Biseptol children's instructions for use of the tablet. Biseptol: indications, dosage for children and adults
100 ml suspension contains
active substances: trimethoprim 0.8 g,
sulfamethoxazole 4.0 g
Excipients: macrogol glyceryl hydroxystearate, aluminum magnesium silicate, carmellose sodium, citric acid monohydrate, sodium hydrogen phosphate dodecahydrate, methyl parahydroxybenzoate, propyl parahydroxybenzoate, maltitol, sodium saccharinate, strawberry flavor, propylene glycol, purified water.
Description
Suspension of white or light cream color with strawberry smell. The suspension is homogeneous after shaking the drug.
Pharmacotherapeutic group
Antibacterial drugs for system use. Sulfonamides and trimethoprim. Sulfonamides in combination with trimethoprim and its derivatives. Co-trimoxazole.
ATX code J01EE 01
Pharmacological properties
Pharmacokinetics
After oral administration in a therapeutic dose, the active substances are rapidly and almost completely (90%) absorbed in the upper segment. small intestine and after 60 min. reach a therapeutic concentration in the blood and tissues, which persists for 12 hours. The maximum concentration of active substances in the blood plasma is reached after 1-4 hours. Plasma protein binding is 66% for sulfamethoxazole and 45% for trimethoprim. The drug is well distributed in the body.
The drug penetrates into the mother's milk and through the placental barrier. Sulfamethoxazole and trimethoprim are metabolized in the liver.
The half-life ranges from 10 to 12 hours.
Pharmacodynamics
Biseptol is a chemotherapeutic combined drug containing sulfamethoxazole and a diaminpyridine derivative - trimethoprim in a ratio of 5:1. Sulfamethoxazole disrupts the utilization of para-aminobenzoic acid, and, consequently, the synthesis of dihydro folic acid. Trimethoprim inhibits an enzyme that is involved in the conversion of dihydrofolate to active tetrahydrofolate. The combination of both components made it possible to obtain a bactericidal effect. Biseptol is active against gram-positive bacteria: streptococci (Streptococcus pneumoniae, S. agalactiae, S. viridans), staphylococci (Staphylococcus aureus, Staphylococcus epidermidis), Listeria monocytogenes, Nocardia asteroides and gram-negative, including most rods Enterobacteriaceae(kinds Salmonella, Shigella, Klebsiella, Proteus mirabilis, Enterobacter, part of the strains Escherichia coli), part of the strains H.influenzae, Legionella spp., Yersinia enterocolitica, Brucella spp., Neisseria meningitidis, Neisseria gonorrhoeae, as well as Pneumocystis carinii. Sticks are resistant to the drug ( Mycobacteriaceae), viruses, most anaerobic bacteria and mushrooms.
Indications for use
Respiratory infections- exacerbation chronic bronchitis, treatment and prevention (primary and secondary) of pneumonia caused by, Pneumocystis carinii in adults and children
Sinusitis, acute otitis media
infections gastrointestinal tract: typhoid fever and paratyphoid, bacillary dysentery(shigellosis), diarrhea, cholera
Sharp and chronic infections urinary system and prostate(urethritis, cystitis, prostatitis)
Chancroid
Brucellosis, osteomyelitis, nocardiosis, actinomycosis, toxoplasmosis and
South American blastomycosis (possibly combined with other
antibiotics)
Dosage and administration
The drug is taken orally during or immediately after a meal with plenty of liquid.
Shake before use until a homogeneous suspension is obtained.
5 ml of suspension contains 200 mg of sulfamethoxazole and 40 mg of trimethoprim.
A measuring cup with a scale is included with the package.
In children, trimethoprim 6 mg and sulfamethoxazole 30 mg per kg of body weight per day are usually used. In severe infections, doses can be increased by 50%.
Children:
Adults and children over 12 years old - Usually 20 ml every 12 hours. The maximum dose (for use in especially severe cases) is 30 ml of suspension every 12 hours.
At acute infections Biseptol should be taken for at least 5 days or until the patient has no symptoms for 2 days. If after 7 days of treatment there is no clinical improvement, the patient's condition should be re-evaluated for possible correction of treatment.
