How is lidase diluted for electrophoresis? Lidaza injections: instructions, price and real consumer reviews

Drug with proteolytic activity

Active ingredient

Release form, composition and packaging

Lyophilisate for the preparation of solution for injection and local application in the form of a lyophilized powder or porous mass, compacted into a tablet, white or white with a yellowish, pinkish, beige, cream or brownish tint.

Glass bottles with a capacity of 5 ml (5) - cardboard packs.
Glass bottles with a capacity of 5 ml (10) - cardboard packs.

Pharmacological action

An enzyme preparation isolated from the testes of cattle. Breaks down the main component of the interstitial substance of connective tissue - hyaluronic acid (mucopolysaccharide, which includes acetylglucosamine and glucuronic acid, is a cementing substance of connective tissue), reduces its viscosity, increases tissue and vascular permeability, facilitates the movement of fluids in the interstitial spaces; reduces tissue swelling, softens and flattens scars, increases range of motion in joints, reduces contractures and prevents their formation. Hyaluronidase causes breakdown hyaluronic acid to and glucuronic acid and thereby reduces its viscosity.

Duration of action when administered intradermally is up to 48 hours.

Indications

- burns, traumatic, postoperative scars;

- long-term non-healing ulcers (including radiation);

- Dupuytren's contracture;

- joint stiffness, joint contractures (after inflammatory processes, injuries), osteoarthritis, ankylosing spondylitis, serious illnesses lumbar discs;

- chronic tendovaginitis, ( skin manifestations), soft tissue hematoma of superficial localization;

— preparation for skin plastic surgery for scar tissue;

— pulmonary tuberculosis (complicated by nonspecific lesions of the bronchi), inflammatory processes in the upper respiratory tract and bronchi with symptoms of obstruction;

- traumatic lesions nerve plexuses And peripheral nerves(plexite, );

- hyphema, hemophthalmos, retinopathy of various etiologies.

Contraindications

- hypersensitivity;

— acute infectious and inflammatory diseases;

- recent hemorrhages;

— acute intercurrent diseases;

— malignant neoplasms;

- fresh hemorrhage in vitreous;

— childhood up to 18 years old;

- concomitant use of estrogens.

For inhalation administration:

- lungs with pronounced respiratory failure;

- pulmonary hemorrhage, hemoptysis.

Dosage

At scar lesions 64 UE (1 ml) is administered subcutaneously (under scar tissue) or intramuscularly (near the site of the lesion) daily or every other day (10-20 injections in total).

At traumatic lesions of the nerve plexuses and peripheral nerves injected subcutaneously into the area of ​​the affected nerve (64 UE in procaine solution) every other day; per course - 12-15 injections. The course of treatment is repeated if necessary.

When used in ophthalmological practice the contents of the bottle are dissolved in 20 ml of water for injection (0.1% solution). The drug is administered subconjunctivally - 0.3 ml, parabulbarly - 0.5 ml, and also by electrophoresis.

Patients with pulmonary tuberculosis with a productive nature of inflammation prescribed in complex therapy to increase the concentration of antibacterial drugs in lesions in the form of injections and/or inhalations. Inhalations are carried out daily 1 time/day. For one inhalation, the contents of the bottle (64 UE) are dissolved in 5 ml of a 0.9% solution. The course of treatment consists of 20-25 inhalations. If necessary, repeat courses are carried out at intervals of 1.5-2 months.

Externally, in the form of bandages soaked in a solution of the drug. To prepare the solution, every 64 units are dissolved in 10 ml of sterile 0.9% sodium chloride solution or boiled water at room temperature. A sterile bandage folded in 4-5 layers is moistened with this solution, applied to the affected area, covered with wax paper and secured with a soft bandage. The bandage is applied daily for 15-18 hours for 15-60 days. At long-term use Every 2 weeks they take a break for 3-4 days.

When used by electrophoresis, 1 bottle of the drug (64 UE) is dissolved in 60 ml of distilled water, 2-3 drops of 0.1% hydrochloric acid solution are added and injected from the anode onto the affected area for 20-30 minutes. The course of treatment is 15-20 sessions.

The application dosing regimen can be alternated with electrophoresis.

The prepared solution must be used within 24 hours.

