liver failure, cancer, etc.) and forced prolonged intake of certain drugs (anticonvulsant, antitumor, painkillers), the doctor must prescribe hepatoprotectors.

Recently, a myth has formed that this class of drugs is just an invention of "greedy" pharmacists who want to cash in on the grief of the sick and produce drugs with dubious effectiveness. Opponents of these drugs rely on the fact that in Europe and the USA liver treatment with such medications is not carried out, since they do not exist in the list of pharmacological agents.

But in the same list there is another group of medicines - cytoprotectors that have a positive effect on the metabolism of the liver, kidneys, heart, dermis, which include hepatoprotectors known to all.

In addition, abroad, hepatoprotectors are called pharmaceuticals, and some companies, for the benefit and convenience of registration, position them as biologically active additives (BAA). Not very honest manufacturers under such hepatoprotectors-dietary supplements really produced drugs that were ineffective, which caused distrust of patients and practitioners.

Meanwhile, acquiring dietary supplements that have not passed clinical trials, which are not effective and do not help, patients are wasting time (for most liver diseases, there is a period when a relapse of the pathology is possible, and then only organ transplantation), hoping that one tablet will solve all their problems .

Patients should clearly understand that the use of clinically proven hepatoprotectors does accelerate liver recovery, but does not cancel diet and basic medications.

Modern hepatoprotectors can mitigate and alleviate liver disease, but they have their own limits of effectiveness, and it is impossible to hope that this is a panacea for all problems with the organ.

Properties and types

There are several classes of hepatoprotectors based on different components and having a specific mechanism of action, but they all have similar properties:

• they are based on natural ingredients;
• they restore the work of a diseased organ and normalize metabolism;
• remove toxins and neutralize their action;
• accelerate the regeneration of hepatocytes, increase their resistance to harmful factors.

According to the mechanism of action, 6 types of hepatoprotectors are distinguished, based on:

• ursodeoxycholic acid;
• flavonoids of other plants;
• animal components;
• essential phospholipids;
• amino acids.

Based on ursodeoxycholic acid

The functions of ursodeoxycholic acid, formerly extracted from bear bile and now synthesized in laboratories, include:

• liver protection. With the help of acid, special particles are produced that neutralize the harmful effects of toxins;
• restoration of bile outflow and liquefaction of the secret, which contributes to normal digestion and its discharge into the intestine;
• lowering cholesterol due to a decrease in its synthesis and dissolution of cholesterol stones;
• strengthening immunity;
• positive effect on the bile ducts.

Ursodeoxycholic acid hepatoprotectors, in addition to the listed properties, have an antioxidant effect. Due to this, liver cells and the whole body are less susceptible to aging. Indications for the appointment of such drugs are:

• toxic liver damage, including alcohol and drugs;
• hepatitis;
• biliary dyskinesia;
• hepatosis;
• stagnation of bile;
• cholangitis;
• cystic fibrosis;
• reflux gastritis;
• dyspeptic syndrome.

The most famous are:

They can be prescribed for long-term treatment (3 to 6 months), and are allowed for children. The disadvantage of the main ingredient is that it cannot be prescribed for:

• acute conditions of the intestine and gallbladder;
• problems with the work of the pancreas;
• renal pathologies;
• pregnancy and HB.

With prolonged treatment, side effects (indigestion) are noted. Therefore, it is not recommended to self-prescribe a medicine to improve health and strengthen the liver. Only the doctor determines the dosage and duration of the course of therapy, depending on the individual characteristics of the patient and the diseases detected.

With milk thistle

The greatest trust was won by preparations with a vegetable basis. The fruits of milk thistle are especially popular, in which many biologically active components (trace elements, vitamins, organic acids) have been found.

Preparations based on milk thistle significantly reduce the toxic effect on the liver, promote the regeneration of cellular structures. In damaged hepatocytes, protein production is stimulated, cell membranes are stabilized, and the loss of trace elements stops, thereby increasing the natural regeneration of liver cells.

Of the most popular drugs can be called:

They are shown with:

• hepatitis;
• cirrhosis;
• steatosis;
• drastic weight loss.

These drugs are used to prevent liver pathologies with long-term medication and chronic alcoholism. They are often well tolerated by patients and rarely cause side effects.

Disadvantages:

• decrease in the effectiveness of oral contraceptives when taken together;
• are not prescribed for lactating and pregnant women;
• are not prescribed for diseases of the female reproductive system (benign tumors, hormonal disorders, malignant neoplasms);
• not compatible with a number of drugs, such as Diazepam, Ketoconazole, (may enhance their effect).

With flavonoids from other plants

Milk thistle tablets are not the only herbal remedies that restore and protect the liver. Celandine, artichoke, pumpkin seeds, fumes officinalis can act as active ingredients in a number of hepatoprotectors.

