Which Lorinden is better? Lorinden - instructions for use, analogs, reviews and release forms (hormonal ointment or cream A and C) medications for the treatment of psoriasis and eczema in adults, children and pregnancy

Ointment for external use Lorinden-S is an anti-inflammatory, antibacterial drug, effectively eliminating infectious skin lesions. Glucocorticosteroid (GCS) in the ointment requires caution and strict adherence to the dose and recommended duration when used.

The drug effectively eliminates complex bacterial infections, relieves swelling, increases local immunity and improves the condition of the epidermis. This is serious medicine– sold in pharmacy chain according to prescriptions, used in a short course.

The drug is produced in aluminum tubes with a volume of 15 g. It is a light-yellowish or gray-brown ointment with a greasy consistency.

Lorinden S ointment:

• Flumethasone pivalate
  • 200 mcg
• Clioquinol
  • 30 mg
• Binding components - Vaseline and Beeswax
  • Add up to 1 g

pharmachologic effect

Flumethasone pivalate - synthetic hormone, similar to the product produced by the adrenal cortex, a catalyst for lipid and carbohydrate metabolism. The substance is absorbed into the skin and prevents the accumulation of neutrophils, which form the inflammatory process and contribute to the formation of exudate.

Flumethasone inhibits the migration of macrophages, helping to inhibit granulation and infiltration. Glucocorticosteroid has a pronounced effect on the processes in connective tissue, providing anti-inflammatory, antiallergic, antipruritic effect.

Clioquinol is a derivative of 8-hydroxyquinoline, an organic compound that has a destructive effect on many fungal and bacterial microorganisms. Among them:

• dermatophytes;
• yeast-like;
• gram-positive bacteria.

Clioquinol helps enhance the antiexudative effect of flumethasone.

Important: joint action active ingredients The ointment suppresses inflammatory and allergic processes, which are often accompanied by concomitant bacterial or fungal infection of the skin.

Lorinden C ointment has a fat-saturating effect on the epidermis, moisturizes well and eliminates dry inflammatory processes of a chronic nature.

The drug penetrates well through the stratum corneum, therefore it is used for conditions that are accompanied by hyperkeratosis.

Local use of flumethasone does not enter the general bloodstream, therefore it does not have a systemic effect of GCS on the body. The effect of the glucocorticosteroid increases when applied to large areas, in skin folds, on open wounds, under bandages. A particularly strong systemic influence is observed in children.

Clioquinol enters the general bloodstream. Slightly metabolized in the area of ​​application, mainly decomposed in the liver, excreted in urine and bile.

Indications for use of ointment

The instructions for use suggest using Lorinden-S ointment for the following pathologies:

1. dermatoses with allergic component complicated by infection;
2. bacterial and fungal infections with attachment allergic reactions from the skin side.

The ointment is an anti-inflammatory medication, used for diseases:

• dermatitis – allergic, seborrheic, contact, atopic;
• psoriasis;
• infection after an insect bite;
• erythema of various nature;
• erythroderma;
• lichen, discoid lupus erythematosus;
• eczema;
• mycoses caused by fungi different types, including deep mycoses;
• impetigo;
• diaper rash complicated by infection.

The ointment is prescribed for dermatoses in which other glucocorticosteroid drugs are ineffective.

Directions for use and dosage

The drug is used externally.

Before applying the ointment, wash the surface of the skin and dry it. At the beginning of therapy, the frequency of use is 2-3 times a day. Lorinden-S is applied thin layer onto the surface without rubbing. At positive dynamics the number of applications is reduced to 1-2 times.

Lorinden-S instructions prescribe use in a course not exceeding 14 days.

For hyperkeratosis and thickening of the skin as a result of scratching, the ointment is applied under the bandages. They are made of gauze or bandage so that air can flow to the wound surface. In this case, treatment is reduced to 7 days. The drug is applied once a day and covered with a bandage.

If the infection is bacterial, do not use bandages.

Daily use of ointment is no more than 2 g.

Lorinden-S, if necessary, is prescribed to children over 10 years of age. Can be used short course on a small surface strictly under the supervision of a doctor (do not use on the face and eyes).

Overdose

If the conditions of use are observed, no signs of overdose are observed. Symptoms of GCS poisoning may appear when long-term use Lorindena-S on large areas of the skin. The drug is gradually withdrawn and rehabilitation therapy is carried out.

Lorinden ointment requires special care when used for children; exceeding the required doses and frequency is unacceptable.

Contraindications and side effects

Lorinden-S is not used for certain diseases and for the treatment of the following conditions:

• viral infections (in particular chickenpox, herpes);
• lupus;
• neoplasms on the skin, including precancerous and oncological;
• syphilitic skin manifestations;
• perioral dermatitis - rashes near the oral cavity;
• acne – vulgar and pink;
• for the treatment of trophic manifestations of varicose veins.

In addition, a ban on the use of:

1. children under 10 years of age, older - strictly according to indications;
2. with individual intolerance to the components;
3. not used with occlusive dressings - tight, without air access;
4. Do not use for a long, uncontrolled course and on large areas of skin.

