Xilen 0.1 instructions for use. Vasoconstrictor nasal drops xylene and features of their use

03.03.2020 -

Xilen (spray form) belongs to the category of drugs for the treatment of nasal diseases. In the instructions for use, the following features of the drug are distinguished:

During pregnancy: with caution
When breastfeeding: with caution
In childhood: with caution

Package

Active ingredient - xylometazoline. Xylen - pharmacological drug based vasoconstrictor substances used to treat the common cold.

Composition and form of release

According to the instructions Xilen is available in the form of nasal drops.

Except active ingredient nasal drops also contain auxiliary components: benzalkonium chloride, disodium edetate, sodium hydrogen phosphate dodecahydrate, potassium dihydrogen phosphate, sodium chloride, water.

Xylene solution is produced in concentrations of 0.1% and 0.05%. In a plastic bottle (or glass) 10 ml of this drug.

Pharmacological action of Xylene

According to the instructions, Xilen has a decongestant effect due to the provision of a local vasoconstrictor effect. With narrowing of the blood vessels of the nasal mucosa, edema and hyperemia decrease, and the patency of the nasal passages is restored, which facilitates nasal breathing and relieves nasal congestion. Xylen begins to have an effect almost immediately after application, the effect lasts up to 10 hours.

Since the drug is used topically, it is practically not absorbed into the blood. Modern methods it is not possible to detect its concentration in the blood after application.

Indications for use

Xylene is used for acute rhinitis caused by viral respiratory infections. Also, the drug is indicated for acute allergic rhinitis, sinusitis, otitis media (as part of complex treatment in order to reduce swelling of the mucous membrane of the nasopharynx). Xylen is used before rhinoscopy ( endoscopic method examination of the nasal passages and nasopharynx).

Contraindications

This drug is contraindicated in case of hypersensitivity to its components, with severe atherosclerosis, arterial hypertension, tachycardia and glaucoma.

Xylene is contraindicated in patients with atrophic rhinitis, as well as in patients who have a history of surgical operations on the meninges. Children under 6 years of age are contraindicated to use a 0.1% solution of this drug, a special children's dosage (0.05% solution) should be used.

Xylen should be used with extreme caution in patients with diabetes mellitus, hyperplasia prostate, hyperthyroidism, and coronary heart disease. If there are contraindications to Xylen, do not use it alone. this drug, talk to your doctor about treatment with similar medicines.

Side effect

With prolonged (or too frequent) use of Xylen, dryness, irritation of the nasopharyngeal mucosa may occur (this may be manifested by sneezing, burning, mucus hypersecretion). Rarely, vomiting may occur headache, palpitations, tachycardia, increased blood pressure, arrhythmia, visual impairment, insomnia, depression. For the occurrence of such side effects, the use of Xylen should be long-term and in excess doses.

The use of Xylen during pregnancy and lactation

The use of Xylen during pregnancy, as well as during breastfeeding, is not recommended. The drug itself does not have a negative effect on the fetus, but it can affect the blood pressure of a pregnant woman, as well as the vascular tone of the placenta.

Dosage and administration

Xilen should be instilled into each nasal passage (after preliminary cleansing) 1-2 drops of a 0.1% solution (for adults and children over the years) no more than 2-3 times a day.

children infancy and children under 6 years of age are recommended to use a 0.05% solution of Xylene, 1-2 drops in each nasal passage once / twice a day.

This drug should not be used more than 3 times a day and for more than 5 days.

Xylen overdose

In case of an overdose, the above symptoms of side effects occur. Treatment is aimed at stopping the use of the drug and eliminating the symptoms that have arisen.

P N002372/01-160709

Tradename: Xylen®

international generic name(INN): xylometazoline

Dosage form:

nasal drops

Compound:

1 ml of solution contains:
active substance: xylometazoline hydrochloride - 0.0005 g or 0.001 g;
Excipients: benzalkonium chloride (in terms of anhydrous), disodium edetate (trilon B), potassium dihydrogen phosphate, sodium hydrogen phosphate dodecahydrate, sodium chloride, purified water.

Description: colorless or slightly colored transparent liquid.

Pharmacotherapeutic group:

anticongestive agent alpha-adrenergic agonist.

ATX code:

Pharmacological properties:

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenergic activity, causes constriction of the blood vessels of the nasal mucosa, thus eliminating swelling and hyperemia of the nasal mucosa, restores the patency of the nasal passages, facilitates nasal breathing. The effect of the drug occurs a few minutes after its use and lasts up to 10 hours.

