Structum can be poured out of the capsule. Structum: instructions for use, analogues and reviews, prices in Russian pharmacies

Active ingredient:

Chondroitin Sulfate Sodium500.00 mg

Excipients :

Talc10.00 mg

The composition of the capsule shell (body and caps):

Gelatin, qs up to 112 mg( qs 100%)

Titanium dioxide (E171). aboutcolo 2.24 mg (2%)

indigotin(E132). aboutcolo0.1014 mg (0.0905%)

Description

Capsule size 0+, opaque, blue, containingconglomeratedcolor powder from whitebeforeyellowish.

Pharmacotherapeutic group

Other non-steroidal anti-inflammatory and antirheumatic drugs. The codeATX : MO1AX25 - Chondroitin sulfate.

Pharmacological properties

A drug for the treatment of osteoarthritis.

Chondroitin-sulphuricacid is an essential component of the ground substance of bone and cartilage.

Indications for use

symptomatic treatment withdelayed action of osteoarthritis of the hip and knee joints.

Contraindications

Hypersensitivity to the active substance or any of the excipients listed in section 6.1. Children under 15 (due to lack of accurate data).

Method of application and dosing regimen

The drug should only be used in adults (over the age of 15 years).

Capsules are taken orally.

Capsules should be swallowed whole with a large glass of water.

One 500 mg capsule twice a day, i.e. 1 g per day.

Use in children: evidence to support the use of honothersoitin sulfatat deteth 0-18 lno, are missing. Therefore, the use of chondroitin sulfate inchildren are not recommended.

special instructions

period pregnant sti and breastfeeding: since no relevant studies have been conducted, the drug is not recommended for use during this period.

Interactions with other drugs and other forms of interaction

Interaction studies have not been conducted.

Side effect

The table below presents the undesirable effects observed in seven clinical studies, including a total of 2244 patients, 1154 of whom received the drug STRUKTUM.

Undesirable effects are presented according toAI with system-organ classificationMedDRA and are listed below as:very often (≥ 1/10), often (≥ 1/100 up to 000 to 100), rarely (≥ 1/10000 to 000) , unknown (cannot be estimated from the available data).

Not on groups with a frequency of "very rare" or "very often" adverse effects were observed, therefore these columns are not included in the table below.

Preferred terms are classified and grouped under high-level grouping terms (HLTL).

Conditions for the same HLTV separated by the symbol ‘ -‘

SIDE EFFECT REPORTS

If you have any adverse reactions, tell your partner about it. treating doctor. This also applies to any adverse reactions not listed in this package insert. You can report adverse reactions to the information database on adverse reactions (actions) to medicinal products, including reports of drug inefficiency detected in the Republic of Belarus (UE "Center for Expertise and Testing in Healthcare" of the Ministry of Health of the Republic of Belarus, ). Reporting onadverse reactions, you help to get more information about the safety of the drug.

Overdose

In case of overdose, symptomatic treatment is prescribed.

Fertillife, pregnancy and lactation

Pregnancy

Application DataChondroitinsulfate in pregnant women absent or limited (less than 300 pregnancies). Animal studies have shown no direct or indirect adverse effects on reproductive toxicity. As a precaution it is recommended to avoid the use of the drug during pregnancy

Lactation

Structum- chondroprotective drug for oral administration. Structum contains the active component of chondroitin sulfate sodium salt. Chondroitin is a substance that is the structural basis of cartilage and bone tissue. The intake of endogenous chondroitin helps to restore and maintain the normal structure of the cartilage matrix by increasing the anabolic activity of chondrocytes and stimulating the synthesis of proteoglycans. In addition, the chondroprotective effect of Structum is realized by inhibiting the activity of interleukin-1 beta, which negatively affects the cartilage matrix, as well as elastase and collagenase enzymes, which lead to excessive degeneration of the cartilage matrix.
Structum also stimulates the synthesis of hyaluronic acid and normalizes the viscosity of the synovial fluid, which helps to normalize the homeostasis of the synovial environment of the joints.
Chondroitin has some antioxidant and enzymatic effect, which leads to inhibition of the development of inflammatory reactions.
When taken orally, Structum active ingredient is rapidly absorbed in the gastrointestinal tract and reaches peak plasma concentrations within 4 hours. Some of the chondroitin accumulates in the synovial fluid.
Chondroitin is excreted mainly by the intestines.

