Curantil what are the dosages. Dosage form Curantil: solution for injection

Pharmacodynamics. Curantil is an antiplatelet agent that inhibits the reverse penetration of adenosine into the intracellular space, thereby increasing its concentration in the blood plasma and the antiplatelet effect on platelets and erythrocytes. In addition, Curantil increases the antiplatelet activity of prostaglandin E1 and in high doses inhibits PDE in platelets, as a result of which cAMP accumulates in them and the release of thromboxane A2 from them is inhibited, which leads to inhibition of platelet aggregation and an increase in their life expectancy. Thanks to the adenosine mechanism, the drug also dilates the coronary arteries, increases coronary blood flow and stimulates the formation of collaterals.
Pharmacokinetics. After oral administration, it is quickly absorbed from the gastrointestinal tract, mainly in the stomach and partially in small intestine. Absorption is highly dependent on pH level gastric juice Therefore, bioavailability has significant individual variations and is 43±13%. About 98% binds to blood plasma proteins and accumulates in the heart and red blood cells. Cmax in blood plasma is observed approximately 60 minutes after oral administration. Dipyridamole is metabolized in the liver by binding to glucuronic acid. T1/2 is 20-30 min. The drug is excreted mainly in bile and feces in the form of monoclucuronide.

Indications for use of the drug Curantil

Stable angina, chronic heart failure, prevention and treatment of myocardial infarction, prevention and treatment of ischemic cerebral circulatory disorders, chronic cerebral circulatory failure, discirculatory encephalopathy, vascular insufficiency, prevention of the formation of arterial and venous blood clots and thromboembolic complications (in combination with acetylsalicylic acid or with anticoagulants), prevention of thromboembolism after heart valve replacement, prevention of placental insufficiency, intermittent claudication, in the composition complex therapy for microcirculation disorders of various origins.

Use of the drug Curantil

Therapy should begin with a gradual increase in dose. The duration of treatment and dose are set individually depending on the indications and tolerability. Curantil can be used for a long course of treatment. Dragees are taken without chewing, with liquid, on an empty stomach or 1 hour before meals.
Adults and children over 12 years of age: 75-225 mg of dipyridamole per day (3-9 tablets) in several doses. If the disease is mild or if the condition improves, you can take 25-50 mg 3 times a day. At severe course disease, the dose can be increased to 600 mg of dipyridamole per day. To prevent thromboembolism in patients simultaneously using anticoagulants or acetylsalicylic acid, the drug is prescribed 75 mg 3-6 times a day.

Contraindications to the use of the drug Curantil

Hypersensitivity to dipyridamole, diffuse stenotic atherosclerosis coronary arteries, subaortic stenosis, unstable angina, acute myocardial infarction, heart failure in the stage of decompensation, arterial hypotension severe, collapse, disorders heart rate, severe renal failure, diseases with an increased risk of bleeding ( peptic ulcer stomach and duodenum, hemorrhagic diathesis).

Side effects of the drug Curantil

Usually mild and transient:
from the cardiovascular system: headache and dizziness of vascular origin, arterial hypotension, skin hyperemia with a feeling of heat, tachycardia, especially when using vasodilators, sometimes - exacerbation of coronary artery disease; with abrupt withdrawal of the drug, unstable angina or myocardial infarction may develop;
from the gastrointestinal tract: nausea, vomiting, diarrhea, dyspeptic disorders;
from the hepatobiliary system: There are reports that dipyridamole is a constituent of gallstones;
from the skin and subcutaneous tissue: skin rash and urticaria;
from the outside immune system: bronchospasm and Quincke's edema are possible;
from the blood system and lymphatic system: very rarely - increased bleeding during or after surgery, in some cases - thrombocytopenia.
from the musculoskeletal system: myalgia;
general disorders: general weakness.

Special instructions for the use of the drug Curantil

In case of lactase deficiency, galactosemia and glucose/galactose malabsorption, the drug should not be used.
Use during pregnancy and lactation. The use of Curantil is possible only after assessing the possible risks and expected benefits.
Use in children. The use of dipyridamole in children under 12 years of age is not recommended because there is insufficient clinical experience.
The ability to influence reaction speed when driving vehicles or working with machinery. Blood pressure may decrease, and the resulting lack of blood supply to the brain may affect the ability to drive vehicles and operate potentially dangerous machinery.

