Diara tablets for diarrhea. Diara treatment of acute and chronic diarrhea

25.03.2020 -

Cracks

LS- 000845

Trade name drug: Diara ®

Dosage form:

Chewable tablets

Compound:

1 chewable tablet contains:

Active substance: loperamide hydrochloride 2.0 mg;

Excipients : polymethylsiloxane, potato starch, lactose (milk sugar), sucrose (sugar), microcrystalline cellulose, colloidal silicon dioxide (Aerosil), aspartame, povidone (Kollidon 90), xylitol (Xylitab 300), lactitol, Kollidon SR, menthol, magnesium stearate, anise oil.

Description: Tablets are white or white with a yellowish tint, flat-cylindrical in shape with a scored line, with the smell of anise. Light marbling is allowed.

Pharmacotherapeutic group: antidiarrheal agent

ATH CODE: [A07 D.A.03]

Pharmacological properties

Pharmacodynamics:

Loperamide, by binding to opioid receptors of the intestinal wall (modulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and prostaglandins). Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, promotes retention feces and reducing the urge to defecate. The action comes quickly and lasts 4-6 hours.

Pharmacokinetics:

Almost completely metabolized by the liver by conjugation. The half-life (T 1/2) is 9-14 hours. It is excreted mainly with bile and kidneys (in the form of conjugated metabolites).

Indications for use:

Symptomatic treatment acute and chronic diarrhea of various origins(allergic, emotional, medicinal, radiation; with changes in diet and quality of food, with metabolic and absorption disorders; how aid with diarrhea of infectious origin.

Regulation of bowel movements in patients with ileostomy.

Contraindications:

Hypersensitivity to the drug, diverticulosis, intestinal obstruction, ulcerative colitis in the acute stage, diarrhea against the background of acute pseudomembranous enterocolitis, as monotherapy for dysentery and other infections gastrointestinal tract(GIT); pregnancy (first trimester), lactation period, children under 6 years of age.

With caution: liver failure.

Directions for use and dosage:

Orally, chewing and drinking water. For adults with acute and chronic diarrhea, an initial dose of 2 tablets (4 mg) is prescribed; then 1 tablet (2 mg) after each act of defecation (in case loose stool); maximum daily dose– 8 tablets (16 mg). Children over 6 years old acute diarrhea 1 tablet (2 mg) is prescribed as an initial dose, then 1 tablet after each act of defecation (in the case of loose stools); the maximum daily dose is 3 tablets (6 mg).

When stool normalizes or if there is no stool for more than 12 hours, treatment with Diara should be discontinued.

Side effect:

Gastralgia, dry mouth, allergic reactions (skin rash), drowsiness, dizziness, intestinal colic, nausea, vomiting, constipation. Extremely rare - intestinal obstruction.

Overdose of the drug:

Symptoms: depression of the central nervous system(CNS) - stupor, impaired coordination of movements, drowsiness, miosis, muscle hypertension, respiratory depression; intestinal obstruction.

Treatment: antidote - naloxone; Given that the duration of action of loperamide is longer than that of naloxone, it is possible reintroduction the last one.

Compound

Description of the dosage form

Tablets are white or white with a yellowish tint, flat-cylindrical in shape, scored, anise smell, light marbling is allowed.

Pharmacological action

Pharmacological action- antidiarrheal.

Pharmacodynamics

Loperamide, by binding to opioid receptors of the intestinal wall (modulation of cholinergic and adrenergic neurons through guanine nucleotides), reduces smooth muscle tone and intestinal motility (by inhibiting the release of acetylcholine and PG). Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, promotes fecal retention and reduces the urge to defecate.

The action occurs quickly and lasts for 4-6 hours.

Pharmacokinetics

Almost completely metabolized by the liver by conjugation. T1/2 - 9-14 hours. Excreted mainly in bile and urine in the form of conjugated metabolites.

Indications of the drug Diara ®

symptomatic treatment of acute and chronic diarrhea of various origins (including allergic, emotional, drug, radiation);

changing the diet and quality of food in case of metabolic and absorption disorders;

as an adjuvant for diarrhea of infectious origin;

regulation of stool in patients with ileostomy.

Contraindications

increased sensitivity to the components of the drug;

diverticulosis;

intestinal obstruction;

ulcerative colitis in the acute phase;

diarrhea due to acute pseudomembranous enterocolitis;

monotherapy for dysentery and other gastrointestinal infections;

I trimester of pregnancy;

lactation period;

childhood up to 6 years old.

