Heparin acre 1000 instructions for use. Heparin-Akrigel - an affordable remedy for varicose veins

Prevention and treatment of thrombophlebitis of superficial veins, post-injection and post-infusion phlebitis, elephantiasis, superficial periphlebitis, lymphangitis, superficial mastitis, localized infiltrates and edema, injuries and bruises (including muscle tissue, tendons, joints), subcutaneous hematoma.

Possible analogues (substitutes)

Active ingredient, group

Dosage form

topical ointment, topical gel

Contraindications

Hypersensitivity to the components of Heparin-Akrigel 1000, ulcerative necrotic processes, traumatic violation of the integrity of the skin.

How to apply: dosage and course of treatment

Outwardly: a column of Heparin-Akrigel 1000 3-10 cm long (0.5-1 g) is applied to the affected area (3-5 cm in diameter) 1-3 times a day.

pharmachologic effect

Anticoagulant of direct action, belongs to the group of medium molecular weight heparins. When applied externally, it has a local antithrombotic, antiexudative, moderate anti-inflammatory effect.

Blocks the formation of thrombin, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of the blood. Gradually released from the gel and passing through the skin, heparin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the resorption of hematomas and blood clots and reducing tissue swelling.

Side effects

Skin hyperemia, allergic reactions to the components of Heparin-Acrigel 1000.

special instructions

Do not apply ghtgfhfn to open wounds, mucous membranes, in the presence of purulent processes.

Interaction

Do not prescribe Heparin-Akrigel 1000 topically simultaneously with NSAIDs, tetracyclines, antihistamines.

Questions, answers, reviews on the drug Heparin-Acrigel 1000

This information is intended for medical and pharmaceutical professionals. The most accurate information about the drug is contained in the instructions supplied with the packaging by the manufacturer. No information posted on this or any other page of our site can serve as a substitute for a personal appeal to a specialist.

Heparin Akrigel is a drug that is part of the conservative treatment of diseases caused by varicose veins. The drug belongs to the group of direct-acting anticoagulants, due to which it accelerates the process of blood clotting. It is intended for external use, as it can effectively eliminate edema, local inflammation and improve tissue microcirculation. What are the indications for use? How to use the tool to achieve a quick effect?

Ingredients of the drug

Heparin Akrigel 1000 is a helium-based drug. The active substance in the composition of the product is sodium heparin at a concentration of 1000 IU. Thanks to the active ingredient, the healing properties of the gel are revealed, which are to reduce the activity of thrombin, which promotes platelet adhesion.

In addition to the main substance, the gel contains auxiliary components:

• Methyl parahydroxybenzoate (inhibits the growth and development of pathogenic microflora).
• Carbomer (cosmetic powder used for desolation of the consistency).
• Trometamol (due to the diuretic effect, eliminates swelling of the intracellular tissue).
• Ethyl alcohol (has antiseptic properties).
• Lavender oil (helps improve tissue microcirculation, and also has bactericidal, antiseptic, antispasmodic properties).
• Nerol oil (eliminates swelling, spasm and soreness).
• Distilled water.

The absorption of the active components of the drug is slow, so its regular use does not lead to an overdose.

Pharmacological effects

When used externally, the gel penetrates the skin, where the active substances begin to act within a few hours. Due to the local action of the drug, it directly affects the area of ​​the pathological process, eliminating the symptoms resulting from the formation of blood clots in the blood vessel. Heparin activates metabolic processes in tissues, which improves the microcirculation of the affected area.

The drug has the following pharmacological effects:

• Antithrombic. Reduces the frequency of vascular thrombosis and promotes the resorption of already formed blood clots.
• Anti-exudative. Removes excess tissue fluid, eliminating puffiness.
• Anti-inflammatory. Helps reduce inflammation in the affected area.

Mechanism of action

The mechanism of action of the drug is based on the antiaggregant and anticoagulant properties of the active substance. After application to the skin, the combined composition of the drug is gradually absorbed into the bloodstream, where it activates the anticoagulant protein. After activation of this mechanism, there is a violation of the transformation of prothrombin into thrombin, the activity of thrombin decreases and the degree of platelet adhesion decreases.

Heparin has the ability to inhibit the formation of fibrin in the blood, which inhibits local tissue immunity and serves as the basis for the formation of clots. It also promotes the resorption of formed blood clots, by accelerating blood circulation in small vessels, and stimulating metabolic processes in tissues.

In what cases is it used

The drug is used for prophylactic and therapeutic purposes in pathological conditions accompanied by the formation of a blood clot in the lumen of peripheral and coronary vessels.

Specialists prescribe a gel for the following diseases:

• thrombophlebitis of superficial vessels;
• local infiltrates;
• swelling of soft tissues;
• damage to the joint and tendon;
• contusion of connective tissue and joint;
• trophic ulcer of the lower leg;
• postinfectious hematomas;
• superficial mastitis;
• lymphedema.

Instructions for use Heparin Akrigel 1000 contains recommendations for the correct use of liniment, intended exclusively for external application.

To achieve the maximum therapeutic effect, the following recommendations should be followed:

• The amount of gel is calculated in such a way that an equal amount of the product is accounted for on a skin area with a diameter of 3-5 cm.
• The product is applied in a thin layer, rubbed with soft circular movements.
• The drug is taken daily from 1 to 3 times a day.

The use of the gel is contraindicated in the presence of open wound surfaces, hemorrhages, purulent processes and impaired blood coagulation.

Features of use for hemorrhoids

The effectiveness of the gel has been proven in the treatment of hemorrhoids. The tool is used in both acute and chronic forms of the pathological process. Regular application of Akrigel 1000 during exacerbation of hemorrhoids serves to prevent thrombosis of hemorrhoids, reduces inflammation, pain, and also eliminates swelling of the soft tissues of the rectal opening. The treatment regimen is selected individually for each patient, taking into account the severity and stage of the pathology.