Pharmacokinetics: At topical application the drug is practically not absorbed, so its concentration in blood plasma is very low (modern analytical methods not defined).

Indications for use:

Used for acute respiratory diseases with the phenomena of rhinitis (runny nose), acute allergic rhinitis, sinusitis, with otitis media (as part of combination therapy to reduce swelling of the nasopharyngeal mucosa), to facilitate rhinoscopy.

Contraindications:

Hypersensitivity to xylometazoline and other components of the drug, arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, surgical interventions on the meninges (in history), pregnancy, lactation, childhood up to 6 years - for a 0.1% solution (0.001 g / ml).

Carefully: ischemic disease heart (angina pectoris), diabetes mellitus, prostatic hyperplasia, hyperthyroidism, children under 2 years of age - for a 0.05% solution (0.0005 g / ml).

Dosage and administration:

Adults and children over 6 years of age are injected with 1-2 drops of a 0.1% solution of xylometazoline in each nasal passage 2-3 times a day. For infants and children under the age of 6 years, a 0.05% solution of 1-2 drops is used in each nasal passage 1-2 times a day. Do not use the drug more than 3 times a day and no more than 3-5 days. Do not use the drug without interruption for more than 3-5 days.

Side effects:
With frequent and/or long-term use- irritation and / or dryness of the mucous membrane of the nasopharynx, burning, paresthesia, sneezing, hypersecretion; rarely - swelling of the nasal mucosa, vomiting, headache, palpitations, increased blood pressure, tachycardia, arrhythmia, insomnia, visual impairment, depression (with prolonged use of high doses).

Overdose:

Symptoms: increased side effects.
Treatment: symptomatic under medical supervision.

Interaction with other drugs:

Incompatible with monoamine oxidase inhibitors (MAO) and tricyclic antidepressants.

Special instructions:

Before use, clean the nasal passages. Should not be used for a long time, for example, when chronic rhinitis. Missed dose: use immediately within 1 hour, do not use after 1 hour; do not double the dose.

Impact on ability to drive vehicle or equipment:
Xylometazoline, in dosages exceeding the recommended ones, can affect the ability to drive a vehicle and engage in other potentially hazardous activities that require concentration and psychomotor speed.

Release form:

Nasal drops 0.0005 g/ml (0.05%) and 0.001 g/ml (0.1%). 10 ml in colorless or light-protective glass bottles, or polymer dropper bottles. Each bottle, along with instructions for use in a pack of cardboard. It is allowed to put pipettes or dropper caps into the pack.

Storage conditions:

In a dry, dark place at a temperature not exceeding 25 ° C.
Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date.

Conditions for dispensing from pharmacies:

Over the counter.

Manufacturer:

OOO LENS-Pharm, a subsidiary of JSC Veropharm

Legal address: 143000. Moscow region, Odintsovo district, pos. Gorki-X, 30a

Address of production and acceptance of claims: 601125. Vladimir region. Petushinsky district. settlement Volginsky, building 95, building 67
or 308013 Belgorod, st. Working, d. 14

Some facts about the product:

Instructions for use

Price in the online pharmacy site: from 29

Pharmacological properties

Xilen is a drug that is characterized by vasoconstrictive qualities. Means of local use. It is prescribed for the treatment of rhinitis and other organs of the ENT biosystem. The product belongs to the group medicinal products that contain xylometazoline. The substance has a pronounced effect. If the material gets on the pituitary surface of the body, then there is a narrowing of the vascular structures. Thus, swelling and hyperemia are reduced. With the development of symptoms of a runny nose, the medicine optimizes the respiratory processes.

When the drug enters the site of the lesion, the absorption process is practically not recorded. As studies show, the amount of the drug in the blood plasma is minimal. It is so low that it is very difficult to determine the amount of material in the plasma of the blood substance.

The composition and packaging of the release

Xylene contains the substance xylometazoline in the form of a hydrochloride compound and auxiliary materials. The pharmaceutical product is produced in the form of a nasal spray.

Indications for use

The drug is prescribed to narrow the blood vascular structures of the pituitary membranes of the nasal cavity. The tool is effective in restoring respiratory processes, eliminating hyperemia, swelling. The appointment has the right to prescribe a highly qualified expert. Only he is able to study the results medical examination to conduct a thorough examination and determine exact dosage medicine Xylen. It is worth noting that the effect of the therapeutic substance occurs almost immediately. Therefore, the patient will quickly feel relief. In this case, the duration of exposure continues for many hours. The remedy is prescribed for the development of eustachitis, sinusitis, otitis media, respiratory pathologies with manifestations various kinds runny nose. Sometimes the product is administered to diagnose a particular pathology that has arisen in the nasal pathology.

