open
close

Salicylic acid on temperature is possible. Acetylsalicylic acid Belmed: instructions for use

04.04.2020 -
Herpes

The action of any complex and multicomponent drug is based on the properties of each of its individual elements. And if a pharmaceutical novelty can be expensive, then very often it is possible to purchase a purely basic component of the drug separately and use it exclusively, saving a considerable amount. Among such simple and effective substances, it is worth highlighting acetylsalicylic acid known to everyone. The drug has been used for many years as a remedy for pain and inflammation, and during all this time many more ways of using it have been found. Consider all aspects of using the tool in more detail.

Acetylsalicylic acid - what is it?

Acetylsalicylic acid is a derivative of salicylic acid, which is used for medical purposes as a non-steroidal anti-inflammatory agent and a product to prevent blood cells from sticking together. The substance itself is represented by white needle-shaped crystals or a fine white powder, which has no pronounced odor, easily dissolves in water and alcohol at temperatures above room temperature. It is offered to patients in the form of tablets, usually at a dosage of 500 mg per tablet.

Composition and action of the drug

As already mentioned, acetylsalicylic acid is a tablet form of the substance, which is nothing more than just a compressed block of the active substance with the addition of several additional components (namely, potato starch, citric and stearic acid, talc and anhydrous silicon dioxide). The drug belongs to the group of analgesics and antipyretics.

Acid has an effect on the body in several ways: it helps fight inflammation, relieves the intensity of pain, lowers the temperature and prevents blood platelets from sticking together (the so-called anti-aggregation effect). The anti-inflammatory effect of the drug develops over 24-48 hours of regular intake, and the product also significantly reduces pain at rest and during motor acts, has a positive effect on morning mobility and improves joint function, removing their swelling. The drug is able to stop even spontaneous pain that may occur during movement or in the postoperative period. At the site of the wound, taking acetylsalicylic acid helps to reduce the intensity of swelling and inflammation.

What is the drug prescribed for: indications

Given all the properties of the drug in question, it is not surprising that there are many indications for its use:

  • febrile syndrome;
  • the need to prevent myocardial infarction in ischemic disease;
  • diseases of the musculoskeletal system, which are accompanied by pain;
  • headache, dental, menstrual, muscle pain, neuralgia;
  • prevention of blood clots;
  • acute thrombophlebitis (inflammation of the walls of a vein and the formation of a blood clot blocking its lumen);
  • rheumatoid arthritis;
  • rheumatic fever and pericarditis.

Instructions for use and dosage

The instructions indicate that the tablets are intended for oral administration. You need to drink them, if necessary, after eating, drinking either plain water or milk. The standard dosage for adults is 1-2 tablets up to 4 times a day (maximum 1000 mg at a time). The maximum daily dose is 6 tablets (this is 3 grams of the substance), an overdose of the drug is very dangerous. At the same time, it is not recommended to take the remedy for longer than two weeks in a row.

As for pediatric patients, the drug cannot be taken before two years, a single dose for a baby over 2 years old is 100 mg, over 3 years old - 150 mg, and so on, 50 mg per 1 year of age until adult dosages are reached.

How to take for blood thinning

In the people you can often hear such an expression as thick blood, but you should not take it literally. Liquid plasma tissue is formed by erythrocytes, platelets and leukocytes, and each of these elements has its own functions. The problem of blood clotting is due to difficulties with platelets - under the influence of certain factors, they begin to coagulate more actively, and as a result, dangerous blood clots form.

Acetylsalicylic acid prevents platelets from sticking together in liquid tissue, thereby being used as an element in the prevention of thrombosis and how. The action of the drug is aimed at improving blood microcirculation, but at the same time, its long-term use can result in problems with the digestive tract. Thus, only a doctor can prescribe such a method. For prevention, a dose of 200-250 mg per day is usually prescribed (half a tablet for several months), and in emergency situations it can be tripled.

How to take headache pills

Pain syndrome of low and medium intensity is one of the indications for the use of the remedy. If you are worried about a headache, then an adult can drink half or a whole tablet. If the situation does not improve, re-admission is allowed after 4 hours and no more than 2 tablets at a time. The daily maximum dose remains relevant - 6 tablets, no more.

Acetylsalicylic acid tablets for colds

Aspirin (this is the same as acetylsalicylic acid) can be used as part of the treatment of a cold, but the drug will not help to cope with the cause of the problem, it will only be useful as an element of symptomatic treatment. So, the tablets will help to cope with the temperature, and will also help in relieving joint pain and headache. Reception in such a situation is carried out according to standard recommendations.

How to use aspirin for fever

In the presence of hyperthermia, it is recommended to take 1-2 tablets at a time. If there is such a need, then you can take it up to 4 times a day with an interval of at least 4 hours, but again, do not forget about the maximum daily dose of 6 aspirin tablets for an adult. The child for fever is given part of the tablet in accordance with the age recommendations described earlier. It should not be forgotten that the acid has an irritating effect on the digestive system, so it is recommended to take it only after eating - so the impact will be minimal.

Hangover

With a hangover syndrome, the property of acid to thin the blood is useful, since alcohol intake acts on the contrary - it increases the viscosity of the liquid tissue. Thus, taking the pill helps to reduce the pressure inside the skull, as well as relieve swelling, that is, their use as part of getting rid of a hangover is effective and possible.

It should be noted right away that it is strictly forbidden to take acid together with alcohol, as this can result in stomach bleeding. With withdrawal symptoms, it is best to take an aspirin effervescent tablet (for example, Upsarin-Upsa), which must be dissolved in water. This additionally helps to minimize the symptoms of dehydration.

For toothache

Aspirin is not the most popular drug for toothache, but it is very successfully used for this purpose. It should be understood that the pill will positively affect the inflammatory process and partially relieve pain, but if the sensations are too pronounced, then there may not be an analgesic result. With an attack of toothache, you can drink 1-2 tablets after meals.

With menstruation

Menstruation in women is often accompanied by severe pain, and they have to be dealt with with the help of medications. The agent in question can be useful in such a situation, but only if the pain syndrome is not too intense. So, for best results, it is recommended to take the tablets 3-4 days, starting 2 days before the onset of menstruation and drinking 1 tablet 2 times a day.

From pressure

It should be understood that aspirin is not a drug for pressure, since it does not directly affect it. But this remedy can be prescribed in the presence of complications of hypertension to thin the blood, as mentioned earlier.

Use for acne on the face

The use of aspirin tablets for the face is a common practice. The mask helps to heed inflammatory processes, get rid of acne, cleanse pores, remove excess sebum and slightly dry the oily skin of the face. To prepare the product, you need to crush 5 tablets of the drug and mix the resulting powder with a tablespoon of liquid honey and half a teaspoon of jojoba oil. The resulting composition is applied to the skin for a quarter of an hour, after which it is removed with warm water.

Aspirin during pregnancy and lactation

The drug can not be called harmless to the fetus. So, within the framework of the first trimester, the intake of such an acid is associated with an increased likelihood of developing various defects in the baby, including the formation of a cleft palate. Within the framework of the second trimester, the reception is possible, but only if there are acute indications and with the permission of the doctor, in the last period of bearing the baby, the reception is completely prohibited.

