Antifungal cream candida. Candida from thrush and other fungal diseases

active substance: Clotrimazole;

1 g of cream contains clotrimazole 10 mg

Excipients: propylene glycol, white soft paraffin, mineral oil, non-ionic emulsified wax, benzyl alcohol, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), butylhydroxytoluene (E 321), sodium dihydrogen phosphate, anhydrous sodium phosphate, purified water.

Dosage form

Basic physical and chemical properties: semi-solid white cream.

Pharmacological group

Antifungal drugs for topical use. Derivatives of imidazole and triazole.

ATX code D01A C01.

Pharmacological properties

Pharmacological.

Clotrimazole has a wide spectrum of antimycotic action. in vitro and in vivo, which includes dermatophytes, blastomycetes, filamentous fungi, and dimorphic fungi.

In experimental studies, the minimum concentrations of clotrimazole that inhibit the development of fungi are 0.062-4 (-8) μg / ml in the substrate. Clotrimazole has a predominantly fungistatic effect. effects in vitro limited to the action on the elements of the fungus, proliferate; fungal spores have low vulnerability. The mechanism of action is to inhibit the synthesis of ergosterol, which leads to the destruction and deterioration of the function of the cytoplasmic membrane of the fungus.

In addition to the antimycotic effect, clotrimazole in vitro inhibits the reproduction of corynebacteria and gram-positive cocci, except for enterococci, at concentrations of 0.5-10 μg / ml in the substrate and acts on Trichomonas at a concentration of 100 μg / ml.

Resistance to clotrimazole is rated as favorable in primarily resistant strains of sensitive fungal species. Secondary resistance develops in primarily susceptible fungal species after treatment and is extremely rare.

Pharmacokinetics.

Pharmacokinetic studies have shown that the absorption of clotrimazole is negligible,<2 и 3-10% застосовання дозы с пиком плазменной концентрации действующего вещества <10 нг / мл.

Indications

Fungal diseases of the skin and mucous membranes caused by dermatophytes, molds and yeasts, as well as other pathogens sensitive to clotrimazole.

Skin infections caused Malassezia furtur(versus versicolor) and Corynebacterium minutissimum(erythrasma).

Candidal vulvitis and candidal balanitis.

Contraindications

Hypersensitivity to clotrimazole or other components of the drug. Hypersensitivity to other imidazoles.

Do not use the cream to treat nails or scalp infections.

Interaction with other medicinal products and other forms of interaction

Clotrimazole may reduce the effect of other local antifungal drugs, in particular polyene antibiotics such as nystatin and natamycin.

Application features

The drug is intended for use only in dermatological practice.

It is forbidden to use the drug in ophthalmic practice. Avoid contact of the drug with the eyes. Do not apply in the eye area.

DO NOT scratch the affected areas of the body that itch, as this leads to the spread of the disease.

There are reports of cross-hypersensitivity reactions, therefore, in the event of an allergic reaction to any antifungal agent from the group of imidazole derivatives, the possibility of such a reaction to another drug in this group should be borne in mind. If an allergic reaction occurs, treatment with clotrimazole should be discontinued.

The use of the cream in the genital area (the vulva and perineum in women or the glans penis and foreskin in men) may reduce the effectiveness and safety of latex products such as condoms and diaphragms. This effect is temporary and can only occur during treatment.

The drug contains benzyl alcohol, so it is used in premature babies and newborns.

Use during pregnancy or lactation.

Clinical studies on the effect of clotrimazole on fertility in women have not been conducted, however, animal studies have not revealed the effect of clotrimazole on fertility. The number of studies using clotrimazole during pregnancy is limited. Animal studies have shown no direct or indirect harmful effects in terms of reproductive toxicity. As a precautionary measure, it is advisable to avoid the use of clotrimazole during the first trimester of pregnancy.

During treatment with clotrimazole, breast treatment should be discontinued.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms.

Does not affect.

Dosage and administration

Adults Candide, cream, apply a thin layer on the affected areas of the skin 1-3 times a day at the rate of 0.5 cm strip of cream on a surface the size of a palm. After applying the cream is easy to rub.

With candidal vulvitis or candidal balanitis in adults, a strip of cream (0.5 cm) is applied in a thin layer to the affected areas 2-3 times a day (on the vulva and perineum in women or on the glans penis and foreskin in men) and rub .

Therapy of candidal vulvitis or candidal balanitis requires the simultaneous treatment of both partners.

To ensure the effectiveness of treatment, depending on the disease, it is necessary to continue the use of Candida, cream, for another 2 weeks after the disappearance of subjective symptoms. The disappearance of symptoms is expected after a course of treatment with Candide:

• with ringworm - 3-4 weeks;
• with erythrasma - 2-4 weeks;
• with multi-colored lichen - 1-3 weeks;
• with candidal balanitis and candidal vulvitis - 1-2 weeks.

If there is no improvement after 4 weeks of treatment, the patient must inform the doctor.

Children.

There is no experience with the use of clotrimazole in children, so this category of patients should not be used.

Overdose

There is no risk of acute intoxication, since it is unlikely that overdose is possible after a single vaginal dose or application to the skin (application on large areas of the skin under conditions conducive to increased absorption), as well as after accidental oral use. There is no specific antidote.

