Nifuroxazide syrup instructions for use. Nifuroxazide syrup: instructions for use, how the drug works and when to take it
Nifuroxazide is a drug with antibacterial and bactericidal action. The drug is prescribed to patients with intestinal infections complicated by the presence of diarrhea (diarrhea). The drug is produced in three countries: Poland, Russia and Germany.
According to doctors, Nifuroxazide is not an antibiotic, despite its antibacterial effect. The drug is one of the nitrofurans and has a targeted effect on pathogenic bacteria that have entered the intestine in one way or another.
Unlike antibiotics, the drug does not affect the normal microflora, does not spread throughout the body with the bloodstream, and is not absorbed into the blood from the digestive tract.
1. Instructions for use
pharmachologic effect
Most of the microorganisms that cause intestinal diseases (staphylococcus, Escherichia coli, Shigella, Vibrio cholerae, Salmonella, Enterobacter, Klebsiella, Yersinia) are sensitive to nifuroxazide. But it is worth noting that this substance is inactive against some strains of Proteus and Pseudomonas.
The drug can act both bactericidal and bacteriostatic (the effect is dose-dependent). When using Nifuroxazide, the synthesis of proteins by the cells of pathogens is disrupted, and the activity of the dehydrogenase enzyme is inhibited.
When prescribing the drug in medium doses, neither the emergence of strains resistant to antimicrobial agents nor the suppression of the growth of normal intestinal microflora was noticed. With an intestinal infection caused by viruses, Nifuroxazide prevents the addition of a secondary infection.
The drug is not absorbed in the stomach and creates a high concentration of the active ingredient in the intestine. The features of the pharmacokinetics of Nifuroxazide are such that it does not have a systemic effect (it enters the blood in a small amount) and is excreted with feces.
Indications for use
Nifuroxazide is prescribed for people suffering from:
Also, the drug is used to prevent infections during abdominal operations.
Mode of application
All dosage forms of Nifuroxazide are intended for oral administration.
Pills
Children over six and adults are prescribed 2 tablets of the drug (200 mg) four times a day (no matter before or after meals). The interval between two "adjacent" receptions should be about 6 hours.
The duration of therapy is 5-7 days. If the child is not yet six years old, a medicine in the form of a suspension is used to treat him.
Suspension
The dosage is determined by the age of the patient:
- babies from 2 to 6 months: 2.5 or 5 ml twice a day;
- children from 6 months to 6 years: 5 ml three times a day every 8 hours;
- adults, children over 6: 5 ml (one scoop) four times a day every 6 hours.
Note: before use, the suspension is thoroughly shaken until a homogeneous mass is obtained.
The nature of the stool is an important indicator of children's health. With diarrhea, it is liquid, and from frequent trips to the toilet, the child loses a lot of fluid. At the same time, the digestibility of nutrients in the intestines is disturbed: food does not stay in it for a long time. It interferes with the absorption of vitamins and the harmful microflora that caused it. Antidiarrheals will help in the treatment. For example, Nifuroxazide, which we will talk about now.
Nifuroxazide is mainly used as an intestinal antiseptic.
When is Nifuroxazide prescribed?
Shown Nifuroxazide for children from 2 months with diarrhea, due to various reasons:
- The predominance of Gram-positive bacteria and some types of Gram-negative bacteria in the intestine (Vibrio cholera, Salmonella, Klebsiella, Shigella, Escherichia coli and Enterobacter).
- Diseases, a symptom of which is diarrhea:, appendicitis, autoimmune chronic gastritis.
- Reception.
- Food poisoning.
Attention! Do not panic if you notice loose stools in a child once, and this has not happened again. Treatment is necessary only in cases where repeated diarrhea occurs during the day.
Additional alarming symptoms can be: nausea and vomiting, fever and feeling unwell, weakness.
For prolonged abdominal pain, see a doctor.
Composition and action of the drug
The active component of the intestinal antiseptic is called nifuroxazide (Nifuroxazide). 5 ml of suspension contains 220 mg of this substance. Additionally, the composition includes:
- sucrose;
- sodium hydroxide;
- carboxypolymethylene;
- distilled water;
- methyl parahydroxybenzoate;
- citric acid monohydrate;
- banana essence (aromatic);
- emulsion that inhibits foaming (Antifoam F).
A drug not absorbed into the blood and is concentrated only in the gastrointestinal tract. In small and medium doses, Nifuroxazide acts as an antibacterial medicine (it stops the reproduction of only harmful bacteria that are sensitive to the active substance). In high - as a bactericidal agent (completely kills the intestinal microflora, including useful ones).