With regard to breastfeeding, the substance can partially penetrate into breast milk, but usually does not cause any side effects in the child, so that a single dose does not require stopping the feeding process. But the use of tablets in the form of a course can lead to certain difficulties, so doctors usually recommend stopping feeding.

Contraindications and side effects

Despite its versatility in use, the drug in question has many limitations in use. So, it can not be used in case of hypersensitivity to the components of the composition, the acute phase of the ulcer of the digestive tract, bleeding in the digestive system, aortic aneurysm with dissection, vitamin K deficiency in the body, disruption of the normal functioning of the liver and kidneys, gout. As for the use to reduce temperature, for this purpose, tablets cannot be used for children under 15 years of age if hyperthermia is the result of a viral disease (for example, influenza).

When taking the drug, side effects may occur, and they are quite serious, so this once again confirms that only the attending physician can prescribe therapy with such a drug. So, the possible consequences are:

  • nausea and vomiting, severe abdominal pain, loose stools;
  • the appearance or intensification of headache, the appearance of tinnitus and dizziness;
  • in the presence of bleeding, the time to stop it may be longer, since the drug reduces the degree of platelet aggregation;
  • bronchospasm, Quincke's edema;
  • the appearance of a rash on the skin;
  • increased symptoms of chronic heart disease;
  • violation of the normal functioning of the urinary system.

Analogues

It should be clarified that acetylsalicylic acid is a substance that is included in many modern drugs as an active ingredient, and its separate tablet form is the most affordable option. In this case, it would be more appropriate to talk not about analogues, but about drugs that include acid: Aspicard, Aspirin, Acecardol, Bufferin, Cardiopyrin, Thrombo ACC, Sanovask, Upsarin-UPSA, Fluspirin, etc.

Video: what aspirin tablets help with

There is a lot of information about Aspirin regarding the methods and options for its use for human health. But it is important to understand that this is not a universal medicine, and it has only a certain list of problems that it can cope with.

Acetylsalicylic acid in an average person who is not initiated into the mysteries of pharmaceutical terminology may not cause any spiritual response. But this is nothing more than the well-known aspirin. Rather, on the contrary: this aspirin is the trade name of acetylsalicylic acid, which, however, is available on pharmacy shelves not only under a “pseudonym”, but also under its original chemical name.

Acetylsalicylic acid is used as an analgesic, antipyretic, antithrombotic and anti-inflammatory agent. At the biochemical level, the mechanism of action of this drug is based on the inhibition of the synthesis of pain mediators and inflammatory reactions of prostaglandins (this occurs due to inhibition of the cyclooxygenase enzyme) and thromboxane aggregants. Acetylsalicylic acid reduces blood flow to the site of inflammation, reduces the permeability of blood vessels, and, consequently, exudation, limits the amount of ATP that goes to maintain the energy consumption of the inflammatory process. The drug reduces the concentration of prostaglandins in the brain centers of pain and thermoregulation, which leads, respectively, to a decrease in pain sensitivity and a decrease in body temperature.

Antiplatelet action is associated with a decrease in the amount of thromboxane.

A drug called "acetylsalicylic acid" in Russia is present only in tablets. The drug should be taken after meals with a sufficient amount of liquid (water, milk, mineral water). Depending on the age of the patient, the recommended single and maximum daily doses of acetylsalicylic acid are, respectively: 0.25-0.5 g and 3.0 g for adults and adolescents from 15 years of age; 0.25 g and 0.5 g for children from 6 to 15 years. It is necessary to maintain an interval between doses of the drug for at least 4 hours with a 3-4-time intake. In terms of the use of acetylsalicylic acid, the patient is given a certain amount of independence: 3 days as an antipyretic and 5 days as an analgesic, after which, if there is no improvement in the condition, it is necessary to consult a doctor. In case of accidental overdose of the drug, vomiting should be artificially induced and activated charcoal should be taken along with some strong laxative. Minor overdoses pass without significant consequences for the body.

Pharmacology

NSAIDs. It has anti-inflammatory, analgesic and antipyretic effects, and also inhibits platelet aggregation. The mechanism of action is associated with the inhibition of the activity of COX, the main enzyme of the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. A decrease in the content of prostaglandins (mainly E 1) in the center of thermoregulation leads to a decrease in body temperature due to the expansion of skin vessels and an increase in sweating. The analgesic effect is due to both central and peripheral action. Reduces aggregation, adhesion of platelets and thrombosis by suppressing the synthesis of thromboxane A 2 in platelets.

Reduces mortality and the risk of myocardial infarction in unstable angina. It is effective in the primary prevention of diseases of the cardiovascular system and in the secondary prevention of myocardial infarction. In a daily dose of 6 g or more, it inhibits the synthesis of prothrombin in the liver and increases the prothrombin time. Increases plasma fibrinolytic activity and reduces the concentration of vitamin K-dependent coagulation factors (II, VII, IX, X). Increases hemorrhagic complications during surgical interventions, increases the risk of bleeding during anticoagulant therapy. Stimulates the excretion of uric acid (impairs its reabsorption in the renal tubules), but in high doses. Blockade of COX-1 in the gastric mucosa leads to inhibition of gastroprotective prostaglandins, which can lead to mucosal ulceration and subsequent bleeding.

Pharmacokinetics

When taken orally, it is rapidly absorbed mainly from the proximal small intestine and, to a lesser extent, from the stomach. The presence of food in the stomach significantly alters the absorption of acetylsalicylic acid.

It is metabolized in the liver by hydrolysis to form salicylic acid, followed by conjugation with glycine or glucuronide. The concentration of salicylates in plasma is variable.

About 80% of salicylic acid binds to plasma proteins. Salicylates easily penetrate into many tissues and body fluids, incl. into the cerebrospinal, peritoneal and synovial fluids. Small amounts of salicylates are found in the brain tissue, traces - in bile, sweat, feces. It quickly crosses the placental barrier and is excreted in small amounts in breast milk.

In newborns, salicylates can displace bilirubin from its association with albumin and contribute to the development of bilirubin encephalopathy.

Penetration into the joint cavity accelerates in the presence of hyperemia and edema and slows down in the proliferative phase of inflammation.

When acidosis occurs, most of the salicylate turns into non-ionized acid, which penetrates well into tissues, incl. into the brain.

It is excreted mainly by active secretion in the tubules of the kidneys in unchanged form (60%) and in the form of metabolites. The excretion of unchanged salicylate depends on the pH of the urine (with alkalization of the urine, the ionization of salicylates increases, their reabsorption worsens, and excretion increases significantly). T 1/2 acetylsalicylic acid is approximately 15 minutes. T1 / 2 salicylate when taken in low doses is 2-3 hours, with increasing doses it can increase up to 15-30 hours. In newborns, the elimination of salicylate is much slower than in adults.