For infections caused Pneumocystis carinii - 120 mg/kg/day every 6 hours for 14-21 days.
The course of treatment for infection urinary tract and acute otitis media- 10 days, shigellosis - 5 days.
Patients with impaired renal function
With creatinine clearance> 30 ml / min, the usual dose is prescribed, with creatinine clearance from 15 to 30 ml / min - half the usual dose, and with a decrease in creatinine clearance to< 15 мл/мин применять Бисептол не рекомендуется.
Side effects"type="checkbox">
Side effects
Usually the drug is well tolerated.
Frequency not known
Nausea, vomiting, lack of appetite, diarrhea, abdominal pain, gastritis, stomatitis, glossitis
Leukopenia, neutropenia, thrombocytopenia
Fever, shivering
Rash, urticaria, much less often polymorphic erythema, itching
Pseudomembranous enterocolitis
Candidiasis
Hypersensitivity reactions that manifest as fever, angioedema, anaphylactoid reactions - pulmonary infiltrates of the type of eosinophilic, allergic alveolitis with cough or shortness of breath
Reversible hyperkalemia, hypoglycemia, hyponatremia
Headache, dizziness, hallucinations, sleep disturbance, depression
Neuropathy (including peripheral neuritis and paresthesia)
Increased activity of transaminases and bilirubin concentration, hepatitis, cholestasis, liver necrosis
photosensitivity
kidney dysfunction, interstitial nephritis, increase in nitrogen
blood urea, serum creatinine, crystalluria, increased diuresis,
especially in patients with edema of cardiac origin
In isolated cases
Agranulocytosis, pancytopenia, megaloblastic, hemolytic anemia, methemoglobinemia
Periarteritis nodosa, allergic myocarditis
Aseptic meningitis
Purpura of Shenlein-Henoch
Rhabdomyolysis
Stevens-Johnson Syndrome
Lyell's syndrome
Arthralgia, myalgia
Contraindications
Hypersensitivity to sulfonamides, trimethoprim and/or
to other components of the drug
Co-administration with dofetilide
Severe impairment of liver or kidney function (creatinine clearance
below 15 ml/min)
Megaloblastic anemia due to folic acid deficiency
Treatment of streptococcal angina
Pregnancy and lactation
Children's age up to 3 months
Drug Interactions"type="checkbox">
Drug Interactions
Biseptol, used simultaneously with diuretics, especially from the thiazide group, increases the possibility of thrombocytopenia with bleeding. May prolong prothrombin time in patients taking anticoagulants (eg warfarin).
Enhances the effect of antidiabetic agents, sulfonylurea derivatives.
Inhibits the metabolism of phenytoin in the liver (increases its half-life to 39%). May also increase the concentration of free methotrexate in plasma (increases the release of methotrexate from its compounds with proteins).
Like other sulfonamides, Biseptol can potentiate the action of oral hypoglycemic drugs from the sulfonylurea group.
With the simultaneous appointment of Biseptol to patients who receive pyrimethamine for the prevention of malaria in doses of more than 25 mg per week, they may develop megaloblastic anemia.
In patients receiving Biseptol and cyclosporine after kidney transplantation, there may be a reversible deterioration in kidney function, manifested by an increase in creatinine levels.
At simultaneous reception with Biseptol, it is necessary to reduce the dose of indomethacin.
It is possible to increase the serum concentration of digoxin, especially in elderly patients, while taking Biseptol.
With the simultaneous use of Biseptol and zidovudine, an increase in the risk of hematological disorders is possible. If it is necessary to use Biseptol and zidovudine, the blood picture should be monitored.
The effectiveness of tricyclic antidepressants may decrease when taken with Biseptol.
Laboratory research
Biseptol may affect the results of determining the concentration of methotrexate in serum by the method of competitive protein binding, when bacterial dihydrofolate reductase is used as a ligand. When determining methotrexate by the radioimmune method, distortion does not occur.