Indications for use

Structum used in the complex therapy of patients suffering from degenerative-dystrophic diseases of the spine and joints, including the drug is prescribed for osteoarthritis and intervertebral osteochondrosis.

Mode of application

Structum intended for oral use. Capsules are recommended to be taken whole (if the integrity of the capsule is damaged, the pharmacokinetic profile may change and the effectiveness of the drug may decrease). The drug Structum is taken regardless of the meal, it is recommended to drink the capsules with a sufficient amount of drinking water. The duration of therapy and the dose of chondroitin sodium sulfate is determined by the doctor.
In degenerative-dystrophic diseases of the spine and joints, as a rule, 1 capsule of Structum is prescribed twice a day.
The recommended therapeutic daily dose is 1000 mg of sodium chondroitin sulfate.
For maintenance therapy, the dose is determined individually.
The duration of the course of therapy with Structum is from 3 to 6 months. If necessary, after 2-5 months, a second course of chondroitin is prescribed.

Side effects

A drug Structum is generally well tolerated by patients. In the course of studies, in some cases, the development of undesirable effects from the digestive tract, including vomiting and nausea, as well as dyspepsia, was noted.
In patients with hypersensitivity to chondroitin while taking Structum, erythema, allergic dermatitis, urticaria, maculopapular rash, and angioedema may develop.
With the development of side effects, it is recommended to stop taking Structum and consult a doctor.

Contraindications

:
Structum should not be prescribed to patients with a history of hypersensitivity reactions to chondroitin sulfate sodium salt or other components of the drug.
In pediatric practice, the use of the drug Structum is allowed only for the treatment of children over 15 years of age.

Pregnancy

:
The drug is not recommended Structum women during pregnancy, since the effect of chondroitin sulfate sodium salt on the development of the fetus and the course of pregnancy has not been studied.
The appointment of the drug Structum during breastfeeding is not recommended. If it is impossible to avoid taking chondroitin sulfate sodium salt during lactation, the issue of interrupting breastfeeding should be resolved.

Interaction with other drugs

Chondroitin sulfate sodium salt with combined use can potentiate the action of antiplatelet agents, fibrinolytic drugs, and anticoagulants.

Overdose

:
When taking high doses of the drug Structum in patients, an increase in the severity of undesirable effects is possible. When taking the drug in doses significantly higher than recommended, hospitalization and monitoring of the patient's condition are indicated. If necessary, carry out symptomatic therapy.

Storage conditions

Capsules Structum should be stored and transported in the original packaging at a temperature of 15 to 25 degrees Celsius.
Subject to the recommendations for storage, the drug Structum is suitable for 3 years after release.

Release form

Capsules Structum 12 pieces in a blister pack made of aluminum foil and polymeric materials, 5 blister packs are enclosed in a cardboard bundle.

Compound

:
1 capsule of the drug Structum contains:
Chondroitin sulfate sodium salt - 500 mg;
Additional ingredients.

Main settings

Name:	STRUKTUM
ATX code:	M01AX25 -

Structum is an oral medication. Its active ingredient is the sodium salt of chondroitin. Chondroitin is a substance that makes up the tissues of bones and cartilage.

Taking Structum leads to replenishment of the required amount of this component in cartilage, bones, helps restore lost stamina, and reduces inflammation.

In this article, we will consider why doctors prescribe Structum, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Structum can be read in the comments.

Composition and form of release

Structum is available in capsules for oral administration: 250 mg, 500 mg. Blisters of 12, 15 and 20 capsules. They are blue in color, the contents are a whitish powder with a creamy tint.

• The active substance is 250 or 500 mg of chondroitin sulfate in powder form.

Clinico-pharmacological group: a drug that regulates the metabolism in cartilage tissue.

