Drugs for joint proposal.

Release form

pills

Indications for use

• for effective maintenance immune status body;
• for the prevention of colds and flu, reducing their duration;
• as aid for chronic inflammatory diseases(rheumatism, polyarthritis, prostatitis, gynecological disorders), exposure to radiation, taking chemotherapy drugs, long-term antibiotic therapy;
• to inhibit the growth and reproduction of streptococcus, staphylococcus, E. coli, influenza viruses, herpes, stomatitis.

2-3 weeks for adults, 2-3 tablets 3 times a day with meals, with plenty of water.

Side effects

Possible allergic reactions

Storage conditions

Store at a temperature not exceeding +25°C.

Special instructions

Vacation conditions

Over the counter

Action

Echinacea is a good immunomodulator. The range of its application is quite wide. It is often used when chronic diseases. Echinacea preparations have therapeutic effect at different pathological conditions by increasing the body's natural defenses. As a result of pharmacological studies, the stimulating effect of echinacea on immune system. This effect manifests itself not only in adults, but also in children with an unstable immune system, as well as in the elderly, in whom the functions of this system are reduced due to the general aging of the body.

Echinacea preparations are used for diseases associated with weakening functional state immune system caused by chronic inflammatory diseases, exposure to ionizing radiation, ultraviolet rays, chemotherapy drugs, long-term antibiotic therapy. When taking echinacea preparations associated with metabolic disorders ( diabetes mellitus, liver diseases), exposure to various chemical compounds of a toxic nature contained in the air and food (heavy metals, pesticides, insecticides, fungicides), stimulation of the immune system is observed.

Echinacea preparations also have antibacterial, antiviral and antimycotic properties. Echinacea preparations inhibit the growth and reproduction of streptococcus, staphylococcus, E. coli, influenza viruses, herpes, stomatitis, are effective in inflammatory diseases (rheumatism, polyarthritis, prostatitis, gynecological disorders), diseases of the upper respiratory tract, at different wound processes (trophic ulcers, osteomyelitis), microbial eczema.

Echinacea preparations are also used with for preventive purposes at the first sign of a cold, at long-term use antibiotics, improving the health of people who have been exposed to radiation or living in areas unfavorable in terms of radiation levels.

Echinacea is used for inflammatory processes and purulent infections skin, soft tissues, mucous membranes (furuncle, abscess, phlegmon, carbuncle, fistula, gingivitis, stomatitis, sinusitis, gastroenteritis, enterocolitis, colpitis, adnexitis, mastitis, cystitis, glomerulonephritis, etc.); septic conditions and toxic syndromes (osteomyelitis, sepsis, septicemia, secondary bacterial and viral infections, prolonged feverish conditions). Echinacea preparations are non-toxic. In large doses, salivation sometimes increases.

In modern medical practice echinacea is one of the most popular medicinal plants, used to treat viral and bacterial infections; V folk medicine its use has a long history.

It is known that healthy body has sufficient potential to combat most known infections. Often this does not require antibiotics or other unsafe medications; To do this, you just need to support and stimulate the body’s immune system in time.

If antibiotics or antivirals are still used, immunostimulation significantly increases their effectiveness, reducing the duration of the disease and the number of complications. Recent studies have shown that the high universal antiviral and antibacterial activity of Echinacea is due to its pronounced immunostimulating effect. It is noteworthy that under the influence of echinacea, stimulation of the immune system occurs even with in good condition the body's defenses, which allows not only to treat, but also to prevent many diseases. The immunostimulating effect of echinacea is manifested in an increase in the number and activity of immune leukocyte cells. The ability of leukocytes to actively absorb and digest bacteria under the influence of echinacea increases by 30-45%; in general, the immune response under the influence of echinacea increases by 50-120%. When taking echinacea, the level of specific antibodies that neutralize viruses and bacteria increases, and the production of a nonspecific antiviral compound, interferon, also increases.

Interferon is the most important “line of defense” of antiviral immunity. The immunostimulating and anti-inflammatory effect of Echinaceae is complemented by a pronounced detoxifying effect. This is due to improvement metabolic processes in the liver and kidneys, which process and eliminate various toxins, metabolic products, heavy metals and radionuclides. IN this drug The effectiveness of echinacea is significantly increased due to its combination with vitamin C, which has a powerful anti-inflammatory effect.

Vitamin C has a diverse positive effect on immunity and the course of infectious diseases. It harmoniously complements echinacea, further increasing the effectiveness of the drug.