Biseptol can interfere with the reaction of creatinine determination using Jaffe alkaline picrinate (increases creatinine levels by approximately 10%).
special instructions"type="checkbox">
special instructions
In elderly patients and old age, as well as at comorbidities liver and kidney or concomitant use of other drugs, there are more high risk the development of severe allergic reactions such as Stevens-Johnson syndrome, Lyell's syndrome and acute liver necrosis. To reduce the risk of such reactions, treatment with Biseptol should be as short as possible, especially in elderly patients.
On first appearance skin rash or any other severe adverse reaction the drug should be discontinued. Patients with a tendency to allergic reactions and bronchial asthma Biseptol should be prescribed with caution.
With the duration of the course of therapy for more than 14 days and / or an increase in the dose of the drug, it is necessary to control the picture of peripheral blood; when pathological changes should take into account the appointment of folic acid.
In elderly patients, as well as in patients with folic acid deficiency or renal insufficiency, hematological changes characteristic of folic acid deficiency may occur.
When prescribing Biseptol to patients who are already receiving anticoagulants, one should be aware of a possible increase in the anticoagulant effect. In such cases, it is necessary to re-determine the clotting time.
The drug should not be administered to patients with hereditary fructose intolerance.
Patients receiving long-term treatment with Biseptol (especially with renal failure) should be regularly taken general analysis urine and monitor kidney function. During treatment, it is necessary to ensure sufficient fluid intake in the body, adequate diuresis to prevent crystalluria.
Due to the possibility of hemolysis, patients with deficiency of glucose-6-phosphate dehydrogenase are prescribed Biseptol only according to absolute indications and in minimal doses.
Caution should be exercised in patients with porphyria or impaired function thyroid gland.
antibacterial combination drug"Biseptol for children" is prescribed for infections genitourinary system(cystitis, urethritis, pyelonephritis), respiratory tract infections (bronchitis, pneumonia, tonsillitis, laryngitis), middle ear infections, meningitis, scarlet fever, osteomyelitis. The drug "Biseptol" is effective for children with diseases of the gastrointestinal tract, such as paratyphoid, dysentery, chronic colitis. The drug is also prescribed for infectious lesions of the skin and soft tissues, including erysipelas, purulent folliculitis, acne, abscesses, furunculosis. Biseptol is known to be used in cholangitis, cholecystitis and toxoplasmosis.
The medicine "Biseptol for children", unlike the drug for adults, is available in special forms. These are tablets and suspension, where the active active substance contains 120 mg. The drug is prescribed to children only from the age of three months, and this applies only to tablets and suspensions. Injections of this drug are strictly prohibited for children under 6 years of age.
The drug "Biseptol for children" can not be taken in the treatment of babies suffering from hyperbilirubinemia. In addition, it is undesirable to assign this medicinal product children with impaired liver, severe diseases of cardio-vascular system and hematopoietic systems. Babies with thyroid disorders can use the medicine only under the supervision of a doctor.
Dosage of the drug
Children aged three to six months are prescribed a suspension of 120 milligrams in the morning and evening. Babies from 7 months to 3 years old can be prescribed from 120 to 240 milligrams also in the morning and at bedtime. For patients who are 4 to 6 years old, the suspension is prescribed at a dosage of 240 to 480 milligrams 2 times a day. Children aged 7 to 12 years are prescribed Biseptol for Children, 480 milligrams of suspension twice a day. Patients older than 12 may be prescribed 960 milligrams of suspension - this maximum dose. It is possible to prescribe this drug in the form of a syrup. It can be taken by children at least one year old. The dosage is saved.
It is not advisable to treat babies with this drug for less than four days. After all the manifestations of the disease have passed, it is recommended to take the medicine for another two days. But it should be noted that the duration of treatment is determined only by a qualified doctor.
When taking the drug "Biseptol", side effects such as vomiting, diarrhea, nausea, dizziness, headache. Usually, side effects are mild and stop shortly after the drug is discontinued. In case of an overdose, they may increase the above side effects.
If your baby was prescribed Biseptol, you need to adjust his diet. You should not give him a lot of green vegetables, cabbage, beans, peas, carrots and tomatoes, as the medicine complicates the work of the intestines and kidneys. In addition, during treatment, long exposure to the sun is undesirable. If a child takes this drug for a long time, a general blood test should be taken periodically, as it can affect In no case should the baby be treated without consulting doctors, since Biseptol for Children is a fairly strong and serious drug some European countries are not assigned to children under 12 at all. It will be useful to support the child's body during treatment with vitamin biologically active additives that are approved by the doctor.