Release form

10 pieces. - cellular contour packings (1) - packs of cardboard.
20 pcs. - cellular contour packings (1) - packs of cardboard.
30 pcs. - cellular contour packings (1) - packs of cardboard.
40 pcs. - polymer cans (1) - packs of cardboard.

Dosage

Individual. For adults, a single dose varies from 40 mg to 1 g, daily - from 150 mg to 8 g; multiplicity of application - 2-6 times / day.

Interaction

With the simultaneous use of antacids containing magnesium and / or aluminum hydroxide, slow down and reduce the absorption of acetylsalicylic acid.

With the simultaneous use of calcium channel blockers, agents that limit the intake of calcium or increase the excretion of calcium from the body, the risk of bleeding increases.

With simultaneous use with acetylsalicylic acid, the effect of heparin and indirect anticoagulants, hypoglycemic agents of sulfonylurea derivatives, insulins, methotrexate, phenytoin, valproic acid is enhanced.

With simultaneous use with GCS, the risk of ulcerogenic action and the occurrence of gastrointestinal bleeding increases.

With simultaneous use, the effectiveness of diuretics (spironolactone, furosemide) decreases.

With the simultaneous use of other NSAIDs, the risk of side effects increases. Acetylsalicylic acid may reduce plasma concentrations of indomethacin, piroxicam.

When used simultaneously with gold preparations, acetylsalicylic acid can induce liver damage.

With simultaneous use, the effectiveness of uricosuric agents (including probenecid, sulfinpyrazone, benzbromarone) decreases.

With the simultaneous use of acetylsalicylic acid and sodium alendronate, severe esophagitis may develop.

With the simultaneous use of griseofulvin, a violation of the absorption of acetylsalicylic acid is possible.

A case of spontaneous hemorrhage in the iris is described when taking ginkgo biloba extract against the background of long-term use of acetylsalicylic acid at a dose of 325 mg / day. It is believed that this may be due to an additive inhibitory effect on platelet aggregation.

With the simultaneous use of dipyridamole, an increase in Cmax of salicylate in plasma and AUC is possible.

With simultaneous use with acetylsalicylic acid, the concentrations of digoxin, barbiturates and lithium salts in the blood plasma increase.

With the simultaneous use of salicylates in high doses with inhibitors of carbonic anhydrase, intoxication with salicylates is possible.

Acetylsalicylic acid at doses less than 300 mg / day has little effect on the effectiveness of captopril and enalapril. When using acetylsalicylic acid in high doses, the effectiveness of captopril and enalapril may decrease.

With simultaneous use, caffeine increases the absorption rate, plasma concentration and bioavailability of acetylsalicylic acid.

With simultaneous use, metoprolol can increase the Cmax of salicylate in plasma.

When using pentazocine against the background of long-term use of acetylsalicylic acid in high doses, there is a risk of developing severe adverse reactions from the kidneys.

With the simultaneous use of phenylbutazone reduces uricosuria caused by acetylsalicylic acid.

With simultaneous use, ethanol can enhance the effect of acetylsalicylic acid on the gastrointestinal tract.

Side effects

From the digestive system: nausea, vomiting, anorexia, epigastric pain, diarrhea; rarely - the occurrence of erosive and ulcerative lesions, bleeding from the gastrointestinal tract, impaired liver function.

From the side of the central nervous system: with prolonged use, dizziness, headache, reversible visual impairment, tinnitus, aseptic meningitis are possible.

From the hemopoietic system: rarely - thrombocytopenia, anemia.

From the blood coagulation system: rarely - hemorrhagic syndrome, prolongation of bleeding time.

From the urinary system: rarely - impaired renal function; with prolonged use - acute renal failure, nephrotic syndrome.

Allergic reactions: rarely - skin rash, Quincke's edema, bronchospasm, "aspirin triad" (combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid and pyrazolone drugs).

Others: in some cases - Reye's syndrome; with prolonged use - increased symptoms of chronic heart failure.

Indications

Rheumatism, rheumatoid arthritis, infectious-allergic myocarditis; fever in infectious and inflammatory diseases; pain syndrome of low and medium intensity of various origins (including neuralgia, myalgia, headache); prevention of thrombosis and embolism; primary and secondary prevention of myocardial infarction; prevention of cerebrovascular accidents by ischemic type.

In clinical immunology and allergology: in gradually increasing doses for prolonged "aspirin" desensitization and the formation of stable tolerance to NSAIDs in patients with "aspirin" asthma and the "aspirin triad".

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, gastrointestinal bleeding, "aspirin triad", a history of indications of urticaria, rhinitis caused by taking acetylsalicylic acid and other NSAIDs, hemophilia, hemorrhagic diathesis, hypoprothrombinemia, dissecting aortic aneurysm, portal hypertension, vitamin K deficiency, liver and / or kidney failure, glucose-6-phosphate dehydrogenase deficiency, Reye's syndrome, children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases), I and III trimesters of pregnancy, lactation period , hypersensitivity to acetylsalicylic acid and other salicylates.

Application features

Use during pregnancy and lactation

Contraindicated for use in the I and III trimesters of pregnancy. In the II trimester of pregnancy, a single dose is possible according to strict indications.

It has a teratogenic effect: when used in the first trimester, it leads to the development of a splitting of the upper palate, in the third trimester it causes inhibition of labor activity (inhibition of prostaglandin synthesis), premature closure of the ductus arteriosus in the fetus, pulmonary vascular hyperplasia and hypertension in the pulmonary circulation.

Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the child due to impaired platelet function, therefore, acetylsalicylic acid should not be used in the mother during lactation.

Application for violations of liver function

Contraindication: liver failure.

Use with caution in patients with liver disease.

Application for violations of kidney function

Contraindication: renal failure.

Use with caution in patients with kidney disease.

Use in children

Contraindication: children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases).

special instructions

Use with caution in patients with diseases of the liver and kidneys, with bronchial asthma, erosive and ulcerative lesions and bleeding from the gastrointestinal tract in history, with increased bleeding or while conducting anticoagulant therapy, decompensated chronic heart failure.

Acetylsalicylic acid, even in small doses, reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. When carrying out long-term therapy and / or the use of acetylsalicylic acid in high doses, a doctor's supervision and regular monitoring of hemoglobin levels are required.

The use of acetylsalicylic acid as an anti-inflammatory agent in a daily dose of 5-8 g is limited due to the high likelihood of side effects from the gastrointestinal tract.

Before surgery, to reduce bleeding during surgery and in the postoperative period, salicylates should be discontinued 5-7 days in advance.

During long-term therapy, it is necessary to conduct a complete blood count and a study of feces for occult blood.

The use of acetylsalicylic acid in pediatrics is contraindicated, since in the case of a viral infection in children under the influence of acetylsalicylic acid, the risk of developing Reye's syndrome increases. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, liver enlargement.

The duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an analgesic and more than 3 days as an antipyretic.

During the treatment period, the patient should refrain from drinking alcohol.

