Nonspecific stimulation of spermatogenesis. The method of complex stimulation of spermatogenesis

Stimulation of spermatogenesis is a painstaking process based on a complex effect on the body. The procedure is based on the use of medications, the normalization of lifestyle, the elimination of addictions and physical activity. Compliance with the main factors of influence on the body increases the production of spermatozoa, increasing their quantitative and qualitative indicators.

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Proper nutrition

Healthy food has a beneficial effect on the body of every person. Inclusion in the daily diet of foods enriched with vitamins, minerals and trace elements increases sperm production. Compensation for the lack of useful components has a positive effect on well-being. Proper nutrition is the foundation of good health and a fulfilling life.

The use of approved products helps to restore the synthesis of spermatozoa. Numerous studies have proven a direct link between enriched food and the production of high-quality ejaculate. A full cycle of sperm maturation is a long process that takes at least 75 days. To obtain high-quality cells, a man needs to constantly eat right. This action is aimed at replenishing the deficiency of useful components and restoring the natural process of sperm production.

For the rapid synthesis of high-quality ejaculate, a man is recommended to consume certain foods:

• citrus fruits, cabbage. They are based on a considerable amount of vitamin C. This is an active component that is directly involved in the process of sperm formation. Vitamin C acts as a natural antioxidant. The primary task of the component is to eliminate toxins and hazardous substances, which positively affects the quality characteristics of the ejaculate;
• beef, bran, sesame seeds. The basis of the presented products contains a large amount of zinc. The trace element is responsible for the rate of cell division and stimulation of spermatogenesis;
• peanut. Peanuts contain saturated fatty acids. The primary task of the component is to increase the production of testosterone. The male hormone is responsible for activating sperm synthesis;
• liver, pumpkin seeds. Foods rich in folic acid. Vitamin B9 improves the quality of sperm. Replenishment of folic acid deficiency guarantees the production of cells that are correct in structure without defects and developmental anomalies;
• green vegetables and fruits. They are rich in vitamin A content. Retinol is a fat-soluble component with a powerful antioxidant effect. Vitamin A restores spermatogenesis, increasing the quantitative indicators of the ejaculate;
• broccoli, spinach, nuts. Foods are rich in vitamin E. Tocopherol has antioxidant properties. It is well absorbed by the body, is responsible for the synthesis of sperm;
• dairy products. Rich in the content of B vitamins. Their deficiency leads to a deterioration in the general condition. The mental and physical activity of the body is disturbed. Replenishing vitamin B deficiency improves overall well-being and restores sperm production.

Doctors urge to give up heavy and unhealthy food. Fried, smoked and fatty foods negatively affect the performance of the body. Available energy resources are spent on food processing, which negatively affects the process of sperm production. The body is not set up to produce high-quality biological material, which complicates the process of fertilization.

Important: a man must eat right. Without replenishing the deficiency of useful components, the normal activity of the reproductive system is impossible. Correction of nutrition towards healthy food is a step towards the restoration of spermatogenesis.

Healthy lifestyle

A healthy lifestyle is the key to the proper and uninterrupted functioning of the organs and systems of the body. In order to restore spermatogenesis, doctors recommend listening to the following tips:

• eliminate bad habits. Alcoholic products and cigarettes negatively affect the quality of sperm produced. Regular consumption of alcoholic beverages inhibits the natural production of ejaculate. Dependence on alcohol and cigarettes violates the integrity of the cells and increases the likelihood of the formation of abnormal spermatozoa, which excludes the conception process;
• resort to the help of bee products. It is noteworthy that the regulation of spermatogenesis is more dependent on honey and its derivatives. Beekeeping products contain a considerable amount of useful components that have a positive effect on the human immune system. It has been proven that bee bread, honey and royal jelly are natural biostimulators of spermatogenesis;
• engage in moderate physical activity. Regular loads during the week have a positive effect on the general condition of a man. The human body is in good shape, all systems and organs work smoothly. Physical activity normalizes the production of high quality sperm;
• adjust sleep and wake patterns. For normal sperm synthesis, a man must get enough sleep. Establishing an eight-hour sleep regimen and moderate activity during the day normalizes the production of active cells;
• make an individual diet with a predominance of healthy and rich food. High-quality food has a positive effect on the body and contributes to saturation with vitamins and minerals. Normalization of useful components in the body is the key to the uninterrupted production of high-quality sperm;
• timely eliminate diseases of the genitourinary system. A man should not ignore the symptoms of inflammatory and infectious pathologies. Timely therapy prevents the development of severe complications, one of which is infertility.