A serious drug is Biseptol for Children. Reviews about him are both positive and negative. He helps kids a lot various infections, but possible side effects, burden on the liver and kidneys, strong allergic reactions. The drug has been known for a long time, tested, but there are more gentle analogues.
Akrikhin KhPK (Russia), Ortat/Pabyanitsky Pharmaceutical Plant Polfa (Poland), Pabyanitsky Pharmaceutical Plant Polfa (Poland)
pharmachologic effect
Antibacterial a wide range, bactericidal, antiprotozoal.
Active against a number of gram-positive (Staphylococcus spp., Streptococcus spp., Listeria monocytogenes, Nocardia asteroides) and gram-negative (Enterobacteriaceae - Shigella spp., Klebsiella spp., Proteus spp., Yersinia spp.; Haemophilus ducreyi, some strains of H.influenzae, Legionella pneumophila, Bordetella pertussis, Brucella spp., Salmonella spp., Enterobacter spp., some strains of Escherichia coli, Vibrio cholerae, Citrobacter spp., Neisseria spp.) microorganisms, as well as Moraxella catarrhalis, Pneumocystis carinii, Toxoplasma gondii, incl. h. resistant to sulfonamides.
The mechanism of action is due to a double blocking effect on the metabolism of bacteria.
Sulfamethoxazole, similar in structure to PABA, is captured by the microbial cell and prevents the incorporation of PABA into the dihydrofolic acid molecule.
Trimethoprim reversibly inhibits bacterial dihydrofolate reductase, disrupts the synthesis of tetrahydrofolic acid from dihydrofolic acid, the formation of purine and pyrimidine bases, nucleic acids; inhibits the growth and reproduction of microorganisms.
Both components are quickly and almost completely absorbed in the gastrointestinal tract.
The maximum concentration in the blood is reached after 1-4 hours, the antibacterial concentration persists for 7 hours.
Both substances are biotransformed in the liver with the formation of inactive metabolites.
They are evenly distributed in the body, pass through histohematic barriers, create concentrations in the lungs and urine that exceed those in plasma.
To a lesser extent accumulate in bronchial secretions, vaginal discharge, secretion and prostate tissue, middle ear fluid, cerebrospinal fluid, bile, bones, saliva, aqueous humor of the eye, breast milk, interstitial fluid.
They have the same elimination rate, the half-life is 10-11 hours.
In children, the elimination half-life is significantly shorter and depends on age.
Excreted by the kidneys in the form of metabolites and unchanged.
Side effects Biseptol
From the digestive tract:
- dyspepsia,
- nausea,
- vomiting,
- anorexic,
- rarely - cholestatic and necrotizing hepatitis,
- increased transaminases and bilirubin,
- pseudomembranous enterocoli,
- pancreati,
- stomat,
- glossitis.
From the side of the hematopoietic organs:
- agranulocyto,
- aplastic anemia,
- thrombocytopenia,
- hemolytic anemia,
- megaloblastic anemia,
- hypoprothrombinemia,
- methemoglobinemia,
- eosinophilia.
From the urinary system:
- crystalluri,
- kidney failure,
- interstitial nephri,
- increased plasma creatinine,
- toxic nephropathy with oliguria and anuria.
Allergic reactions:
- hives,
- toxic epidermal necrolysis (Lyell's syndrome,
- stevens-johnson syndrome,
- allergic myocardi,
- erythema multiforme,
- exfoliative dermatitis,
- edema Quink,
- redness of the sclera,
- increase in body temperature.
Others:
- hyperkalemia,
- hyponatremia,
- aseptic meninges,
- peripheral neuritis,
- headache,
- depression,
- arthralgia,
- myalgi,
- weakness,
- photosensitivity.