Candide is a drug (tablets) that corresponds to the group of antiseptics and antimicrobials for the treatment of gynecological diseases. The following features of the application are characteristic of the drug:

• During pregnancy: contraindicated
• When breastfeeding: with caution

Package

Compound

Cream Candide in the composition contains the active ingredient clotrimazole, as well as auxiliary components: white petrolatum, propylene glycol, emulsion cetomacrogol wax, liquid paraffin, butylhydroxytoluene, propyl parahydroxybenzoate, methyl parahydroxybenzoate, benzyl alcohol, sodium hydrogen phosphate, sodium dihydrogen phosphate dihydrate, purified water.

The Candide solution in the composition contains the active ingredient clotrimazole, as well as glycerol and propylene glycol as additional components.

Vaginal tablets contain clotrimazole as an active ingredient, as well as additional ingredients: purified talc, starch, magnesium stearate, lactose, silicon dioxide, propyl paraben, methyl parahydroxybenzoate, sodium carboxymethyl starch.

Release form

The medicine has several forms of release. Candide gel 2%, cream for external use 1%, powder for external use 1%, topical solution 1%, as well as vaginal tablets (candles) Candide are currently being produced.

• The cream is a homogeneous substance of white color, contained in an aluminum tube of 20 g.
• Solution for local use, transparent, colorless, has a viscous consistency. The bottle contains 15 g of the product.
• Powder for external use (powder) is contained in a plastic bottle of 30 g.

pharmachologic effect

The drug produces a local antibacterial and antifungal effect, also has an antiprotozoal and trichomonacid effect. There is a wide range of antifungal effects.

The antimycotic effect of clotrimazole (the active component of the drug is an imidazole derivative) occurs due to a violation of the synthesis of ergosterol, which is part of the fungal cell membrane. As a result, the permeability of the membrane changes and subsequent cell lysis occurs.

The interaction of fungicidal concentrations with mitochondrial and peroxidase enzymes is noted, and as a result, the concentration of hydrogen peroxide increases to the level of toxicity. As a result, the fungal cells are destroyed.

Fungistatic and fungicidal activity was noted against dermatomycetes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), molds and yeast-like fungi (Candida spp., Torulopsis glabrata, Pityrosporum orbiculare, Rhodotorula genus).

Also, clotrimazole demonstrates activity against the causative agent of multi-colored lichen.

The agent is effective against gram-positive bacteria and a number of gram-negative bacteria. Subject to the use of high concentrations, the agent is active against Trichomonas vaginalis.

Pharmacokinetics and pharmacodynamics

Through the skin and mucous membranes, clotrimazole is poorly absorbed, therefore, when using the drug externally, there is no systemic effect. When applied externally in the epidermis, a higher concentration of clotrimazole is observed than in the subcutaneous tissue and in the dermis.

When administered intravaginally, the absorption of clotrimazole is from 3% to 10% of the dose that is administered. Within 2 to 3 days, there are small concentrations of the active substance in the blood and a high level of concentration in the vaginal secretion.

The metabolism of clotrimazole in the liver is noted.

Indications for use

The drug Candide is used if the patient has the following diseases or symptoms:

• pityriasis versicolor, versicolor;
• mycocystops and skin folds;
• erythrasma;
• superficial candidiasis that cause yeast, mold and other fungi, dermatophytes, as well as a number of other pathogens that demonstrate sensitivity to clotrimazole;
• mycoses, in which there is a complication of secondary pyoderma;
• candidal vulvitis;
• candidal balanitis;
• skin candidiasis;
• candidal paronychia;
• candidiasis of the anus and external genitalia;
• fungal diaper dermatitis.

A solution of Candide for the oral cavity is used for stomatitis of candidal origin.

Vaginal tablets are used to treat genital infections, as well as genital superinfections caused by microorganisms sensitive to clotrimazole.

Candide is also used to sanitize the birth canal in preparation for childbirth.

Contraindications

Gel, cream, Candide drops and other forms of the drug are not used in case of hypersensitivity to clotrimazole or to other components of this drug. Do not prescribe during menstruation, in the first trimester of pregnancy, carefully used to treat women during breastfeeding.

Side effects

The manifestation of the following side effects may develop when using this remedy:

• urticaria, itching, burning sensation and tingling where the cream was applied;
• erythema, edema, blisters, peeling and irritation of the skin.

If such manifestations are noted, it is necessary to cancel Candide ointment and Candide B.

When using Candida intravaginally, the development of local irritation is rarely noted, which, as a rule, disappears on its own with further treatment. Also, with intravaginal use of the drug, the development of such negative effects is possible:

• itching, burning;
• vaginal discharge and swelling of its mucosa;
• headache;
• frequent urination and intercurrent cystitis;
• pain during intercourse;
• burning sensation in the genitals of a man.

Instructions for use Candida (Method and dosage)

Cream Candide, instructions for use

The ointment is applied externally. Before applying the product, you must first clean and dry those areas of the skin that have been affected. For cleaning, soap with a neutral pH value is used. The cream is applied in a thin layer and gently rubbed into the skin, doing this two to three times a day. Treatment lasts as long as the doctor prescribes. Its duration depends on the location and severity of the disease, as well as on the effectiveness of treatment.

In the treatment of dermatomycosis, the course of application is at least 4 weeks; in the treatment of pityriasis versicolor, the cream needs to be applied from 1 to 3 weeks. People who suffer from fungal diseases of the skin of the legs, the cream should be applied regularly for at least two weeks after the symptoms of the disease have disappeared.