Side effects

Allergic reactions; with long-term use - local irritating effect.

Overdose

Symptoms: chills, nausea, dizziness, tachycardia, decreased blood pressure, local edema, urticaria, erythema.

Treatment: administration of epinephrine, corticosteroids; antihistamines.

Drug interactions

Improves the absorption of drugs administered subcutaneously or intramuscularly, enhances the effect local anesthetics.

Special instructions

The solution should not be administered through a catheter into which solutions containing cations have previously been injected.

Solutions for injection are prepared with 0.9% sodium chloride solution or 0.5% procaine solution, for inhalation - with 0.9% sodium chloride solution, for electrophoresis - with distilled water.

Before starting treatment, it is advisable to conduct a test with intravenous injection of 20 μl of hyaluronidase.

The drug should not be injected into areas infectious inflammation and tumors.

Hyaluronidase should not be used for acute hemorrhages.

Impact on the ability to drive vehicles and operate machinery

The use of the drug does not affect the management vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Pregnancy and lactation

The drug should be prescribed with caution during pregnancy and lactation.

Use in childhood

Use is contraindicated for people under 18 years of age.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored in a place protected from light, out of reach of children, at a temperature not exceeding 15°C. Shelf life - 2 years. Do not use after the expiration date stated on the package.

Lidaza is an enzyme medicine for external use. The instructions for use indicate that injections in ampoules for injection and local electrophoresis of 64 UE in solution are widely used in medicine to reduce swelling and eliminate scars.

Release form and composition

Lidase powder has white, it is prepared by lyophilization (drying a solution under vacuum). The main active ingredient of the drug is the enzyme hyaluronidase, its content in one ampoule is 64 IU (units of action).

Ampoules with Lidaza powder are packaged in packs of 10 pieces. A cardboard box contains one package of ampoules and instructions for use of the drug.

Pharmacological action

The basis of this medication is the enzyme hyaluronidase, which is isolated from the testes of cattle. Thanks to this enzyme, the use of Lidase causes the breakdown of hyaluronic acid (which is a cementing component of connective tissue), reduces its viscosity, increases tissue and vascular permeability, softens scars and reduces swelling. The drug reduces and prevents contractures.

Indications for use

What does Lidaza help with? The drug is prescribed for the treatment of many diseases, as well as specific symptoms. In the list of indications for use this drug includes:

• superficial soft tissue hematoma;
• hemophthalmos;
• scarring of various nature origin (postoperative, traumatic or burn);
• skin diseases, including scleroderma;
• retinopathy;
• joint contractures that occur after injury or inflammation;
• diseases affecting the lumbar spine;
• inflammation of the upper respiratory tract accompanied by obstruction;
• osteoarthritis;
• chronic tendovaginitis;
• ulcers, the healing period of which is prolonged;
• ankylosing spondylitis;
• joint stiffness;
• neuritis, plexitis;
• hydrocephalus;
• myocardial infarction;
• hyphema.

Instructions for use

Lidase in injections is prescribed for the treatment of scar lesions:

• Subcutaneously - by injection under scar tissue;
• Intramuscularly - by injection into the area that borders the site of the lesion.

As a rule, Lidaza injections are prescribed in a dosage of 1 ml daily or every other day. The course of treatment includes from 10 to 20 injections.

Lidaza injections (subcutaneously) are also prescribed for the treatment of peripheral nerves and traumatic lesions of the nerve plexuses. The medication is administered into the area of ​​the affected nerve in an amount of 1 ml every other day. The course of treatment includes 12-15 injections, which can be repeated if necessary.

In ophthalmology, electrophoresis with Lidase is used, and the drug can be administered subconjunctivally (0.3 ml each) and parabulbarly (0.5 ml each).

In the treatment of pulmonary tuberculosis, which is a productive inflammation, Lidaza is usually prescribed as part of complex therapy to increase the concentration of antibacterial drugs in the affected areas.

The medicine is prescribed:

• In the form of injections - daily;
• In the form of inhalations - daily, 5 ml once a day, a course of 20-25 inhalations.

External use of Lidase is effective in the form of bandages that are soaked in a drug solution.