Almost everyone in the home medicine cabinet has acetylsalicylic acid (aspirin) - a drug known to everyone as an assistant for hangovers and colds. Aspirin is included in the list of the most common medicines in the people and belongs to the group of analgesics, has analgesic and antipyretic properties. It is able to reduce body temperature, fight migraines and febrile illnesses, and also resist inflammatory processes occurring in the human body.

The drug is very popular in medicine, as it is universal in its qualities and, in addition to the listed properties, is able to prevent diseases of the cardiovascular system, fight rheumatism and resist diseases of a different nature. In order to find out what other effects aspirin can have on the human body, we will study the detailed instructions for the drug, its properties and instructions for use.

Acetylsalicylic acid. Instructions for use

On the shelves of pharmacies, aspirin can be found in its pure form, as well as in the composition of other medicines. Combined type preparations containing acetylsalicylic acid have special specifics and Available in powder, capsule and other forms. As for pure aspirin, these are usually 250 or 500 mg tablets. For children under the age of twelve, the drug is provided with a lower dosage and is available in the form of tablets of 100 mg.

Properties of acetylsalicylic acid

This drug has a wide spectrum of action: eliminates pain, thins the blood, lowers the temperature, stops inflammation. When it is used, the level of blood density decreases, having blood clots dissolve, which normalizes circulation in large vessels and capillaries. Improved supply of oxygen to the brain quickly and effectively eliminates pain in the head, reduces internal pressure and reduces inflammation in the tissues. After ingestion, aspirin begins to act on the body after 5-15 minutes.

Many doctors believe that the use of this drug for a hangover is dangerous, as there is a risk of developing gastritis, cirrhosis, and damage to brain cells.

Dosage and method of application

In order to ensure maximum effectiveness of the drug it is recommended to take acetylsalicylic acid orally one hour after a meal. The maximum single dose of acetylsalicylic acid for a healthy adult is two tablets. In diseases of the gastric mucosa, it is recommended to reduce the dose to half. Children under 12 years of age are prescribed the drug at the rate of 25 mg per kilogram of the child's weight. For people who have had a myocardial infarction, the dose is 1 tablet per day or half a tablet in two doses.

It is necessary to take the drug with water or milk. The duration of treatment with acetylsalicylic acid should be no more than 5 days at intervals of 8 hours.

It is forbidden to take the drug at the same time as alcohol. When eliminating the signs of alcohol syndrome, experts recommend taking a pill six hours after taking the last serving of alcohol-containing drinks.

For the strongest effectiveness, it is best to take an effervescent aspirin for a hangover. For example, dissolve an Alka-Seltzer tablet in a glass of warm water and drink it on an empty stomach. This method acts on the body faster and does not irritate the gastric mucosa. In its pure form, in this case, aspirin is best combined with Regidron or activated charcoal.

Indications for use

The drug is prescribed to patients:

And also in order to prevent thromboembolism in atrial fibrillation, vasculitis and valvular heart disease and to alleviate the condition in case of poisoning and hangover.

Side effects and contraindications

When taking acetylsalicylic acid, side effects:

Aspirin is contraindicated in the following cases:

  • with increased sensitivity to the drug;
  • in case of exacerbated phases of ulcerative lesions and bleeding in the organs of the gastrointestinal tract;
  • with "aspirin" asthma, diathesis, portal hypertension, vitamin K deficiency and gouty arthritis;
  • with liver and kidney failure;
  • in the 1st and 3rd trimester of pregnancy and lactation.

Acetylsalicylic acid for hangover

A hangover in the human body occurs due to excessive consumption of alcohol-containing drinks. The severity of the syndrome is influenced not only by the amount of alcohol consumed, but also by the weight and gender of the person, as well as the quality of alcohol and the body's ability to resist the action of the toxin. Hangover symptoms such as headache and weakness can be eliminated with the help of analgin and other medicines, along with aspirin.

hangover cure is the most popular among drugs, which quickly eliminate almost all manifestations of alcohol intoxication. However, it is worth understanding what processes occur in the body during a hangover period and whether aspirin can be considered exactly the medicine that can improve health.

The action of acetylsalicylic acid after a hangover

It should be noted that alcohol has a negative effect on all organs of the human body due to its rapid penetration into the blood and, accordingly, its distribution in all systems inherent in human physiology.

Systematic excessive drinking regardless of the strength and quality, it can lead to cirrhosis or stroke, since when ethanol is combined with blood, blood cells stick together, which disrupts the movement of oxygen molecules and cellular respiration of tissues, and clots are formed that can block large arteries and small capillaries; and here the consequences are sad - there is a death of many cells, the actions of which are necessary for the human body. Ethanol is able to briefly influence the expansion of blood vessels, and after that there is a strong narrowing, which, in an unfavorable combination with thick blood, ends in a stroke.

Severe headaches are caused by a spasm of capillaries that occurs in the brain. Severe intoxication is possible with such ensuing consequences as: heaviness in the head, nausea, dehydration and indigestion.

Aspirin is able to quickly and effectively affect the processes associated with the deterioration of health after a hangover and instantly change the situation, since the drug has a wide range of therapeutic properties, among which:

At the same time, aspirin is not able to do the impossible and eliminate toxins from the human body that remain after the breakdown of ethanol, not in its properties. Therefore, in the treatment of a hangover, it is recommended to use combination drugs. with the ability to remove alcoholic poisons.

Use of aspirin for a hangover

In order to usefully get rid of a hangover syndrome, it is important to know how much to take acetylsalicylic acid tablets and how not to harm your own health. For this it is necessary to follow the instructions for use and observe the permissible dosage.

Aspirin should be taken with caution, given the state and level of hangover. Before use, dissolve in water, this will avoid dehydration of the body and the drug will act much faster. It is necessary to drink tablets from the established calculation (1000 mg of aspirin per 70 kg of weight) after 6 hours after drinking alcohol-containing drinks.

Many people wonder: is it possible to use the drug before drinking alcohol in order to avoid serious consequences and not suffer from a hangover syndrome.

According to the instructions for the prevention of hangover syndrome it is recommended to take two tablets of the drug for 24 hours in two divided doses (1 tablet every 12 hours), it is allowed to take the drug earlier, but no later than 2 hours before drinking alcohol. Experts do not recommend drinking tablets with drinks incompatible with the drug: juices, carbonated drinks, coffee and tea.

You can drink acetylsalicylic acid with a hangover syndrome or its prevention in any form. The most optimal option is considered to be Aspirin Upsa or Upsarin effervescent tablets.

To avoid intoxication of the body after a feast, it is recommended to combine taking the drug with a temporary protein diet, this gives a high probability that the state of the body will please with the consequences, because the liver is cleansed and, thus, a significant part of the load is removed from it. It is necessary to exclude from the diet: sausage, meat, mushrooms, beans and peas. They can be replaced with fermented milk products, salads, various cereals or sauces, vegetables and fruits.

Contraindications to the use of aspirin for a hangover

There are cases when taking aspirin with a hangover syndrome does not help, but becomes dangerous for a person. Particular care in the use of the drug is required from people suffering from diseases of the stomach, intestines, liver and kidneys. Do not take aspirin and pregnant women, as well as asthmatics and children.