International Classification of Diseases (ICD-10)

H66 Otitis media purulent type unspecified; J00 Acute nasopharyngitis; J01 Acute sinusitis; J30 Rhinitis of vasomotor and allergic type; J31 Chronic rhinitis, nasopharyngitis and pharyngitis; J999* Diagnosis of pathologies of the respiratory system.

Side effects

Before using the product, it is recommended to consult a doctor. After all, non-compliance with certain rules can cause accidental signs in the form of dry skin, paresthesia, irritation of the membrane, increased runny nose, reddening of the cavity. If the patient has found similar or other painful symptoms then he should stop using the substance immediately. Known cases of tachycardia, arrhythmia, depression, dysfunction visual perception, improving performance blood pressure, gag reflexes, insomnia.

Contraindications

Instructions for use of the drug stipulates contraindications for its use. Their list includes hyperthyroidism, atrophic-type rhinitis, high blood pressure, severe atherosclerosis, glaucoma, increased sensitivity to certain pharmaceutical ingredients, and tachycardia. If the patient's medical history contains an item on surgical interventions on a part of the brain, or the patient is in a position, the remedy is not prescribed. The same applies to women who are breastfeeding. The drug is actively used in pediatrics. However, the doctor must take into account the dosage of the drug. With special care, a remedy is prescribed for the development of diabetic pathology, prostatic hyperplasia, angina pectoris.

Application during pregnancy

According to the results of studies, Xylen can harm the development of a child in the womb. Therefore, it is dangerous to administer the drug during pregnancy. If there is a need to use the medicine during breastfeeding, then it should be stopped immediately and the baby should be transferred to artificial nutrition.

Method and features of use

The main component of the drug leads to a narrowing of the vascular structures of the circulatory biosystem. Therefore, the patient almost immediately feels relief - swelling and redness disappear, air passes through the nasal cavities easily. Thus, the quality of human life is improved. The patient should remember that frequent injection of the drug leads to the opposite effect - the pituitary surface swells even more, a headache occurs. Xilen is prescribed for the treatment of various types of rhinitis, pollinosis, sinusitis. The medical specialist will tell you about the possibility of introducing the material. Only he, on the basis of a medical examination, an analysis of the individual characteristics of a person, the course of the course of the disease, is able to determine the rate and duration of the use of the substance. Before you begin the procedure, you should carefully prepare the nasal passages. To do this, they are cleaned of mucus and other layers. This will help the agent to quickly absorb into the tissues and eliminate negative symptoms. How much to inject substances in one procedure, the doctor knows. The patient must remember that the interval between manipulations should be at least 8 hours. Otherwise, all symptoms may increase, which will cause a deterioration in the person's condition. The duration of the therapeutic effect should not exceed 5 days. The same applies to analogues of vasoconstrictor drugs. After them, it is allowed to use pharmaceutical products on a natural basis. They are not considered aggressive drugs and have a gentle effect on the human body. The dosage of the substance should be strictly monitored. Doubling it is not allowed. Therefore, if after using the drug the patient does not experience any improvement, then you should immediately stop administering the drug and consult a doctor. Only he has the right to change the treatment regimen, taking into account individual characteristics person. In addition to the spray, drug manufacturers offer drops. They are assigned to children only from 2 years. In this case, the dosage at this age and up to 6 years should not exceed 1-2 drops of a 0.05% solution. Older minors and adult patients can administer Xilen 2 times more. Another form of medicine is known - gel. It also applies to nasal pharmaceutical products. The main feature of the substance is the ability to qualitatively and painlessly remove crusts from the nose. The gel is injected into the cavity several times in 24 hours. It is forbidden to use the medicine for children under 7 years of age. How to use all forms of medicine for people with dysfunctions of the kidneys and liver, after 65 years, the doctor will indicate.

Interaction with other drugs

The agent may react with other medicines. So, it is known that it cannot be combined with tricyclic antidepressants. The same goes for monoamine oxidase inhibitors. Before using the remedy, the patient must report all the drugs that he is currently taking. This will prevent the development of accidental signs, complications, parallel pathologies.