How to use the drug for external hemorrhoidal formations:

• Before applying the product, it is necessary to carry out hygiene procedures in the anus, while not using aggressive detergents.
• A small amount of gel is applied to a bandage or cotton pad.
• The compress is placed on the inflamed area.

With the internal form of hemorrhoids, the following method of applying liniment is used:

• It is necessary to clean the rectum, having previously placed a microclyster, and then carry out hygiene procedures.
• From a sterile gauze cut, make a rectal tampon in the form of an oblong cone.
• Soak the swab with ointment, insert in a circular motion into the rectal canal to a depth of 2-3 cm.

When introducing a medicinal swab into the anal canal, patients should be careful, because there is a risk of injury to the cavernous formations and the development of bleeding. In the acute phase of the disease, rubbing the liniment is prohibited, as this can provoke a rupture of the vascular wall.

The therapeutic course is about two weeks, and the number of applications varies from 2 to 3 times a day.

Ointment should be taken with caution in patients who suffer from arterial hypertension, diabetes mellitus, bronchial asthma. Dose adjustment is carried out with tuberculosis in the active phase, liver failure, during radiation therapy.

It is necessary to observe precautions in the elderly category of patients, especially in women. During pregnancy, the remedy is prescribed if the beneficial properties exceed the possible harm, however, in accordance with strict indications.

What can replace

Analogues of a medicinal product, drugs with similar indications for use, pharmacological effect, and mechanism of action. However, the concentration of the active substance may vary slightly, which affects the cost of the product. As a rule, more expensive substitutes contain additional components that enhance the effect of the active substance. It is necessary to replace the liniment only after consultation with a specialist.

Overview of the most popular drug analogues:

• Lyoton 1000. The active substance is sodium heparin, which prevents blood clotting and dissolves the formed blood clots. The drug is used in violation of the venous outflow, thrombophlebitis.
• Heparin ointment. The active ingredient is heparin, which destroys clots and prevents the formation of new ones. The content of benzyl nicotinate causes the expansion of the vascular wall, which improves the absorption of heparin.
• Venolife. The combined composition of the drug contains two active ingredients: sodium heparin and dexpanthenol. There is an improvement in tissue metabolism, restoration of damaged tissue, increased absorption of heparin.

Heparin Akrigel 1000 is used in diseases caused by thrombosis of blood vessels and to eliminate concomitant symptoms. Regular use of the gel allows you to achieve remission of varicose veins, as well as prevent its progression. However, the remedy must be used as prescribed by a specialist, with regular monitoring of the blood coagulation system.

Reviews

Evgenia, 36 years old
For a long time I felt heaviness in my legs, there was a pronounced swelling and soreness throughout the day. Therefore, on the recommendation of a friend, I purchased Lyoton Akrigel. The advantage of the gel is its availability and compliance with the declared characteristics. The product was applied twice a day, the effect was noticeable after 7 days of use. Significantly improved skin condition, eliminated swelling and pain. A minor drawback is the stickiness of the ointment during application and the feeling of a film.

Nikolai, 40 years old
I was diagnosed with a thrombus in the upper thigh, so it is necessary to constantly use anticoagulant drugs that prevent the progression of the pathology. As prescribed by the doctor, I used Lyoton gel for some time, but it grew in price, and I had to give it up. My wife helped me choose a cheaper analogue, not inferior in pharmacological effects to its predecessor. Heparin Akrigel is a domestic drug, but in composition it practically does not differ from its foreign counterpart.

Ekaterina, 32 years old
The last pregnancy and childbirth provoked the appearance of varicose veins of the lower extremities. Swollen veins are visible on the skin, and knots have formed in some areas. The condition was accompanied by severe burning, heaviness and pain. The pharmacy recommended me to buy Heparin Akrigel. At this time, I was satisfied with the medicine, as it helped to reduce the manifestations of the pathology, and after application it does not leave greasy spots.

How to completely and permanently get rid of varicose veins!

Varicose veins cause serious complications and consequences. There is a way that helps to permanently get rid of varicose veins. read NEXT

Heparin-acrigel 1000, instructions for use of the drug, indications for use, how it helps with varicose veins and hemorrhoids. Other analogues of the drug, reviews of doctors and buyers. All detailed information in our article.

Heparin-acrygel 1000

With the modern rhythm of life, diseases such as varicose veins and hemorrhoids have become common. Varicose veins are a consequence of a sedentary lifestyle, unhealthy food, excess weight and genetic inheritance.

How I got injured after the show and cured varicose veins!

How I got injured after the show and got rid of varicose veins forever! Roza Syabitova shared her secret in THIS ARTICLE!

Since Heparin has a stimulating effect on blood flow and a strengthening effect on vein tissues, it is used to prevent thrombosis and to dissolve existing formations.

Application in proctology is based on the same principles, the gel has a good effect on hemorrhoids.

The active substance quickly removes hematomas and blood clots.

The drug can be gently injected into the anus if there are internal hemorrhoids and a gauze bandage can be applied externally. The main convenience is that no trace remains on things.

Producing country

The drug is produced in Russia, Staraya Kupavna, Noginsk district, Moscow region, by a well-known in pharmacology plant JSC “Chemical-Pharmaceutical Plant “AKRIKHIN”.

Another drug is produced mass of small pharmaceutical enterprises in post-Soviet countries. Be careful, read who the manufacturer is on the packaging and find out the information before buying.

After 1 course, varicose veins disappear forever!

I have been looking for a long time how to cure varicose veins. I tried all the methods and I liked this one. My results are in THIS ARTICLE!