How to use the gel also depends on the severity and characteristics of the course of the disease. As a rule, the remedy is rubbed into the affected area 2-3 times a day. It is advisable to use the gel for another 3-4 weeks in order to completely eliminate possible relapses.

Candide solution, instructions for use

The remedy in the form of a solution is prescribed for large lesions of the skin, as well as for lesions of the scalp. If the patient is prescribed Candide drops, the instructions for use must be carefully followed. If the oral cavity is affected with a cotton swab, the solution is applied 10-20 drops, doing this 3-4 times a day. It is important to treat all affected areas very carefully. Use the remedy until the clinical symptoms disappear.

Instructions for the powder

Candide powder is applied externally, it must be applied to areas of the skin that have been affected, 3-4 times a day. It is important to apply regularly. The duration of therapy depends on the severity of the disease, as well as on the localization of the disease. To completely cure the disease, sometimes treatment continues after the disappearance of severe symptoms. The duration of treatment is usually 4 weeks. Patients with pityriasis versicolor are recommended to use the drug for 1-3 weeks, patients suffering from erythrasma are shown to be treated for 2-4 weeks.

The remedy in the form of vaginal tablets is administered intravaginally, this should be done in the supine position, legs bent. It is necessary to use the tablets once a day, before going to bed. In order to sanitize the birth canal, one tablet (500 mg of the drug) is administered.

Overdose

When using the cream in high doses, there are no manifestations of reactions, as well as life-threatening conditions.

If the drug was taken orally, the patient may develop nausea, vomiting, gastralgia, anorexia, pollakiuria, and allergic manifestations. The development of hallucinations, drowsiness is rarely noted. There is no specific antidote; when administered orally, Candide is prescribed activated charcoal, and symptomatic therapy is also practiced.

Interaction

The effect of clotrimazole is reduced with the simultaneous use of Nystatin, Amphotericin B, Natamycin, which is why Candide ointment and other forms of the drug should not be used in the treatment of these drugs.

In general, when using the cream simultaneously with other drugs, the negative effects of other drugs are unknown, since there is a low resorption capacity of clotrimazole.

Terms of sale

Available without a doctor's prescription.

Storage conditions

It is necessary to protect all forms of Candida from children, store at a temperature of 2 to 25 ° C.

Shelf life

Candide ointment can be stored for 4 years, Candide solution can be stored for 3 years.

special instructions

Do not apply the product to the skin in the eye area.

When using the drug, you should periodically monitor the condition of the liver of a patient who suffers from liver failure.

If during use signs of high sensitivity appear, treatment with the drug should be discontinued.

If there is no effect of treatment when using the remedy for 4 weeks, it is necessary to confirm the diagnosis by visiting a specialist.

The use of the product does not affect the ability to drive vehicles and work with precise mechanisms.

Do not apply the product for external use to those areas of the skin on which there are violations of the integrity.

To prevent the development of urogenital reinfection, it is important to treat both sexual partners simultaneously.

If the vagina and labia are affected, Candide cream and vaginal tablets should be used simultaneously.

Analogues

There are a number of drugs with a similar effect. These drugs are Antifungol, Imidil cream, Imidil, Candizol, Amiklon, Kanesten, Candid-B6, Clotrimazole, Candibene, etc. The price of analogs depends on the manufacturer, the form of release, and the packaging of the drug.

Cream Candide and Candide B have a similar effect, however, Candide B, in addition to clotrimazole, also contains beclomethasone as an active ingredient.

For kids

The Candide remedy in the form of a solution is used for stomatitis in children, it must be used in accordance with the instructions and on the recommendation of a doctor. The tool is also used in the treatment of a number of fungal diseases, in particular, it is used to treat babies from thrush. Candida from thrush in newborns and children is used strictly according to the doctor's prescription.

Candide for newborns

Candide solution for newborns is used to treat candidiasis in infants. It is necessary to carry out procedures for thrush in infants after feeding. To carry out such a procedure, a few drops of the solution (3-4 drops) are applied to a cotton swab or swab, after which they carefully lubricate those areas in the oral cavity that have been affected. This procedure should be carried out three times a day. Already after 2-3 days there should be clear signs of improvement.

During pregnancy and lactation

There is no clinically established evidence that the use of Candide locally during pregnancy, as well as during breastfeeding, adversely affects the health of a woman or an unborn child. But it is important that the decision to use the remedy during the second and third trimesters of pregnancy, as well as during lactation, is made by a doctor.

Do not apply the product to the mammary glands during lactation.

Cream Candide represents a number of preparations of high antibacterial, antifungal action, which have an extensive degree of application. The main substance in the composition ensures the effectiveness of the drug. To familiarize yourself with the connection, you should consider in detail the main characteristics of the drug.

The active substance Clotrimazole disrupts the synthesis of ergosterol, which is the active component of fungal cells and contributes to its further destruction. The drug affects a large number of strains of mycotic bacteria and is effective in the occurrence of multi-colored lichen.

Candide is not absorbed into the general circulation when applied to the skin, and when administered intravaginally, the concentration in the blood is observed after 3 days. The drug is metabolized in the liver and excreted from the body along with faeces.