A healthy lifestyle is responsible for the normal functioning of the body as a whole. Every man is capable of following the basics of the right rhythm. According to studies, a habit is formed within three weeks.

Regular performance of a new skill accelerates the adaptation of the body, which ultimately guarantees good health. Systematic adherence to the rules of a healthy life is the key to high-quality and healthy cells in the ejaculate.

Physical exercise

An important aspect in the formation of high-quality sperm is moderate physical activity. A man does not have to perform certain exercises or follow the basics of therapeutic exercises. It is enough to choose any sport and set the goal of regularity. Daily jogging, overcoming long distances, walking or exercising in the gym - all this together has a beneficial effect on the general condition of a man.

Physical activity accelerates the activity of organs and systems. The body becomes more resilient, additional opportunities open up. An increase in energy reserves in conjunction with proper nutrition has a positive effect on the production of high-quality sperm. It is enough for a man to follow the basic rules:

• regularity;
• lack of overwork;
• smooth increase in load;
• quality rest.

Without sports, the body begins to be lazy. A person is not able to engage, his mood falls, which negatively affects the general well-being and self-esteem. Modern medicine encourages people to include physical culture in their lives. Sport helps in solving most problems, including impaired sperm production.

Use of drugs

It is possible to restore spermatogenesis by classical methods. Their category includes drug effects on the body. The modern pharmacological market has a mass of effective means to restore the production of healthy cells. The use of drugs alone is not allowed. A man needs to visit a doctor to identify the causes of impaired sperm production and to prescribe comprehensive recovery measures.

There are a lot of drugs to improve spermatogenesis, all of them are conventionally divided into several groups:

• hormonal agents (Omnadren);
• biologically active additives (Speroton);
• vitamin complexes (Doppelhertz);
• homeopathic remedies (Ubiquinone).

Hormonal drugs are taken urgently according to the doctor's indications. It is forbidden to use drugs of the presented category on your own.

Incorrect dosage leads to a violation of the hormonal background and the development of complications. The primary task of drugs is to restore the natural process of testosterone production. Dietary supplements improve the quality of spermatozoa. Medicines of the presented category are used in combination with other drugs. The main task of dietary supplements is to fill the deficiency of useful components. It is not recommended to use them on their own. Supplements are prescribed taking into account the characteristics of each person. Additional properties of dietary supplements include:

• restoration of blood circulation;
• prevention of stagnant processes in the pelvis;
• improved sperm concentration;
• restoration of the synthesis of male hormones.

Vitamin complexes are useful for the whole organism. The main task of drugs is to fill the deficiency of components. It is necessary to take vitamin complexes with the approval of a doctor, after the studies. A blood test for the quantitative composition of certain substances helps to choose the optimal type of drug.

Homeopathic medicines are based on natural ingredients. The presence of components of animal and vegetable origin eliminates the development of allergic reactions. Natural remedies have a positive effect on the process of spermatogenesis. Doctors recommend using homeopathic remedies in combination with other medicines.

Additionally, doctors distinguish a group of adapted medicines. These include:

• Spermstrong. Dietary supplement rich in B vitamins, trace elements and minerals. It has a beneficial effect on the quality of sperm, improves sexual desire, has a general strengthening effect;
• sperm plant. Contains herbal ingredients. The action of the drug is aimed at stimulating the production of sperm, improving fertility. Due to the natural composition, the drug is suitable for all healthy men. Used as prescribed by a doctor in an individual dosage;
• Prostatinol. The product contains pumpkin seeds, glycine, ginseng and additional natural ingredients. Prostatinol improves spermatogenesis, increases the quantitative and qualitative characteristics of the ejaculate. The drug shows effectiveness in functional disorders of the prostate. It has a positive effect on chronic diseases;
• Ecostimulin. Hormonal agent with the function of stimulating spermatogenesis. It is used exclusively according to the indications of a doctor. Self-administration of tablets is dangerous for the development of complications.