Indications for use
infections respiratory tract:
- bronchitis (acute and chronic, prevention of relapses), bronchiectasis, pleural empyema, lung abscess, pneumonia (treatment and prevention), incl. caused by Pneumocystis carinii in AIDS patients;
- urinary tract: urethritis, cystitis, pyelitis, pyelonephritis, prostatitis, epididymitis;
- urogenital: gonorrhea, chancre, venereal lymphogranuloma, inguinal granuloma;
- Gastrointestinal tract: bacterial diarrhea, shigellosis, cholera (as part of combination therapy), typhoid fever and paratyphoid fever (including bacteriocarrier), cholecystitis, cholangitis, gastroenteritis caused by enterotoxic strains of E. coli; skin and soft tissues: acne, furunculosis, pyoderma, erysipelas, wound infections, soft tissue abscesses;
- ENT organs: otitis media, sinusitis, laryngitis;
- surgical;
- septicemia, meningitis, osteomyelitis (acute and chronic), brain abscess, acute brucellosis, South American blastomycosis, malaria (Plasmodium falciparum), toxoplasmosis and whooping cough (as part of complex therapy).
Contraindications Biseptol
Hypersensitivity (including to sulfonamides or trimethoprim), hepatic or kidney failure, B12 deficiency anemia, agranulocytosis, leukopenia, glucose-6-phosphate dehydrogenase deficiency, pregnancy, lactation, childhood(up to 2 months - for oral administration, up to 6 years - for parenteral administration), hyperbilirubinemia in children.
Method of application and dosage
Inside, after eating, with a sufficient amount of liquid.
The dose is set individually.
Children:
- from 2 to 5 years - 240 mg 2 times a day;
- from 6 to 12 years - 480 mg 2 times a day.
With pneumonia - 100 mg / kg / day (based on sulfamethoxazole), the interval between doses is 6 hours, the course is 14 days.
With gonorrhea - 2000 mg (calculated as sulfamethoxazole) 2 times a day with an interval of 12 hours.
Adults and children over 12 years of age:
- 960 mg 2 times a day,
- with long-term therapy - 480 mg 2 times a day.
The course of treatment is 5-14 days, with severe course and/or when chronic form diseases, a single dose can be increased by 30-50%.
If the course of treatment exceeds 5 days and / or an increase in dose is necessary, therapy should be carried out under hematological control; when the blood picture changes, it is necessary to prescribe folic acid at a dose of 5-10 mg / day.
Overdose
Symptoms:
- anorexic,
- nausea,
- vomiting,
- weakness,
- stomach pain,
- headache,
- drowsiness,
- hematuria and crystalluria.
Treatment:
- gastric lavage,
- fluid injection,
- correction of electrolyte disturbances.
If necessary - hemodialysis.
Chronic overdose is characterized by depression bone marrow(pancytopenia).
Treatment and prevention:
- the appointment of folic acid (5-15 mg daily).
Interaction
NSAIDs, antidiabetic drugs (sulfonylurea derivatives), diphenin, indirect anticoagulants, thiazide diuretics, barbiturates enhance therapeutic (and side) effects (displace from the connection with plasma proteins and increase the concentration in the blood), anestezin and novocaine - reduce (because PABA is formed as a result of their hydrolysis).
Hexamethylenetetramine (urotropine), vitamin C increase crystalluria (cause acidification of urine).
Increases the effect of phenytoin, difenin, warfarin.
Reduces the reliability of oral contraception (inhibits the intestinal microflora and reduces the enterohepatic circulation of hormonal compounds).
Pyrimethamine increases the chance of megaloblastic anemia.
special instructions
Patients with impaired renal function should adjust the dose depending on creatinine clearance.
Use with caution in case of a possible deficiency of folic acid, aggravated allergic history, bronchial asthma, disorders of the liver and thyroid gland.
If a rash, cough, arthralgia, and other symptoms appear, the intake should be stopped immediately.
Long-term administration is carried out with systematic monitoring cellular composition peripheral blood, functional state liver and kidneys.
Excessive sun and UV exposure should be avoided.
The risk of side effects is much higher in AIDS patients.
The simultaneous administration of folic acid to HIV-infected patients increases the likelihood of developing resistance to sulfonamides in strains of Pneumocystis carinii.
Storage conditions
List B.