The medicine is excreted with feces.
The time of action is the first few hours after ingestion. It depends on the dose taken and the condition of the intestine. On average, it is 6-12 hours. The drug is excreted within a few days along with feces.
Christina left a comment:
Nifuroxazide is an effective remedy for diarrhea. It quickly eliminates diarrhea, keeping the body's water balance normal. At the end of the course of treatment, the intestines are completely freed from pathogens. But, despite the fact that the drug is practically devoid of side effects, consult a pediatrician before using it.
Alisa Nikitina
Capsules 100 mg:
Hard gelatin capsules No. 1 cylindrical shape with yellow hemispherical ends.
Capsules 200 mg:
Hard gelatin capsules No. 0 cylindrical shape with yellow hemispherical ends.
Compound
Each capsule contains:
active substance: nifuroxazide - 100 mg or 200 mg;
Excipients: sucrose, magnesium stearate, modified corn starch (Starch 1500).
The composition of the gelatin capsule shell:
Gelatin, titanium dioxide E171, quinoline yellow E104, azorubine E122, crimson
4R E124, purified water.
Release form
Capsules 100 mg, 200 mg.
Pharmacotherapeutic group
Antidiarrheal, anti-inflammatory, antimicrobial agents for the treatment of intestinal infections.
ATX code
Indications for use
Treatment of acute diarrhea of bacterial origin caused by susceptible strains of Staphylococcus spp., Salmonella spp., Escherichia coli in the absence of signs of invasion (for example, deterioration in general condition, fever, toxic infection, etc.) in addition to rehydration therapy.
The dose and method of rehydration (oral or intravenous) is determined depending on the severity of diarrhea, age, condition of the patient, the presence of concomitant diseases.
Method of application and dosage
Nifuroxazide-LF is taken orally, regardless of food intake, at regular intervals.
Adults - 800 mg (4 capsules of 200 mg or 8 capsules of 100 mg) per day, divided into 4 doses.
Children over 6 years old - 600-800 mg (3-4 capsules of 200 mg or 6-8 capsules of 100 mg) per day, divided into 3-4 doses.
For the treatment of acute diarrhea, the drug must be taken within 3 days. If after this the symptoms of the disease do not disappear, you should consult a doctor.
The duration of taking nifuroxazide should not exceed 7 days.
Side effect
From the hematopoietic and lymphatic system:
One case of granulocytopenia has been described.
From the gastrointestinal tract:
In cases of individual hypersensitivity to nifuroxazide, abdominal pain, nausea and exacerbation of diarrhea may occur. In the event of the appearance of such symptoms of low intensity, there is no need for special therapy or discontinuation of the use of nifuroxazide. With the development of the above symptoms of significant intensity, you should stop taking the medication. In the future, the patient should not take nitrofuran derivatives.
From the skin and subcutaneous tissue:
Perhaps the development of allergic reactions (skin rash, urticaria, Quincke's edema, anaphylactic reactions).
In case of hypersensitivity reactions, such as shortness of breath, swelling of the face, tongue, lips, skin rash, itching, you should immediately stop using the drug.
In the event of adverse reactions, including those not listed in this leaflet, you should stop using the drug and consult a doctor.
Contraindications
- allergic reactions to 5-nitrofuran derivatives;
- hypersensitivity to any of the components of the drug;
- fructose intolerance, glucose-galactose malabsorption syndrome or sucrase and isomaltase deficiency (due to the presence of sucrose in the preparation).
- children's age up to 6 years.
Overdose
Overdose symptoms are not known. In case of exceeding the dose, gastric lavage and symptomatic treatment are recommended.
Use during pregnancy and lactation
The use of nifuroxazide during pregnancy:
There are no clinical data regarding the use of nifuroxazide during pregnancy. Animal studies do not show any direct or indirect effect on the course of pregnancy, the development of the embryo or fetus, the course of childbirth or the development of the child after childbirth.
Nifuroxazide is preferably not used in pregnant women. Before prescribing the drug, the attending physician should carefully weigh the expected benefits and risks of its use.
The use of nifuroxazide during breastfeeding:
Due to the lack of sufficient clinical data, caution should be exercised when prescribing nifuroxazide to women who are breastfeeding.
Precautionary measures
During treatment with nifuroxazide, the use of alcoholic beverages is contraindicated, because. alcohol increases the body's sensitivity to the drug and can provoke a disulfiram-like reaction, which is expressed by exacerbation of diarrhea, vomiting, abdominal pain, skin flushing, a feeling of heat in the face and upper body, noise in the head, shortness of breath, tachycardia, a feeling of fear.