Important: the use of medications is appropriate for severe disorders in the development of spermatogenesis. Minimal deviations are eliminated through the normalization of lifestyle.

Normally, the process of spermatogenesis takes 75 days. The presented period can vary from 50 to 90 days, which is not considered a pathology. In case of deviations from the norm and the absence of natural fertilization, doctors recommend taking a complete spermogram. Based on the results of the procedure, the doctor will determine the quantitative indicators of the cells. In case of violations, complex measures will be prescribed to restore normal spermatogenesis. It is not recommended to ignore violations, they can indicate the development of severe pathologies, including congenital anomalies and oncological processes. Delaying treatment is dangerously fatal (in the case of malignant neoplasms).

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Stimulation of spermatogenesis is used in cases where it is required to temporarily improve sperm counts. Such a need arises when conceiving naturally or when using assisted reproductive technologies. The method is shown only to those men who have various types of pathospermia, which do not give the opportunity to have children.

How is spermatogenesis stimulated?

You can improve the spermogram with the help of special preparations, as well as subject to certain recommendations. Medical support includes the appointment of vitamins and trace elements that play an important role in the processes of spermatogenesis. Among them are the following:

• Folic acid.
• Zinc.
• L-carnitine.
• Selenium.
• Vitamin E.
• Glutathione.

If the indicators of the ejaculate have deteriorated due to concomitant diseases, then specific therapy is prescribed. For example, antibiotics are prescribed to eliminate sexually transmitted infections, and hormonal disorders are corrected with the help of appropriate drugs.

• Rejection of bad habits.
• Sufficient sleep.
• Regular physical activity.
• Exclusion of hypothermia or overheating of the body.
• Proper nutrition.
• Normalization of body weight.
• Eliminate stress.

To achieve these goals, other specialists can be involved, for example, a dietitian, a psychologist.

• Fast - without kilometer queues and dozens of additional studies.
• Effective - thanks to the well-established schemes, our specialists will prescribe exactly those drugs that are most likely to restore reproductive function.
• Safe - we carefully monitor that the prescribed treatment does not harm the patient.

The participation of oxidative stress in the development of sperm predetermined the use of various antioxidants (vitamins, trace elements, biologically active substances) in the correction of spermatogenesis disorders. Antioxidants reduce exposure to reactive oxygen species, and therefore reduce oxidative stress, which negatively affects spermatozoa.

Currently, in the course of numerous studies, it has been found that the deterioration of sperm parameters is the reason for not getting pregnant. According to a 2011 Cochrane review, between 30% and 80% of men are unable to have children as a result of the damaging effects of oxidative stress on sperm.

Factors leading to violations

Factors leading to impaired development of spermatozoa, as well as damage to the genetic material in spermatozoa (DNA) as a result of oxidative stress, are:

• testicular developmental disorders
• wrong lifestyle
• overweight
• smoking
• overheating
• excessive physical activity
• lack of natural antioxidants
• electromagnetic radiation
• infectious and inflammatory processes
• varicocele
• diabetes
• influence of toxic substances

The main antioxidants are vitamins (A, B, C, E), trace elements, alpha-lipoic (thioctic) acid, polyunsaturated fatty acids, amino acids.

When to Correct

Correction of violations of ejaculate parameters is advisable when planning pregnancy, as well as when preparing men to participate in programs of assisted reproductive technologies. The training package includes an initial examination of men, based on the results of which a decision is made to conduct therapy with various schemes for the use of drugs (antioxidants). Often, correction is required in a fairly short time, which made it possible to develop schemes for the use of parenteral forms of drugs for a faster onset of their action.

Improving ejaculate performance through non-specific stimulation is of high importance, since the state of spermatozoa is directly related to the possibility of pregnancy. The AltraVita clinic successfully uses drug schemes for stimulating spermatogenesis. They are effective even in cases where the cause of the violation of sperm quality cannot be found out. After a few months, the man's fertility is restored, and he can conceive a child naturally, without resorting to the use of assisted reproductive technologies.

Infertility and problematic long-term attempts at conception are tested by many couples. Men and women, wishing to become parents in the foreseeable future, are storming medical centers and laboratories, undergoing comprehensive examinations. It often turns out that conception does not occur through the fault of a man, namely, due to the insufficient fertility of his sperm. In order to improve the activity or speed of movement of spermatozoa, stimulation of spermatogenesis is necessary. How to improve the quality of sperm and increase its fertility, and will be discussed in this article.