With caution: liver failure.

Side effects

Gastralgia, dry mouth, allergic reactions (skin rash), drowsiness, dizziness, intestinal colic, nausea, vomiting, constipation. Extremely rare - intestinal obstruction.

Directions for use and doses

Inside, chewing and drinking water.

For adults for acute and chronic diarrhea, the initial dose is 4 mg (2 tablets), then 2 mg (1 tablet) after each act of defecation (in the case of loose stools). The maximum daily dose is 16 mg (8 tablets).

Children over 6 years old for acute diarrhea, the initial dose is 2 mg (1 tablet), then 2 mg (1 tablet) after each act of defecation (in the case of loose stools). The maximum daily dose is 6 mg (3 tablets).

If stool normalizes or there is no stool for more than 12 hours, treatment with Diara should be discontinued.

Overdose

Symptoms: depression of the central nervous system (stupor, loss of coordination of movements, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.

Treatment: antidote - naloxone. Given that the duration of action of loperamide is longer than that of naloxone, repeated administration of the latter is possible. Symptomatic treatment is the appointment of activated carbon, gastric lavage, mechanical ventilation. Medical supervision is required for at least 48 hours.

Special instructions

If there is no effect within 48 hours, you should stop using the drug and consult a doctor.

Release form

Chewable tablets. 4, 6, 7 or 10 tablets each. in blister packs made of PVC film and printed varnished aluminum foil. 1, 2 or 3 blister packs are placed in a cardboard pack.

Manufacturer

JSC Pharmaceutical Enterprise Obolenskoye, Russia. 142279, Moscow region, Serpukhov district, Obolensk village, bldg. 7-8.

Conditions for dispensing from pharmacies

Over the counter.

Storage conditions for the drug Diara ®

In a dry place, protected from light, at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life of Diara ®

3 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
A09 Diarrhea and gastroenteritis of presumably infectious origin (dysentery, bacterial diarrhea)	Bacterial diarrhea
	Bacterial dysentery
	Bacterial infections of the gastrointestinal tract
	Bacterial gastroenteritis
	Diarrhea bacterial
	Diarrhea or dysentery of amoebic or mixed etiology
	Diarrhea of infectious origin
	Diarrhea during antibacterial therapy
	Traveler's diarrhea
	Traveler's diarrhea due to changes in diet and diet
	Diarrhea due to antibiotic therapy
	Dysenteric bacteria carriage
	Dysenteric enteritis
	Dysentery
	Bacterial dysentery
	Dysentery mixed
	Gastrointestinal infection
	Gastrointestinal infections
	Infectious diarrhea
	Infectious disease of the gastrointestinal tract
	Gastrointestinal tract infection
	Infection biliary tract and gastrointestinal tract
	Gastrointestinal infection
	Summer diarrhea
	Nonspecific acute diarrhea of infectious nature
	Nonspecific chronic diarrhea of infectious nature
	Acute bacterial diarrhea
	Acute diarrhea due to food poisoning
	Acute dysentery
	Acute bacterial gastroenteritis
	Acute gastroenterocolitis
	Acute enterocolitis
	Subacute dysentery
	Chronic diarrhea
	Refractory diarrhea in patients with AIDS
	Staphylococcal enteritis in children
	Staphylococcal enterocolitis
	Toxic diarrhea
	Chronic dysentery
	Enteritis
	Infectious enteritis
	Enterocolitis
K52.2 Allergic and nutritional gastroenteritis and colitis	Nutritional colitis
	Allergic gastroenteropathy
	Allergic colitis
	Gastroenteritis alimentary
	Allergic gastroenteritis
	Allergic diarrhea
	Drug-induced gastroenteritis
K59.1 Functional diarrhea	Diarrheal syndrome
	Diarrhea
	Diarrhea of non-infectious origin
	Diarrhea after gastrectomy
	Diarrhea with long-term enteral feeding through a tube
	Diarrhea with electrolyte imbalance
	Diarrhea in children
	Prolonged diarrhea
	Nonspecific diarrhea
	Acute diarrhea
	Persistent diarrhea
	Diarrhea
	Diarrhea (diarrhea)
	Diarrhea syndrome
	Functional diarrhea
	Chronic diarrhea
	Chronic diarrhea
	Enterocolitis of non-infectious origin
K90.9 Intestinal malabsorption, unspecified	Impaired absorption of vitamin B1 in the intestine
	Impaired absorption of iron in the gastrointestinal tract
	Insufficient absorption of iron from the gastrointestinal tract
	Insufficient absorption of food
T66 Unspecified radiation effects	Radiation sickness
	Radiation diarrhea
	Gastrointestinal syndrome during irradiation
	Radiation sickness
	Radiation damage to mucous membranes
	Chronic exposure
	Osteoradionecrosis
	Acute radiation sickness
	Acute and chronic radiation injuries
	Acute radiation syndrome during radiation therapy
	Subacute and chronic radiation sickness
	Radiation neuropathy
	Radiation edema
	Radiation damage to the nervous system
	Radiation immunodeficiency
	Radiation syndrome
	Radioepithelitis
	Acute radiation syndrome
	Condition after irradiation
	Cytopenia due to previous radiation or chemotherapy
	Radiation cytopenia
	Cytopenia due to radiation therapy
	Cytopenia due to chemotherapy
Y57.9 Adverse reactions during therapeutic use of drugs and medicinal products, unspecified	Allergic drug reactions
	Allergic reactions to medications
	Allergic reactions to drugs
	Allergic reactions to medications
	Allergic reactions to taking drugs
	Allergic reactions to taking radiocontrast agents
	Allergic reactions due to medications
	Drug allergy
	Anaphylactic reactions to drugs
	Anaphylactic reactions to taking drugs
	Hepatotoxic substances
	Hepatotoxic effect of drugs
	Drug-induced diarrhea
	Idiosyncrasy to medications
	Toxic idiosyncrasy
	Drug addiction
	Drug-induced leukopenia
	Drug fever
	Drug intolerance
	Drug-induced liver damage
	Drug-induced lung injury
	Undesirable effects of drugs
	Acute allergic reaction to medications
	Toxic reactions to drugs
Z72.4 Inappropriate diet and bad habits in nutrition	Dyspepsia caused by unusual foods or overeating
	Long-term diet therapy
	Long-term or low-calorie diets
	Gastrointestinal disorders caused by poor diet
	Inadequate nutrition
	Irregular eating
	Unbalanced diets
	Overeating
	Food poisoning
	Errors in diet
	Dieting
	Following a strict diet
	Special diets
Z93.2 Presence of ileostomy	Ileostomy