Interactions of the drug Curantil

Xanthine derivatives (caffeine, theophylline) can weaken or completely neutralize the effect of the drug, so they should not be prescribed simultaneously. During treatment with Curantil, you should refrain from frequent drinking of strong coffee or tea. The effect may be enhanced under the influence of the drug antihypertensive drugs, and also reduce the anticholinergic activity of distigmine. Curantil may enhance the effect of anticoagulants and acetylsalicylic acid, therefore, when using them simultaneously, it is necessary to take into account possible increase risk of intolerance to these drugs.

Overdose of the drug Curantil, symptoms and treatment

Symptoms: general vasodilation, accompanied by hypotension, tachycardia, a feeling of warmth in the body, flushing of the facial skin, weakness and dizziness.
Treatment: it is necessary to rinse the stomach or induce vomiting; carry out measures to reduce absorption, prescribe adsorbents and other symptomatic therapy. The vasodilating effect of dipyridamole can be stopped by intravenous administration of aminophylline (50-100 mg over 1 min). Sublingual nitroglycerin is used to relieve an attack of angina.

Storage conditions for the drug Curantil

In a dark place at a temperature not exceeding 25 °C.

List of pharmacies where you can buy Curantil:

• Saint Petersburg

Photo of the drug

Latin name: Curantyl

ATX code: B01AC07

Active substance: Dipyridamole

Manufacturer: Berlin-Chemie AG (Germany)

Products webpage: berlin-chemie.ru

Description is valid on: 07.11.17

In this article you can find instructions for use medicinal product Chimes. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Curantil in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Curantil, if available structural analogues. Use for the treatment of circulatory disorders and the prevention of thrombosis in adults, children, as well as during pregnancy and lactation. Composition and contraindications of the drug.

Chimes- vasodilator with myotropic action. It has an inhibitory effect on platelet aggregation and improves microcirculation.

Dipyridamole (the active ingredient of the drug Curantil) dilates arterioles in the coronary blood flow system, and when taken in high doses, in other parts of the circulatory system. However, unlike organic nitrates and calcium antagonists, the expansion of larger coronary vessels not happening.

The vasodilatory effect of dipyridamole is due to two different mechanisms of inhibition: inhibition of adenosine uptake and inhibition of phosphodiesterase.

In vivo, adenosine is found at concentrations of approximately 0.15-0.20 µM. This level is maintained due to the dynamic balance between ejection and reuptake. Dipyridamole inhibits the uptake of adenosine by endothelial cells, erythrocytes and platelets. After the administration of Curantil, an increase in the concentration of adenosine in the blood and an increase in adenosine-induced vasodilation are detected. At higher doses, platelet aggregation caused by adenosine is inhibited, and the tendency to thrombus formation decreases.

The breakdown of cAMP and cGMP, which suppress platelet aggregation, occurs in platelets under the action of corresponding phosphodiesterases. At high concentrations, dipyridamole inhibits both phosphodiesterases; at therapeutic concentrations in the blood, it inhibits only cGMP phosphodiesterase. As a result of stimulation of the corresponding cyclases, the power of cAMP synthesis increases.

As a pyrimidine derivative, dipyridamole is an interferon inducer and has a modulating effect on the functional activity of the interferon system, increases the reduced production of interferon alpha and gamma by blood leukocytes. The drug increases nonspecific resistance to viral infections.

Compound

Dipyridamole + excipients.

Pharmacokinetics

Dipyridamole is almost completely bound to plasma proteins. Dipyridamole accumulates in the heart and red blood cells. Dipyridamole is metabolized in the liver by binding to glucuronic acid. It is excreted in bile as a monoglucuronide.

Indications

• treatment and prevention of ischemic cerebral circulatory disorders;
• encephalopathy;
• primary and secondary prevention of coronary artery disease, especially in case of intolerance to acetylsalicylic acid;
• prevention of arterial and venous thrombosis and treatment of their complications;
• prevention of thromboembolism after heart valve replacement surgery;
• prevention of placental insufficiency during complicated pregnancy;
• when planning pregnancy;
• microcirculation disorders of any type (as part of complex therapy);
• prevention and treatment of influenza, ARVI (as an interferon inducer and immunomodulator) - for taking the drug in a dose of 25 mg.

Release forms

Film-coated tablets 25 mg.

Film-coated tablets N 25 (25 mg).

Film-coated tablets N 75 (75 mg).