Lorinden-S is not applied to the skin of the face; after using the drug, you should wash your hands thoroughly to prevent contact with your eyes.

After drug therapy, microflora resistance may develop and a secondary infection may develop at the site of prolonged application of the drug. In this case, other antibacterial or antifungal agents are prescribed.

Important: use with caution in patients with age-related or atrophic changes in the skin - thinning and degenerative conditions.

Pregnancy and lactation

The drug is not used to treat pregnant women in the first trimester. In the future, the doctor must calculate the risks for the mother and fetus. Lorinden-S is used only when there is a risk of developing irreversible consequences without its use.

Research on the transition of the active components of the ointment into breast milk not enough, so during lactation the medicine is used with caution.

It is acceptable to use it in a short course on a small area of ​​the epidermis, excluding the mammary glands.

Side effects

After using the medicine, some patients noted the development of the following reactions:

• burning and itching skin at the site of application;
• acne:
• inflammation of the follicles - hair follicles;
• striae;
• increased skin dryness.

With prolonged use, more serious and lasting changes skin:

1. purpura;
2. hirsutism;
3. pigmentation changes;
4. atrophic changes in the skin;
5. allergic manifestations;
6. telangiectasia – changes in small vessels.

A systemic effect of GCS on the body is also possible.

special instructions

When using the ointment, remember the following:

• During use, the product is not immunized due to a decrease in the effectiveness of vaccines due to interaction with active substances.
• Lorinden may increase the side effects of medications used. medicines– anticoagulants, nitrates, diuretics, cardiac and antihistamines.

At simultaneous use For other local medications, take an hour's break before applying and rinse the skin well.

Consider the composition of Lorinden-A:

• Flumethasone pivalate
  • 200 mcg
• Salicylic acid
  • 30 mg
• Binding components - Vaseline, Propylene glycol and Lanolin
  • 50 mg

Both drugs contain glucocorticosteroids in the same amount. Their difference lies in the second active component.

The drug is also hormonal, it is used for skin pathologies accompanied by severe keratinization of tissues. Due to salicylic acid, the drug has a pronounced keratolytic effect and improves the penetration of flumethasone into the dermis. Salicylic acid (SA) is a non-steroidal anti-inflammatory drug that has keratoplasty, drying and antiseptic effects.

In addition, SA promotes vasoconstriction and reduces the severity of inflammation. Cleanses the skin well, promotes exfoliation, cleanses pores and sebaceous glands.

The ointment is used for the following diseases:

• dermatitis, including seborrheic;
• neurodermatitis;
• horny eczema;
• psoriasis;
• blistering rashes;
• photodermatitis;
• hyperkeratosis;
• dyshidrosis;
• allergic dermatoses with increased keratinization;
• lichen planus.

Both Lorinden ointments have almost the same application features, contraindications and side effects. Both are available by prescription.

The use of the drug Lorinden-A is allowed for up to 3 weeks. It can be used with an occlusive dressing, which enhances the effect of the ointment.

If the epidermis is extremely dry, a larger volume of the product may be applied.

Important: which drug to give preference to in treatment - Lorinden-S or Lorinden-A, the doctor decides after identifying the diagnosis. Independent use of both drugs is unacceptable.

Analogues

The drug Lorinden-S has the following analogues:

1. Dexamethasone;
2. Trimistin;
3. Locacorten;
4. Fluvet;
5. Lorinden-A;
6. Betasalin;
7. Oxycort;
8. Flumethasone;
9. Diprosalik.

Some of the drugs have different active substance, but a similar scope of use.

A drug with antibacterial, antifungal and anti-inflammatory effects for external use

Active ingredients

Clioquinol
- flumethasone pivalate (flumetasone)

Release form, composition and packaging

Ointment for external use in the form of fatty mass white with a light yellow or gray tint; The presence of isolated soft clusters of crystals is allowed.

Excipients: white beeswax, .

15 g - aluminum tubes with a varnished inner surface (1) - cardboard packs.

pharmachologic effect

Combined preparation for external use, the effect of which is due to the constituents active ingredients- glucocorticoid flumethasone and antibacterial agent clioquinol.

Flumethasone- synthetic glucocorticoid for local application with moderate anti-inflammatory activity. It has a fast-onset anti-inflammatory and anti-allergic effect. Due to the local vasoconstrictive effect, it reduces exudative reactions.

Clioquinol has antibacterial activity against some gram-positive and gram-negative microorganisms and a weak antifungal effect.

Pharmacokinetics

Suction

After application, flumethasone penetrates the stratum corneum of the skin, is able to be absorbed to a small extent into the blood and has systemic action. The absorption of flumethasone is enhanced when used on thin skin, in the area of ​​folds, on the face, when using occlusive dressings and applied to large areas of skin. The absorption of GCS in children is stronger than in adults.

Metabolism

Flumethasone absorbed through the skin is metabolized in the liver.