Thanks to cryotreatment, "Echinacea P" preserves essential oils, glycosides, amides, antibiotic polyacytylenes, inulin. "Echinacea P" is rich in nutrients, including B vitamins, iron, necessary for the formation of red blood cells, calcium, necessary for strong bones and teeth, selenium, for the ability to resist disease, as well as silicon, necessary for the formation of tissues.

Compound

Echinacea purpurea herb powder 50 mg, vitamin C 10 mg, lactose.

Contraindications

Individual intolerance to components during pregnancy and breastfeeding

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Echinacea preparations are used for diseases associated with a weakened functional state of the immune system, caused by chronic inflammatory diseases, exposure to ionizing radiation, ultraviolet rays, chemotherapy drugs, and long-term antibiotic therapy. When taking echinacea preparations associated with metabolic disorders (diabetes mellitus, liver disease), exposure to various chemical compounds of a toxic nature contained in the air and food (heavy metals, pesticides, insecticides, fungicides), stimulation of the immune system is observed.

Echinacea preparations also have antibacterial, antiviral and antimycotic properties. Echinacea preparations inhibit the growth and reproduction of streptococcus, staphylococcus, E. coli, influenza viruses, herpes, stomatitis, are effective against inflammatory diseases (rheumatism, polyarthritis, prostatitis, gynecological disorders), diseases of the upper respiratory tract, and various wound processes (trophic ulcers, osteomyelitis) , microbial eczema.

Echinacea preparations are also used for prophylactic purposes at the first signs of a cold, during long-term use of antibiotics, and for improving the health of people who have been exposed to radiation or living in areas with unfavorable radiation levels.

Echinacea is used for inflammatory processes and purulent infections of the skin, soft tissues, mucous membranes (furuncle, abscess, phlegmon, carbuncle, fistula, gingivitis, stomatitis, sinusitis, gastroenteritis, enterocolitis, colpitis, adnexitis, mastitis, cystitis, glomerulonephritis, etc.) ; septic conditions and toxic syndromes (osteomyelitis, sepsis, septicemia, secondary bacterial and viral infections, prolonged febrile conditions). Echinacea preparations are non-toxic. In large doses, salivation sometimes increases.

In modern medical practice, Echinacea is one of the most popular medicinal plants used to treat viral and bacterial infections; in folk medicine its use has a long history.

It is known that a healthy body has sufficient potential to fight most known infections. Often this does not require antibiotics or other unsafe medications; To do this, you just need to support and stimulate the body’s immune system in time.

If antibiotics or antiviral agents are still used, then immunostimulation significantly increases their effectiveness, reducing the duration of the disease and the number of complications. Recent studies have shown that the high universal antiviral and antibacterial activity of Echinacea is due to its pronounced immunostimulating effect. It is noteworthy that under the influence of echinacea, stimulation of the immune system occurs even in the normal state of the body’s defenses, which makes it possible not only to treat, but also to prevent many diseases. The immunostimulating effect of echinacea is manifested in an increase in the number and activity of immune leukocyte cells. The ability of leukocytes to actively absorb and digest bacteria under the influence of echinacea increases by 30-45%; in general, the immune response under the influence of echinacea increases by 50-120%. When taking echinacea, the level of specific antibodies that neutralize viruses and bacteria increases, and the production of a nonspecific antiviral compound, interferon, also increases.

Interferon is the most important “line of defense” of antiviral immunity. The immunostimulating and anti-inflammatory effect of Echinaceae is complemented by a pronounced detoxifying effect. This occurs due to the improvement of metabolic processes in the liver and kidneys, which process and eliminate various toxins, metabolic products, heavy metals and radionuclides. In this preparation, the effectiveness of Echinacea is significantly increased due to its combination with vitamin C, which has a powerful anti-inflammatory effect.

Vitamin C has a diverse positive effect on immunity and the course of infectious diseases. It harmoniously complements echinacea, further increasing the effectiveness of the drug.

Thanks to cryo-treatment, "Echinacea P" preserves essential oils, glycosides, amides, antibiotic polyacytylenes, and inulin. Echinacea P is rich in nutrients including B vitamins, iron for the formation of red blood cells, calcium for strong bones and teeth, selenium for the ability to resist disease, and silicon for tissue formation.

Discount coupon code: 45982857

Enter the code for this coupon on the checkout page in the field Coupon and receive an additional 10% discount on the order value.

Dietary supplement NOT A MEDICINE
* Dietary supplements are not medicines and can only be used to prevent certain types of diseases and maintain the functional activity of organs, as well as as an adjuvant in complex therapy a number of diseases.