Instructions for use and dosage

The dose of the drug is selected depending on the severity of the disease and the individual response of the patient.

For the prevention and treatment of cerebrovascular accidents, as well as for prophylaxis, 75 mg is prescribed 3-6 times a day. The maximum daily dose is 450 mg.

To reduce platelet aggregation, Curantil is prescribed at a dose of 75-225 mg per day in several doses. In severe cases, the dose can be increased to 600 mg per day.

For the prevention of influenza and ARVI, especially during epidemics, Curantil N25 and Curantil 25 are prescribed 50 mg (2 tablets or 2 dragees) per day in 1 dose. The drug is taken once a week for 4-5 weeks.

To prevent relapses of ARVI in patients who often suffer from respiratory viral infections, Curantil N25 and Curantil 25 are prescribed 100 mg per day (2 tablets or tablets 2 times a day with an interval between doses of 2 hours). The drug is taken once a week for 8-10 weeks.

The tablets should be taken on an empty stomach, without breaking or biting, with a small amount of liquid. The duration of the course of treatment is determined by the doctor.

Side effect

• heartbeat;
• tachycardia (especially with simultaneous use of other vasodilators);
• bradycardia;
• flushes of blood to the face;
• facial skin hyperemia;
• coronary steal syndrome (when using the drug at a dose of more than 225 mg per day);
• decrease in blood pressure;
• nausea, vomiting;
• diarrhea;
• pain in the epigastric region;
• thrombocytopenia, changes in the functional properties of platelets;
• bleeding;
• increased bleeding during or after surgical intervention;
• dizziness;
• noise in the head;
• headache;
• skin rash;
• hives;
• weakness;
• feeling of ear fullness;
• myalgia;
• rhinitis.

Contraindications

• acute myocardial infarction;
• unstable angina;
• widespread stenotic atherosclerosis of the coronary arteries;
• subaortic aortic stenosis;
• heart failure in the stage of decompensation;
• arterial hypotension;
• collapse;
• severe arterial hypertension;
• severe heart rhythm disturbances;
• chronic obstructive pulmonary diseases;
• chronic renal failure;
• liver failure;
• hemorrhagic diathesis;
• diseases with an increased risk of bleeding (including peptic ulcer of the stomach and duodenum);
• hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The drug can be used during pregnancy according to indications.

The use of the drug during lactation is possible only if the expected benefit from treatment exceeds possible risk.

Use in children

special instructions

With simultaneous consumption of tea or coffee (contain xanthine derivatives), the vasodilating effect of Curantil may decrease.

Impact on the ability to drive vehicles and operate machinery

Caution should be exercised when driving vehicles and operating machinery, since as a result of a drop in blood pressure while taking Curantil, the ability to concentrate and speed of psychomotor reactions may deteriorate.

Drug interactions

With the simultaneous use of Curantil with anticoagulants or acetylsalicylic acid, the antithrombotic effect of the latter increases and, accordingly, the risk of developing hemorrhagic complications.

With simultaneous use, Curantil enhances the effect of antihypertensive drugs.

At joint use Curantil may weaken the anticholinergic effects of cholinesterase inhibitors.

When used simultaneously, xanthine derivatives weaken the vasodilator effect of Curantil.

Analogues of the drug Curantil

Structural analogues of the active substance.

"Curantil" is a drug widely used in cardiological, obstetric and therapeutic practice. The product has combined action, which allows it to be used for the treatment of pathologies and complications of various origins.

Most often, "Curantil" is prescribed to pregnant women with manifestations of toxicosis of the second and third degrees, as well as disturbances in the formation or functioning of the placenta.

Pharmacological action of the drug

"Curantil" has a pronounced therapeutic effect, starting from 3-4 days of use. Therapeutic effect achieved thanks to pharmacological properties drugs, including:

• dilation of blood vessels, improvement of blood circulation;
• decreased platelet aggregation;
• increased activity human interferon;
• increased resistance to viruses;
• immunomodulatory effect.

When is it appointed?

"Curantil" is rarely used as the main component of therapy - most often the drug is included in combined scheme treatment of diseases of various origins. Diagnoses and pathologies for which it is advisable to prescribe the drug are indicated in official instructions.

In cardiology:

• disruption of cerebral circulatory processes;
• encephalopathy (damage to certain areas of the brain) of the dyscirculatory type;
• thrombosis of veins and arteries (treatment and prevention);
• heart valve replacement ( rehabilitation period after surgery to prevent thromboembolism).