The composition of the drug is based on the content of active and auxiliary components:

• Clotrimazole;
• Petrolatum;
• propylene glycol;
• Liquid wax;
• Paraffin;
• Alcohol;
• Hydrophosphate sodium;
• Purified water;
• Glycerol;
• Silicon dioxide;
• Lactose;
• Starch.

The drug is presented in the form of a white cream in aluminum tubes weighing 20 grams, a solution for external application in a vial of a viscous consistency with an active substance in the amount of 15 grams, powder with a capacity of 30 grams and vaginal suppositories in a carton.

Appointments, contraindications, side effects

Candide has extensive indications for use and is effective in the following cases:

The medicine has a small number of contraindications:

• Pregnancy (first trimester);
• Breast-feeding;
• Allergy to Clotrimazole;
• period of menstruation.

When using the medication, side effects such as:

• Allergic manifestations (urticaria, itching);
• Inflammatory processes on the skin;
• vaginal discharge;
• The occurrence of cystitis;
• Pain during intercourse;
• Burning in the genital area in men.

The occurrence of negative effects when taking the medicine is a reason to contact your doctor, who will prescribe the correct dosage and treatment regimen!

Instructions for use

Methods of using Candida depend on the form of release of the drug and do not cause any difficulties with their implementation.

Excessive use of the drug can lead to signs of poisoning, therefore, in this case, appropriate therapy should be carried out (taking adsorbents and gastric lavage).

Candide is freely available and sold without a prescription. The shelf life of the drug is 4 years. After the expiration of time, the use is strictly prohibited! Storage conditions at a temperature of 2-25 degrees in a dry, dark place out of the reach of children.

Additional indications and analogues

Candide is not used in ophthalmology and is not applied to the eye area. When using the drug, it is necessary to control liver parameters, since changes in the composition of the blood are possible.

If allergic manifestations occur, the application of the drug should be stopped, and in the absence of positive dynamics for a long time (4 weeks or more), you should consult a doctor for advice.

The drug is used only on intact skin. The appearance of thrush involves the therapy of both partners to avoid re-infection. Candida is not prohibited while driving a car or operating other devices that require concentration of attention.

The cost of the drug ranges from 250-400 rubles, depending on the form of release of the drug. With contraindications to the use of Candida, close analogues of the drug can be used. List of main synonyms of the original.

1. Antifungol. An effective analogue of Candida antifungal action. The main substance Clotrimazole has a depressing effect on various strains of fungi. The drug is intended for the treatment of dermatophytosis, mycoses of various etiologies, gynecological pathologies, thrush. Contraindications: pregnancy, breastfeeding, allergic manifestations. The price is 200–250 rubles.
2. Ketoconazole. An inexpensive analogue of the original in the form of tablets, vaginal suppositories and creams. Indications for use: ringworm, epidermophytosis in the groin, feet, nails, pityriasis versicolor, seborrheic dermatitis. The drug should be excluded in case of allergies and open wounds on the skin. The price is 200–210 rubles.
3. Lomexin. One of the best and most effective Candida analogues presented as vaginal capsules, cream and ointment. The medicine is intended for the treatment of bacterial fungal infections of the skin, vulvovaginal candidiasis, vaginal trichomoniasis. The drug is not recommended during pregnancy, breastfeeding, menstruation, allergies, children's age category. The price is 400–450 rubles.
4. Metrogyl plus. A cheap substitute for the original in gel form. The combination of Metronidazole and Clotrimazole provides the antifungal effect of the drug. The scope of the drug is the treatment of bacterial vaginosis, fungal infections, vulvovaginal candidiasis. Contraindications: epilepsy, leukopenia, liver dysfunction, pregnancy (first trimester), allergic manifestations. The price is 200–250 rubles.

When replacing or choosing a suitable Candida analogue, you should seek advice from your doctor!

In this medical article, you can get acquainted with the drug Candide. The instructions for use will explain in which cases you can take a cream, gel, solution or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Candide, from which you can find out if the medicine helped in the treatment of candidiasis (thrush) and other types of mycoses in adults and children, for which it is also prescribed. The instructions list Candida analogues, drug prices in pharmacies, as well as its use during pregnancy.

Synthetic broad-spectrum antifungal drug is Candide. Instructions for use indicate that vaginal tablets or suppositories 500 mg, cream 1%, gel 2%, solution 1% are used to treat fungal infections of the mucous membranes and skin.

Release form and composition

The drug is produced in the following dosage forms:

1. gel Candide 2%;
2. powder for external use 1%;
3. vaginal tablets (candles) Candide;
4. solution for topical application 1%;
5. cream for external use 1%;
6. Candide B6 - vaginal tablets 100 mg (analogue of suppositories);
7. Candide B - cream for external use.

The cream is a homogeneous substance of white color, contained in an aluminum tube of 20 g.

The cream contains the active ingredient clotrimazole, as well as auxiliary components: white petrolatum, propylene glycol, emulsion cetomacrogol wax, liquid paraffin, butylhydroxytoluene, propyl parahydroxybenzoate, methyl parahydroxybenzoate, benzyl alcohol, sodium hydrogen phosphate, sodium dihydrogen phosphate dihydrate, purified water.

Solution for local use, transparent, colorless, has a viscous consistency. The bottle contains 15 g of the product. The Candide solution in the composition contains the active ingredient clotrimazole, as well as glycerol and propylene glycol as additional components.