It's all about nutrition

Proper nutrition is the foundation of health, a fulfilling life and longevity. This postulate is well known to everyone. But not everyone knows that certain products can stimulate and increase or, conversely, worsen spermatogenesis.

The physiology of a man is designed in such a way that the full cycle of maturation of male germ cells, or spermatogenesis, takes place in the testicles for 3 months. Gradual division of the progenitor cell leads to the formation of known cells with a flagellum, capable of translational movements. Now it becomes clear that the products consumed during this 3-month development cycle can both increase the mobility and activity of sperm, increase their nominal number during ejaculation, and act on these indicators in the opposite direction.

Consider the products and the substances and vitamins they contain that are useful for stimulating spermatogenesis. To improve the quality of sperm, doctors recommend:

1. All foods containing vitamin C. This biologically active substance is known as the strongest antioxidant. Vitamin C prevents the excessive formation of free oxygen radicals that negatively affect spermatogenesis. With sufficient enrichment of the body with this substance, the process of cell division occurs much more actively and more correctly. Foods rich in vitamin C are citrus fruits, cabbage.
2. The trace element zinc is actively involved in the improvement and stimulation of spermatogenesis, optimizing cell division and increasing the rate of forward movement of spermatozoa. Foods such as beef, bran, sesame seeds are involved in stimulating progenitor cell division.
3. Regular consumption of peanuts increases the level of unsaturated fatty acids in the blood, which positively affects the level of the male sex hormone testosterone. It is testosterone that is involved in the activation and improvement of spermatogenesis.
4. Folic acid (vitamin B9) with regular use can improve the quality of spermatogenesis. A sufficient amount of this substance in the body guarantees the absence of damaged genetic material in male germ cells, which has a positive effect on the heredity of the unborn child. Liver, yeast, bread, pumpkin seeds are traditionally rich in folic acid, used to stimulate spermatogenesis and are known to improve potency.

To improve spermatogenesis, you need to eat right.

In order for a man to produce truly fertile seminal fluid during ejaculation, the listed products and their components should be eaten at least 3-4 times a week. It is this frequency that stimulates spermatogenesis and helps to increase the fertility of the ejaculate.

What can you find in a pharmacy

In the retail pharmacy network, there are currently many drugs in tablets and capsules to stimulate spermatogenesis. They are sold without a prescription and, according to the instructions, cause an increase in the number of active spermatozoa, increase the speed of their forward movement. These properties allow you to increase the likelihood of rapid conception. Let's analyze the most popular drugs with the above properties:

• Spermstrong is a dietary supplement. A positive effect on the quality of the ejaculate is achieved due to the special composition of the drug. 1 capsule contains arginine, L-carnitine, vitamins C, E, B6, as well as zinc, selenium and manganese. In addition to improving the quality of sperm during ejaculation, the manufacturer reports a positive effect of the drug on libido, as well as a general strengthening effect on the body. It is recommended to take courses 2 times a day.
• A sachet containing a water-soluble powder called Spermplant. The medicine contains fructose, L-carnitine, citric acid, taurine, nettle extract and arginine. These substances, which improve sperm fertility during ejaculation, are approved for use by almost everyone. The exception is cases of individual intolerance. Reception mode - 1 sachet per day. The minimum course of treatment is 1 month. If necessary, the drug can be repeated after a 10-15 day break.
• The drug Prostatinol has established itself as improving the quality of sperm in diseases of the prostate gland. It is especially effective in chronic inflammatory processes leading to infertility. Such properties are determined by the pumpkin seed extract contained in the composition, sabal palm fruit extract, alanine, glutamine, glycine, and ginseng extract. An important feature - the drug prevents premature ejaculation. The recommended frequency of administration is 1 capsule 2 times a day.
• The Doppelherz Spermaktiv complex optimizes erectile function, improves the ejaculation process, and also stimulates spermatogenesis. The preparations contain trace elements such as calcium, magnesium, zinc, silicon, selenium. Vitamins present in the composition - B12, C, B2, B1, D3, folic acid. It is necessary to take 1 tablet 1 time per day. The course of treatment is 1 month.
• The drug Ecostimulin contains the hormone chorionic gonadotropin, which is produced first by the corpus luteum and then by the placenta during pregnancy. Chorionic gonadotropin is known in medicine for its spermatogenesis stimulating properties. It is contraindicated to take this medication if a man has hormone-dependent tumors and cryptorchidism. The mode of reception is determined individually by the attending physician.