The drug will harm if you combine it with glucocorticosteroids; in the case of existing diseases of the gastrointestinal tract, acetylsalicylic acid will cause bleeding in the stomach, and the chemical reaction provoked by the ingestion of aspirin into alcohol will corrode the walls of the stomach.

The threat to the stomach occurs with an alcohol concentration of 20% or more, and aspirin in this case will only increase the negative impact. The most dangerous consequences during the combination of alcohol and this drug relate to people with the first and second blood groups.

It is necessary to refrain from taking the drug for people who suffer from stomach ulcers.. The exacerbation of this chronic disease will lead to the discovery of internal bleeding, a severe form of anemia will occur, which will subsequently serve as an iron deficiency in the body; the level of blood thinning will increase, which will cause heavy and prolonged bleeding.

It is also worth considering that overdose acetylsalicylic acid, in addition to the possibility of provoking a stroke and cirrhosis, can cause a heart attack, so it is important to understand the properties and effects of the drug on the human body and drink pills strictly according to the instructions, and for people who are contraindicated in the drug, completely refuse it.

Attention, only TODAY!

active ingredient: acetylsalicylic acid;

1 tablet contains acetylsalicylic acid (in terms of 100% substance) 500 mg;

excipients: microcrystalline cellulose, croscarmellose sodium, anhydrous colloidal silicon dioxide (aerosil), magnesium stearate, lemon flavor, anhydrous citric acid.

Dosage form. Pills.

Basic physical and chemical properties: tablets of white or almost white color, round shape, with a flat surface, with a notch and a facet, with a slight lemon odor. Marbling is allowed on the surface of the tablets.

Pharmacotherapeutic group.

Analgesics and antipyretics. Acetylsalicylic acid. ATX code N02B A01.

Pharmacological properties

Pharmacodynamics.

Acetylsalicylic acid belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) with analgesic, antipyretic and anti-inflammatory properties. Its mechanism of action is the irreversible inactivation of cyclooxygenase enzymes, which play an important role in the synthesis of prostaglandins.

Acetylsalicylic acid is used orally in doses of 0.3 to 1 g to relieve pain and conditions accompanied by fever, such as the common cold, to reduce fever and relieve joint and muscle pain.

Acetylsalicylic acid inhibits platelet aggregation by blocking the synthesis of thromboxane A 2 .

Pharmacokinetics.

After oral administration, acetylsalicylic acid is rapidly and completely absorbed from the gastrointestinal tract. During and after absorption, it turns into the main active metabolite - salicylic acid. The maximum concentration of acetylsalicylic acid in the blood plasma is reached after 10-20 minutes, salicylates - after 20-120 minutes.

Acetylsalicylic and salicylic acids are completely bound to plasma proteins and are rapidly distributed in the body.

Salicylic acid crosses the placenta and is excreted in breast milk.

Salicylic acid is metabolized in the liver. The metabolites of salicylic acid are salicyl uric acid, salicylphenol glucuronide, salicylacyl glucuronide, gentisic and gentisin uric acids.

The kinetics of excretion of salicylic acid is dose-dependent, since metabolism is limited by the activity of liver enzymes. The elimination half-life is dose-dependent and increases from 2-3 hours at low doses to 15 hours at high doses. Salicylic acid and its metabolites are excreted from the body mainly by the kidneys.

clinical characteristics.

Indications

  • Treatment of mild to moderate, acute pain syndrome (headache, toothache, joint and muscle pain, back pain).
  • Symptomatic treatment of fever and / or pain in colds.

Contraindications

  • Hypersensitivity to acetylsalicylic acid, other salicylates or to any component of the drug.
  • Bronchial asthma caused by the use of salicylates or other NSAIDs in history.
  • Acute gastrointestinal ulcers.
  • Hemorrhagic diathesis.
  • Severe renal failure.
  • Severe liver failure.
  • Severe heart failure.
  • Combination with methotrexate at a dosage of 15 mg / week or more (see the section "Interaction with other medicinal products and other forms of interaction").

Special Security Measures

Acetylsalicylic acid is used with caution in:

  • hypersensitivity to analgesic, anti-inflammatory, antirheumatic drugs, as well as in the presence of allergies to other substances;
  • history of gastrointestinal ulcers, including chronic or recurrent peptic ulcer or history of gastrointestinal bleeding;
  • simultaneous use of anticoagulants;
  • impaired renal function or circulatory disorders (such as vascular disease of the kidneys, congestive heart failure, dehydration, massive surgery, sepsis or significant blood loss), since acetylsalicylic acid may further increase the risk of kidney damage and cause acute renal failure;
  • liver function disorders.

In patients with allergic complications, including bronchial asthma, allergic rhinitis, urticaria, pruritus, mucosal edema and nasal polyposis, as well as their combination with chronic respiratory tract infections and in patients with hypersensitivity to NSAIDs during treatment with acetylsalicylic acid acids may develop bronchospasm, an attack of bronchial asthma or other hypersensitivity reactions.

During surgical operations (including dental), the use of drugs containing acetylsalicylic acid may increase the likelihood of the appearance / increase in bleeding, which is due to the inhibition of platelet aggregation for some time after the use of acetylsalicylic acid.

When using small doses of acetylsalicylic acid, the excretion of uric acid may decrease. This can lead to gout in patients with reduced uric acid excretion.

In patients with deficiency of glucose-6-phosphate dehydrogenase, acetylsalicylic acid can cause hemolysis or hemolytic anemia. Factors that increase the risk of hemolysis are, for example, the use of high doses of the drug, fever or acute infections.

Prolonged use of analgesics can lead to headaches.

Frequent use of painkillers can cause temporary kidney damage with a risk of kidney failure (analgesic nephropathy). The risk is especially high when several different analgesics are used simultaneously.

Interaction with other drugs and other types of interactions.

Contraindicated combinations

The use of acetylsalicylic acid with methotrexate at doses of 15 mg / week or more, it increases the hematological toxicity of methotrexate (decrease in renal clearance of methotrexate by anti-inflammatory agents and displacement of methotrexate by salicylates from association with plasma proteins).

Combinations to be used with caution

When using acetylsalicylic acid with methotrexate at doses less than 15 mg / week, the hematological toxicity of methotrexate increases (reduction in the renal clearance of methotrexate by anti-inflammatory agents and displacement of methotrexate by salicylates from the association with plasma proteins).

Simultaneous use ibuprofen prevents irreversible inhibition of platelets by acetylsalicylic acid. Treatment with ibuprofen in patients at risk of cardiovascular disease may limit the cardioprotective effect of acetylsalicylic acid.

With the simultaneous use of high doses of salicylates with NSAIDs(due to a mutually reinforcing effect) increases the risk of ulcers and gastrointestinal bleeding.

With the simultaneous use of acetylsalicylic acid and anticoagulants increased risk of bleeding.

Simultaneous use with uricosuric agents, such as benzobromarone, probenecid, reduces the effect of excretion of uric acid (due to competition for the excretion of uric acid by the renal tubules).

digoxin the concentration of the latter in the blood plasma increases due to a decrease in renal excretion.