Vaginal tablets contain clotrimazole as an active ingredient, as well as additional ingredients: purified talc, starch, magnesium stearate, lactose, silicon dioxide, propyl paraben, methyl parahydroxybenzoate, sodium carboxymethyl starch.

Powder for external use (powder) is contained in a plastic bottle of 30 g. Instructions are included in the box with the drug.

pharmachologic effect

Candide tablets, vaginal gel, powder, solution and cream are antifungal drugs widely used in the treatment of various candidal diseases. The active substance of this product perfectly penetrates into all layers of the skin, destroying bacterial cells.

The active ingredient of the drug (clotrimazole) has a detrimental effect on yeast, yeast-like and mold fungi (Candida, Torulopsis, Rhodoturola), some strains of gram-positive and gram-negative microorganisms (Gardnerella vaginalis, Corynebacterium minutissimum, Bacteroides spp., Staphylococcus spp., Streptococcus spp.) and dermatophytes (Epidermophyton, Trichophyton, Microsporum).

Indications for use

What helps Candide? The drug is used if the patient has the following diseases or symptoms:

• candidal vulvitis;
• candidal paronychia;
• erythrasma;
• candidal balanitis;
• skin candidiasis;
• mycoses of the feet and skin folds;
• superficial candidiasis that cause yeast, mold and other fungi, dermatophytes, as well as a number of other pathogens that demonstrate sensitivity to clotrimazole;
• mycoses, in which there is a complication of secondary pyoderma;
• fungal diaper dermatitis;
• candidiasis of the anus and external genitalia;
• pityriasis versicolor, versicolor versicolor.

A solution of Candide for the oral cavity is used for stomatitis of candidal origin.

Vaginal tablets are used to treat genital infections, as well as genital superinfections caused by microorganisms sensitive to clotrimazole.

Candide is also used to sanitize the birth canal in preparation for childbirth.

Candide vaginal tablets or suppositories

It is administered intravaginally, deeply, in the “lying on the back” position with slightly bent legs. 500 mg once (in the evening). A second course of treatment is possible after consulting a doctor. For the rehabilitation of the birth canal, a single administration of 1 table is recommended.

Instructions for use of the Candide solution for children

For the treatment of the oral cavity from the fungus for children, only a solution of Candide 1% for topical use is used. In no case should you use a solution for external use. These are two drugs with completely different effects on the mucous membranes. In the instructions for use of the drug, the Candide solution states that 10-15 drops of the product are applied to a cotton swab, which then processes all the mucous membranes of the oral cavity. Treatment of the oral cavity is carried out 2 - 3 times a day after the child has eaten. It is first necessary to remove white plaque from the mucous membranes.

Galina Kiryunina: “With this folk remedy, I defeated the MILK FOREVER! You only need…”

The effectiveness of the use of Candida from thrush in children is noticeable already on the 2nd - 3rd day, since the drug stops the reproduction of the fungus in the oral cavity. The advantage of the drug is also that it acts exclusively locally, so it does not enter the bloodstream. Candide drops for children may be contraindicated in those who have hypersensitivity to clotrimazole, which is the active ingredient of the drug, or to any substance that is part of the drug. Of the side effects in the treatment of the oral cavity with a solution, there may be:

• Burning in the mouth
• bad taste
• Nausea if the remedy is in the throat

At what age can children be used, treatment features

In recent decades, invasive fungal infections have increased worldwide and have become a major cause of illness and death, especially in immunocompromised people. One of the reasons for the marked increase in the number of these problematic infections is the increase in the number of patients with immunosuppressive conditions.

Ointment Candide is considered an effective, safe and well-tolerated drug with an unusual chemical composition. It is widely used in the treatment of thrush, skin, vulvovaginal and oropharyngeal fungal infections.

The drug's few side effects and uncomplicated metabolic profile have earned it worldwide acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections and skin and nail fungus. Due to its usefulness, clotrimazole is included in the list of essential medicines by the World Health Organization.

Skin infections caused by candida or dermatophytes are effectively treated with topical application of clotrimazole.

Candide in the form of a cream is well tolerated and does not cause adverse reactions in patients.

Instructions for using Candide cream:

Before applying Candide cream, wash your hands thoroughly with soap and water;
Rinse the affected area with running water at room temperature;
Apply antifungal cream in an even thin layer;
The drug is used only as directed by a doctor, dosing regimen 2-3 times a day;
The therapeutic course lasts an average of 1 month;
The medication is applied not only until the complete disappearance of clinical symptoms, since 100% destruction of the fungal infection occurs after 2 weeks;
When applying Candide cream, attention should be paid to hard-to-reach places, in particular, interdigital spaces;
In complicated candidal infections, the doctor must choose a comprehensive treatment using various dosage forms.

Children of preschool and primary school age can use Candide cream in exceptional cases when it is necessary to get rid of the fungus on the skin. Dosage forms intended for intravaginal use are prohibited for children under 12 years of age. For children under 3 years of age, the drug is completely contraindicated.

How to identify oral candidiasis

To confirm the diagnosis, it is enough to take a swab from the oral mucosa and send it to a microbiological laboratory, which will sow the fungi. If necessary, they are sent for FGDS to confirm or exclude the diagnosis of esophageal candidiasis.

So if you're worried:

• Itching, pain in the mouth;
• When examining the mouth - whitish overlays or curdled masses or dense plaque, when you try to remove which the mucous membrane begins to bleed, then a diagnosis of oral candidiasis is likely.