Components of the drug "Echinacea P":

Echinacea purpurea contains hydroxycinnamic acids, polysaccharides, flavonoids, saponins, tannins, echinacoside and other compounds. Scientists argue about which of them are to a greater extent determine pharmacological properties Echinacea. But most herbalists are confident that it is their complex effects that make the plant so useful. Therefore, it is so important to use not Echinacea extracts, but the whole plant, which became possible thanks to cryo-treatment.

Vitamin C - a powerful antioxidant that reduces the effect free radicals, improves immunity, protects against aging and the effects of stress.

• for the prevention and complex therapy of infectious and colds; - to activate the protective functions of the body, has anti-inflammatory, antibacterial, antiviral, antifungal effects;
• to cleanse the body, has anti-allergic, diuretic properties, accelerates metabolism.

Adults take 2-3 tablets 3 times a day during meals with plenty of water. Duration of treatment is 2–3 weeks.

Contraindications:

Individual intolerance to components, pregnancy, breastfeeding. Consult your doctor before use.

Immunity booster program:

• 1 table each 2 times a day (morning and evening). The best way administration - under the tongue. The course duration is at least 1 month. If necessary, repeat the course with a break of 5–10 days (a break is mandatory);
• 1 table each 2 times a day in the morning during meals;
• (with insufficient function thyroid gland, which is observed in approximately 95% of the population) or “Echinacea P”, 2-3 tables. 3 times a day during meals, with plenty of water. Duration of treatment is 2–3 weeks.

The thyroid gland controls the level of immunoglobulins, which are responsible for immunity. If a person has hypofunction of the thyroid gland, then the level of globulins will be low; not a single immunomodulator will help. Because modern people live mainly in cities, suppression of thyroid function is observed

Drugs for joint proposal:

Differences from similar drugs:

• The main advantage of the drug is that in the production of Echinacea P, thanks to cryoprocessing technology, the whole plant is used, that is, the substances in the drug are present in the ratio that nature created. This is what makes the use of echinacea safe, because scientists currently do not have a consensus on the main active substance Echinacea. As a result, competing companies make completely different extracts from this plant - based on hydroxycinnamic acids, inulin, polysaccharides, phenylpropanoids, lectins. And the concentration of any one substance can disrupt the immune system. This plant can only be used in its entirety;
• more efficient similar drugs, thanks to the content of vitamin C - a powerful antioxidant;
• much lower chance of manifestation allergic reactions, since the echinacea used to make the drug “Echinacea P” is now cultivated in Russia, and it has been proven that the plant is best suited for those people in whose territories it grows.

Release form: pills.

Quantity: 100 pcs.

Package:№ 100.

Details

Storage conditions:

Store in a dry place at room temperature.

Documentation:

TU 9197-015-41395157-06 as amended. No. 1, 2

SGR No.RU.77.99.88.003.E.004812.03.15 dated 03/17/2015

Patents, awards, etc.:

• There is a quality mark “Penza Mark”.

Manufacturer: PARAPHARM LLC, Russia, 440026, Penza, st. Sverdlova, 4 (production address: Russia, 440034, Penza, Kalinina St., 116-A).

Echinacea purpurea– a natural storehouse of substances necessary for the health of every person.

In the grass of this amazing plant contains:

• Vitamins A, C, E.
• A huge number of essential macro- and microelements, including iron, calcium, silicon, manganese, magnesium, selenium.
• Organic acids (palmitic, linoleic and many others).
• Echinocin and echinolone (natural antioxidants).
• Tannins and resins, essential oils, polysaccharides

Pharmacological action:

• Being a powerful immunomodulator, it creates a reliable barrier against the causative agents of many infectious diseases.
• Promotes renewal of cellular structure.
• Regulates metabolic processes in the body, normalizes the functioning of the endocrine system.
• It has a tonic effect on the body as a whole.
• Stimulates brain activity: strengthens memory, allows you to better concentrate.
• Improves the functioning of the heart and blood vessels.
• Increases potency.

11 reviews for Echinacea P 100 tablets

Irina - 31.10.2019

I bought this supplement for my child to strengthen his immune system. It helped, I started getting sick less often. Now they see us more often in the kindergarten, otherwise they haven’t left quarantine for weeks.

Dexter - 01.10.2019

I switched to echinacea from bronchomunal. Not only did he not help, but he also started a revolution in his guts. I spent 2 weeks in the infectious diseases department. Echinacea is 6 times cheaper, but it works many times better.