Removal

It is excreted through the kidneys and to a lesser extent with bile, mainly in the form of compounds with glucuronic acid, and a small part unchanged.

Indications

The drug is used for dry inflammatory diseases, especially allergic etiology, sensitive to corticosteroids (complicated by secondary bacterial infection), occurring with excessive keratinization and excessive itching:

• seborrheic dermatitis;
• atopic dermatitis;
• contact ;
• exudative erythema multiforme;
• psoriasis;
• lichen planus.

Contraindications

• hypersensitivity to flumethasone (or any corticosteroids), clioquinol and any excipient drug;
• bacterial, fungal and viral (incl. chicken pox, herpes simplex) skin infections;
• rosacea and acne vulgaris;
• perioral dermatitis;
• perianal itching;
• diaper dermatitis;
• tuberculous or syphilitic skin lesions;
• skin neoplasms, incl. precancerous;
• phlebitis, trophic ulcers shins associated with;
• burns;
• post-vaccination period;
• I trimester of pregnancy;
• breastfeeding period;
• children under 2 years of age (no data on safety and effectiveness).

Carefully:

• application to large areas of skin, wounds, damaged skin, use in large doses, as well as long-term therapy with GCS (especially in children over 2 years of age);
• application to facial skin and intertriginous skin (skin folds, armpits, groin area, bends of arms and legs);
• application to the skin around the eyes or eyelids (risk of developing glaucoma, cataracts), incl. in patients with glaucoma or cataracts;
• atrophic changes in the subcutaneous tissue, especially in the elderly.

Dosage

The drug is used externally.

The ointment is applied in a thin layer to the affected areas of the skin with massaging movements to improve penetration. In cases of excessive lichenification or hyperkeratosis, the drug must be used under an occlusive dressing, which must be changed every 24 hours.

U adults the drug should be used no more than 1-2 times a day. The course of continuous therapy is no more than 2 weeks, on the facial skin - no more than 7 days. During the week, you can use no more than 1 tube of ointment (15 g).

Lorinden S is contraindicated children under 2 years old.

In children, due to a higher ratio of body surface area to body weight than in adults, dysfunctions of the hypothalamic-pituitary-adrenal system are more easily developed and undesirable reactions characteristic of GCS occur, incl. growth and development delay.

U children over 2 years old the drug Lorinden C should be used with great caution, only 1 time/day on small areas of the skin under the supervision of a physician, in short courses; should not be used on the face.

Side effects

Frequency of occurrence adverse reactions classified according to WHO recommendations as follows: very often (≥1/10), often (≥1/100 and<1/10), нечасто (≥1/1000 и <1/100), редко (≥1/10 000 и <1/1000), очень редко (<1/10 000), частота неизвестна (невозможно оценить по доступным данным).

Side effects are rare and reversible.

From the skin and subcutaneous tissue: frequency unknown - acne-like symptoms, post-steroid purpura, atrophy of the epidermis and subcutaneous tissue, dry skin, hypertrichosis or alopecia, depigmentation or hyperpigmentation of the skin, skin atrophy and striae, telangiectasia, perioral dermatitis, inflammation of the hair follicles, secondary infections, skin irritation. Sometimes urticaria or a maculopapular rash may occur, which may worsen existing skin diseases.

From the side of the organ of vision: frequency unknown - decreased visual acuity. When using the drug on the skin of the eyelids, glaucoma or cataracts can sometimes develop, and in rare cases, central serous chorioretinopathy (CSC).

Systemic disorders: frequency unknown - with long-term use and/or application to large surfaces of the skin, when using occlusive dressings and during therapy in children, symptoms of hypercortisolism may develop (hyperglycemia, glycosuria, reversible inhibition of adrenal cortex function, manifestations of Itsenko-Cushing syndrome, delayed growth and development in children, arterial hypertension, decreased immunity), as a manifestation of the resorptive effect of flumethasone.

Overdose

The drug Lorinden C, when applied externally, can be absorbed in quantities sufficient to cause the development of systemic effects of GCS. The development of an acute overdose is unlikely. However, if flumetasone, like other corticosteroids, is applied to large areas of affected skin with increased resorption capacity, for a long time or using an occlusive dressing, or in case of long-term use in children, symptoms of hypercortisolism may develop.

If symptoms of overdose occur, the patient should stop using the drug and consult a doctor immediately.

Treatment: the drug should be discontinued, gradually reducing the frequency of its application or replacing it with a less strong GCS, under the supervision of a physician due to the risk of adrenal insufficiency.

Drug interactions

During therapy with Lorinden C, vaccinations and immunizations should not be performed due to the immunosuppressive effect of the drug.

The drug should not be prescribed in combination with other drugs for external use.

When the drug is absorbed into the systemic circulation, flumethasone reduces the effectiveness of insulin, oral hypoglycemic agents, anticoagulants, and reduces the concentration of praziquantel in the blood serum.