They are distinguished by a minimum number of side effects, the ability to eliminate spasm of the gallbladder, improve the outflow and production of bile. For example, Allohol, which is not a hepatoprotector, also consists of herbal ingredients, but causes a lot of side effects. These drugs are prescribed for:

• hepatitis of various origins;
• dyskinesia of the gallbladder;
• cholecystitis;
• cirrhosis;
• hepatosis;
• exhaustion.

Among the shortcomings, the ability to provoke allergies and upset stools is noted. Not intended for pregnant and lactating women. The list of popular drugs includes:

With ingredients of animal origin

Preparations made from porcine liver are able to regenerate human liver hepatocytes, since they are as similar as possible in composition. Due to the detoxification and antioxidant action, they treat hepatitis, hepatosis and cirrhosis of the liver. Of the positive qualities note:

• the ability to remove toxins from the body;
• accelerate the regeneration of hepatocytes;
• restore lost liver function.

• high risk of allergies;
• the risk of developing immunopathological syndromes in acute forms of hepatitis;
• they are not suitable for the prevention of liver disease.

Clinically tested hepatoprotectors of this group include:

1. Sirepar, which has a detoxifying, liver-restoring effect.
2. Hepatosan with metabolic, restoring the functions of hepatocytes, action.

With essential phospholipids

According to statistics, these drugs are most common in the post-Soviet regions. They are obtained from soybeans. Phospholipids are products of lipid metabolism, which are a kind of bricks for building cells.

These substances are involved in the transport of nutrients, cell division and differentiation, they activate various enzymatic systems. The advantages of hepatoprotectors based on essential phospholipids include:

• the ability to quickly restore hepatocytes at the molecular level;
• protection against toxins and viruses;
• improving the action of interferons;
• preventing the formation of scar tissue.

These medicines include:

They are prescribed for:

• acalculous cholecystitis;
• hepatitis;
• hepatosis;
• cirrhosis;
• neurodermatitis;
• psoriasis.

Of the shortcomings, the need for prolonged use of drugs is noted in order to feel their effectiveness. Sometimes phospholipids cause bile stasis. In addition, they quickly break down in the stomach, and only a small proportion of the active substances get to their intended purpose - to the liver.

Other types

In the liver, amino acids are involved in the production of phospholipids, break down fats, quickly restore hepatocytes, and remove toxins. The most popular acid in this class of hepatoprotectors is ademetionine, an amino acid involved in various biochemical processes in the body. It improves the quality of bile, reduces its toxicity, promotes the rapid outflow of bile acids. Also used:

Used in the treatment of:

• fatty hepatosis;
• hepatitis A;
• pancreatitis.

The list of essential drugs includes:

These drugs are more likely to cause side effects than others. These include the occurrence of such violations:

• diarrhea;
• nausea;
• pain in the epigastric region.

Patient experience

Consider the opinions of patients regarding the effectiveness of hepatoprotectors:

Anton: “I have had epilepsy since I was 21. As soon as anticonvulsant therapy was selected, the neurologist prescribed Karsil. I did not believe that I would need it, since I drank handfuls of AEDs and did not want to add more drugs to them. But after 3 years, the liver tests worsened, and the liver had to be cleaned. Since then, I drink hepatoprotectors twice a year and follow diet number 5.

Anna: “Six months after giving birth, I was diagnosed with gallstone disease due to polyhydramnios during gestation. The uterus blocked the discharge of bile, because of which stagnation occurred and stones formed. I could not be fully treated, since most of the drugs cannot be taken by lactating women, so I kept to a diet and drank Borjomi.

No-shpu was prescribed as an anesthetic. All this time I felt disgusting, experienced colic, nausea, heaviness in my side and pain. When I stopped feeding, I went for an ultrasound. They said that from my 0.2 cm stones, they turned into 0.6 cm stones.

The doctor prescribed Ursofalk 2 capsules at night. After 3 months, I underwent a second examination, which showed that my stones began to dissolve. I have been taking the drug for a year now, and I hope that the next diagnosis will show a positive result.”

Vera Olegovna: “She was registered with her illness and regularly donated blood. Phosphogliv was prescribed to me by my doctor. I can’t say that he somehow protected my liver and improved my condition. It happened that I did not drink hepatoprotectors for years, and sometimes I drank it regularly. Didn't notice any difference.

Each time I used them, I felt sick and, interestingly, I got a runny nose. When finally the diagnosis was removed and the main treatment stopped, the liver tests returned to normal. This was not associated with hepatoprotectors. It was worth giving up the drugs - and everything returned to normal. I consider these drugs the usual pumping of money.

Today there is a huge number of hepatoprotectors. Attitudes towards them are different for both patients and doctors. Experts consider Heptral, Hofitol, Essentiale, Ursosan, Karsil, Silimar to be the most effective of them and recommend taking it for any liver dysfunction.

But, despite the popularity and apparent safety of these drugs, treatment should not be started without consulting a specialist. Each medication has its own indications and contraindications. With an illiterate approach and non-compliance with the recommendations, you can aggravate your condition and cause irreparable harm to health.