Anton - 30.09.2019

Since I started taking echinacea, they began to see me at work more often)) In the fall, I didn’t get out of sick leave, the bosses already began to look askance. And I can’t even count how much money I saved on medications. A very useful tool.

Milan - 29.08.2019

The cheapest echinacea I bought and the most useful, as it turned out. The same case when high price doesn't say anything yet. I have been strengthening the immunity of the whole family with this drug for several seasons now and I confidently recommend it.

Julia - 16.04.2019

A very useful remedy during the cold season. I take 3 jars for the whole family at once. I used to buy Immunal, but it costs three times more. And I won’t say that there is any significant difference in action between them.

Katerina - 16.04.2019

I have been taking this supplement for several years, and during this time it has helped me save a lot of money on medications. I won’t say that I don’t get sick at all in winter, but much less often than before. But even if I catch a cold, after 3-4 days I’m already invigorated)

Score Score 5 out of 5

Elena - 14.11.2018

When I was young I had to work a lot in cold rooms. The picker. Packer. Storekeeper. You won’t find a good job in our little town during the day. But we need to raise the children somehow. I grow them alone. I started getting sick often. As soon as your feet get cold, you’ll immediately get a cold and unpaid sick leave. This is where my grandmother’s experience came in handy. She was the village healer. She also told us, her grandchildren, about herbs. But then we turned a deaf ear to everything. But now I had to remember. “If you get sick often, brew echinacea,” my grandmother often used to say. Where can I get this echinacea now? I went to the pharmacy. There are several echinacea preparations from different manufacturers. Which one to choose? Thank you, the pharmacist suggested: “Take this one - Echinacea P.” These tablets are made using a special technology. All useful substances remain intact and not destroyed.” I bought it. I started drinking as written in the instructions. 2 tablets 3 times a day. I drank for about a month. And – pah, pah, pah – now I’m a different person. Throughout the entire winter and spring, I never got sick with anything serious. Now, for prevention, I always drink “Echinacea P” and give it to my children so that they don’t get sick either.

Margarita11 - 24.05.2018

I have been drinking echinacea for a year now and have not gotten sick. No flu or cold virus. I don’t even get a sore throat. Previously, I was on bed rest twice a year. Unique plant! I heard about him from friends. At first I brewed the herb, then I found out that it can be taken in the form of herbal tablets. And what? It's even more convenient. You can take it on a trip so as not to get sick. Echinacea P is always with me. The whole family now drinks to avoid getting sick in the winter. And the price is very pleasing - on average about 100 rubles per jar. It’s a pity that our pharmacy doesn’t have it, you have to order it online. And I like everything about the drug.

"Echinacea P" composition:
Echinacea purpurea herb powder 50 mg,
vitamin C 10 mg,
lactose

Echinacea

Echinacea- a good immunomodulator.
The range of its application is quite wide. It is often used for chronic diseases.

Echinacea preparations have a therapeutic effect in various pathological conditions by increasing the body's natural defenses.
As a result of pharmacological studies, the stimulating effect of Echinacea on the immune system has been proven.
This effect manifests itself not only in adults, but also in children with an unstable immune system, as well as in the elderly, in whom the functions of this system are reduced due to the general aging of the body.

Echinacea preparations used for diseases associated with a weakened functional state of the immune system caused by chronic inflammatory diseases, exposure to ionizing radiation, ultraviolet rays, chemotherapy drugs, and long-term antibiotic therapy.
When taking echinacea preparations associated with metabolic disorders (diabetes mellitus, liver disease), exposure to various chemical compounds of a toxic nature contained in the air and food (heavy metals, pesticides, insecticides, fungicides), stimulation of the immune system is observed.

Echinacea preparations also have antibacterial, antiviral and antimycotic properties.
Echinacea preparations inhibit the growth and reproduction of streptococcus, staphylococcus, E. coli, influenza viruses, herpes, stomatitis, are effective against inflammatory diseases (rheumatism, polyarthritis, prostatitis, gynecological disorders), diseases of the upper respiratory tract, and various wound processes (trophic ulcers, osteomyelitis) , microbial eczema.

Echinacea preparations are used for prophylactic purposes at the first signs of a cold, during long-term use of antibiotics, and for improving the health of people who have been exposed to radiation or living in areas with unfavorable radiation levels.

Echinacea is used for inflammatory processes and purulent infections of the skin, soft tissues, mucous membranes (furuncle, abscess, phlegmon, carbuncle, fistula, gingivitis, stomatitis, sinusitis, gastroenteritis, enterocolitis, colpitis, adnexitis, mastitis, cystitis, glomerulonephritis, etc.) ; septic conditions and toxic syndromes (osteomyelitis, sepsis, septicemia, secondary bacterial and viral infections, prolonged febrile conditions).
Echinacea preparations are non-toxic. In large doses, salivation sometimes increases.