When using the drug simultaneously with androgens, estrogens, oral contraceptives, anabolic steroids, antipsychotics, carbutamide, azathioprine, anticholinergics, antihistamines, tricyclic antidepressants, nitrates, diuretics and cardiac glycosides, the risk of developing side effects of GCS increases.

Due to the content of flumethasone, Lorinden S can enhance the effect of immunosuppressive drugs and weaken the effect of immunostimulating drugs.

special instructions

The course of continuous therapy should not exceed 2 weeks.

Avoid contact of Lorinden S ointment with the eyes and mucous membranes.

If, with external use of Lorinden C ointment, signs of irritation, increased dry skin or allergies are observed, as well as increased side effects or effects not specified in the instructions, the patient should stop treatment and consult a doctor.

With long-term use and/or application to large surfaces of the skin, wounds, damaged skin, use in large doses, when using occlusive dressings and when used in children, systemic absorption of GCS is possible; it is possible to suppress the function of the hypothalamic-pituitary-adrenal system and develop symptoms of hypercortisolism.

During drug therapy, periodic monitoring of the function of the adrenal cortex is necessary by determining the concentration of cortisol in the blood and urine after stimulation of the adrenal glands with adrenocorticotropic hormone (ACTH).

In case of development of a secondary bacterial or fungal infection, it is necessary to prescribe external use of an antibacterial or antifungal drug. If symptoms of infection persist, use of Lorinden S should be discontinued until the infection has resolved.

Lorinden S should be applied with caution to the skin around the eyes or eyelids due to the risk of developing glaucoma or cataracts, incl. in patients with a history of these diseases, because an exacerbation of the course of these diseases may occur.

If a patient experiences symptoms such as blurred vision or other visual disturbances, consider referring the patient to an ophthalmologist to determine possible causes of the disturbance, which may include cataracts, glaucoma, or rare diseases such as central serous chorioretinopathy.

Lorinden S should be used with extreme caution on the skin of the face and intertriginous skin (skin folds, armpits, groin, folds of the arms and legs) due to increased absorption of GCS through thin skin and the possibility of side effects (telangiectasia, skin atrophy, perioral dermatitis) even after short-term use.

Lorinden S is used with caution under an occlusive dressing due to increased absorption of GCS into the blood; the development of atrophy of the epidermis, stretch marks and the addition of infection is possible.

The drug should be used with caution in case of atrophic changes in the subcutaneous tissue, especially in the elderly.

Lorinden S should be used with extreme caution in patients with psoriasis, due to the possible relapse of the disease caused by the development of tolerance, the risk of generalized pustular psoriasis and general toxicity due to pressure ulcers.

Clioquinol, which is part of the drug Lorinden S, may increase the risk of neurotoxicity with long-term use or use of an occlusive dressing.

Use in pediatrics

Lorinden C ointment should be used with caution, especially as long-term therapy, in children over 2 years of age, since in this group of patients, due to a higher ratio of body surface area to body weight than in adults, hypothalamic-pituitary dysfunction may develop faster -adrenal system and undesirable effects characteristic of GCS may occur, incl. growth and development delay.

Impact on the ability to drive vehicles and operate machinery

Lorinden S ointment does not affect the ability to drive vehicles and machines.

Pregnancy and lactation

Pregnancy

The use of Lorinden S is contraindicated in the first trimester of pregnancy. It is possible to use the drug for the treatment of pregnant women in the second and third trimesters as prescribed by the attending physician if the expected benefit to the mother outweighs the potential risk to the fetus. In these cases, therapy should be short-term and limited to small areas of skin.

Animal studies have shown that corticosteroids have a teratogenic effect when administered orally, even in small doses. Also, a teratogenic effect was observed in animals when potent corticosteroids were applied to the skin.

Controlled studies aimed at studying the teratogenic effect of flumethasone when applied topically in women during pregnancy have not been conducted.

Breast-feeding

There is no data on the amount of flumethasone that passes into breast milk when used externally. If it is necessary to use the drug Lorinden C during lactation, breastfeeding should be discontinued.

Use in childhood

Contraindicated for use in children under 2 years of age (there are no data on safety and effectiveness).

Use in old age

The drug should be used with caution in elderly patients with atrophic changes in the subcutaneous tissue.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 3 years. Do not use after the expiration date.

This page provides a list of all analogues of Lorinden S by composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.

• The cheapest analogue of Lorinden S:
• The most popular analogue of Lorinden S:
• ATX classification: Flumethasone in combination with antiseptics
• Active ingredients/composition: clioquinol, flumethasone

Cheap analogues of Lorinden S

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Popular analogues of Lorinden S

The list of drug analogues based on statistics of the most requested drugs

All analogues of Lorinden S

The above list of drug analogues, which indicates substitutes Lorinden S, is the most suitable because they have the same composition of active ingredients and coincide in indications for use

Different composition, may have the same indication and method of use

To compile a list of cheap analogues of expensive drugs, we use prices that are provided to us by more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our website is always up to date as of the current day. If you have not found the analogue you are interested in, please use the search above and select the medicine you are interested in from the list. On the page of each of them you will find all possible analogues of the drug you are looking for, as well as prices and addresses of pharmacies where it is available.