Indications for use

In what cases is the medicine "Struktum" indicated? It can help with some diseases of the musculoskeletal system. It is worth listing some of them:

• arthrosis (in particular, primary);
• osteoarthritis of large joints;
• osteoarthritis of the spine;
• intervertebral osteochondrosis;
• osteochondrosis of the joints.

Other diseases of the joints and spine of a degenerative-dystrophic nature.

Pharmacological properties

Chondroitin is a complex mucopolysaccharide belonging to the group of glycosaminoglycans.

After taking Structum, there is an acceleration of synthetic processes in chondrocytes. They increase the amount of produced intercellular substance of cartilage tissue. This ensures the accumulation of amorphous complexes around them and fibrous formations. Activated cartilage cells increase the total cartilage volume due to internal synthesis, which allows regeneration of damaged areas.

The substance is obtained by deep cleaning and fermentation of cartilage taken from the trachea of ​​chickens. Compared to other analogues of Structum, this drug contains the most sulfated chondroitin. This allows you to attract and accumulate more fluid in the cartilage, which improves the elastic and elastic properties of the articular cartilage.

Instructions for use

According to the instructions for use, Structum is taken orally. Capsules should be drunk as a whole, because if their integrity is damaged, the pharmacological properties of the drug may decrease.

• For adults and adolescents aged 15 years and older, the drug is prescribed at a dose of 1 g / day - 500 mg 2 times / day. The recommended duration of the initial course of treatment is 6 months. The therapeutic effect of the drug persists for 3-5 months after its withdrawal, depending on the location and stage of the disease.

If necessary, it is possible to conduct repeated courses of treatment, the duration of which is set individually.

Contraindications

Structum is contraindicated:

• pregnant and lactating mothers;
• with hypersensitivity to the drug;
• patients with inflammatory processes of the venous walls in the extremities;
• with a tendency to hemorrhage and bleeding;
• children under the age of 15.

Side effects

The following side effect of Structum is possible:

• symptoms of gastric and intestinal dyspepsia (belching, nausea, vomiting, heaviness in the abdomen, loose stools);
• allergic reactions (urticaria, erythematous rashes, itching).

In general, Structum is safe to use and rarely causes negative effects on the body. This is due to the physiological nature of the drug and its organic inclusion in metabolism (including phosphorus-calcium).

Pregnancy and lactation

Struktum's analogs

Structural analogues for the active substance:

• Artra Chondroitin;
• Artradol;
• Artrin;
• Kartilag Vitrum;
• Mukosat;
• Chondrogard;
• Chondroitin;
• Chondroitin sulfate sodium;
• Chondroxide;
• Chondroxide gel;
• Chondroxide ointment;
• Hondrolon;
• Khonsurid.

Attention: the use of analogues must be agreed with the attending physician.

Price

The average price of STRUKTUM capsules in pharmacies (Moscow) is 1,550 rubles.

Terms of dispensing from pharmacies

The drug is approved for use as a means of OTC.

Popular Articles

Structum: application

Structum regulates the metabolism in cartilage and improves the process of its recovery. The active substance of the drug chondroitin sodium sulfate is obtained from the cartilage of the trachea of ​​young chickens by deep purification and fermentation. Compared to analogues, chondroitin in this preparation has a higher degree of sulfate content, due to which it attracts and retains the maximum amount of fluid in the cartilage, thereby increasing the elasticity and elasticity of cartilage in the joints. The structure of chondroitin in this preparation is most similar to that of a human, and also has the lowest molecular weight, due to which it more actively penetrates into the synovial fluid. The drug nourishes and restores cartilage in the joints, normalizes the structure of hyaluronic acid, which reduces friction of the articular surfaces, lubricating them. Structum inhibits the resorption of bone tissue, retains calcium in the bones, preventing it from being washed out of the body. The drug is prescribed for osteochondrosis and osteoarthrosis.