With the simultaneous use of high doses of acetylsalicylic acid and oral antidiabetic drugs from the group of sulfonylurea or insulin derivatives, the hypoglycemic effect of the latter is enhanced due to the hypoglycemic effect of acetylsalicylic acid and the displacement of sulfonylurea associated with blood plasma proteins.

Diuretics in combination with high doses of acetylsalicylic acid, they reduce glomerular filtration due to a decrease in the synthesis of prostaglandins in the kidneys.

Systemic glucocorticosteroids(with the exception of hydrocortisone, which is used for replacement therapy in Addison's disease). When using acetylsalicylic acid simultaneously with corticosteroids the level of salicylates in the blood decreases and the risk of overdose after the end of treatment increases, as well as the risk of developing gastrointestinal bleeding.

ACE inhibitors in combination with high doses of acetylsalicylic acid, they cause a decrease in glomerular filtration as a result of inhibition of vasodilatory prostaglandins and a decrease in the hypotensive effect.

Selective serotonin reuptake inhibitors. The risk of bleeding from the upper gastrointestinal tract increases due to the possibility of a synergistic effect.

When used simultaneously with valproic acid acetylsalicylic acid displaces it from its association with blood plasma proteins, increasing the toxicity of the latter.

Ethanol promotes damage to the mucous membrane of the gastrointestinal tract and prolongs the bleeding time due to the synergism of acetylsalicylic acid and alcohol.

Application features

Use during pregnancy or lactation.

Pregnancy

Acetylsalicylic acid can be used during pregnancy only when other drugs are not effective and only after an assessment of the risk/benefit ratio.

Inhibition of prostaglandin synthesis can adversely affect pregnancy and/or embryonic/intrauterine development. Available data from epidemiological studies indicate the risk of miscarriage and fetal malformations after the use of prostaglandin synthesis inhibitors in early pregnancy. The risk increases with increasing dose and duration of therapy. According to research data, the relationship between taking acetylsalicylic acid and an increased risk of miscarriage has not been confirmed.

The present increased risk of gastroschisis cannot be excluded with the use of acetylsalicylic acid. Early pregnancy (months 1-4) has not been associated with an increased risk of malformations.

During the I and II trimester of pregnancy, drugs containing acetylsalicylic acid should not be prescribed without a clear clinical need. In women who are likely to be pregnant, or during the first and second trimester of pregnancy, the dose of drugs containing acetylsalicylic acid should be as low as possible, and the duration of treatment should be as short as possible.

During the third trimester of pregnancy, all inhibitors of prostaglandin synthesis can affect the fetus as follows:

  • cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension);
  • impaired renal function with the possible subsequent development of renal failure with oligohydramnios.

Inhibitors of prostaglandin synthesis can affect the woman and fetus at the end of pregnancy in this way:

  • the possibility of prolonging bleeding time, an antiplatelet effect that can occur even after very low doses;
  • inhibition of uterine contractions, which can lead to a delay or lengthening of the duration of labor.

Given this, acetylsalicylic acid is contraindicated during the third trimester of pregnancy.

Fertility

There are some indications that drugs that inhibit the synthesis of prostaglandins can interfere with reproductive function in women due to the effect on ovulation. This phenomenon is reversible and disappears after discontinuation of treatment.

Period of breastfeeding

Salicylates and their metabolites pass into breast milk in small amounts.

Since no adverse reactions have been observed in infants whose mothers took acetylsalicylic acid, it is usually not necessary to interrupt breastfeeding. With prolonged use of the drug or the use of acetylsalicylic acid in high doses, the issue of stopping breastfeeding should be resolved.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms.

There was no effect on the ability to drive a car and other mechanisms.

Dosage and administration

Acetylsalicylic acid is taken orally after meals with a sufficient amount of liquid.

Acetylsalicylic acid should not be used for longer than 3-5 days without consulting a doctor.

Adults and children over 15 years old.

1-2 tablets as a single dose. Re-admission is possible after 4-8 hours. The maximum daily dose should not exceed 4 g (8 tablets).

Notifications .

For patients with concomitant impaired liver or kidney function, it is necessary to reduce the dose of the drug or increase the interval between applications.

Children.

The drug is used for children from 15 years.

Preparations containing acetylsalicylic acid should not be used in children with acute respiratory viral infections (ARVI), which are accompanied or not accompanied by fever, without consulting a doctor. Some viral illnesses, especially influenza type A, influenza type B, and chickenpox, are at risk of developing Reye's syndrome, which is a very rare but life-threatening condition that requires urgent medical attention. The risk may be increased if acetylsalicylic acid is used as a concomitant drug, but a causal relationship has not been proven in this case. If these conditions are accompanied by prolonged vomiting, this may be a sign of Reye's syndrome.

Overdose

Salicylate toxicity (use of more than 100 mg / kg / day for more than 2 days can cause toxicity) is possible through chronic intoxication, which arose as a result of long-term therapy, as well as through acute intoxication (overdose), which is potentially life-threatening and the causes of which can be, for example , accidental use by children or overdose.

Chronic intoxication salicylates may be latent, since its signs are nonspecific. Moderate chronic intoxication caused by salicylates, or salicylism, usually occurs only after repeated use of large doses.

Symptoms. Dizziness, ringing in the ears, deafness, excessive sweating, nausea and vomiting, headache, confusion. These symptoms can be controlled by lowering the dose. Ringing in the ears is possible when the concentration of salicylates in the blood plasma is more than 150-300 mcg / ml. More serious adverse reactions are observed when the concentration of salicylates in the blood plasma is more than 300 mcg / ml.

About acute intoxication evidenced by a pronounced change in the acid-base balance, which depends on the age of the patient and the severity of intoxication. In children, the most characteristic manifestation is metabolic acidosis. The severity of the condition cannot be assessed solely on the basis of the concentration of salicylates in the blood plasma. The absorption of acetylsalicylic acid may be slowed down due to delayed gastric release, the formation of calculi in the stomach.

Due to the complex pathophysiological effects, signs and symptoms of salicylate poisoning may include:

Mild to moderate intoxication - tachypnea, hyperpnea, respiratory alkalosis; increased sweating, nausea and vomiting.

Moderate to severe intoxication - respiratory alkalosis, accompanied by compensatory metabolic acidosis, hyperpyrexia. From the respiratory system: from hyperpnea, non-cardiogenic pulmonary edema to respiratory arrest and asphyxia. From the side of the cardiovascular system: from arrhythmia, arterial hypotension to cardiac arrest. There is also dehydration, oliguria up to renal failure; impaired glucose metabolism, ketosis; gastrointestinal bleeding; hematological changes - from platelet suppression to coagulopathy. From the nervous system: toxic encephalopathy and depression of the central nervous system, which manifests itself in the form of drowsiness, depression of consciousness before the development of coma and convulsions.