Seek medical attention if possible.

If it is not possible to get an appointment with a doctor, then buy a Candide oral solution and, without delay, start treatment. In a couple of days you should feel much better. If there is no effect from the treatment, consult a doctor.

And after recovery - lead a healthy lifestyle, keep your hands clean, spend more time in the fresh air, take multivitamins in spring and autumn.

The effect of the drug Candide B in the fungus

Candide B is an antifungal drug that is widely used in dermatology, gynecology and other fields of medicine. The drug is characterized by high efficiency and the achievement of a quick result.

Candida b hormonal or not

The composition of the drug contains a glucocorticosteroid - beclomethasone, which means that the drug belongs to hormonal.

Method of application and dosage

The cream is intended for external use. It must be applied to clean and dry damaged areas of the dermis.

It is necessary to carry out medical manipulations 2-3 times a day. Rub the ointment with light massage movements and leave until absorbed.

Therapy of candidiasis should last 2-4 weeks after the elimination of all clinical symptoms of the pathology, in order to ensure mycological cure and prevent recurrence of the disease.

Candida b with thrush in women

For the treatment of thrush in women, Candide B6 is used, which is produced in the form of vaginal suppositories. They are effective in fungal genital infections, the development of which was influenced by yeast-like fungi of the genus Candida or Trichonomas vaginalis. It is necessary to apply suppositories once a day for 2 weeks.

In pediatrics, the drug is not widely used, so there is no experience in using the drug in children. Prolonged use of the drug in a child may lead to an increased risk of adrenal suppression.

During pregnancy lactation

During the period of bearing a child and HB, the drug is not used. It can be prescribed only if the possible benefit to the woman's body outweighs the potential harm to the fetus or baby.

The intravaginal form of the drug is prohibited for use in the 1st trimester of pregnancy. A high dose of clotrimazole leads to the development of embryotoxic action. There is no information on whether the active substance is excreted in breast milk.

Side effects

The drug under consideration, subject to dosage, is well tolerated. But with long-term therapy, the development of side symptoms is possible:

• allergies, redness of the skin and mucous membranes;
• burning and tingling in the area of ​​application of the cream;
• urticaria, erythema;
• itching, blistering;
• swelling, irritation of the vaginal mucosa and peeling.

With the development of such symptoms, therapy with Candide B should be discontinued.

Interaction with other drugs and alcohol

Co-administration of the drug with Amphotericin B, Nystatin will reduce the effect of clotrimazole. A combination of the drug with systemic antibacterial and antimicrobial agents, as well as with forms for external and intravaginal use, is allowed. Before combining Candide with other drugs, you should consult your doctor.

Special instructions for use

The drug is allowed to be used only in the treatment of dermatological pathologies. If you use the cream as part of the complex therapy of candidiasis in the anogenital areas, then you can milk the pronounced positive results and the patient's recovery.

If glucocorticoids are used on large areas of the skin or occlusive dressings are used, this can lead to systemic absorption of the drug. Symptoms such as pyoderma, folliculitis, or a rash may also develop.

Vacation and storage conditions

It is necessary to keep the medicine in a place where there is no light, there is no access for children, and the temperature is not higher than 25 ° C. The product must be used within 3 years from the date of issue.

Pharmacodynamics

All azole-type antifungals interfere with the biosynthesis of ergosterol, which is considered the main component of the fungal cytoplasmic membrane.

Ergosterol performs a function similar to cholesterol in animal cell membranes.

Clotrimazole is considered a fungistatic rather than a fungicidal drug, although, as with many antimicrobial drugs, this distinction is not absolute, as it is fungicidal at higher concentrations.

The action of the drug is due to its interference in the biochemistry of the fungal cell.

Clotrimazole disrupts the synthesis of a vital protein of the fungal cell, which is not present in the human body. Depending on the dose, the drug either disrupts the reproduction of fungi, or causes their death.

Candide cream is safe for humans - the protein it affects is not produced in the human body.

The drug is effective against the following types of fungi:

• dermatophytes;
• mold fungi;
• yeast-like fungi;
• causative agents of multi-colored lichen and erythrasma.

There is moderate activity against staphylococci and streptococci. This avoids bacterial complications during treatment.

Candide B instructions for use dosage and method

An overdose of the drug is unlikely. When used correctly, it practically does not occur. If the cream is applied to the vaginal mucosa or the glans penis, absorption is somewhat faster, but overdose cases have also not been recorded.

In case of an overdose of beclomethasone (usually as a result of long-term use in large skin areas, especially with impaired integrity, as well as in the case of long-term use in children), undesirable side reactions may occur associated with insufficiency of the function of the adrenal cortex and suppression of their function.

Treatment consists in the abolition of Candida B and the appointment of the necessary symptomatic therapy.

Description of Candide cream ointment and its use for nail fungus

Price

• In the Moscow region - from 100 to 1000 rubles.
• In St. Petersburg - from 60 to 700 rubles.
• In other regions of Russia, the price is slightly lower.

The cost of the product depends on the region, the form of release and the pharmacy where they buy.

Where can I buy

The drug is quite widely distributed in city pharmacies. Links to online pharmacies:

1. apteka.ru.
2. rigla.ru.
3. apteka-ifk.ru.

Sold without a prescription.