Capsules Structum

Structum is available in the form of capsules (erroneously called tablets) with different dosages of the active substance - 250 and 500 mg. They must be taken orally, that is, inside, washed down with water. Once in the gastrointestinal tract, the drug is absorbed through the mucous membranes and accumulates in the synovial fluid, which prevents friction between the joints. Capsules can be taken by adults and children over 15 years old, 1 gram per day, divided into two doses of 500 mg. The course of treatment is long and is six months. The therapeutic effect persists for several months. The doctor, if necessary, may prescribe a second course of treatment.

Which is better: Structum, Teraflex or Artra?

Teraflex and Artra are also prescribed for osteochondrosis, osteoporosis, osteoarthritis, spondylosis. But they differ from Structum in that they contain not only chondroitin sulfate, but also glucosamine. This substance is involved in the formation of glycosaminoglycans, which form the basis of cartilage tissue, has an antioxidant effect, protects cartilage from the negative effects of glucocorticosteroids and anti-inflammatory drugs. It also has mild anti-inflammatory properties. In combination, these two active components potentiate the action of each other. Teraflex is sold in the form of capsules for oral administration, Artra - in the form of tablets with 500 mg of glucosamine and 500 mg of chondroitin. Which drug to choose is up to your doctor, who will take into account all the indications and contraindications.

Structum: original instructions for use

Name:

Structum (Structum)

Pharmacological
action:

Structum - chondroprotective drug for oral use.
Structum contains the active component of chondroitin sulfate sodium salt.
Chondroitin is a substance that is the structural basis of cartilage and bone tissue.
The intake of endogenous chondroitin helps to restore and maintain the normal structure of the cartilage matrix by increasing the anabolic activity of chondrocytes and stimulating the synthesis of proteoglycans.
In addition, the chondroprotective effect of Structum is realized by inhibiting the activity of interleukin-1 beta, which negatively affects the cartilage matrix, as well as elastase and collagenase enzymes, which lead to excessive degeneration of the cartilage matrix.
Structum also stimulates the synthesis of hyaluronic acid and normalizes the viscosity of the synovial fluid, which contributes to the normalization of homeostasis of the synovial environment of the joints.
Chondroitin has some antioxidant and enzymatic effect, which leads to inhibition of the development of inflammatory reactions.
When taken orally, Structum active ingredient is rapidly absorbed in the gastrointestinal tract and reaches peak plasma concentrations within 4 hours.
Some of the chondroitin accumulates in the synovial fluid.
Chondroitin is excreted mainly by the intestines.

Indications for
application:

Osteoporosis;
- periodontal disease;
- fractures (to accelerate the formation of callus);
- degenerative-dystrophic diseases of the joints and spine.

Mode of application:

Structum is intended for oral administration.
Capsules are recommended to be taken whole (if the integrity of the capsule is damaged, the pharmacokinetic profile may change and the effectiveness of the drug may decrease).
The drug Structum is taken regardless of the meal, it is recommended to drink the capsules with a sufficient amount of drinking water.
The duration of therapy and the dose of chondroitin sodium sulfate is determined by the doctor.
In degenerative-dystrophic diseases of the spine and joints, as a rule, 1 capsule of Structum is prescribed twice a day.
The recommended therapeutic daily dose is 1000 mg of sodium chondroitin sulfate. For maintenance therapy, the dose is determined individually.
The duration of the course of therapy with Structum is from 3 to 6 months.
If necessary, after 2-5 months, a second course of chondroitin is prescribed.

Side effects:

From the skin and subcutaneous tissues: infrequently - erythema, urticaria, eczema, maculopapular rash (with or without itching) and / or edema.
From the gastrointestinal tract: rarely - nausea, vomiting.
From the side of the immune system: single - angioedema (Quincke's edema).

Contraindications:

Hypersensitivity to chondroitin sulfate;
- tendency to bleeding;
- thrombophlebitis;
- pregnancy, lactation (breastfeeding);
- in pediatric practice, the use of the drug Structum is allowed only for the treatment of children over 15 years of age.

With various forms of periodontopathy, the course of treatment should be continued for at least 3 months.
There are clinical data on the use of chondroitin sulfate in elderly patients with atherosclerosis, while there was a slight decrease in the concentration of cholesterol and triglycerides in the blood plasma.