Diarrhea may strike at the wrong time. But its symptoms can be suppressed with the help of special antidiarrheal medications. The effect occurs almost immediately after their use. One such remedy is Diara. Let's find out how the drug affects the body and in what cases it should be used.

How the drug works

Diara ( Latin name- Diara) is a drug belonging to the group antidiarrheal drugs. The active component included in its composition reduces the tone of smooth muscles internal organs and intestinal motility. As a result, its peristalsis is inhibited, which helps slow down the movement of feces. As a result, the patient is not bothered frequent urge to defecation. The effect of using the drug occurs within a few minutes, and it lasts from 4 to 6 hours.

Composition and release forms

Diara is available in the form of enteric-coated capsules and chewable tablets.

Each capsule contains 2 mg of loperamide, the main substance of the drug. Scroll auxiliary components for this dosage form:

corn starch.

The capsule body is painted gray, and its lid is green. Inside the capsule there is a white powdery substance (sometimes with a yellow tint).

Capsules deliver better active substance into the intestines, since their contents are protected from the aggressive environment of the stomach by the membrane

Each tablet contains 2 mg of loperamide. It also includes:

anise oil;
silicone oil;
thickener aerosil;
sweetener E951;
povidone;
potato starch;
sucrose;
lactose;
pentanpentaol;
alcohol derived from lactose;
magnesium salt of stearic acid;
Kollidon SR;
microcrystalline cellulose;
menthol.

White or yellowish Diara tablets have a flat-cylindrical shape and smell of anise oil.

Why is the drug prescribed?

Indications for use of Diara are:

infectious diarrhea (in combination with other drugs);
sharp or chronic forms non-infectious nature;
metabolic disorders and absorption processes in the intestines (due to poor quality nutrition or changes in diet).

Diara is also prescribed to regulate bowel movements for patients after ileostomy - surgery to remove the hole. ileum out through the abdominal wall to drain feces and gases. The product can be used to treat diarrhea in children over 6 years of age and women on II and III trimester pregnancy.