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Lorinden C price

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Lorinden C instructions

INSTRUCTIONS
on the use of the drug
Lorinden S

Lorinden S - ointment - corticosteroid in combination with antiseptics for use in dermatology.

The properties of Lorinden C ointment are due to the combined action of Flumethasone pivalate and Clioquinol.

Flumethasone pivalate is a synthetic corticosteroid with a moderate anti-inflammatory effect. When used in the form of an ointment, it has a local effect of moderate intensity. It has lipophilic properties, easily penetrates the stratum corneum of the skin and has a long-term anti-inflammatory, antiallergic and antiallergic effect. When used externally, Flumethasone pivalate suppresses the formation of prostaglandins and leukotrienes in the skin due to inhibition of the activity of phospholipase A 2 and a decrease in the release of arachidonic acid from phospholipids of cell membranes. Inhibits phagocytosis and the release of interleukins and other cytokines that cause inflammatory processes. Suppresses the release of histamine and the appearance of local allergic reactions, weakens proliferative processes. Due to local vasoconstriction action reduces exudative reactions. Reduces protein synthesis and collagen deposition.

Clioquinol has an antibacterial effect against gram-positive and gram-negative bacteria, as well as a weak antifungal effect.

Pharmacokinetics.

Flumethasone pivalate easily penetrates into the stratum corneum of the skin, where it accumulates. It is not metabolized in the skin. In small quantities it can enter the body when used externally and in this case have a systemic effect. After penetration through the skin, the drug is metabolized in the liver, excreted in the urine and in minor amounts. quantities with bile in the form of glucuronide conjugates and unchanged. The absorption of Flumethasone pivalate increases when used on delicate skin in areas of folds or the face, on skin with damaged epidermis or affected by an inflammatory process. The use of an occlusive dressing, which leads to an increase in the temperature and humidity of the skin, also increases the absorption of Flumethasone pivalate. In addition, absorption increases with frequent use of the drug or when used over large areas of the skin. Absorption through the skin in young people is more intense than in older patients.

Clioquinol has a local effect and is practically not absorbed into the blood.

Indications for use:

Lorinden C ointment is used in the local treatment of skin lesions without exudation, complicated by bacterial infection, accompanied by itching and hyperkeratosis: seborrheic dermatitis, atopic dermatitis, allergic contact dermatitis, erythema multiforme, lupus erythematosus, psoriasis, lichen planus.

Mode of application:

The drug Lorinden C is intended for topical use. The ointment is applied in a thin layer to the affected skin 1-2 times a day. Treatment should not be carried out continuously for more than 2 weeks. It cannot be used on the facial skin for more than 1 week. It is recommended to use no more than 1 tube during the week.

In case of increased lichenification or excessive hyperkeratosis, it is allowed to use an occlusive dressing, which should be changed every 24 hours.

Side effects:

From the skin and subcutaneous tissue: acne, pyslasteroid purpura, inhibition of epidermal growth, atrophy of subcutaneous tissue, dry skin, burning sensation, irritation, itching, excessive body hair growth or alopecia, discoloration or hyperpigmentation of the skin, atrophy and loss of skin integrity, telangiectasia , perioral dermatitis, inflammation of the hair follicles, secondary infections. In some cases, urticaria, maculopapular rash or exacerbation of existing changes may appear.

On the part of the visual organs: when used externally on the skin of the eyelids, cataracts or glaucoma can sometimes develop.

Others: absorption of the active substance into the blood can cause systemic side effects inherent in Flumethasone pivalate. They occur mainly in case of long-term use of the drug when used on large areas of the skin, under an occlusive dressing or used in children.

Systemic side effects of Flumethasone pivalate are typical for corticosteroids, including dysfunction of the hypothalamic-pituitary-adrenal system, Cushing's syndrome, inhibition of growth and development in children, hyperglycemia, glycosuria, edema, arterial hypertension, increased sensitivity to infections, decreased immunity; neurotoxic effects are possible with topical use of Clioquinol, especially in cases of long-term use or use under an occlusive dressing.

In persons with individual intolerance to the components of the drug, hypersensitivity reactions are possible.

Contraindications:

Contraindications to the use of Lorinden S ointment are:

Hypersensitivity to Flumethasone pivalate, other corticosteroids, Clioquinol or other components of the ointment.

Viral (eg, chicken pox, herpes simplex), fungal or bacterial (such as tuberculosis) skin infections, skin neoplasms, acne and rosacea, perioral and diaper dermatitis, anal itching, vulvar itching, inflammation or ulcers of varicose veins.

Do not use on large areas of skin, especially if the integrity of the skin is damaged, for example, with burns.

Pregnancy:

Animal studies have confirmed that glucocorticosteroids have a teratogenic effect even when taken orally in small doses.

Teratogenic effects have also been confirmed with external use of GCS. There have been no controlled studies of possible teratogenic effects with external use of Flumethasone pivalate in pregnant women.