A course of treatment

The course of treatment depends on the degree of the disease, approximately 3-14 days. Many patients say that a 2-week course of treatment helped to forget about the problem of hemorrhoids, but there are also neglected options. In this case, it is better to listen to the doctor's prescription.

With varicose veins 3-7 days, but can be extended by the attending physician up to 1 month.

Release form

The form of the drug is a transparent gel, slightly yellow in color, has its own slight odor. The tube is made of thin aluminum, in a cardboard box, instructions inside.

The composition of the drug

The drug accrues a good and rich composition, the main active ingredient is Heparin sodium (Heparin sodium).

pharmachologic effect

The drug is considered as a direct anticoagulant. The medication does not allow the creation of blood clots. Increases the stability of cerebral vessels, brain hyaluronidase ceases to be active, at the same time, lipoprotein lipase becomes active.

Akrigel has a hypolipidemic effect.

The gel relieves the inflammatory process in varicose veins, retains fluid, activates tissue metabolism, increases the rate of disappearance of blood clots, edema and hematomas on tissues.

Mode of application

The drug is applied to a dry painful area, approximately 1 cm of gel per 1 cm of skin and lightly rubbed into the skin with light clockwise movements. It is desirable to repeat the procedure several times a day until the desired result is obtained.

With hemorrhoids, the drug must be carefully injected into the anus. Carefully and a small amount, approximately 1-3 cm of gel.

Indications for use

What helps Heparin-acrigel 1000?

Doctors often prescribe as a prophylactic or therapeutic agent for such diseases:

Get rid of varicose veins and arrange your personal life!

How I overcame the problem with the figure and got rid of varicose veins on my legs! My method is tried and true. My story is on MY BLOG HERE!

• superficial mastitis;
• varicose veins;
• thrombophlebitis;
• post-infusion phlebitis;
• elephantiasis;
• lymphangitis;
• edema;
• subcutaneous hematoma;
• in case of injury;
• bruising of tissues and tendons;
• haemorrhoids.

The gel is often used in the treatment of varicose veins in the early stages or after surgical procedures in advanced states of the disease.

In order not to wait until the intervention is simply necessary, consult a doctor as soon as possible.

If in the evening you feel tired in your legs, pulling pain, itchy skin and at the same time you observe swelling in yourself.

For hemorrhoids, if you feel itching, pain in the anus during and after stool, when walking or when making sudden movements, consult a doctor.

The sooner the disease is detected, the easier it is to cure it without surgery.

Contraindications

The medication has many advantages and an extensive list of indications, it also has a number of contraindications:

1. Hypersensitivity to one of the components of the gel.
2. If, after an injury or intervention, the tissue cover is broken, and there is an open wound, the drug is not applied to the damaged area.
3. If blood clotting has decreased, as a result of any disease, it is forbidden to apply the gel.
4. With the appearance of a trophic ulcer.
5. If thrombocytopenia, a decrease in the number of platelets, increased bleeding and problems with stopping bleeding are detected.
6. In women during menstruation or the threat of a breakdown.
7. After any surgical interventions, accompanied by heavy bleeding.

Side effects

During the period of use of acrygel, allergic reactions may occur.

You need to try the gel on a small area of ​​\u200b\u200bthe skin, if no reactions are found, feel free to use it in treatment.

It happened that the patient had nausea or simply a decrease in appetite, indigestion. With such side effects, it is recommended to immediately stop treatment and consult your doctor.

The attending physician, who knows why you used this particular drug, will find out which of the components has a side effect and select one of its analogues.

During pregnancy and lactation

Here you need to weigh the benefits and harms, and if you cannot do without treatment, it is possible to use heparin-containing drugs, but under the strictest supervision of doctors.

What help from bruises

Often the gel is used for bruises, it is advised by pharmacists in pharmacies, and it really helps.

If compared with heparin ointment, you can see the content of the active substance sodium heparin is 10 times more.

This allows you to activate tissue metabolism and accelerate the process of skin recovery. The gel is quickly absorbed into the skin, has a pleasant aroma, relieves puffiness.

If the drug is at hand and applied immediately, you can avoid the appearance of a bruise at all, if the bruise is minor.

Best before date

After the expiration of the specified period, its use is prohibited.

Gel Heparin-acrygel 1000: instructions for use

Packing photo

Price in Russia: where to buy in Moscow, St. Petersburg

You can buy a 30-gram tube of Heparin-Akrikhin 1000 gel:

1. In Moscow within 300 rubles.
2. In St. Petersburg (St. Petersburg) up to 250 rubles.
3. In Novosibirsk, about 200 rubles.
4. In Yekaterinburg from 210 to 230 rubles.
5. In pharmacies of the country in other cities, the price of the goods is 200 - 300 rubles.

1. Moscow - 310 rubles. St. Petersburg - 280 rubles.
2. Novosibirsk - 230 rubles.
3. Yekaterinburg - 240 rubles.
4. In pharmacies of the country in other cities 220 - 320 rubles.

You can purchase the gel by visiting the online store, if not available, you can order home.

Each pharmacy in the capital, as well as an online pharmacy in any city in Russia, offers a function like home delivery. Within Moscow free and cheap delivery.

Delivery is convenient, you need to click a couple of times on your tablet, phone or laptop, or make a phone call, and get your medication without leaving your home.

For a 50-gram tube in Ukraine they ask for 250 - 300 UAH.

Heparin-acrygel 1000 or Lyoton 1000: which is better

Now there is a lot of controversy on the Internet that Heparin-Akrigel 1000 and Lyoton 1000 are the same, Lyoton just takes money from customers for advertising and the brand. Is this really so, let's compare them according to several criteria.