Release form

Ointment Candide is available in the form:

1. Cream.
2. Solution (drops).
3. dry powder.
4. Tablets.
5. Gel.

What to choose

The cream is more suitable for the treatment of periungual skin and cuticles.

To get rid of nail fungus (onychomycosis), it is better to choose a solution and tablets for combination therapy.

The composition of the drug

1 g of ointment contains:

• Clotrimazole. The active substance, a synthetic antifungal agent, is widely used in pharmaceuticals and stops growth and kills most known fungi.
• Vaseline, paraffin. Ointment base.
• Propylparaben. Plays the role of a preservative.
• emulsion wax. Plays the role of an emulsifier.
• Butylated hydroxytoluene. Phenol-based substance. It was added to the composition because of its good antioxidant properties.
• Methylparaben. A preservative that has effective effects is also a powerful antiseptic and has a good antifungal effect.
• Alcohol and water.

Analogues

Candide has several analogues, they have similar effects, but still differ:

1. Triderm - requires more frequent application, because it is quickly absorbed. Leaves no marks on clothes.
2. Akriderm GK - has not only an antifungal effect, but also helps with allergic reactions or inflammatory skin lesions.
3. Other ointments based on clotrimazole.

Cheap analogues

1. Kanesten - 128 rubles. (20 g).
2. Clotrimazole - 60 rubles. (20 g). It is included in Candida as the main active ingredient, but is also produced separately without auxiliary substances.

Drug properties

The ointment has antiprotozoal and antibacterial properties. This makes it effective against:

• Erythrasm;
• depriving;
• Mycosis;
• Onychomycosis;
• Milkmaids.

How it works

The action of the ointment is based on damage to the walls of fungal cells. This leads to a halt in their development. The disease remains on the nail, but stops spreading, so full treatment lasts until a new nail grows.

Instructions for use

Candide has a shelf life of 4 years. Store the ointment in a place protected from light, where the temperature should not exceed 25 ° C. Hide from children.

Official instructions (263 KB).

Mode of application

Before using the ointment, the affected area should be washed with soap and dried. Then apply a thin layer of the product and rub it well into the sore spot. Repeat the procedure until complete recovery.

Dosage

It is best to apply the ointment in a thin layer and not overdo it. However, if smeared uncontrollably, there will be no serious consequences associated with an overdose. In this regard, Candide is safe if there are no contraindications.

Features of use with other drugs

If used together with a remedy such as Nystanin, then the effect will be significantly reduced and the application will be much less effective. If the patient takes antibiotics, the effect will be exactly the same.

Contraindications

The drug should not be used by a nursing woman or in the first trimester of pregnancy. Irreversible consequences for the developing fetus are possible. An individual contraindication is an allergy to the components of the ointment.

Side effects

1. Hives.
2. The formation of redness on the skin.
3. Peeling.
4. Edema.
5. Severe allergic reaction to the composition of the product.

If this happens, you should immediately contact the doctor who prescribed the remedy, as standard methods of treating side effects may not be effective.

Pros and cons of the tool

Positive:

• Small price;
• A small list of contraindications.

Negative sides:

Some may experience side effects.

Video review of a remedy from a doctor:

special instructions

With the simultaneous appointment of Candide cream and nystatin, the effectiveness of Candide may decrease.

After an acute episode has been treated, follow-up prophylaxis (supportive care) is important. Patients are more likely to adhere to a medication regimen when antifungal therapy is administered orally, but oral treatment carries a greater potential for systemic toxicity and drug interactions.

It is better not to apply the drug if the integrity of the skin and mucous membranes is broken.

The effect of the drug on pregnant and lactating women has not been fully studied. The use of Candide cream during the period of bearing a child and when feeding him is not recommended.

Preparations containing clotrimazole in fixed combination with betamethasone dipropionate are not recommended for the treatment of diaper dermatitis.

For the treatment of candidiasis localized in the oral cavity in young children and newborns, doctors recommend using the Candide solution. It is gently applied to the mucous membrane and tongue with a cotton swab. Candide in the form of a solution helps to get rid of the formed white plaques on the oral mucosa. During treatment, personal hygiene, processing of nipples, toys and bottles is of great importance.

Candide ointment instruction for use recommends using strictly for local treatment - application to the skin area affected by fungi. Special dosage forms in the form of vaginal tablets and gel are intended exclusively for use in the vagina, the gel can be applied to the mucous membrane of the penis.

The solution for the oral cavity can only be used for the treatment and prevention of candidal stomatitis. It is not allowed to use drugs in an inappropriate way. The instruction also recommends that you carefully consider age restrictions, follow the dosage regimen and the recommendations of your doctor in order to effectively cure the disease and avoid complications.

If you experience any unpleasant symptoms associated with treatment, you should consult a doctor. If there is a need to use any other drug along with Candide, you should consult a specialist for drug compatibility.

If possible, long-term treatment should be avoided, especially in childhood (due to the risk of adrenal suppression). When used on large areas of the body, absorption of beclomethasone into the systemic circulation is possible.

The cream should not be applied to the mucous membranes and the area around the eyes. Avoid contact with eyes.

In the event of the development or spread of Candida B infection, it is required to cancel and prescribe the appropriate antimicrobial treatment.

Bacteria thrive in warm, humid conditions, so the skin must be thoroughly cleansed and dried before application.