Interaction
other medicinal
by other means:

With the simultaneous use of the drug Structum, it is possible to enhance the effect of indirect anticoagulants, antiplatelet agents and fibrinolytics.

Structum is a chondroprotector that helps restore the structure of the cartilage matrix.

Regulates the metabolism in cartilage tissue and improves the process of its recovery. The active substance - sodium chondroitin sulfate - is obtained from the cartilage of the trachea of ​​young chickens by deep purification and fermentation.

In Structum capsules, chondroitin has a high degree of sulfate content, which allows it to attract and retain the maximum amount of fluid in the cartilage, increasing the elasticity and elasticity of cartilage in the joints.

The structure of chondroitin in the preparation is similar to human + has a low molecular weight, due to which it more actively penetrates into the synovial fluid. Structum nourishes and restores cartilage in the joints, normalizes the structure of hyaluronic acid, which reduces friction of the articular surfaces, lubricating them.

The drug inhibits the resorption of bone tissue, retains calcium in the bones, preventing it from being washed out of the body.

Composition of 1 capsule Structum:

• chondroitin sulfate sodium - 250 mg or 500 mg;
• talc;
• titanium dioxide, indigo carmine dye, gelatin.

It has an effect on metabolic processes in fibrous and hyaline cartilage, stimulates the biosynthesis of glycosaminoglycans, helps to reduce degenerative processes in the cartilaginous tissue of the joints, slows down bone resorption and reduces calcium loss, and accelerates the processes of bone tissue restoration.

Indications for use

What helps Structum? According to the instructions, the drug is prescribed in the following cases:

• osteoarthritis and other degenerative-dystrophic diseases of the spine and joints;
• periodontal disease;
• osteoporosis;
• intervertebral osteochondrosis;
• fractures (for faster formation of callus).

Instructions for use Structum 500 mg, dosage

The capsules are intended for oral administration. They are taken whole, without chewing and drinking plenty of water.

The standard dosage according to the instructions for use is 1 capsule of Structum 500 mg per day. The duration of the course of treatment is 6 months.

In some cases, during the first 3 weeks, it is possible to take an increased dosage - 750 mg (capsule 500 mg + 250 mg), then switch to the standard dosage.

The instruction warns that after the start of the use of Structum 500 mg, the therapeutic effect is not felt immediately, but after a few weeks, since time must pass for the accumulation of chondroitin in the synovial fluid.

The therapeutic effect usually lasts for several months (3-5 months). If necessary, the course of treatment can be repeated.

With simultaneous use with other drugs, it is possible to increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Structum:

• Digestive system - nausea, accompanied by periodic vomiting.
• Allergic reactions - a rash on the skin, itching, characteristic changes resembling a nettle burn (urticaria), the appearance of red spots (erythema).

Contraindications

Structum is contraindicated in the following cases:

• hypersensitivity to chondroitin sulfate or other components;
• tendency to bleeding;
• thrombophlebitis;
• pregnancy, lactation (breastfeeding);
• children under 15 years of age.

Overdose

The main symptoms of an overdose are diarrhea, vomiting, and nausea. With prolonged use in excessively high doses (from 3000 mg per day) - hemorrhagic rashes.

Treatment is symptomatic.

Analogues Structum, price in pharmacies

If necessary, you can replace Structum 500mg with an analogue of the active substance - these are drugs:

1. Artradol,
2. Glucosamine
3. Artroker,
4. Sustilak,

When choosing analogues, it is important to understand that the instructions for use of Structum 500mg, the price and reviews for drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Structum capsules 500 mg 60 pcs. - from 1450 to 1803 rubles, according to 508 pharmacies.

Store at a temperature not exceeding 25 °C. Keep away from children. Shelf life - 3 years. Terms of dispensing from pharmacies - without a prescription.

Artra or Structum - which is more effective?

Based on the comparison of the compositions and Structum, we can conclude that the action of Artra is more complex, since it additionally contains glucosamine, which protects cartilage tissue from various damages. Otherwise, it is worth remembering that injectable drugs have greater bioavailability, and the treatment of joint pathology should be multicomponent.