Lorinden C ointment can be used by pregnant women only for a short time, on small areas of the skin and only if, in the opinion of the doctor, the benefits outweigh the possible risks of use. The use of the drug in the first trimester of pregnancy is contraindicated.

The extent to which Flumethasone pivalate is excreted into breast milk when used externally is unknown. With oral administration of GCS, a significant amount of these hormones, which could affect the body of the newborn, was not found in breast milk. However, it is recommended to use Lorinden C ointment with caution in women during breastfeeding. In some cases In cases, you can use the drug for a short time on small areas of the skin. Do not use Lorinden ® C ointment on the skin of the mammary glands.

Interaction with other drugs:

When GCS is used externally, no interactions with other drugs have been identified.

Excipients: white wax, white soft paraffin.

Additionally:

Do not use continuously for more than 2 weeks. With prolonged use on large areas of the skin, the incidence of side effects increases. The use of the drug should be stopped immediately if its use leads to itching, dryness or allergic reactions of the skin.

During external use of Flumethasone pivalate, the secretion of adrenocorticotropic hormone (ACTH) by the pituitary gland may decrease due to inhibition of the pituitary-supranarcosal junction, the level of blood cortisol and iatrogenic Cushing's syndrome may appear, disappears after cessation of treatment. In case of increased infection at the site of application of the drug, additional use of antibacterial, antifungal drugs. If symptoms of infection do not disappear, use of the drug should be discontinued.

Avoid applying the drug to the eyelids or the skin around the eyes in patients with narrow or wide angle glaucoma, as well as in patients with cataracts, given the possibility of increased symptoms of the disease.

Contact of the drug with the eyes and mucous membranes should be avoided.

Use on the skin of the face, groin and axilla only if particularly necessary, since increased absorption and a high risk of side effects (telangiectasia, perioral dermatitis) are possible, even after short-term use.

The use of ointment under an occlusive dressing should be limited to exceptional situations due to the possibility of atrophy and defects of the epidermis, and superinfection.

The drug should be used with caution in the presence of subcutaneous tissue atrophy, mainly in elderly people.

During the treatment of chronic conditions, for example, psoriasis or chronic eczema, the drug should not be abruptly discontinued. It should be used with caution in patients with psoriasis, since local use of GCS in this case can lead to relapses of the disease due to the development of tolerance, the risk of spreading pustular psoriasis and systemic toxicity due to skin dysfunction.

The ability to influence reaction speed when driving vehicles or other mechanisms

The drug does not limit mental and motor abilities, as well as the ability to drive vehicles or other mechanisms.

The drug should not be used by children under 12 years of age. Children over 12 years of age should use the drug with caution. It is allowed to use the ointment in some cases on small areas of the skin. The drug should not be applied to the skin of the face.

Children may absorb proportionately more corticosteroids and are therefore more susceptible to systemic side effects. This is due to the fact that children have an underdeveloped skin barrier and a larger skin surface area relative to body weight compared to adults.

All information is presented for informational purposes and is not a reason for independent prescription or replacement of medication.

Trade (proprietary) name: LORINDEN S

International nonproprietary name:

No

Dosage form:

ointment

Compound:

1 gram of ointment contains:
Active substances: Flumethasone pivalate 0.20 mg, Clioquinol (Iodochloroxyquinoline) 30.0 mg
Excipients: white wax, white Vaseline.

Description: White with a light yellow or gray tint, a fatty soft mass with a characteristic odor.

Pharmacotherapeutic group:

glucocorticosteroid and antimicrobial agent

ATC: D07BB01

Pharmachologic effect:
Lorinden S is a combination drug, the effect of which is determined by the components included in its composition. As a result of the combined effect of flumethasone and clioquinol (iodochloroxyquinoline), the drug suppresses the development of inflammatory and allergic skin reactions complicated by bacterial and fungal infections.

Flumethasone is a synthetic bifluorinated glucocorticosteroid for topical use. It has anti-inflammatory, antiallergic, antipruritic, decongestant and vasoconstrictor effects. When exposed to the skin, the marginal accumulation of neutrophils is prevented, which leads to a decrease in inflammatory exudate and the production of lymphokines, inhibition of macrophage migration, and a decrease in the processes of infiltration and granulation. Like other glucocorticosteroids, flumethasone reduces the production of prostaglandins and leukotrienes by inhibiting the activity of phospholipase A2 and reducing the release of arachidic acid from cell membrane phospholipids. Causes a reduction in the basic substance of connective tissue, weakens proliferation and exudative reactions in the skin. It has a local vasoconstrictor effect, which also reduces exudative reactions. It is an inhibitor of cellular kinins with proteolytic activity.

Clioquinol (iodochlorooxyquinoline): is a derivative of 8-hydroxyquinolines. Active against dermatophytes and yeast fungi (Microsporon, Trichophyton, Candida albicans) and gram-positive bacteria (Staphylococcus, Enterococcus). Strengthens the antiexudative effect of flumethasone.