Overdose

With the introduction of Xylene for long period spasms occur depression, tachycardia, changes in blood pressure. For accidental use significant amount substance must be taken to the hospital immediately. There is no specific antidote. However, medical specialists recommend post-syndromic treatment, which will restore the normal functioning of the heart and blood vessels.

Analogues

The list of alternative medicines includes - Dlyanos, Rinon, Galazolin, Xymelin and other means. An experienced doctor can pick up an analogue.

Terms of sale

The medicine is sold by prescription only.

Storage conditions

The product must be in special place where there is no access for minors and sunbeams. Temperature regime - 15-20°C. Shelf life - 3 years. After its expiration, the disposal of Xylene will certainly follow.

Other synonyms: Brizolin, Grippostad Rino, Doctor Theiss, Asterisk NOZ (spray), Influrin, Xylobene, Nosolin, Olint, Rinomaris, Suprima-NOZ, Farmazolin, Espazolin.

Price

average price online*, 72 p. (0.05% fl-cap 10ml)

Where can I buy:

Instructions for use

Xylene - nasal drops based on xylometazoline. The drug has a vasoconstrictive effect and facilitates breathing through the nose. Suitable for the treatment of newborns.

Indications

Xylen nasal drops are used to restore nasal breathing in case of:

ARI with a runny nose;
acute allergic rhinitis;
sinusitis;
otitis media ( additional remedy to reduce swelling of the nasopharyngeal mucosa).

Also, the drug is used in preparation for rhinoscopy to facilitate the procedure.

Dosage and administration

Xylene is used intranasally - injected into the nasal passages. Before instillation of the drug, the nostrils must be thoroughly cleaned of mucus.

Dosage for children over 6 years of age and adults: 1-2 drops of a 0.1% solution in each nostril 2-3 times a day.

For children under 6 years of age (including infants): 1-2 drops of a 0.05% solution in each nostril 1-2 times a day.

The maximum duration of treatment is 5 days. Then you need to take a break, after which you can continue therapy.

Contraindications

Absolute contraindications for the use of Xylen:

intolerance to xylometazoline or other components of the drug;
hypertension;
severe atherosclerosis;
glaucoma;
atrophic rhinitis (dry);
tachycardia;
previously transferred operations on the membranes of the brain.

With caution, the drug should be used when:

angina;
diabetes;
hyperthyroidism;
prostate hyperplasia.

For the treatment of children under 6 years of age, it is forbidden to use drops at a concentration of 0.1%, they can only instill a 0.05% solution into their nose.

Pregnancy and lactation

It is forbidden to use the drug for pregnant and lactating women. The doctor may prescribe Xilen to his patient, but first he must conduct an examination and correlate possible benefit for the mother with risks to the fetus and child.

Overdose

With an overdose of the drug, side effects are exacerbated. In such cases, you should immediately stop using the drops and consult a doctor for symptomatic treatment.

Side effects

With frequent and / or prolonged use of the drug increases the risk of developing side effects.

Among them:

irritation, dryness and burning of the nasal mucosa;
sneezing
increase in the amount of allocated secret;
paresthesia.

With prolonged use of high doses of the drug in rare cases, there are:

swelling of the nasal mucosa;
vomit;
headache;
tachycardia;
feeling of heartbeat;
insomnia;
visual disturbances;
high blood pressure;
depression.

Composition and form of release

The drug is available in the form of nasal drops. In appearance it is a clear liquid, colorless or slightly colored. Drops are sold in 10 ml bottles with a dropper cap.

Active substance drug - xylometazoline at a concentration of 0.1% or 0.05%.

Auxiliary components: benzalkonium chloride, disodium edetate (trilon B), potassium dihydrogen phosphate, sodium chloride, sodium hydrogen phosphate dodecahydrate, water for injection.

Pharmacology and pharmacokinetics

The action of Xylen is based on xylometazoline, a local vasoconstrictor with alpha-adrenergic activity.

The drug constricts the vessels of the nasal mucosa. As a result, its edema and hyperemia are eliminated, the patency of the nasal passages is restored and breathing is facilitated.

The medicine begins to act within a few minutes after it is injected into the nostrils. The duration of the effect is up to 10 hours.

With topical application of Xylen, its absorption is minimal. Therefore, the concentration of xylometazoline in the blood is achieved insignificant.

Interaction with other drugs

special instructions

High doses of xylometazoline can reduce the speed of psychomotor reactions and impair concentration. In such cases, it is not recommended to drive and perform work associated with a danger to life.