Contraindications

Diara should not be taken if the patient has been diagnosed with the following diseases or states:

children's age (up to 6 years);
first 3 months of pregnancy;
lactation period;
monotreatment of gastrointestinal tract infections;
intestinal obstruction;
diverticulosis (protrusion of the walls) of the colon;
colitis of ulcerative type in the acute phase;
individual hypersensitivity to the composition of the product.

You cannot treat diarrhea with Diara if the stool disorder is caused by pseudomembranous inflammation of the colon and small intestine in the acute phase.

Special instructions

Most of the loperamide contained in Diara is excreted from the body in bile. Therefore, people suffering liver failure, caution should be exercised when using this device.

You can use Diara without a doctor's instructions for sudden onset diarrhea. But if the drug does not help within two days after taking the first dose, you should consult a doctor.

Treatment with drugs based on loperamide is accompanied by suppression of the central nervous system and a slowdown in mental reactions. Therefore, patients taking Diara should be careful when performing potentially dangerous types of work and driving a vehicle.

At simultaneous administration opioid analgesics (Morphine, Codeine, Promedol), persistent constipation develops.

How to take Diara correctly for adults and children - instructions

Diara should be taken after each trip to the toilet, regardless of meals. The rules for taking the drug are the same for both children and adults. Capsules must be swallowed whole, and tablets must be chewed thoroughly. Both dosage forms You need to drink plenty of water (1 glass is enough).

In childhood, it is best to use tablets, as they are easier to take if the child does not know how to swallow capsules.

If the stool has returned to normal or has not been present for 12 hours or more, treatment with the drug is stopped.

Possible side effects

During treatment with Diara, the following adverse reactions may occur:

dry mouth;
stomach pain;
skin rashes of an allergic nature;
lethargy and drowsiness;
dizziness;
paroxysmal pain in the intestines (colic);
constipation;
nausea and vomiting.

In very rare cases, taking Diara causes patients to develop intestinal obstruction.

Overdose

With excessive use of Diara, signs of overdose develop:

intestinal obstruction;
depressed breathing;
hypertonicity of muscle tissue;
constriction of the pupils;
impaired coordination of movements;
stupor and drowsiness.

If the symptoms described above occur, seek medical attention medical care. Treatment of an overdose of loperamide is based on the administration of an antidote (naloxone), a substance that blocks the effect of medicinal product. Since the effect of naloxone wears off faster than the effect of taking Diara, the patient is given it twice.

In case of overdose, gastric lavage and taking adsorbents are also prescribed ( activated carbon, Polysorb, Smecta, Povidone). If respiratory depression occurs, the patient is connected to a ventilator (artificial pulmonary ventilation) and left under observation for 2 days.

Prices for the drug and conditions for dispensing from pharmacies

Approximate cost of Diara depending on the form of release:

capsules (10 pcs.) - about 35 rubles;
tablets (12 pcs.) - from 90 rubles.

Diara refers to medicines dispensed without a doctor's prescription.

What can be replaced

Diara has many analogues in active component- loperamide. They all have the same indications and contraindications, as well as side properties. But they are released different countries and pharmaceutical companies. Therefore, their prices vary greatly.

Table: brief overview of Diara analogues based on active ingredient

Photo gallery: analogues of Diara based on the active component

Loperamide-Acri is produced by Russian pharmaceutical company"Akrikhin"
Loperamide Shtad is produced by the Russian company "NIZHFARM" Loperamide tablets are produced by the Russian company Ozon. Imodium - English analogue of Diara
Lopedium is produced by the Swiss company Sandoz.

Antidiarrheal symptomatic drug

Active ingredient

Loperamide hydrochloride (loperamide)

Release form, composition and packaging

◊ Capsules size No. 3, with body gray and a dark green lid; the contents of the capsules are white or white powder with a yellowish tint.

Excipients: magnesium stearate, corn starch, microcrystalline cellulose.

◊ Chewable tablets white or white with a yellowish tint, flat-cylindrical in shape, scored, with the smell of anise; Light marbling is allowed.

Excipients: polymethylsiloxane, potato starch, lactose, sucrose, microcrystalline cellulose, colloidal silicon dioxide (Aerosil), aspartame (Kollidon 90), xylitol (Xylitab 300), lactitol, Kollidon SR, menthol, magnesium stearate, anise oil.