In a place protected from light, at room temperature.
Questions about the use of various medicines Children always have a lot of questions. After all, not in all situations it is permissible to use them in babies. For example, quite often parents are interested in whether Biseptol is harmful to children.
"Biseptol" in its effect is a drug for the destruction of pathogens in the form of bacteria. However, it does not belong to the category of antibiotics at all. It consists of two active component: sulfamethoxazole and trimethoprim. They act on pathogens in the following way - they destroy bacterial cells and prevent their reproduction. This drug as a result of various conducted clinical research showed its high efficiency against bacteria such as staphylococci, streptococci, salmonella, listeria and microbacteria. 
Most often, such a drug is recommended to be used when various reasons usage strong means– different antibiotics – impossible. Therefore, parents quite often turn to Biseptol in order not to feed their child with antibiotics. The main thing is to correctly follow the instructions for use for children for Biseptol.
Naturally, it should be remembered that such a remedy still belongs to the category of potent, so it is not intended for self-treatment. Its use, especially in children, must be approved by a doctor.
When this drug is prescribed: subtleties and nuances
This drug indicates that it is successfully used to get rid of a number of pathologies. And they are not always in the same category. So, for example, "Biseptol" is often prescribed when:
- various respiratory diseases, which include such serious problems as pneumonia, bronchitis, etc.
- angina;
- sinusitis;
- otitis;
- various infections caused by intestinal pathogens;
- infectious and inflammatory processes formed in the excretory system;
- skin infections.
The composition and form of release of this drug
In order to better understand the principle of operation this drug worth looking at its name. Just as it is translated from Latin directly says that there are 2 components that fight the processes of decay and inflammation.
Modern pharmaceuticals offers several forms of release at once:
- tablets for adults;
- tablets for children;
- suspension for children;
- ampoules.
Tablets for children are usually prescribed rarely. After all, only adult children can take such variants of the drug correctly and adequately. The most commonly used suspension. Remember that for "Biseptol" suspension, instructions for use for children should be followed as accurately as possible. It is a more pleasant-tasting medicine, which, moreover, is more convenient to swallow.
Ampoules are most often used in a hospital or are used to prepare medicinal solutions.
What are the usual dosages for children
This drug is allowed to be used in children aged 6 weeks of life, i.e. from 1.5 months. Naturally, for such crumbs, only a suspension is prescribed, because. They still don't know how to swallow pills. The instructions usually include detailed diagram taking the drug. The standard dosage for babies is 5 ml - this is translated into ordinary dishes as an ordinary teaspoon. You can give the drug once both in the morning and in the evening - in this situation, this does not play any critical role.
In the event that it is already possible to agree with yours, i.e. he is already quite old, he was prescribed a tablet form of the drug, it is worth giving it like this:
- children under 5 years old, 2 tablets at a dosage of 120 mg twice;
- schoolchildren under 12 years old use a dosage of 480 mg a couple of times a day - this is one tablet in the appropriate dosage;
- children from 12 years of age should take 2 tablets with a dosage of 480 g twice a day.
How long the treatment will take is determined in each case, taking into account various indications. Treatment courses, even according to average estimates, can take from 5 to 14 days.
What are the rules for taking the drug in the form of a suspension
If there are usually no questions about taking pills, then with the Biseptol suspension, everything is far from always 100% obvious. So, for example, in the description of the drug and methods of its use, it is usually indicated that it is necessary to shake the agent before use. But only in reality, rarely does anyone really follow the instructions. And this is necessary. After all, any suspension consists of at least 2 parts: liquid and powder. When settling, they separate and active substance appears at the bottom. And if you take the drug without shaking, you can get a placebo effect when you just drank some water. The medicine at this moment remained at the bottom.
Due to the fact that doctors, counting on children, create a drug in liquid form with a sweet taste, kids like it. And it is advised to keep it out of the reach of children. Otherwise, there is a risk of overdose, the results of which will be simply unpredictable.
Rules for taking the drug: what should be strictly observed
Although Biseptol is not an antibiotic in the full sense of the word, you need to drink it correctly to get the desired effect. So, a 12-hour break in taking the medicine is mandatory, so you need to choose your time so that this gap remains unchanged.