To prepare it, an ampoule with the medication is dissolved in 10 ml of water (boiled, not higher than room temperature) or a 0.9% sterile NaCl solution, after which a sterile dressing is moistened (in 4-5 layers). After application to the affected area, it is covered with wax paper and, if necessary, secured with a soft bandage. The dose of the solution depends on the area of ​​affected skin.

Lidaza dressings should be used daily for 15 days to two months. The procedure time is 15-18 hours. For long-term treatment, you should take a break of 3-4 days every 2 weeks of therapy.

To carry out electrophoresis with Lidase 300 IU, the drug should be dissolved in 60 ml of distilled water, add a few drops of 0.1% HCl solution. The procedure time is 20-30 minutes, the course of treatment is 15-20 procedures.

Electrophoresis with Lidase can be alternated with an application dosing regimen. The solution prepared for the procedures must be used within 24 hours. Lidase solution should not be administered through a catheter that has previously been used to administer solutions containing cations.

Read also: how to take it for arthrosis.

Contraindications

Absolute:

• pulmonary hemorrhage, pulmonary tuberculosis with severe insufficiency respiratory function, hemoptysis (for inhalation use);
• simultaneous use of estrogens;
• fresh vitreous hemorrhage (for inhalation use);
• malignant tumors (for inhalation use);
• increased individual sensitivity to hyaluronidase;
• infectious and inflammatory diseases in the acute phase;
• children's and adolescence up to 18 years old;
• recent hemorrhages.

Relative (Lidase is used with caution):

• breastfeeding period;
• pregnancy period.

Side effects

As a rule, Lidaza is well tolerated even in complex forms of diseases and high sensitivity of patients. In extremely rare cases, an allergic reaction may occur and manifest as skin lesions.

During pregnancy and breastfeeding

Prescribe with caution during pregnancy and lactation.

Special instructions

The solution should not be administered through a catheter into which solutions containing cations have previously been injected. Solutions for injection are prepared with 0.9% sodium chloride solution or 0.5% procaine solution, for inhalation - with 0.9% sodium chloride solution, for electrophoresis - with distilled water.

Before starting treatment, it is advisable to conduct a test with intradermal injection of 20 μl of hyaluronidase. It should not be injected into areas of infectious inflammation and tumors.

Drug interactions

This drug enhances the effect of (local) anesthetics and is often used to improve the absorption of drugs.

Lidase is recommended to be used very carefully when used concomitantly with other medications, since there is a high probability of increased absorption, which cannot be predicted, and it is also possible to increase systemic action.

Analogues of the drug Lidaza

Analogues are determined by structure:

1. Ronidaza.
2. Hyaluronidase.
3. Lidaza-M.

Vacation conditions and price

The average cost of Lidaz (ampoules 64 UE, 10 pcs.) in Moscow is 315 rubles. Requires a prescription.

The shelf life of the powder is 2 years from the date of its manufacture. After preparing the solution, it must be used within an hour.

The instructions for use recommend storing unopened Lidaza ampoules in a dark place, protected from light, at an air temperature no higher than +15º C.

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Manufacturer: RUE "Belmedpreparaty" Republic of Belarus

ATS code: B06AA03

Farm group:

Release form: Liquid dosage forms. Solution for injection.

General characteristics. Compound:

Pharmacological properties:

Indications for use:

Important! Get to know the treatment

Directions for use and dosage:

Features of application:

Side effects:

Interaction with other drugs:

Contraindications:

Overdose:

Vacation conditions:

Over the counter

Package:

Lyophilized powder for the preparation of injection solution 64UE in bottles in package No. 5.

Drugs with proteolytic activity are used to treat various diseases. Their therapeutic effectiveness is associated with the ability of the drug to act on collagen cartilage, break down necrotic tissue, and liquefy viscous secretion, exudate and blood clots. It should also be noted that such medications are actively used for scleroderma, hematomas, ankylosing spondylitis, etc. In addition, the mentioned agents improve the absorption of injection solutions, local anesthetics and radiocontrast agents.

The most prominent representative similar drugs"Lidaza" performs. Reviews of the effectiveness of this medicine will be described at the end of the article. Also in it you will find information about the form in which the mentioned medication is produced, whether it has contraindications, etc.

Composition and form of the medicinal product

The medication in question is produced using the testes of cattle (cattle). This drug is based on the enzyme hyaluronidase, as well as additional substances.