They have a lot in common:

• active substance Heparin Sodium is included in the composition in equal amounts;
• penetrate into blood vessels and deep-lying tissues;
• form of preparations - gel;
• do not leave marks on clothes;
• the smell is characteristic, weakly expressed;
• used to prevent or treat the same diseases.

But there are a couple of significant differences:

1. Lyoton is patented.
2. Since Lyoton is produced by the huge Italian pharmaceutical association Menarini Group with the strictest observance of technology, the quality of the drug causes more confidence among buyers. But the first drug is produced by many different small post-Soviet pharmaceutical plants in several countries. Here it is more difficult to trust manufacturers.
3. Akrigel wins in price over Lyoton, because due to the promotion and patent, Lyoton gel is more expensive.

Therefore, many are content with a domestic drug and run the risk of running into a fake.

Contact your doctor with this question, he knows your condition better and will select the drug that is right for you.

If you decide to save money, check the information and reviews about the manufacturer before purchasing the drug, and you will not lose anything.

Analogues are cheaper

Many use Lyoton 1000 and do not even think about analogues, which are much cheaper. After all, we are used to believing advertising.

In addition to the fact that there is Heparin-Akrikhin 1000, as previously written, there are also such well-known options as Heparin ointment, Troxerutin and Detralex.

The ointment is much cheaper, but it is not as effective. It contains several times less Heparin Sodium, so it does not give such an effect.

Troxerutin differs from the gel in its active ingredient - troxerutin. Detralex has diosmin, hesperidin, but the substances have similar pharmacological effects.

The form of release of medicines for varicose veins are in the form of tablets (capsules) or ointments (gels).

How to cure varicose veins! An amazing discovery in the history of medicine.

A real example of how you can get rid of varicose veins forever! A proven method in the history of a famous blogger on THIS SITE!

The effectiveness of treatment always depends on a properly selected integrated approach. Tablets tone blood vessels, relieve all inflammatory processes, improve blood circulation. And an external preparation will relieve superficial symptoms.

Instructions for the use of the medicinal product

Trombless ®

Trombless

Heparin-Akrikhin 1000

gel for external use

Heparin-Akrikhin 1000 -1000 IU (0.00833 g with sodium heparin activity 120 IU / mg);

ethanol (ethyl alcohol), methyl parahydroxybenzoate (nipagin, methylparaben), propyl parahydroxybenzoate (nipazol, propylparaben), diethanolamine (2,2-iminodiethanol), carbomer (carbopol), water (purified water) - up to 1 g.

The gel is colorless or with a slight yellowish tint, transparent, with a specific odor.

Direct acting topical anticoagulant

Direct anticoagulant, has anti-inflammatory, antiproliferative, anti-edematous and analgesic effects. Reduces platelet aggregation, binds to antithrombin III, preventing the transition of prothrombin to thrombin. Inhibits thrombin activity. Reduces the activity of hyaluronidase, increases the fibrinolytic properties of the blood. Trombless

improves microcirculation and activates tissue metabolism, thereby accelerating the resorption of hematomas and blood clots, ultimately restoring vein patency, clinically this is accompanied by a pronounced analgesic and anti-inflammatory effect.

A small amount of heparin is absorbed from the surface of the skin into the systemic circulation. The maximum concentration of heparin in the blood is observed 8 hours after application. Excretion of heparin mainly occurs through the kidneys, the half-life is 12 hours.

Thrombophlebitis of superficial veins; localized infiltrates and soft tissue edema; subcutaneous hematomas (including hematomas after phlebectomy), injuries and bruises of the joints, tendons, muscle tissue.

Contraindications

Hypersensitivity to the components of the drug; ulcerative-necrotic, purulent processes on the skin; traumatic violation of the integrity of the skin; increased tendency to bleeding, thrombocytopenia.

It is possible to use the drug during pregnancy and lactation, if the potential benefit to the mother outweighs the risk to the fetus and child.

Outwardly. A column of gel 3-10 cm long is applied with light rubbing movements to the skin over the affected area 1-3 times a day. The gel is applied daily, on average from 3 to 7 days. The duration of treatment is determined by the doctor.

Side effects

With prolonged use of the drug, local reactions are possible in the form of skin hyperemia, allergic reactions.

Overdose

Due to low systemic absorption, overdose is unlikely.

The combined use of the gel with indirect anticoagulants can cause prolongation of the prothrombin time.

The gel is not prescribed topically simultaneously with non-steroidal anti-inflammatory drugs, tetracyclines, antihistamines.

special instructions

The drug should not be used for bleeding, as well as on open wounds, on mucous membranes and in purulent processes.

Release form

Gel for external use 1000 IU/g. 10, 20, 30, 40, 50 g in aluminum tubes or polyethylene laminate tubes. Each tube, along with instructions for the medical use of the drug, is placed in a cardboard pack.

Storage conditions

At a temperature not higher than 25 °C.

Keep out of the reach of children.

Best before date

3 years. Do not use the drug after the expiration date.

Holiday conditions

Without recipe.

OAO Nizhpharm, Russia

603950, Nizhny Novgorod,

GSP-459, st. Salganskaya, 7

The information on the page was verified by the therapist Vasilyeva E.I.

DETAILS: What is heparin ointment used for?

The manufacturer of the medicine is OJSC “Chemical-Pharmaceutical Plant “AKRIKHIN” Russia

Heparin Akrigel 1000 is a gel based on heparin. This means that the composition includes the active substance - heparin sodium, at a dosage of 1000 IU - this is a direct-acting anticoagulant, a component that slows down blood clotting, and also dissolves blood clots that have already appeared.