Changes in laboratory and other indicators: alkalemia, alkaluria, acidemia, aciduria, changes in blood pressure, ECG changes, hypokalemia, hypernatremia, hyponatremia, changes in renal function, hyperglycemia, hypoglycemia (especially in children). Elevated levels of ketone bodies, hypoprothrombinemia.

Treatment.

Treatment of intoxication caused by an overdose of acetylsalicylic acid is determined by the severity, clinical symptoms and is provided by standard methods that are used for poisoning (gastric lavage, activated charcoal, forced diuresis). All measures taken should be aimed at accelerating the removal of the drug and restoring the electrolyte and acid-base balance. Depending on the state of acid-base balance and electrolyte balance, infusion administration of electrolyte solutions is carried out. In severe poisoning, hemodialysis is indicated.

Adverse reactions

From the gastrointestinal tract. Dyspepsia, epigastric pain and abdominal pain, heartburn; in some cases - inflammation of the gastrointestinal tract, erosive and ulcerative lesions of the gastrointestinal tract, which can in rare cases cause gastrointestinal bleeding and perforation with appropriate laboratory and clinical manifestations.

Rarely - transient liver failure with an increase in the level of hepatic transaminases.

From the blood and lymphatic system. Due to the antiplatelet effect on platelets, acetylsalicylic acid may increase the risk of bleeding. There were such bleeding as perioperative bleeding, hematomas, urogenital bleeding, nosebleeds, bleeding from the gums; rarely or very rarely - serious bleeding, such as gastrointestinal bleeding and cerebral hemorrhage (especially in patients with uncontrolled arterial hypertension and / or with the simultaneous use of antihemostatic agents), which in isolated cases can be life-threatening.

Bleeding can lead to acute and chronic posthemorrhagic anemia/iron deficiency anemia (due to the so-called latent microbleeding) with associated laboratory findings and clinical symptoms such as asthenia, skin pallor, and hypoperfusion.

In patients with severe glucose-6-phosphate dehydrogenase deficiency, hemolysis and hemolytic anemia have been reported.

From the immune system. In patients with individual hypersensitivity to salicylates, allergic reactions may develop, including symptoms such as rash, urticaria, itching, eczema, rhinitis, nasal congestion, lowering blood pressure. Very rarely, severe hypersensitivity reactions have been observed, including anaphylactic shock, angioedema, non-cardiogenic pulmonary edema. In patients with bronchial asthma, an increase in the incidence of bronchospasm is possible; mild to moderate allergic reactions that potentially affect the skin, respiratory system, gastrointestinal tract and cardiovascular system.

From the side of the nervous system. Headache, dizziness, hearing loss; ringing in the ears and confusion may be signs of an overdose.

From the urinary system. There is evidence of impaired renal function and the development of acute renal failure.

Shelf life. 4 years.

Do not use after the expiry date stated on the packaging.

Storage conditions

Store in original packaging at temperatures up to 25 °C.

Keep out of the reach of children.

Package

10 tablets in a blister; 10 tablets in a strip.

10 tablets in a blister, 2 blisters in a pack.

Holiday conditions. Over the counter.

Manufacturer

1. PJSC "Kyivmedpreparat".

2. PJSC "Galicpharm".

The location of the manufacturer and the address of the place of its activity.

1. Ukraine, 01032, Kyiv, st. Saksaganskogo, 139.

2. Ukraine, 79024, Lviv, st. Oprishkovskaya, 6/8.

Acetylsalicylic acid (lat. Acidum acetylsalicylicum).
Formula: C9H8O4
Graphic formula:

Pharmacological group

Non-narcotic analgesics / antiplatelet agents, non-steroidal anti-inflammatory drugs (NSAIDs), salicylic acid derivatives.

pharmachologic effect

Pharmacokinetics

When taken orally, it is rapidly absorbed mainly from the proximal small intestine and, to a lesser extent, from the stomach. The presence of food in the stomach significantly alters the absorption of acetylsalicylic acid.

It is metabolized in the liver by hydrolysis to form salicylic acid, followed by conjugation with glycine or glucuronide. The concentration of salicylates in plasma is variable.

About 80% of salicylic acid binds to plasma proteins. Salicylates easily penetrate into many tissues and body fluids, incl. into the cerebrospinal, peritoneal and synovial fluids. Small amounts of salicylates are found in the brain tissue, traces - in bile, sweat, feces. It quickly crosses the placental barrier and is excreted in small amounts in breast milk.

In newborns, salicylates can displace bilirubin from its association with albumin and contribute to the development of bilirubin encephalopathy.

Penetration into the joint cavity accelerates in the presence of hyperemia and edema and slows down in the proliferative phase of inflammation.

When acidosis occurs, most of the salicylate turns into non-ionized acid, which penetrates well into tissues, incl. into the brain.

It is excreted mainly by active secretion in the tubules of the kidneys in unchanged form (60%) and in the form of metabolites. The excretion of unchanged salicylate depends on the pH of the urine (with alkalization of the urine, the ionization of salicylates increases, their reabsorption worsens, and excretion increases significantly). T1 / 2 acetylsalicylic acid is approximately 15 minutes. T1 / 2 of salicylate when taken in low doses is 2-3 hours, with increasing doses it can increase up to 15-30 hours. In newborns, the elimination of salicylate is much slower than in adults.

Method of application and dosage

Acetylsalicylic acid is taken orally, preferably after meals, drinking plenty of water, dosages are individual and depend on the disease.

For adults, the instruction recommends using acetylsalicylic acid 3-4 times a day, 1-2 tablets (500-1000 mg), while the maximum daily dose is 6 tablets (3 g). The maximum duration of the use of acetylsalicylic acid is 14 days.

In order to improve the rheological properties of blood, as well as an inhibitor of platelet adhesion, ½ tablet of acetylsalicylic acid is prescribed per day for several months. For myocardial infarction and for the prevention of secondary myocardial infarction, the instruction for acetylsalicylic acid recommends taking 250 mg per day. Dynamic disorders of cerebral circulation and cerebral thromboembolism suggest taking ½ tablet of acetylsalicylic acid with a gradual increase in the dose to 2 tablets per day.

Acetylsalicylic acid is prescribed for children in the following single doses: over 2 years old - 100 mg, 3 years old - 150 mg, four years old - 200 mg, over 5 years old - 250 mg. Children are recommended to take acetylsalicylic acid 3-4 times a day.