It is also worth remembering that Biseptol is recommended to be given to children only after meals. Otherwise, you greatly risk the health of your baby, because this leads to the development serious problems with the stomach, because the drug, getting on the mucous membrane, irritates it.
Must be kept full course treatment. Only in this way can the effect be achieved. Therefore, do not limit yourself to three days when five is shown, even if there are noticeable improvements.
Many people consider Biseptol. In fact, it does not belong to this group of drugs, but is a drug to combat a variety of harmful bacteria. Inflammation of the respiratory system, intestinal and other bacterial infections may be indications for the use of Biseptol for
Composition and pharmacological properties
Biseptol belongs to the sulfanilamide group bacterial preparations, but has an effect even on bacteria resistant to sulfonamides. This is because it includes two components that enhance each other's action. These are trimethoprim and sulfamethoxazole, with the latter in the composition five times more. This combination is also called co-trimoxazole. In such proportions, they perfectly destroy gram-positive and gram-negative bacteria and microorganisms. Substances in turn block the metabolism in the cells of microbes and they die. First, sulfamethoxazole prevents the synthesis of dihydrofolic acid, and trimethoprim prevents it from turning into tetrahydrofolic acid. It is the latter that is necessary for the development of bacteria.
From the action of Biseptol, intestinal, dysentery and typhoid bacilli, salmonella, staphylococci, streptococci and other harmful microorganisms die. He does not provide antiviral action, does not kill anaerobic and mycobacteria. The drug has a systemic effect, that is, it is absorbed into the blood fairly quickly. Its maximum amount is reached within three hours, and the action lasts seven. After that, it is excreted in the urine during the day.
In a milliliter of suspension, sulfamethoxazole is 40 mg, and trimethoprim is five times less, that is, 8 mg. Excipients, which are included, are common for syrup. Among them are polypropylene glycol, citric acid, strawberry flavor, water. In addition to the suspension, there is also a tablet form of the drug, but it is prescribed only for adults and children after twelve years of age.
Did you know? Doctors have calculated that there are now about 1,400 independent infectious diseases.
Indications for use
From 6 months to 3 years
For children after six months and up to three years, the attending physician may increase the dose of the drug from 2.5 to 5 ml. You need to take it the same way, after twelve hours.
3-6 years old
From the age of three to six years, 5 to 10 ml of the drug is prescribed every half a day.
6-12 years old
After six years and up to twelve, the maximum single dose of Biseptol is 10 ml with the same intake frequency.
Over 12 years old
After twelve years, you can take not 20 ml of the drug twice a day. The doctor, observing a sick child, decides how many days to give the child Biseptol. As a rule, the course of treatment lasts from five to seven days with acute forms infections.
Precautionary measures
The drug should be used with caution if there are diseases of the liver, kidneys, hematopoietic system and asthma. If any reactions occur in the form of a rash or blisters on the skin, you should immediately stop taking the medicine and consult a doctor. This may be a symptom of Steven-Johnson syndrome. While taking Biseptol, it is necessary to do laboratory and monitor indicators.
Did you know? After using penicillin, Australian Ashley Morris developed an allergy to water. This is the only case in the world.
Carefully need to take the drug along with other medicines. With simultaneous use with hypoglycemic agents, warfarin and phenytoin, their effect is enhanced. If you take Biseptol with diuretics, then the risk of bleeding increases. It is necessary to strictly observe the dosage of the drug.
Contraindications and side effects
There are contraindications when taking Biseptol suspension, namely:
- individual intolerance to any component of the drug;
- serious violations of the kidneys and liver;
- serious diseases of the heart and blood vessels;
- anemia;
- very low maintenance in the blood glucose-6-phosphate dehydrogenase;
- violations of the function of blood formation;
- the drug is contraindicated in combination with dofetilide;
- should not be taken by children under three months of age.
For many years, Biseptol suspension has been a proven and reliable tool in the fight against various childhood infections. It must be remembered that the instructions for use are informative in nature and only a doctor can prescribe the dose and time of taking the drug. T Since the medicine has a pleasant taste, it must be kept out of the reach of children.