Currently, this product is available in several forms:

• powder intended for external use;
• Lidase solution, or rather the lyophilisate for its preparation; it can be used for both injection and topical application;
• lyophilisate intended for the preparation of a solution (for local and external use).

It should also be said that some doctors prescribe suppositories with Lidase to their patients. However, it should be borne in mind that such suppositories are not produced on an industrial scale. They can be ordered at a pharmacy using a special doctor's prescription.

Pharmacology

All of the listed forms of medication can be purchased in Moscow pharmacies without a doctor's prescription (with the exception of suppositories). But before you buy such a drug, you should understand why it is prescribed and how it works.

According to the instructions, this is an enzyme medicine isolated from the testes of cattle (cattle). It is capable of breaking down such an element of the intermediate substance of connective tissue as hyaluronic acid. By the way, the latter is a mucopolysaccharide. It contains glucuronic acid and acetylglucosamine. These components are cementing substances of connective tissue. The medication in question is able to reduce its viscosity, increase vascular and tissue permeability, and also facilitate the movement of fluid in the interstitial spaces. In addition, Lidase injections reduce tissue swelling, soften and flatten scars, increase the range of joint movements, reduce contracture and prevent their formation.

The duration of action of this drug when administered intradermally is 2 days.

Indications for use of the drug

The drug "Lidaza" can be used to treat many diseases, as well as eliminate specific symptoms. According to the instructions, this medication is prescribed for:

• joint stiffness;
• scars of various origins (postoperative, traumatic or burn);
• osteoarthritis;
• prolonged ulcers;
• chronic tendovaginitis;
• skin diseases, including scleroderma;
• joint contracture that occurs after inflammation or injury;
• hydrocephalus;
• ankylosing spondylitis;
• diseases that affect the lumbar spine;
• retinopathy;
• myocardial infarction;
• hyphema;
• inflammation of the respiratory tract upper paths which is accompanied by obstruction;
• neuritis, plexitis;
• soft tissue hematoma (on the surface);
• hemophthalmia.

Contraindications

After purchasing the medicine in pharmacies in Moscow or other cities of Russia, you should definitely read the instructions. According to her, enzyme preparation not recommended for use when:

• acute inflammatory and infectious diseases;
• hypersensitivity to the constituent ingredients;
• previous hemorrhage;
• at a minor age.
• acute in nature.

For inhalation procedures, Lidaza is contraindicated in patients with:

• malignant tumor;
• regular hemoptysis;
• continuous bleeding;
• respiratory failure;
• tuberculosis of any form;
• pulmonary hemorrhage;
• hemorrhage in

Directions for use

How should Lidaza be administered? A consumer review will not answer the question posed. You need to see a doctor for it.

When the medication is administered subcutaneously or intramuscularly. In the first case, the injection is given directly under the scar, and in the second - as close as possible to the affected area.

The dosage of this medicine is 1 ml once a day for 20 days.

At ophthalmological diseases treatment is carried out by electrophoresis, as well as by instilling a 0.1 percent solution into the eyes. In this case, Lidase is combined with an antibiotic.

For tuberculosis and respiratory diseases, the medication is recommended to be used in the form of injections or inhalations.

In gynecological practice, Lidaza is used in the form of suppositories and injections. Suppositories (1 piece) are inserted into the vagina once a day every 2 days. The course of therapy is 10 injections.

If necessary, use dressings, use a special solution "Lidase". How to dilute this medicine? It is diluted with boiled water, as well as 10 ml of a 9 percent sterile sodium chloride solution. These components are mixed in a container, where the bandage is subsequently placed. After this, it is applied to the affected area, and placed on top and secured with a bandage.

Side effects

Can it cause side effects drug "Lidaza"? Consumer reviews quite often contain information that the medication in question is well tolerated, including when the patient is highly sensitive and has a complex form of the disease.

In very rare cases, this remedy may contribute to the development allergic reaction, which manifests itself in the form of skin lesions.

How it works medicinal product"Lidaza"? Reviews of this product will be described at the very end of this article. Also from it you will learn about the purposes for which the mentioned medication is used, what forms of release it has, what is included in its composition, how it is used, and so on.