Indications

Acetylsalicylic acid is prescribed for:

  • acute rheumatic fever, pericarditis (inflammation of the serous membrane of the heart), rheumatoid arthritis (damage to the connective tissue and small vessels), rheumatic chorea (manifested by involuntary muscle contractions), Dressler's syndrome (combination of pericarditis with inflammation of the pleura or pneumonia);
  • pain syndrome of mild and moderate intensity: migraine, headache, toothache, pain during menstruation, osteoarthritis, neuralgia, pain in the joints, muscles;
  • diseases of the spine, accompanied by pain syndrome: sciatica, lumbago, osteochondrosis;
  • febrile syndrome;
  • the need to develop tolerance to anti-inflammatory drugs in patients with the "aspirin triad" (a combination of bronchial asthma, nasal polyps and intolerance to acetylsalicylic acid) or "aspirin" asthma;
  • prevention of myocardial infarction in coronary heart disease or in the prevention of relapse;
  • the presence of risk factors for painless myocardial ischemia, coronary heart disease, unstable angina;
  • prevention of thromboembolism (blockage of a vessel by a thrombus), valvular mitral heart disease, prolapse (dysfunction) of the mitral valve, atrial fibrillation (loss of atrial muscle fibers of the ability to work synchronously);
  • acute thrombophlebitis (inflammation of the vein wall and the formation of a blood clot that closes the lumen in it), pulmonary infarction (blockage of the vessel supplying the lung by a thrombus), recurrent pulmonary embolism.

Contraindications

Hypersensitivity (including "aspirin" asthma, "aspirin" triad), hemorrhagic diathesis (von Willebrand's disease, hemophilia, telangiectasia), heart failure, aortic aneurysm (dissecting), erosive and ulcerative acute and recurrent diseases of the gastrointestinal tract, acute hepatic or renal failure, gastrointestinal bleeding, hypoprothrombinemia (before treatment), thrombocytopenia, vitamin K deficiency, glucose-6-phosphate dehydrogenase deficiency, thrombotic thrombocytopenic purpura, breastfeeding, pregnancy (I and III trimester), age up to 15 years when using as an antipyretic. Limit the intake of acetylsalicylic acid in case of hyperuricemia, nephrolithiasis, gout, peptic ulcer, severe disorders of the kidneys and liver, bronchial asthma, COPD, nasal polyposis, uncontrolled arterial hypertension.

Side effect

From the digestive system: nausea, vomiting, anorexia, epigastric pain, diarrhea; rarely - the occurrence of erosive and ulcerative lesions, bleeding from the gastrointestinal tract, impaired liver function.

From the side of the central nervous system: with prolonged use, dizziness, headache, reversible visual impairment, tinnitus, aseptic meningitis are possible.

From the hemopoietic system: rarely - thrombocytopenia, anemia.

From the blood coagulation system: rarely - hemorrhagic syndrome, prolongation of bleeding time.

From the urinary system: rarely - impaired renal function; with prolonged use - acute renal failure, nephrotic syndrome.

Allergic reactions: rarely - skin rash, Quincke's edema, bronchospasm, "aspirin triad" (combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid and pyrazolone drugs).

Others: in some cases - Reye's syndrome; with prolonged use - increased symptoms of chronic heart failure.

Overdose

Symptoms. With a mild form of drug intoxication, nausea, vomiting, abdominal pain, dizziness, tinnitus, headache are possible. In severe cases - confusion, tremor, suffocation, metabolic acidosis, coma, collapse. Lethal doses are possible: for adults - above 10 g, for children - above 3 g.

Treatment. Correction of acid-base balance, water-electrolyte balance, infusion of solutions of sodium bicarbonate, sodium lactate.

drug interaction

  • With the simultaneous use of antacids containing magnesium and / or aluminum hydroxide, slow down and reduce the absorption of acetylsalicylic acid.
  • With the simultaneous use of calcium channel blockers, agents that limit the intake of calcium or increase the excretion of calcium from the body, the risk of bleeding increases.
  • With simultaneous use with acetylsalicylic acid, the effect of heparin and indirect anticoagulants, hypoglycemic agents of sulfonylurea derivatives, insulins, methotrexate, phenytoin, valproic acid is enhanced.
  • With simultaneous use with GCS, the risk of ulcerogenic action and the occurrence of gastrointestinal bleeding increases.
  • With simultaneous use, the effectiveness of diuretics (spironolactone, furosemide) decreases.
  • With the simultaneous use of other NSAIDs, the risk of side effects increases. Acetylsalicylic acid may reduce plasma concentrations of indomethacin, piroxicam.
  • When used simultaneously with gold preparations, acetylsalicylic acid can induce liver damage.
  • With simultaneous use, the effectiveness of uricosuric agents (including probenecid, sulfinpyrazone, benzbromarone) decreases.
  • With the simultaneous use of acetylsalicylic acid and sodium alendronate, severe esophagitis may develop.
  • With the simultaneous use of griseofulvin, a violation of the absorption of acetylsalicylic acid is possible.
  • A case of spontaneous hemorrhage in the iris is described when taking ginkgo biloba extract against the background of long-term use of acetylsalicylic acid at a dose of 325 mg / day. It is believed that this may be due to an additive inhibitory effect on platelet aggregation.
  • With the simultaneous use of dipyridamole, an increase in Cmax of salicylate in plasma and AUC is possible.
  • With simultaneous use with acetylsalicylic acid, the concentrations of digoxin, barbiturates and lithium salts in the blood plasma increase.
  • With the simultaneous use of salicylates in high doses with inhibitors of carbonic anhydrase, intoxication with salicylates is possible.
  • Acetylsalicylic acid at doses less than 300 mg / day has little effect on the effectiveness of captopril and enalapril. When using acetylsalicylic acid in high doses, the effectiveness of captopril and enalapril may decrease.
  • With simultaneous use, caffeine increases the absorption rate, plasma concentration and bioavailability of acetylsalicylic acid.
  • With simultaneous use, metoprolol can increase the Cmax of salicylate in plasma.
  • When using pentazocine against the background of long-term use of acetylsalicylic acid in high doses, there is a risk of developing severe adverse reactions from the kidneys.
  • With the simultaneous use of phenylbutazone reduces uricosuria caused by acetylsalicylic acid.
  • With simultaneous use, ethanol can enhance the effect of acetylsalicylic acid on the gastrointestinal tract.

Use with caution in patients with diseases of the liver and kidneys, with bronchial asthma, erosive and ulcerative lesions and bleeding from the gastrointestinal tract in history, with increased bleeding or while conducting anticoagulant therapy, decompensated chronic heart failure.

Acetylsalicylic acid, even in small doses, reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. When carrying out long-term therapy and / or the use of acetylsalicylic acid in high doses, a doctor's supervision and regular monitoring of hemoglobin levels are required.

The use of acetylsalicylic acid as an anti-inflammatory agent in a daily dose of 5-8 g is limited due to the high likelihood of side effects from the gastrointestinal tract.

Before surgery, to reduce bleeding during surgery and in the postoperative period, salicylates should be discontinued 5-7 days in advance.

During long-term therapy, it is necessary to conduct a complete blood count and a study of feces for occult blood.

The use of acetylsalicylic acid in pediatrics is contraindicated, since in the case of a viral infection in children under the influence of acetylsalicylic acid, the risk of developing Reye's syndrome increases. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, liver enlargement.

The duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an analgesic and more than 3 days as an antipyretic.

During the treatment period, the patient should refrain from drinking alcohol.

Terms and conditions of storage

According to the instructions, acetylsalicylic acid should not be stored in a place where the air temperature can rise above 25 ° C. In a dry place and at room temperature, the drug will be suitable for 4 years.



Acne treatment
Hair care