There are no data on the negative impact of Candid B cream on the patient's ability to drive vehicles or other mechanisms.

Name:

Candide (Candid)

Pharmacological
action:

antifungal drug with a wide range of activities.
The active ingredient in Candida is clotrimazole- is a derivative of imidazole. Its antifungal effect is due to a violation of the production of ergosterol, which is part of the fungal cell membrane. As a result of the action of clotrimazole, the permeability of the cell membrane changes, which leads to cell lysis. Small doses of the drug have a fungistatic effect, large doses have a fungicidal effect, including on non-proliferating cells. Fungicidal concentrations of clotrimazole are able to interact with peroxidase and mitochondrial enzymes, contributing to an increase in the concentration (up to a toxic level) of hydrogen peroxide, which, in turn, also leads to the death of fungal cells.

Candide active against mold, yeast-like fungi(Rhodoturola, Torulopsis, Candida) and dermatophytes(Microsporum, Epidermophyton, Trichophyton), the causative agent of erythrasma, pityriasis multicolor, as well as Aspergillus, Malassezia furfur, gram-positive bacteria (Staphylococcus spp., Corynebacterium minutissimum, Streptococcus spp.) and gram-negative (Gardnerella vaginalis, Bacteroides spp.), and Trichomonas vaginalis.
Absorption of clotrimazole with intravaginal administration ranges from 3 to 10% of the administered dose. For 48-72 hours, low concentrations of the drug in the blood and high in the vaginal secretion remain. Clotrimazole is metabolized to inactive metabolites in the liver.

Indications for
application:

Candide used in therapy:

Mycosis of nails;
- multicolored lichen;
- dermatophytosis of the head, legs, body;
- skin candidiasis;
- candidal vulvitis;
- candidal paronychia;
- candidal balanitis;
- candidiasis of the anus and external genitalia;
- erythrasma;
- fungal diaper dermatitis.

It is used in the treatment of genital infections caused by Candida or Trichomonas vaginalis fungi, and genital superinfections caused by clotrimazole-sensitive microorganisms.
Candide is prescribed for the rehabilitation of the birth canal in preparation for childbirth.

Mode of application:

A small amount of lotion, gel or cream rub into a dry and clean area affected skin 2-3 times a day. It is recommended to continue therapy with Candide after the disappearance of the symptoms of the disease for another 3-4 weeks to prevent relapses and complete mycological cure.
Candide in the form of a lotion (solution) recommended for use in extensive lesions of the skin and scalp.
Candide in the form of vaginal tablets injected deeply, intravaginally, in the supine position, with bent legs. Candide is prescribed once at bedtime, 500 mg.
When using Candida for the sanitation of the birth canal, it is enough to inject 500 mg of the drug (1 tablet) once.

special instructions

To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary.

With trichomoniasis, for more successful treatment, together with Candide, other drugs with a systemic effect (for example, metronidazole orally) should be used.

With simultaneous infection of the labia and adjacent areas (candidiasis vulvitis), local treatment with Candide cream should be additionally carried out.

During pregnancy, treatment with vaginal tablets should be carried out without an applicator.

In patients with hepatic insufficiency, the functional state of the liver should be periodically monitored.

If signs of hypersensitivity or irritation appear, treatment is stopped.

If there is no effect within 4 weeks, the diagnosis should be confirmed.

Side effects:

For outdoor use Candida in rare cases, local irritation occurs, which disappears on its own with continued treatment.

For intravaginal use Candida may cause burning, itching, vaginal discharge, swelling of the vaginal mucosa, headache, frequent urination, gastralgia, intercurrent cystitis, pain during intercourse, burning sensation in the partner's penis.

Contraindications:

- specific skin lesions (including tuberculosis, chicken pox, herpes simplex, measles, syphilis);
- skin reactions at the vaccination site;
- Hypersensitivity to the components of the drug.
– I trimester of pregnancy;
- the period of menstruation.

Carefully:
- period of breastfeeding.

Interaction
other medicinal
by other means:

When administered vaginally Clotrimazole reduces the activity of Amphotericin B and other polyene antibiotics. With simultaneous use with nystatin the activity of clotrimazole may decrease.

Pregnancy:

In clinical and experimental studies has not been installed that the use of the drug during pregnancy or breastfeeding has a negative impact on the health of the woman or the fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor.

Overdose:

The use of the drug in high doses does not cause any reactions and conditions that are life-threatening.

Symptoms(in case of unintended use of the drug inside): anorexia, nausea, vomiting, gastralgia, abnormal liver function; rarely - drowsiness, hallucinations, pollakiuria, allergic skin reactions.

Treatment: the appointment of activated charcoal, if necessary - symptomatic therapy; there is no specific antidote. in aluminum tubes of 20 g; in a pack of cardboard 1 tube.

Candide solution for external use 1% applications:

in plastic bottles of 20 ml, in a cardboard pack 1 bottle.

Candide Powder for external use application of 1% white, with a characteristic odor.
1 g of powder contains clotrimazole 10 mg;
in plastic bottles of 30 g, in a cardboard pack 1 bottle.

Candide Solution for local application 1% colorless, transparent, viscous.
1 ml of solution contains clotrimazole 10 mg;
excipients: propylene glycol - 495 mg; glycerin - 495 mg;
in dropper bottles of 15 ml, in a carton pack 1 bottle