In addition to heparin, the composition also contains:

• Methyl parahydroxybenzoate (has an inhibitory effect on yeast and fungi).
• Carbomer 940, 980 (gel/cream stabilizer).
• Trometamol (prevents the appearance of edema, has a diuretic effect).
• Ethanol.
• Lavender oil (capable of having an anticonvulsant, bactericidal, antiseptic and regenerating effect). It improves microcirculation.
• Nerol oil (capable of having anticonvulsant, antispasmodic and decongestant effects).
• Purified water.

Release form - heparin gel / ointment for external use is produced in a tube of 20, 30, 40 or 50 g.

Description of the drug

– Anticoagulant of direct action, belongs to the group of medium molecular weight heparins. In blood plasma, it activates antithrombin III, accelerating its anticoagulant effect. Violates the transition of prothrombin to thrombin, inhibits the activity of thrombin and activated factor X, to some extent reduces platelet aggregation.

For unfractionated standard heparin, the ratio of antiplatelet activity (antifactor Xa) and anticoagulant activity (APTT) is 1:1.

Increases renal blood flow; increases the resistance of cerebral vessels, reduces the activity of cerebral hyaluronidase, activates lipoprotein lipase and has a hypolipidemic effect. Reduces the activity of surfactant in the lungs, suppresses excessive synthesis of aldosterone in the adrenal cortex, binds adrenaline, modulates the ovarian response to hormonal stimuli, increases the activity of parathyroid hormone.

There is evidence of immunosuppressive activity in heparin.

In patients with coronary artery disease (in combination with ASA) reduces the risk of acute coronary artery thrombosis, myocardial infarction and sudden death. Reduces the frequency of recurrent heart attacks and mortality in patients with myocardial infarction. In high doses, it is effective for pulmonary embolism and venous thrombosis, in small doses it is effective for the prevention of venous thromboembolism, incl. after surgical operations.

With intravenous administration, blood coagulation slows down almost immediately, with intramuscular injection - after 15-30 minutes, with s / c - after 20-60 minutes, after inhalation, the maximum effect is after a day; the duration of the anticoagulant action, respectively, is 4-5, 6, 8 hours and 1-2 weeks, the therapeutic effect - the prevention of thrombosis - lasts much longer. Deficiency of antithrombin III in plasma or at the site of thrombosis may reduce the antithrombotic effect of heparin.

When applied externally, it has a local antithrombotic, antiexudative, moderate anti-inflammatory effect. Blocks the formation of thrombin, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of the blood. Penetrating through the skin, heparin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots and reducing tissue swelling.

Pharmacotherapeutic action

Heparin-Acrigel, due to its active ingredient, is able to suppress the appearance of blood clots. The cream can also be used for swelling and inflammation in the early stages of the disease.

• When used externally, the cream enhances microcirculation in tissues and activates metabolic processes. In this regard, doctors often recommend this gel for veins from bruises, as it effectively dissolves hematomas, improves lymphostasis.
• If you use this drug according to the scheme for a long time (only on the recommendation of a doctor), you can get rid of varicose veins in already advanced conditions. Such treatment, in some cases, allows you to get rid of the disease without surgery.

DETAILS: Ziman analogues are cheaper. Ziman - instructions for use

This drug is also effective for hemorrhoids. It is allowed to be used both during exacerbation and in chronic forms of the disease. During an exacerbation, Heparin-Akrigel reduces the risk of cavernous vein thrombosis, reduces inflammation, relieves swelling and pain.

1. To obtain a positive effect, doctors show the use of the gel according to the scheme. It must be applied in a thin layer on the anal area 3 times a day. The duration of treatment is at least 3 days. As a rule, treatment is carried out for 2 weeks.
2. Instructions for use shows the use of Heparin-Akrigel in acute hemorrhoidal thrombosis, as it is able to quickly resolve blood clots and hematomas.
3. With internal hemorrhoids, the drug can be injected into the anus. To do this, it must be smeared on a cotton swab and inserted into the anus. If this option of therapy does not suit you, you can buy suppositories with heparin in the composition at the pharmacy.
4. If the patient has an external form of the disease, the gel is applied to a gauze pad and applied to the external bumps with an adhesive plaster.
5. In the acute phase of hemorrhoids, rubbing the gel is prohibited, since this type of application of the cream can provoke a breakthrough of the vascular wall and severe bleeding.

In addition to the above properties, this drug, due to the heparin in the composition, is often shown to be used after the surgical removal of proctological pathologies.

List of analogues

Note! The list contains synonyms for Heparin-Akrikhin 1000, which have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from Eastern Europe: Krka, Gedeon Richter, Actavis, Egis, Lek, Geksal, Teva, Zentiva.

Release form (by popularity)	price, rub.
Heparin-Akrikhin 1000
Gel 1000ME / g 30g (Akrikhin HFC OAO (Russia)	278
Viatromb
Heparin
1000 thousand IU / g 30g gel (Tatkhimfarmpreparaty JSC (Russia)	182.60
5000 IU 5ml №5 vial Belmed (Belmedpreparaty RUP (Belarus)	460.50
5000 IU 5ml №5 fl Elfa (Elfa NPC ZAO (Russia)	545.40
Fl 5000 IU 5ml N5 Belmed (Belmedpreparaty RUP (Belarus)	581.70
5000 IU / ml 5ml №5 r - r d / vv p / c (Slavyanskaya apteka OOO (Russia)	584.40
5000 IU 5ml No. 5 fl Synthesis (Sintez OJSC (Russia)	662.90
Heparin 1000
Heparin J
Heparin Lechiva
Heparin sodium
Heparin sodium
Heparin sodium* (Heparin sodium*)
Heparin solution for injections 5000 IU/ml
Heparin Sandoz
Heparin-Acrigel 1000
1 thousand IU / g 30g gel (Akrikhin KhFK OAO (Russia)	274
Heparin-Bynergia
Heparin Sodium Brown
Bottle 5000 IU / ml, 5 ml, 10 pcs. (Brown Melsungen, Germany)	1257
Heparin-Richter
Heparin-Ferein
Vials 5000 IU / ml, 5 ml, 5 pcs. (Bryntsalov, Russia)	587
Heparin sodium salt
Heparin solution for injections 5000 IU/ml
Lavenum
Gel, 50 g (Sintez AKOMP, Russia)	306
Lyoton 1000
Gel 30g (A.Menarini Manufacturing Loggia (Italy)	405
Gel 50g (A.Menarini Manufacturing Loggia (Italy)	546.30
Gel 100g (A.Menarini Manufacturing Loggia (Italy)	859
Trombless
Gel 1000E for g 30g (Nizhpharm JSC (Russia)	261
Gel 1000E for g 50g (Nizhpharm JSC (Russia)	350.40
Trombless Plus
Gel 30g (Nizhpharm OJSC (Russia)	317
Thrombogel
Thrombogel 1000
Thrombophobe