In obstetrics/gynecology:

• placental insufficiency;
• other pathologies of the placenta, accompanied by circulatory disorders;
• hypoxia resulting from a lack of oxygen molecules due to impaired blood microcirculation in the vessels of the placenta.

In general (family) therapy:

• viral infections(flu, ARVI, etc.);
• decreased immunity;
• rehabilitation period after surgery (as an immunomodulator).

How to use?

Curantil tablets and dragees should be swallowed whole. Drink liquid without caffeine or sugar. The dosage of the drug is selected by the attending physician taking into account tolerability, established diagnosis and associated chronic diseases.

Note! For maximum effectiveness, the drug should be taken on an empty stomach.

Contraindications

The list of restrictions for prescribing "Curantil" is quite impressive, therefore independent use is strictly prohibited this drug. The use of "Curantil" is contraindicated for the following diagnoses/conditions:

• heart failure in the stage of decompensation (dysfunction);
• collapse;
• heart rhythm disturbance;
• myocardial infarction ( acute stage);
• exacerbation of gastric/duodenal ulcers;
• diathesis of hemorrhagic type;
• atherosclerosis of the coronary arteries;
• subaortic aortic stenosis;
• high or low blood pressure;
• angina pectoris (in the absence of stability).

Also, the drug is not prescribed to children under 12 years of age and to patients with severe forms renal and liver failure.

No cases of overdose have been recorded to date.

Use during pregnancy

"Curantil" is one of the frequently prescribed drugs during pregnancy. It is prescribed by the observing gynecologist or obstetrician to normalize the condition of the fetus when various violations in the functioning of the child's place (placenta). The placenta consists of a huge number of small blood vessels and capillaries through which nutrients are transported. Vitamins and oxygen to the fetus.

When disruptions occur in the circulatory system, the fetus does not receive enough useful elements and oxygen molecules, which can affect its growth and development. The drug of choice for normalizing the functioning of the placenta is “Curantil” (as the safest and effective drug).

Remember that you cannot prescribe the drug yourself.

Use during lactation

The use of "Curantil" is not contraindicated during breastfeeding with the permission of the attending physician, who assessed the ratio of possible risks and benefits to a woman’s health.

Side effects

The drug is generally well-tolerated, but side effects have still been diagnosed. Most often, patients complain of digestive disorders, epigastric pain, cardiac disorders and skin reactions.

This manifests itself the following signs:

• nausea;
• diarrhea;
• headaches (possibly dizziness);
• myalgia;
• facial redness;
• increased heart rate;
• allergies (in the form of skin manifestations).

Important! When prescribing to patients with unstable blood pressure, the hypotensive effect of Curantil should be taken into account.

Composition and release form

The main component of the drug, which has angioprotective and immunomodulatory effects, is dipyridamole. Depending on the content of the main component, the drug is available in three dosage forms:

• dragees containing 25 mg of dipyridamole (100 pieces per pack);
• coated tablets containing 25 mg of dipyridamole (120 pieces per pack);
• coated tablets containing 75 mg of dipyridamole (40 pieces per pack).

Pharmacokinetics

The main part of dipyridamole is absorbed from the stomach (a minimal amount is absorbed from the large intestine). "Curantil" binds perfectly to plasma proteins (98%) and is metabolized in the liver. It reaches its maximum concentration 60 minutes after administration, accumulating mainly in red blood cells and heart muscle.

special instructions

During treatment with Curantil, any drinks containing caffeine (tea, cocoa, coffee, etc.) should be excluded from the diet, as they significantly reduce the effectiveness of the therapy.

Curantil is a myotropic vasodilator that effectively slows platelet aggregation and improves blood circulation in small vessels (capillaries).

The active substance - dipyridamole - in therapeutic dosages improves blood microcirculation in the coronary circulatory system, and in more high dosages and in other parts of the circulatory system. The main difference between Curantil and organic nitrates and calcium antagonists is that there is no dilation of large coronary vessels.

Maximum concentration active substance tablets are fixed in the blood plasma within an hour after ingestion.

The use of Curantil tablets during pregnancy is indicated to prevent blockage of the blood vessels of the placenta - in some cases this allows to avoid severe complications associated with insufficient blood supply to the child.