The drug is not prescribed as monotherapy for the treatment of intestinal infections accompanied by septicemia.
If during the period of drug treatment symptoms of dehydration appear, it is necessary, depending on the clinical condition of the patient, to carry out rehydration therapy (for adults - about 2 liters of fluid per day).
In the event of hypersensitivity reactions, such as shortness of breath, skin rash, itching, the use of the drug should be discontinued.
Nifuroxazide should be used with a strict diet, excluding juices, raw vegetables and fruits, spicy and indigestible foods.
In the case of persistent diarrhea after 3 days of treatment, an in-depth diagnosis should be carried out, the purpose of which is to determine the cause of the symptoms, and consideration should be given to starting antibiotic therapy.
In the case of severe invasive diarrhea, antibiotic therapy is necessary, since nifuroxazide is not absorbed from the gastrointestinal tract.
The ability to influence the reaction rate when driving vehicles or while working with other mechanisms
The drug does not affect the ability to drive a car and work with other mechanisms.
Interaction with other drugs
Drinking alcohol during treatment with nifuroxazide may cause disulfiram-like reactions. While taking nifuroxazide, the simultaneous administration of other oral agents should be avoided due to the strong adsorption properties of the drug.
Storage conditions and shelf life
Store in a place protected from moisture and light at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Shelf life - 2 years.
Do not use after the expiry date stated on the package.
Package
10 capsules in a blister pack made of PVC film and aluminum foil.
Three blister packs, together with instructions for use, are placed in a pack of cardboard.
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Prices NIFUROXAZIDE in the cities of Ukraine
Vinnitsa 51.25 UAH/pack.
NIFUROXAZIDE ..... 36.5 UAH / pack.
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Smooth 54.47 UAH/pack.
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Today in pharmacies you can see many medicines for the treatment of intestinal infections in adults and children. Modern doctors most often, when an upset stomach occurs, they prescribe the drug "Nifuroxazide" to patients. The instruction attached to the medicinal product contains detailed information about it. Before starting treatment, the patient must be familiar with its contents.
Description of the drug
The drug is available in the form of a suspension (syrup) and tablets. Intended for oral use. Both dosage forms are equally effective in the treatment of intestinal infections. Nifuroxazide tablets are yellow in color, they have a round biconvex shape, covered with a smooth shell. Placed in blister packs. Each of them contains 24 tablets. The blisters are individually packed in cardboard boxes.
The drug "Nifuroxazide" (syrup) is available in the form of a yellow solution with a pleasant taste and banana aroma. Each vial contains 90 ml of the product. For ease of use, the suspension is sold with a double-sided measuring spoon. The vials are individually placed in cardboard boxes.
Composition of tablets and syrup
Each tablet contains 100 mg of the active ingredient nifuroxazide. In addition to it, the composition of this dosage form of the drug includes magnesium stearate, starch, talc, gelatin, silicon dioxide. The shell of the tablets contains hydroxypropyl methylcellulose, talc, polyethylene glycol, titanium dioxide, dye.
In suspension, for every 100 ml of the drug, there are 4 g of the active substance nifuroxazide. In addition to it, the composition of the syrup includes carboxypolymethylene, sodium hydroxide, citric acid monohydrate, methyl parahydroxybenzoate, water, sucrose, banana flavor.
Indications for use, effect on the body
The drug "Nifuroxazide" is a broad-spectrum antibacterial drug. It is prescribed for acute and chronic diarrhea caused by Gram-positive and Gram-negative bacteria. Also, the drug "Nifuroxazide" is used to treat diarrhea caused by dysbacteriosis after taking antibiotics. Effective in eating disorders, autoimmune gastritis and diarrhea caused by appendicitis.
The drug "Nifuroxazide" (tablets and syrup to the same extent) is concentrated in the human digestive tract and acts within a short time after the start of treatment. It is not absorbed in the intestines and is excreted along with the feces. The drug does not have a systemic effect on the human body, does not affect the intestinal microflora and is not displayed on the chemical composition of the blood.
Contraindications, features of admission
It should be remembered that only a doctor should prescribe the medication "Nifuroxazide". The instructions for the drug contain general information about it, so it is forbidden to prescribe it yourself, based on the manufacturer's recommendations. Do not also forget that, like any other medicine, Nifuroxazide has contraindications and has a number of side effects on the body. Treatment with the drug, carried out under the supervision of a doctor, will avoid its negative impact on a person.
Contraindications to taking Nifuroxazide are:
- children under 2 months of age;
- prematurity;
- intolerance to individual components of the drug.