How to smear the gel?

Heparin-Acrigel should be applied to previously clean and dry skin. It is recommended to rub the cream with light circular movements until it is completely absorbed. It is allowed to apply the product no more than 3 times per day.

The course of treatment is several days. As soon as improvement occurs, swelling and inflammation will pass - the use of the drug must be stopped.

If the patient has a trophic ulcer, it is impossible to apply the remedy over it. In this case, the gel is applied to the surface around the wound.

DETAILS: Candles for hemorrhoids - inexpensive and effective candles for hemorrhoids with bumps

Side effects

As a rule, the gel is well tolerated and no allergy occurs. In some cases, when applying the cream, a burning sensation of the area of ​​​​application is possible.

1. Patients who use Heparin-Acrigel should be aware that this gel cannot be used simultaneously with certain drugs. For instance:
2. Simultaneous use of this gel with other anticoagulants and NSAIDs can increase the decrease in blood clotting.
3. The simultaneous use of Heparin-Akrigel with antihistamines, thyroxine, tetracycline group drugs, ergot and nicotine alkaloids significantly reduces their effect.

Varicose veins are a disease of blood vessels, as a result of which blood circulation is disturbed and insufficiency of venous valves occurs.

A modern sedentary lifestyle, along with abundant fatty foods, bad habits and some diseases, are the most common.

The composition of the medicine

One gram of the drug includes:

How does heparin work:

pharmachologic effect

Heparin-Akrigel inhibits the formation of blood clots, can be used as an anti-inflammatory and decongestant drug.

This is caused by blocking the formation of thrombin, inhibition of hyaluronidase activity, and activation of the fibrinolytic properties of blood.

When used locally, it serves to enhance microcirculation in tissues and to activate the metabolic process. Heparin increases the rate of resorption of hematomas, blood clots and improves lymphostasis.

Long-term use of the drug may eliminate the need for surgical intervention in the initial stages of varicose veins.

Use in proctology

The tool is used in proctology for treatment. It prevents and reduces the risk of cavernous vein thrombosis.

For therapeutic treatment and prevention, it is recommended to apply the gel in a thin layer on the anal area. Course of treatment: 3 times a day from three days to two weeks.

Preparations containing heparin in their composition have the ability to quickly resolve hematomas and blood clots. The instructions for Heparin-Acrigel 1000 recommend its use for the treatment of acute.

Also, this composition is indicated after surgical removal of proctological pathologies. The gel is quickly absorbed into the skin and does not leave marks on the linen.

For the treatment of external bumps, a gauze pad with the applied preparation is applied to them and fixed with an adhesive plaster.

In the acute phase of the disease, the gel cannot be rubbed in - this can provoke a breakthrough of the vascular wall and profuse bleeding.

Indications for use in phlebology

Heparin-Akrigel can be used to treat the beginning. The main signs of the disease are:

• feeling of heaviness and fatigue in the legs;
• nagging pain;
• edema that appears in the evening;
• skin itching.

The visible effect of the treatment is achieved in a long time - at least two weeks.

Also, the tool is used externally as a preventive and therapeutic drug for:

• post-infusion and
• lymphangitis,
• elephantiasis,
• superficial mastitis,
• localized injuries, bruises of muscle and joint tissues, tendons, edema and subcutaneous hematomas.

Contraindications to prescribing medication

Despite all the advantages of the gel, it has a lot of contraindications:

In women, menstruation, the threat of miscarriage and a recent birth can become a contraindication.

Particular attention should be paid to the high sensitivity to heparin. Do not use drugs with this substance to treat open wounds, abrasions, mucous membranes and necrotic ulcers.

In the active phase of tuberculosis, radiation sickness, both types of diabetes mellitus, chronic renal and hepatic insufficiency, some heart diseases and elderly patients, heparin is prescribed under constant laboratory monitoring of blood clotting.

A halving of the indicators serves as a signal to stop the use of the drug.

Instructions for use

The gel is applied to clean, dry skin in 0.5-1 grams (a strip of ointment 3-5 cm long) with an area of ​​​​5 to 20 cm2 and rubbed in a circular motion until completely absorbed. Apply no more than three times a day.

The course of treatment lasts several days until the inflammation is completely removed. If necessary, it can be extended by a doctor up to one month.

The drug is applied to the site of initial sclerotic changes. It is impossible to apply to the wound surface or apply - the surface around them is treated.

A side effect may be a slight burning sensation of the area of ​​application.

special instructions

External use of the drug Heparin-Akrigel 1000 has no special contraindications, except for polyvalent allergies and necrotic ulcers.

Increased bleeding and thrombocytopenia also require caution when prescribing.

Use during pregnancy

The gel does not cross the placenta and does not harm the unborn baby. It also does not enter breast milk from the mother's body.