There are many drugs to stimulate spermatogenesis.

Despite the fact that almost all of the described drugs can be purchased independently at a pharmacy without a prescription, a preliminary consultation with an andrologist-urologist will be correct. The doctor will determine the optimal drugs and the correct regimen for taking them.

Additional Methods

In those situations where a man strictly complied with the doctor's requirements, including eating right, giving up alcohol and nicotine, taking prescribed dietary supplements, and stimulation was ineffective and there was no improvement in sperm properties, the doctor may recommend hospitalization. This is necessary for a more thorough examination and treatment. Perhaps the appointment of drugs for stimulation in injection or drip form.

Physiotherapeutic methods have proven themselves well for stimulating spermatogenesis, namely laser exposure to the male genital organs. The laser has a beneficial effect on the functioning of the gonads, is involved in stimulating the production of full and active spermatozoa, and also helps to increase their number.

Improving the properties of sperm is not easy, but in most cases it is quite feasible task. You need to take a responsible approach to your diet, lifestyle, and also follow the doctor's prescriptions. This helps to improve the activity of male germ cells, which increases the likelihood of rapid conception.

The invention relates to medicine, namely to urology and andrology, and can be used for complex stimulation of spermatogenesis. To do this, against the background of drug therapy, a laser is applied in contact with the scrotum area. Laser exposure is carried out by low-intensity laser radiation with a wavelength of 0.63 μm with an output power of 30 mW. In this case, a single dose of exposure is 0.2 J/cm 2 . Procedures are carried out daily. The course of treatment is 10-15 procedures. The method allows to increase the antioxidant status in tissues, reduce the level of lipid peroxidation, normalize testicular microcirculation, improve intraorganic hemodynamics, and thereby stimulate spermatogenesis, the method also allows for effective treatment of patients both in the early postoperative periods and in any urological pathology complicated by impaired spermatogenesis.

The invention relates to the field of medicine, namely to urology and andrology, and can be used in the complex treatment of urological pathology complicated by impaired spermatogenesis.

One of the main theories of decreased spermatogenic function of the testicles is hypoxic. Violation of the outflow of blood from the testicle, spasm of intraorganic vessels and arteriovenous shunting are accompanied by a drop in the partial tension of oxygen in the tissues. First, compensatory activation of aerobic enzymes is detected in the testicles. Then the pathways of organ metabolism are oriented towards the anaerobic type of energy generation. Against the background of prolonged hypoxia, dystrophic changes develop in the convoluted seminiferous tubules, which end in atrophy. In addition, due to the friendly vasomotor reaction of paired organs, circulatory disorders in most cases are bilateral in nature.

A known method of stimulating the spermatogenic and androgen-producing functions of the male gonads (RF patent No. 2040258, class A61K 31/708, 2006). This method includes medical treatment.

The disadvantage of this method is the low efficiency due to the fact that the drugs do not penetrate the hemato-testicular barrier and have the necessary effect on the tissue of the testicles.

A known method of complex stimulation of spermatogenesis, including contact laser exposure to the scrotum against the background of drug therapy (RF patent No. 2342962, class A61N 5/067, 2008).

In this method, to stimulate spermatogenesis against the background of drug therapy, the scrotum area is additionally exposed to pulsed IR laser radiation ( = 0.89 μm), while the pulse power is 1.3-1.4 W, the pulse repetition rate is 600 Hz, the dose is 0 .2 J/cm 2 for a course of 5-7 minutes for 10-12 days, daily. The following are used as medicines: multivitamins, antioxidant drugs that stimulate spermatogenesis, increase sperm motility and reduce sperm viscosity.

The disadvantages of this method is that the effect of the infrared laser (=0.89 μm) is performed in a pulsed mode and the power of each pulse reaches 4.1 watts. This rather harsh effect can be a damaging factor on the surrounding tissues of a growing organism, so it is advisable to stimulate spermatogenesis in this way no earlier than 4-6 months after the operation (with complete healing of the surrounding tissues). However, the greatest effectiveness of complex treatment will be achieved when each of the methods included in the complex will have an impact on the corresponding link in the early approximate terms.