Shelf life

Storage conditions

Xylen should be stored in a dark place at temperatures up to +25 degrees. Keep away from children.

Xylene (active substance - xylometazoline) is a local vasoconstrictor from the group of alpha-adrenergic agonists for use in otolaryngological practice to facilitate nasal breathing. The nose, along with the throat, actually acts as an entry gate for the infection to enter the body. It is the nasal cavity that is the very " Brest fortress”, which takes on the main viral-bacterial “artillery” strike. In this regard, one of the most topical issues in the autumn-winter period, relief of cold symptoms and an increase in the quality of life should be considered if the infection has not bypassed you. The reason for the surge of acute respiratory infections there are a number of factors, including the accumulation of "sneezing-coughing" human masses in enclosed spaces, hypothermia, seasonal weakening of the immune system, the functioning of the heating system, etc. So, central heating contributes to a catastrophic decrease in humidity, as a result of which the mucous membrane of the nasal cavity dries up, its blood supply worsens and makes it more vulnerable to viral and bacterial infections. All this greatly increases the chances of pathogenic microorganisms to safely bypass the mucous membrane of the nasal cavity and oropharynx and systemically penetrate the body. First alarm bells of the infection that has occurred are rhinorrhea, swelling of the nasal mucosa and difficulty in nasal breathing - in other words, everything that is popularly called the word runny nose, and in the international classifier of diseases - acute rhinitis. For all the trouble of its manifestation, it is necessary to indicate that with a runny nose and sneezing, the body is trying to protect itself from foreign particles. The secretion secreted by the mucous membrane contains such factors immune system like the enzyme lysozyme and leukocytes. They protect the body from viral and bacterial invasion. On the background developing disease the nasal mucosa is forced to work literally for wear and tear. The blood vessels dilate to allow the air in the nasal passages to warm more quickly and deliver the white blood cells to their destination.

As a result, edema of the mucous membrane develops, which causes the very difficulty breathing characteristic of the common cold. To more effectively remove foreign agents, mucus production increases significantly. So, during rhinitis, the mucous membrane of the human nasal cavity is capable of producing about 1.5 liters of mucus per day. However, it is obvious that sitting with folded arms, when it pours from your nose like a bucket, and you can only breathe through your mouth, is quite difficult. In this regard, the pharmacological industry has created a huge number of drugs that can stop cold symptoms and facilitate nasal breathing. One of these medicines is a domestic anticongestive drug xylene. When it enters the mucous membrane of the nasal cavity, it causes vasoconstriction, as a result of which the blood flow to the inflamed areas decreases and the edema resolves. When applied topically, xylene is practically not absorbed into the systemic circulation, which minimizes it. side effects. Moreover, the concentrations of xylometazoline - the active substance of the drug - are so small that they cannot be determined by modern analytical methods.

Xylen is available in two dosage forms: nasal drops and spray. The duration of use of the drug is on average from 7 to 14 days. The specific therapeutic dose is determined by the currently used dosage form and the age of the patient. Xylene should be used with caution in children under 2 years of age. The same applies to pregnant or lactating women, who should only use the drug if the expected benefit to the mother outweighs potential risks for a child or fetus. The drug is not recommended to be taken for a long period of time, for example, when rhinitis has turned into chronic form. Xylene is incompatible with monoamine oxidase inhibitors and tricyclic antidepressants.

Pharmacology

Vasoconstrictor for topical use in ENT practice. Alpha adrenomimetic. When applied to mucous membranes, it causes vasoconstriction, as a result of which local hyperemia and edema decrease. With rhinitis, it facilitates nasal breathing.

Pharmacokinetics

When applied topically, it is practically not absorbed, plasma concentrations are so small that they cannot be determined by modern analytical methods.

Release form

10 ml - polymer bottles (1) - packs of cardboard.

Dosage

Apply topically for 7-14 days. The dose depends on the dosage form and age of the patient.

Interaction

Incompatible with MAO inhibitors and tricyclic antidepressants.

Side effects

With frequent and / or prolonged use: irritation of the mucous membrane, burning, tingling, sneezing, dryness of the nasal mucosa, hypersecretion.

Rare: swelling of the nasal mucosa (more often with long-term use), palpitations, disturbances heart rate, increased blood pressure, headache, vomiting, sleep disorders, visual disturbances.

With prolonged use in high doses: depressive state.