Sharing with other medicines

It is worth knowing that the simultaneous use of Heparin Akrigel and:

• anticoagulants and NSAIDs enhances the decrease in blood clotting;
• taking antihistamine (anti-allergic) drugs, thyroxine, tetracycline group drugs, ergot alkaloids and nicotine together with this drug significantly reduces the effect of these drugs.

An overdose of the agent is impossible due to the low absorption of this component.

Community Opinion

From the reviews of patients who used Heparin Akrigel 1000 for treatment, you can learn a lot of useful information.

Heparin Akrigel 1000 is a lifesaver for our family. Bruises in children pass much faster, and in my case the drug relieves evening swelling from the legs.

Larisa, 40 years old

Difficult childbirth "rewarded" with hemorrhoids. They advised Heparin Akrigel 1000. I smeared the knot 3 times a day and after 2 weeks I forgot about this sore.

Marina, 28 years old

Have used for a long time. The drug is expensive, but it works well. Recently, a pharmacy offered to try Heparin-Acrigel 1000 instead. The result is no worse, but it costs much less.

Sergey, 35 years old

The product works great, but it is very greasy and smells unpleasant. Lioton, of course, is much more expensive, but it is quickly absorbed and does not leave marks on clothes, and the smell is much better. Is it really worth overpaying for the smell, because it is a medicine, not a perfume?

Natalia, 24 years old

What else does the market offer?

The price of Heparin-Acrigel 1000 is 230-270 rubles per 30 grams.

There are a lot of gels and ointments based on heparin, produced by domestic and foreign manufacturers, which are almost complete analogues of Heparin-Akrigel 1000:

• one of the most popular and affordable is 25 grams, the cost of which varies depending on the company from 50 to 90 rubles;

The use of the drug Heparin-Akrigel 1000 can significantly alleviate the course of existing vascular diseases and prevent the development of those that begin.

Dosage form

gel for external use

Composition

heparin 1000 IU;

Excipients: methyl parahydroxybenzoate, carbomer 940 or 980, trometamol, rectified ethyl alcohol, lavender oil, neroli oil, purified water.

Pharmacodynamics

It has a moderate anti-inflammatory and anti-edematous effect, prevents the formation of blood clots.

Side effects

Skin allergic reactions, skin hyperemia.

Selling Features

Released without a prescription

Special conditions

It is not recommended to use for bleeding, as well as on open wounds, mucous membranes and in the presence of local purulent processes. Use with extreme caution in case of increased vascular permeability. The use of the gel is not recommended for deep venous thrombosis.

Indications

Thrombophlebitis of superficial veins; localized infiltrates and soft tissue edema; injuries of tendons and joints, bruises of soft tissues and joints.

Contraindications

Hypersensitivity to any of the components of the drug, ulcerative-necrotic changes in the skin at the sites of the intended application of the gel, traumatic violation of the integrity of the skin, reduced blood clotting, thrombocytopenia

drug interaction

Prices for Heparin-Akrigel in other cities

Buy Heparin-Acrigel,Heparin-Akrigel in St. Petersburg,Heparin-Akrigel in Novosibirsk,Heparin-Akrigel in Yekaterinburg,Heparin-Akrigel in Nizhny Novgorod,Heparin-Akrigel in Kazan,Heparin-Akrigel in Chelyabinsk,

In this article, you can read the instructions for using the drug Heparin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Heparin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Heparin in the presence of existing structural analogues. Use for the treatment of thrombophlebitis, hemorrhoids, varicose veins in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Heparin- anticoagulant of direct action, belongs to the group of medium molecular weight heparins. In blood plasma, it activates antithrombin 3, accelerating its anticoagulant action. Violates the transition of prothrombin to thrombin, inhibits the activity of thrombin and activated factor 10, to some extent reduces platelet aggregation.

For unfractionated standard heparin, the ratio of antiplatelet activity (antifactor 10a) and anticoagulant activity (APTT) is 1:1.

Increases renal blood flow; increases the resistance of cerebral vessels, reduces the activity of cerebral hyaluronidase, activates lipoprotein lipase and has a hypolipidemic effect. Reduces the activity of surfactant in the lungs, suppresses excessive synthesis of aldosterone in the adrenal cortex, binds adrenaline, modulates the ovarian response to hormonal stimuli, increases the activity of parathyroid hormone. As a result of interaction with enzymes, it can increase the activity of brain tyrosine hydroxylase, pepsinogen, DNA polymerase and reduce the activity of myosin ATPase, pyruvate kinase, RNA polymerase, pepsin.

There is evidence of immunosuppressive activity in heparin.

In patients with coronary artery disease (in combination with ASA) reduces the risk of acute coronary artery thrombosis, myocardial infarction and sudden death. Reduces the frequency of recurrent heart attacks and mortality in patients with myocardial infarction. In high doses, it is effective for pulmonary embolism and venous thrombosis, in small doses it is effective for the prevention of venous thromboembolism, incl. after surgical operations.

With intravenous administration, blood coagulation slows down almost immediately, with intramuscular injection - after 15-30 minutes, with subcutaneous injection - after 20-60 minutes, after inhalation, the maximum effect is after a day; the duration of the anticoagulant action, respectively, is 4-5, 6, 8 hours and 1-2 weeks, the therapeutic effect - prevention of thrombosis - lasts much longer. Deficiency of antithrombin 3 in plasma or at the site of thrombosis may reduce the antithrombotic effect of heparin.

When applied externally, it has a local antithrombotic, antiexudative, moderate anti-inflammatory effect. Blocks the formation of thrombin, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of the blood. Penetrating through the skin, heparin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots and reducing tissue swelling.

Composition

Sodium heparin + excipients (injections).

Heparin sodium + Benzocaine + Benzyl nicotinate + excipients (heparin ointment).