In accordance with this, the task was set, aimed at expanding the functionality of the method through the use of sparing laser exposure in any urological pathology complicated by impaired spermatogenesis, including in the early stages of postoperative intervention.

To solve this problem in the method of complex stimulation of spermatogenesis, including contact laser exposure to the scrotum area against the background of drug therapy, characterized in that the laser exposure is carried out with low-intensity laser radiation with a wavelength of 0.63 μm, an output power of 30 mW, while a single dose exposure is 0.2 J/cm 2 and the course of treatment is 10-15 procedures performed daily.

It is known that in addition to specialized photoreceptors, there are quite a lot of photoacceptors in the human body. These include hemoglobin, cyclic nucleotides, iron and copper, containing the enzymes catalase, superoxide dismutase, c-cytochrome oxidase, redox cycle enzymes, pigments, molecular oxygen and other substances. For example, an increase in catalase activity as a result of irradiation with red laser light has a positive effect on the antioxidant system of the body with subsequent physiological effects in various diseases, including inflammatory diseases. The processes activated by this enzyme include the detoxification of peroxides, aldehydes, and ketones, which are cytotoxic agents. Reactivation of superoxide dismutase leads to an increase in the antioxidant status in tissues and a decrease in the level of lipid peroxidation, etc. This leads to the normalization of testicular microcirculation and improvement of intraorganic hemodynamics, which, in turn, contributes to the stimulation of spermatogenesis.

We examined 27 patients with varicocele before and after surgery for varicocele (mostly, the Palomo-Erokhin operation was performed).

In most patients before surgery, violations in the spermogram were detected (decrease in the total number of spermatozoa, the percentage of active-motile ones, an increase in the number of pathological spermatozoa, etc.).

The method is carried out as follows. After an operation, for example, a varicocele, or in case of other urological pathology with impaired spermatogenesis, against the background of drug therapy, which, as a rule, includes the intake of membrane stabilizers, antioxidants, multivitamin complexes, Aevit vitamins, which normalize the permeability of the vascular wall, increase tissue resistance to hypoxia, normalize tissue respiration, in addition to the area of ​​the scrotum, a contact laser effect is performed using a biophysical apparatus that generates low-intensity laser radiation in a constant mode with a wavelength of 0.63 μm, an output power of 30 mW. In this case, a single dose of exposure is 0.2 J/cm 2 , and the course of treatment is 10-15 procedures performed daily.

The time of laser exposure with a wavelength of 0.63 μm was determined by the formula:

T=DS/P (I-),

where D is the radiation dose (J / cm 2);

S - irradiation area (cm 2);

P - laser output power (mW) for ( =0.63 μm);

Reflection coefficient (measured by a laser biophotometer = 0.63 µm).

Such a course was conducted in operated patients a few days after surgery. Practically in all patients, a dynamic study revealed an improvement in spermogram parameters.

A specific example of the method

Example 1. Patient Ch., aged 15, was admitted after the Palomo-Erokhin operation on the left with a diagnosis of oligoasthenospermia. There are no complaints. Testicles of normal size, palpation is not changed. There is no recurrence of varicocele. Pathological changes were found in the ejaculate. Quantity in 1 ml 18 million, active-sub. 3%, weakly sub. 37%, fixed 60%, pathological 40%, total number 27 mln. this single dose of exposure was 0.2 J/cm 2 and the course of treatment 12 procedures performed daily.

In the control study of the ejaculate after treatment, a significant improvement was revealed: the number in 1 ml is 34 million, active sub. 33%, weakly sub. 30%, fixed 37%, pathological 25%, total 68 million.

The use of this method will provide effective treatment of patients both in the early postoperative period and in any urological pathology complicated by impaired spermatogenesis.

CLAIM

A method for complex stimulation of spermatogenesis, including contact laser exposure to the scrotum area against the background of drug therapy, characterized in that laser exposure is carried out with low-intensity laser radiation with a wavelength of 0.63 μm, an output power of 30 mW, while a single dose of exposure is 0.2 J/cm 2 , and the course of treatment is 10-15 procedures performed daily.