4 pcs. - contour cellular packaging (1) - cardboard packs.
4 pcs. - contour cell packaging (2) - cardboard packs.
4 pcs. - contour cell packaging (3) - cardboard packs.
6 pcs. - contour cellular packaging (1) - cardboard packs.
6 pcs. - contour cell packaging (2) - cardboard packs.
6 pcs. - contour cell packaging (3) - cardboard packs.
7 pcs. - contour cellular packaging (1) - cardboard packs.
7 pcs. - contour cell packaging (2) - cardboard packs.
7 pcs. - contour cell packaging (3) - cardboard packs.
10 pcs. - contour cellular packaging (1) - cardboard packs.
10 pcs. - contour cell packaging (2) - cardboard packs.
10 pcs. - contour cell packaging (3) - cardboard packs.

Pharmacological action

Antidiarrheal drug. , by binding to opioid receptors of the intestinal wall (modulation of cholinergic and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and prostaglandins). Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, promotes fecal retention and reduces the urge to defecate.

The action occurs quickly and lasts for 4-6 hours.

Pharmacokinetics

Loperamide hydrochloride is almost completely metabolized by the liver by conjugation. T1/2 is 9-14 hours. It is excreted mainly in bile and urine in the form of conjugated metabolites.

Indications

Symptomatic treatment of acute and chronic:

- allergic, emotional, medicinal, radiation origin;

- when changing the diet and quality of food, when metabolism and absorption are impaired;

- as an adjuvant for diarrhea of infectious origin.

Regulation of bowel movements in patients with ileostomy.

Contraindications

- diverticulosis;

- intestinal obstruction;

- ulcerative colitis in the acute phase;

- diarrhea due to acute pseudomembranous enterocolitis;

— monotherapy for dysentery and other gastrointestinal infections;

— I trimester of pregnancy;

- lactation period;

- children under 6 years of age;

- hypersensitivity to the components of the drug.

WITH caution the drug should be used for.

Dosage

The drug should be taken orally with water.

For adults at acute and chronic diarrhea prescribed in an initial dose of 4 mg (2 tablets or 2 capsules), then 2 mg (1 tablet or 1 capsule) after each act of defecation in case of loose stools. The maximum daily dose is 16 mg (8 tablets or 8 capsules).

Children over 6 years of age Prescribe 2 mg (1 tablet or 1 capsule) after each bowel movement in case of loose stools. The maximum daily dose is 6 mg (3 tablets or 3 capsules).

If stool normalizes or there is no stool for more than 12 hours, treatment with Diara should be discontinued.

Side effects

From the outside digestive system: gastralgia, dry mouth, intestinal colic, nausea, vomiting, constipation; very rarely - intestinal obstruction.

From the side of the central nervous system: drowsiness, dizziness.

Allergic reactions: .

Overdose

Symptoms: depression of the central nervous system (stupor, loss of coordination of movements, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.

Treatment: antidote - naloxone. Given that the duration of action of loperamide is longer than that of naloxone, repeated administration of the latter is possible.

Symptomatic treatment:, gastric lavage, mechanical ventilation. Medical supervision is required for at least 48 hours.

Drug interactions

Data about drug interactions Diara drug is not provided.

Registration number: LS-000845-300518
Trade name: Diara®
International generic name(INN): Loperamide
Dosage form: chewable tablets

Compound:
1 chewable tablet contains:
Active ingredient: loperamide hydrochloride - 2 mg;
Excipients: polymethylsiloxane, potato starch, lactose monohydrate, sugar (sucrose), microcrystalline cellulose, colloidal silicon dioxide (Aerosil), aspartame, povidone (Kollidon 90), xylitol, lactitol, Kollidon SR [polyvinyl acetate, povidone K-30, sodium lauryl sulfate , silicon dioxide], menthol, magnesium stearate, anise oil.

Description: round flat-cylindrical tablets of white or white with a yellowish tint, with a chamfer and a score, with a characteristic odor. Light marbling is allowed.

Pharmacotherapeutic group: Antidiarrheal agent.

ATH CODE:

Pharmacological properties:

Pharmacodynamics:
Loperamide, by binding to opioid receptors of the intestinal wall (modulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and Pg). Slows down peristalsis and increases the transit time of intestinal contents, increases the tone of the anal sphincter, helps retain feces and reduce the urge to defecate.
The action occurs quickly and lasts 4-6 hours.
Pharmacokinetics:
Almost completely metabolized by the liver by conjugation. T1/2 (half-life) - 9-14 hours. Excreted mainly with bile and kidneys (in the form of conjugated metabolites).