Sodium heparin 1000 IU + excipients (gel Akrikhin 1000).

Other forms such as tablets do not exist.

Pharmacokinetics

Heparin does not cross the placenta well due to its high molecular weight. Not excreted in breast milk.

Indications

Prevention and therapy:

• deep vein thrombosis;
• thromboembolism of the pulmonary artery (including in diseases of peripheral veins);
• thrombosis of the coronary arteries;
• thrombophlebitis;
• unstable angina;
• acute myocardial infarction;
• atrial fibrillation (including accompanied by embolism);
• DIC;
• prevention and therapy of microthrombosis and microcirculation disorders;
• thrombosis of the renal veins;
• hemolytic uremic syndrome;
• mitral heart disease (prevention of thrombosis);
• bacterial endocarditis;
• glomerulonephritis;
• lupus nephritis;
• prevention of blood coagulation during operations using extracorporeal methods of blood circulation;
• preparation of non-clotting blood samples for laboratory purposes and blood transfusion
• prevention and treatment of thrombophlebitis of superficial veins;
• post-injection and post-infusion phlebitis;
• external hemorrhoids;
• inflammation of postpartum hemorrhoids;
• trophic ulcers of the lower leg;
• elephantiasis;
• superficial periphlebitis;
• lymphangitis;
• superficial mastitis;
• localized infiltrates and edema;
• injuries and bruises without violating the integrity of the skin (including muscle tissue, tendons, joints);
• subcutaneous hematoma.

Release forms

Ointment for external use.

Solution for intravenous and subcutaneous administration (injections in ampoules for injection).

Gel for external use.

Instructions for use and dosage

Ampoules

Intravenous (infusion or injection) or subcutaneous (famous injections in the abdomen), the initial dose is intravenous (injection) 5000 IU, maintenance: continuous IV infusion - 1000-2000 IU / h (20000-40000 IU / day), previously diluted in 1000 ml of isotonic NaCl solution; regular intravenous injections - 5000-10000 IU every 4-6 hours; subcutaneously (deeply) - 15000-20000 IU every 12 hours or 8000-10000 IU every 8 hours.

Ointment

Apply externally. The ointment is applied in a thin layer to the affected area (at the rate of 0.5-1 g (2-4 cm of ointment) per area with a diameter of 3-5 cm) and the ointment is gently rubbed into the skin. The ointment is applied 2-3 times a day daily until the inflammation disappears, on average from 3 to 7 days. The possibility of a longer course of treatment is determined by the doctor.

In case of thrombosis of external hemorrhoids, the ointment is applied to a calico or linen pad, which is applied directly to the thrombosed nodes and fixed. The ointment should be applied daily until the symptoms disappear, on average from 3 to 14 days, for the same purpose, you can use a swab soaked in heparin ointment, which is inserted into the anus.

Side effect

• bleeding of the gastrointestinal tract and urinary tract;
• bleeding at the injection site, in areas subjected to pressure, from surgical wounds;
• hemorrhages in organs;
• hematuria;
• thrombocytopenia;
• nausea, vomiting;
• loss of appetite;
• diarrhea;
• skin hyperemia;
• medicinal fever;
• hives;
• rhinitis;
• skin itching and feeling of heat in the soles;
• bronchospasm;
• collapse;
• anaphylactic shock;
• thrombocytopenia (may be severe up to death) with the subsequent development of skin necrosis, arterial thrombosis, accompanied by the development of gangrene, myocardial infarction, stroke;
• osteoporosis;
• spontaneous fractures;
• soft tissue calcification;
• irritation, pain, hyperemia, hematoma and ulceration at the injection site;
• transient alopecia;
• hypoaldosteronism.

Contraindications

• bleeding;
• diseases accompanied by a violation of blood coagulation processes;
• suspicion of intracranial hemorrhage;
• aneurysm of cerebral vessels;
• hemorrhagic stroke;
• dissecting aortic aneurysm;
• antiphospholipid syndrome;
• malignant arterial hypertension;
• subacute bacterial endocarditis;
• erosive and ulcerative lesions of the gastrointestinal tract;
• severe lesions of the liver parenchyma;
• cirrhosis of the liver with varicose veins of the esophagus;
• malignant neoplasms in the liver;
• shock conditions;
• recent surgical interventions on the eyes, brain, prostate, liver and biliary tract;
• condition after spinal cord puncture;
• menstruation;
• threatened miscarriage;
• childbirth (including recent);
• hypersensitivity to heparin.

Use during pregnancy and lactation

Use during pregnancy is possible only under strict indications, under close medical supervision.

May be used during lactation (breastfeeding) according to indications.

special instructions

Use with caution in patients suffering from polyvalent allergies (including bronchial asthma), with arterial hypertension, dental procedures, diabetes mellitus, endocarditis, pericarditis, in the presence of an intrauterine contraceptive, with active tuberculosis, radiation therapy, liver failure, chronic renal failure, in elderly patients (over 60 years, especially women).

Use with caution externally for bleeding and conditions of increased bleeding, thrombocytopenia.

During treatment with heparin, monitoring of blood coagulation parameters is necessary.

For dilution of heparin, only physiological saline is used.

With the development of severe thrombocytopenia (a decrease in the number of platelets by 2 times from the original number or below 100,000 / µl), it is necessary to urgently stop the use of heparin.

The risk of bleeding can be minimized with careful evaluation of contraindications, regular laboratory monitoring of blood clotting, and adequate dosing.

Ointment or gel is not applied to open wounds, mucous membranes, is not used for ulcerative necrotic processes.

drug interaction

The anticoagulant effect of heparin is enhanced with the simultaneous use of anticoagulants, antiplatelet agents and non-steroidal anti-inflammatory drugs (NSAIDs).