Form and composition of the medical product

Today, the drug "Lidaza" (reviews about it are ambiguous) goes on sale in several forms. Let's list them right now:

• powder for external use;
• lyophilisate intended for the preparation of a solution for topical use and injection;
• lyophilisate intended for the preparation of a solution for external and local use.

In what other forms can the drug Lidaza be purchased? Reviews from experts say that this drug is also available in the form of suppositories. However, it is almost impossible to find candles in pharmacies, since they are not produced on an industrial scale. This form is made according to a special doctor’s prescription.

What does Lidaza contain? Instructions for use, reviews from experienced specialists indicate that this medication is made from the testes of cattle. The main active enzyme of this drug is hyaluronidase. The drug also contains other excipients(depending on the form of the medication).

Pharmacological features of the drug

What properties does it have? medicine"Lidaza"? Reviews (injections are most often prescribed to patients) from doctors say that hyaluronic acid is a specific substrate that is part of the enzyme hyaluronidase. Moreover, hyaluronic acid itself is a mucopolysaccharide, which includes acetylglucominase and glucuronic acid.

How does the drug Lidaza affect a person? Reviews from doctors inform patients that hyaluronic acid is quite important for the body. It's very viscous. Thanks to this property, this substance seems to “cement” connective tissues, or rather the spaces between them, thereby improving joint mobility, softening scars, promoting the resorption of hematomas, as well as reducing and eliminating contractures.

It should also be said that hyaluronic acid helps reduce tissue swelling and facilitate the mobility of fluids in the interstitial spaces.

The maximum effectiveness of this drug is observed when it is used at the very beginning of the disease.

Pharmacokinetic parameters of the drug

Stimulation of the movement of interstitial fluid, as well as tissue permeability, is achieved as a result of the breakdown of hyaluronic acid to glucuronic acid and glucosamine. It should also be noted that the viscosity of hyaluronic acid is restored in the process of decreasing the concentration of hyaluronidase.

Indications for use of the product

Now you know what the drug Lidaza is. Why should patient reviews about this medication be studied before starting therapy? The fact is that this product has a huge number various indications. Therefore, patient reviews about it can be of a completely different nature.

So for what purpose is the drug in question used? It can be prescribed to treat various diseases, as well as eliminate specific symptoms:

• joint stiffness;
• scars of various origins (traumatic, postoperative or burn);
• joint contractures that occur after inflammation or injury;
• prolonged ulcers;
• chronic tenosynovitis;
• osteoarthritis;
• skin diseases, as well as scleroderma;
• ankylosing spondylitis;
• diseases affecting lumbar region spine;
• retinopathy;
• neuritis and plexitis;
• hydrocephalus;
• hyphema;
• myocardial infarction;
• inflammation of the airways, which are accompanied by obstruction;
• soft tissue hematomas (on the surface);
• hemophthalmos.

Contraindications for use

• previous hemorrhage;
• hypersensitivity to the constituent components;
• acute intercurrent diseases;
• childhood (until adulthood);
• acute infectious and inflammatory diseases.

When using the drug by inhalation, the following contraindications are mentioned:

• pulmonary hemorrhage;
• malignant tumor;
• regular hemoptysis;
• continuous bleeding;
• tuberculosis in all forms;
• hemorrhage into the vitreous body.

Directions for use

To treat scar lesions, the medication is administered subcutaneously or intramuscularly. IN the latter case the injection is made as close as possible to the lesion, and in the first - directly under the scar.

The dose of this drug is 1 ml once a day for 15-20 days. If the scars are shallow, then injections can be performed every other day.

Ophthalmic diseases are treated using electrophoresis, as well as by instilling a 0.1% solution into the eyes. With this therapy, antibiotics are additionally used.

Traumatic lesions of peripheral nerves and nerve plexuses are treated using subcutaneous administration medications directly into the lesion (at a dose of 64 UE). In this case, the drug is combined with a solution of procaine. The procedures are carried out every other day (15 injections).

In the treatment of tuberculosis and respiratory diseases, the medication is prescribed in the form of injections or inhalations. The latter are especially often used in severe cases in combination with other drugs.

Inhalations are done every day for a month at a dose of 320 CU. If therapeutic effect was not achieved, then a second course of therapy is prescribed after 2 months.