Thanks to its fatty base, the ointment has a water-repellent effect and forms a protective film that protects the skin from external moisture. Providing a deep fat-saturating and softening effect, the ointment is most suitable for treating patients with dry and thinned skin.

Pharmacokinetics:

After applying Lorinden S ointment to the skin, the active components easily penetrate the stratum corneum of the skin. Flumethasone pivalate penetrates the stratum corneum of the skin, is practically not absorbed, and does not have a systemic effect. Absorption of flumethasone pivalate from the skin increases with frequent use and/or when used over large areas of skin, when applied to the delicate skin of the face or skin folds, to skin with damaged epidermis or to areas of skin affected by a painful process, as well as when using an occlusive dressing. , increasing humidity and local temperature. Penetration into the deep layers of skin under an occlusive dressing is approximately 100 times greater than when simply applied to the affected areas. Absorption of flumethasone pivalate from the skin in children is more pronounced than in adults. Flumethasone pivalate is practically not metabolized in the skin. After absorption, the drug is mainly metabolized in the liver. It is excreted in the form of metabolites and a small amount unchanged in the urine and bile.

Clioquinol, when used as an ointment, can be slightly absorbed through the skin and bind to blood plasma proteins. Partially biotransformed in the liver and excreted in the urine.

Indications:

• allergic dermatoses complicated by the addition of a bacterial infection caused by flora sensitive to clioquinol:
  • dermatitis (including allergic, contact, occupational, seborrheic, solar),
  • eczema;
  • psoriasis (especially old cases), incl. psoriasis of the scalp;
  • erythema multiforme;
  • erythroderma;
  • atopic dermatitis (common neurodermatitis);
  • pruritus,
  • dermatoses that are not treatable with other glucocorticosteroids (including lichen planus, discoid lupus erythematosus);
  • hives;
  • secondary infections from insect bites.
• bacterial and fungal infections of the skin, complicated by the development of local allergic reactions:
  • impetigo;
  • infected diaper rash;
  • dermatomycosis, actinomycosis, blastomycosis, sporotrichosis.

Contraindications:

Hypersensitivity to the components of the drug.
Viral skin diseases (herpes, chickenpox), skin tuberculosis, skin manifestations of syphilis, neoplasms and precancerous skin conditions (skin cancer, nevus, atheroma, epithelioma, melanoma, hemangioma, xanthoma, sarcoma). Acne vulgaris and rosacea, perioral dermatitis, trophic ulcers of the leg associated with varicose veins, conditions after vaccination. Skin infections (for occlusive dressings).
Do not use the drug in children under 10 years of age.

Directions for use and dosage:

Externally.
The ointment is applied in a thin layer to the affected areas. At the beginning of treatment, the drug is used no more than 2-3 times a day, when positive dynamics appear - 1-2 times a day.

The drug should not be used for more than 2 weeks. If there is a need to use a bandage, a bandage that allows air to pass through should be used. In case of excessive lichenification and hyperkeratosis, the ointment is used only under an occlusive dressing once every 24-48 hours. The drug should not be used for more than 1 week.

If there is no need, do not use more than 2 g of ointment during the day.

In adolescents over 10 years of age, use only in exceptional cases on limited areas of the skin, avoid applying the drug to the skin of the face.

Side effects:
Rarely: burning, itching, steroid acne, stretch marks, dry skin, folliculitis. With long-term use - skin atrophy, local hirsutism, telangiectasia, purpura, pigmentation disorders; when applied to large surfaces, systemic manifestations of the glucocorticosteroid are possible.

Overdose:

Overdose is extremely rare. If the drug is used incorrectly and for a long time on large skin surfaces, systemic side effects of the glucocorticosteroid may occur. When treating an overdose, the drug is discontinued gradually and symptomatic therapy is prescribed.

Interaction with other drugs:

During treatment with Lorinden S, vaccinations and immunizations should not be carried out due to the immunosuppressive effect of the drug.

Do not prescribe in combination with other drugs for topical use. When the drug is resorbed into the general bloodstream, the glucocorticosteroid reduces the effectiveness of insulin, oral hypoglycemic drugs, antihypertensive drugs, anticoagulants, reduces the content of salicylates in the blood, and reduces the concentration of praziquantel in the blood serum. Increase the risk of side effects: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotics, bucarban, azathioprine (cataracts); anticholinergics, antihistamines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia); cardiac glycosides (digitalis intoxication).

Special instructions:

Do not apply the drug to the skin of the face. It is not recommended to exceed the course of treatment. Do not use for a long time on large skin areas. Avoid getting the ointment in your eyes. With prolonged use of glucocorticosteroids over large areas of skin, the incidence of side effects increases.

If a secondary infection occurs at the site of application of the ointment, agents with a more pronounced antibacterial or antifungal effect should be used.

Use with caution in persons with atrophic skin changes, especially in the elderly.
With prolonged use, microorganisms resistant to clioquinol may appear. For fungal diseases with secondary allergization, the drug is used in exceptional cases, under medical supervision.