Additionally, Curantil has a pronounced effect of stimulating the human immune system - this is due to the action of dipyridamole ( active substance), as a pyrimidine derivative, and its ability to stimulate the synthesis of interferon. The immunomodulatory effect is of great importance for the prevention and treatment of viral diseases, including ARVI and influenza.

Kurantil 25, photo

After oral administration, the drug is quickly absorbed into the gastrointestinal tract, mainly in the stomach and only partially in the small intestine. Metabolism occurs in the liver by binding to glucuronic acid.

Indications for use

What does Kurantil help with? The drug is prescribed in the following cases:

• prevention and treatment of acute myocardial infarction or recovery period;
• stable angina;
• prevention of postoperative thrombosis;
• treatment and prevention of placental insufficiency, especially when we're talking about about aspirin intolerance;
• prevention of thromboembolism after heart valve replacement surgery;
• microcirculation disorders as part of complex therapy;
• prevention of viral diseases, ARVI, influenza.

Reviews from doctors characterize Curantil as effective and quite inexpensive drug, effectively coping with the stated treatment goals.

Instructions for use Curantil, dosage

The tablets are taken orally before meals, washed down with a small amount clean water. Dosages depend on indications:

To prevent platelet aggregation: dosage from 75 to 225 mg per day in several doses, if necessary, the dosage is increased to 600 mg/day.

For the prevention of ARVI and influenza, Curantil 75 mg is prescribed once a day for a course of 2-2.5 months. To prevent relapses - 100 mg per day according to the regimen: 50 mg Curantil 2 times a day, 1 time per week for 10 weeks.

For the treatment of coronary heart disease - the standard dosage is 1 tablet of Curantil 75 mg every 8 hours. As prescribed by the doctor, the dosage may be increased.

Curantil is not contraindicated during pregnancy, however, before prescribing it, it is necessary to compare the possible risk to the fetus and the likely benefit.

Side effects and contraindications

When using Curantil in standard dosages, there is a risk of encountering side effects minimal. However, you may experience:

• palpitations, tachycardia (especially with simultaneous use of other vasodilators);
• bradycardia, flushing of the face, flushing of the facial skin, drop in blood pressure.
• nausea, vomiting, diarrhea, pain in the epigastric region.
• thrombocytopenia, changes in the functional properties of platelets;
• dizziness, noise in the head;
• headache;
• allergic reactions, skin rash, urticaria;
• weakness, feeling of ear congestion;
• arthritis, myalgia, rhinitis

In most cases side effects decrease with more long-term use drug.

Contraindications

The main contraindications to the prescription of Curantil tablets of any dosage:

• acute myocardial infarction;
• unstable angina;
• widespread stenotic atherosclerosis of the coronary arteries;
• subaortic aortic stenosis;
• heart failure in the stage of decompensation;
• arterial hypotension;
• collapse;
• severe arterial hypertension;
• severe heart rhythm disturbances;
• chronic obstructive pulmonary diseases;
• chronic renal failure;
• liver failure;
• hemorrhagic diathesis;
• diseases with an increased risk of bleeding (incl.
• peptic ulcer of the stomach and duodenum);
• hypersensitivity to the components of the drug.

Overdose

Symptoms of an overdose of Curantil are associated with the therapeutic effect of the drug to dilate blood vessels - hyperemia, a drop in blood pressure, the appearance of weakness, rapid heartbeat, and a feeling of warmth in the body are manifested.

Treatment - creating conditions for accelerated removal of the active substance: gastric lavage, taking sorbents. Additionally, intravenous administration of aminophylline at a dosage of 50-100 mg may be required. If an attack of angina occurs, it is necessary to use nitroglycerin tablets or spray.

Analogues of Curantil, list of drugs

You can replace Curantil with analogues according to therapeutic effect- This the following drugs, list:

1. Clopidogrel.
2. Tromboneti.
3. Plavix.
4. Cardiomagnyl.
5. Aspecard.
6. Godasal.
7. Aspicor.
8. Zilt.
9. Brilinta.
10. Atrogrel.
11. Magnicor.
12. Atherocardium.

Important - instructions for use of Curantil, price and reviews do not apply to analogues and cannot be used as a guide to the use of drugs of similar composition or action. All therapeutic prescriptions must be made by a doctor. When replacing Curantil with an analogue, it is important to consult a specialist; you may need to change the course of therapy, dosages, etc. Do not self-medicate!