It is important to bear in mind that the remedy "Nifuroxazide" (tablets) is not prescribed to babies who are under 3 years old. It is more convenient for young children to give the drug in the form of syrup.
If necessary, the drug "Nifuroxazide" can be prescribed to pregnant and lactating women, however, the treatment of such patients should be carried out under the close supervision of a physician.
It is forbidden to combine taking the drug with the use of alcoholic beverages. The combination of Nifuroxazide with alcohol can provoke the development of a disulfiram-like effect in the patient, which manifests itself in the form of a deterioration in the general condition, increased diarrhea, nausea, vomiting, shortness of breath, increased heart rate, and the onset of a panic state.
Side effect
Starting treatment, you need to familiarize yourself with what side effects the drug "Nifuroxazide" can have on a person. The instruction lists the following symptoms that may occur against the background of its use:
- allergic reaction in the form of itching and rash on the skin;
- dyspnea;
- discomfort in the digestive tract (nausea, vomiting, abdominal pain).
If these side effects occur, a person should stop taking the medication and consult a doctor.
Doses of the drug, overdose
The drug "Nifuroxazide" for children in the form of a suspension is prescribed depending on their age and weight. Babies from 2 months to six months are prescribed 2.5-5 ml in the morning and evening (after 12 hours). Small patients aged 6 months to 6 years are given 5 ml of syrup 3 times a day. For children over 6 years of age and adults, the drug is prescribed 5 ml 4 times a day.
The drug "Nifuroxazide" in tablet form for babies from 3 to 6 years old is prescribed 0.5 tablets four times a day. Children over 6 years of age and adults should take 1 tablet 4 times a day.
The doctor, based on the general condition of the patient, may increase or decrease the dosage of the drug recommended in the instructions. All portions of Nifuroxazide must be taken at regular intervals, regardless of meals. Suspension and tablets are recommended to be washed down with a sufficient amount of boiled water. It is not recommended to take the medicine for more than 7 days. If during the use of the drug the patient does not feel better or his condition worsens, he needs to see a doctor as soon as possible.
To date, nothing is known about the symptoms of an overdose of Nifuroxazide. The instruction advises in case of a significant excess of the dose of the medicine, as soon as possible, make the patient gastric lavage and show it to the doctor.
Adults should be aware that the drug "Nifuroxazide" in suspension has a pleasant sweet taste and is very popular with kids. In order to prevent children from swallowing a large dose of medicine on their own, it must be hidden from them in inaccessible places.
Compatibility with other drugs, influence on transport management
Not all drugs can be combined with the drug "Nifuroxazide". Its use is contraindicated simultaneously with sorbents and drugs containing alcohol. Interactions with other groups of drugs in this medical product have not been identified.
The drug "Nifuroxazide" does not affect the attention and reaction rate of a person, so it can be taken by drivers and people working at machine tools and other high-risk facilities.
Shelf life, cost and analogues
The drug, regardless of the dosage form, should be kept at temperatures up to 25 degrees Celsius. The drug "Nifuroxazide" (syrup) is stored in a sealed state for 3 years, the shelf life of the tablets also does not exceed 3 years. It should be borne in mind that after opening the vial with the suspension should be used within two weeks.
Not only the instruction is of interest to people to whom the doctor prescribed the drug "Nifuroxazide". The price of this medicine worries them no less. To date, the average cost of the drug in tablet form is 230 rubles. The drug "Nifuroxazide" in the form of a suspension will cost the buyer 280 rubles per bottle.
The drug has analogues, among which are Ersefuril, Enterofuril, Lecor, Nifurozid-Health. It is not recommended to independently replace the Nifuroxazide medication prescribed by the doctor with another medicine. The decision on the possibility of replacing the drug should be taken by the doctor who prescribed it.
The drug "Nifuroxazide": reviews
The drug "Nifuroxazid" does not belong to cheap drugs, so many people, before buying it at a pharmacy, are interested in how effective it is in treating diarrhea. Since doctors prescribe this drug to patients quite often, there are plenty of reviews about it. According to people who had to be treated with Nifuroxazide, it has a noticeable therapeutic effect already on the second or third day after the start of the intake. It is well tolerated by patients of all ages and rarely causes the side effects described in the instructions.
The drug "Nifuroxazide" (suspension and tablets) is a modern medical drug for the treatment of diarrhea. Its advantages are efficiency, a small list of contraindications, good tolerance and the possibility of use in both adults and children (with the exception of infants under 2 months old). The disadvantages of the drug include its high cost and short shelf life of the syrup after opening the bottle.