Use in pregnant women and during lactation
There have been no controlled studies on the possible teratogenic effect of topical use of flumethasone and iodochlorooxyquinoline in pregnant women, so the drug can be used topically in pregnant women only if the benefit expected for the mother outweighs the possible risk to the fetus. Do not use in the first trimester of pregnancy.

It is not known to what extent flumethasone and clioquinol, when administered topically, are excreted in breast milk.

Therefore, special care should be taken when prescribing the drug to nursing mothers. In exceptional cases, use only for a short time on limited areas of the skin and do not use on the skin of the mammary glands.

Impact on the ability to drive vehicles and maintain machinery in motion
The drug does not limit psychophysical activity, the ability to drive vehicles or maintain moving mechanisms.

Release form
Ointment - 15 g in aluminum. Each tube is in a cardboard box with instructions for use.

Storage conditions:

Store at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date
3 years. Do not use after the date indicated on the package.

Conditions for dispensing from pharmacies
List B. By doctor's prescription.

Manufacturer's name and address
Pharmaceutical plant "Jelfa" A .0. 58-500 Jelenia Gyra st. W.Pola 21, Poland

Representative office of the Elfa Pharmaceutical Plant A.O. in Russia: Moscow, Prospekt Mira, 74, building 1, office 92.

The drug includes active ingredients: flumethasone pivalate And clioquinol , as well as Vaseline and white wax.

Release form

Lorinden S is available in the form of ointment, 15 g in tubes.

pharmachologic effect

This medicine has antimicrobial , antipruritic , antiallergic And anti-inflammatory action.

Pharmacodynamics and pharmacokinetics

The active component of the drug is Flumethasone , is a synthetic bifluorinated corticosteroid intended for external use. The substance has anti-inflammatory ,antiallergic , antipruritic , decongestant And vasoconstrictor Effect. By acting on the skin, the drug helps prevent marginal accumulation , reducing inflammatory exudate and the production of lymphokines, inhibits the migration of macrophages, reduces the processes of infiltration and granulation, and so on.

Clioquinol or iodochlorohydroxyquinoline refers to 8-hydroxyquinoline derivatives. Its activity is manifested against yeast fungi, dermatophytes, and gram-positive bacteria. In addition, the antiexudative effect is enhanced Flumethasone .

Combined impact Flumethasone And Clioquinol suppresses the development of various inflammatory and allergic reactions on skin surfaces, which can be complicated by bacterial or fungal infections.

Thanks to its fatty base, the ointment has a softening and water-repellent effect, which is provided by a protective film that protects the skin from moisture. This drug is suitable for use by patients with dry and thin skin.

After applying the product to the skin, its active substances penetrate the stratum corneum. Wherein flumethasone pivalate is not absorbed into the bloodstream and does not have a systemic effect. Increased absorption occurs as a result of frequent use of the ointment or its application to large areas of the skin. This can also be expected when using the product on the face, in skin folds, in places of injury, under an occlusive dressing. It should be noted that in children the effect of the substance is especially pronounced. Clioquinol as part of the ointment, it is absorbed through, binding to blood plasma proteins.

The active substances are slightly metabolized in the skin structure. Mostly this process occurs in the liver. The components are then excreted from the body in urine or bile.

Indications for use of the drug

Lorinden C ointment is prescribed for various skin lesions caused by:

• gram-positive bacteria;
• dermatophytes;
• yeast mushrooms.

Contraindications for use

This drug is not prescribed for:

• skin;
• viral skin lesions, for example, or;
• with manifestations on the skin;
• precancerous conditions and skin tumors;
• perioral dermatitis ;
• period after vaccination;
• trophic ulcers , caused by ;
• under 10 years of age;
• hypersensitivity.

Side effects

The use of the drug Lorinden C can cause: burning, stretch marks, folliculitis , and dry skin. Long-term use leads to the development of: purpura, skin , telangiectasia, pigmentation disorders, local . When the product is applied to large areas for a long time, side effects characteristic of GCS may occur.

Lorinden S ointment, instructions for use (Method and dosage)

According to the instructions for Lorinden S ointment, it should be applied to the surface of the skin in a fairly thin layer. At the initial stage of treatment, the daily frequency should not exceed 2-3 times. After relief of acute symptoms, it is reduced to 1-2 times. The average course of treatment is 2 weeks.

Overdose

Excessive use of the drug can cause various systemic undesirable effects of GCS, for example: Cushing's syndrome , erosive lesions of the gastrointestinal tract, muscle weakness, suppression of the adrenal cortex, . Such cases require discontinuation of the external agent and further treatment, depending on the symptoms.

Interaction

The simultaneous use of Lorinden S and other external agents is not permissible. When the drug is applied to large areas of the skin, absorption Flumethasone can reduce the effect insulin , other hypoglycemic agents, antihypertensive drugs and anticoagulants. In addition, the risk of negative effects of anticholinergic drugs, anabolic steroids, oral contraceptives,