In modern medical practice, Echinacea is one of the most popular medicinal plants used to treat viral and bacterial infections; in folk medicine its use has a long history.

It is known that a healthy body has sufficient potential to fight most known infections.
Often this does not require antibiotics or other unsafe medications; To do this, you just need to support and stimulate the body’s immune system in time.

If antibiotics or antiviral agents are still used, then immunostimulation significantly increases their effectiveness, reducing the duration of the disease and the number of complications.
Recent studies have shown that the high universal antiviral and antibacterial activity of Echinacea is due to its pronounced immunostimulating effect.

Under the influence of echinacea, stimulation of the immune system occurs even in the normal state of the body’s defenses, which makes it possible not only to treat, but also to prevent many diseases.
The immunostimulating effect of Echinacea is manifested in an increase in the number and activity of immune cells - leukocytes.

The ability of leukocytes to actively absorb and digest bacteria under the influence of Echinacea increases by 30-45%; in general, the immune response under the influence of echinacea increases by 50-120%.
When taking Echinacea, the level of specific antibodies that neutralize viruses and bacteria increases, and the production of a nonspecific antiviral compound, interferon, also increases.
Interferon is the most important “line of defense” of antiviral immunity.

The immunostimulating and anti-inflammatory effect of Echinacea is complemented by a pronounced detoxifying effect.
This occurs due to the improvement of metabolic processes in the liver and kidneys, which process and eliminate various toxins, metabolic products, heavy metals and radionuclides.

In this preparation, the effectiveness of Echinacea is significantly increased due to its combination with vitamin C, which has a powerful anti-inflammatory effect.

Vitamin C has a diverse positive effect on immunity and the course of infectious diseases.
It harmoniously complements Echinacea, further increasing the effectiveness of the drug.

Thanks to cryotreatment, "Echinacea P" preserves essential oils, glycosides, amides, antibiotic polyacytilenes, inulin.
Echinacea P is rich in nutrients including B vitamins, iron for the formation of red blood cells, calcium for strong bones and teeth, selenium for the ability to resist disease, and silicon for tissue formation.

Spreading:
The homeland of Echinacea species is North America.
In Russia "Echinacea purpurea" began to be grown in early XIX V.

When studying commercial preparations of Echinacea from the crude fresh juice of the plant in vitro, stimulation of the production of cytokines by macrophages was shown: IL-1, alpha-TNF and IL-6 and an increase in the antibody-dependent cytotoxicity of peripheral blood mononuclear cells under the influence of Echinacea extract.
In the experiment, Echinacea root extract was systematically added to food for 1-2 weeks. causes a significant increase absolute number NK cells and red monocytes bone marrow and spleen.
The immunomodulatory effect is also demonstrated by changes in the lysosomal and peroxidase activity of peritoneal macrophages and mouse spleen cells when using aqueous alcoholic extracts of the root various types echinacea in vivo.

Echinacea purpurea extract in vitro stimulates the phagocytosis of granulocytes and monocytes; similar data were obtained for the homeopathic preparation Echinacea angustifolia D1.
Intravenous administration of Echinacea purpurea polysaccharides stimulates phagocytosis of neutrophilic harnulocytes, adhesion to the endothelium and mobilization of neutrophils from the red bone marrow.
An experiment on mice showed stimulation of phagocytosis, metabolic and bactericidal activity of peritoneal macrophages when added to food alcohol solution various types of Echinacea, as well as an increase in the weight of the spleen.

Inhibition of free radical oxidation processes and other effects.

Taking Echinacea preparations helps to inhibit the process of lipid peroxidation, reduce the unsaturation of the lipid complex of sweat and blood and the level of free cholesterol.

Contraindications and side effects

Experiments on rats and mice did not reveal toxic or mutagenic effects after a four-week use of average therapeutic doses of Echinacea purpurea preparations.

A generally accepted contraindication is for diseases associated with hyperactivation of autoimmunity and for joint use with immunomodulators, as well as with allergies to the drug.
Cross immunity with other plants of the Asteraceae family is possible.
There is evidence that high concentrations of Echinacea purpurea may cause deficiency cellular immunity and damage human reproductive cells.

The possibility of hepatotoxicity of Echinacea preparations is being considered. long-term use, in particular when used concomitantly with other hepatotoxic drugs such as anabolic steroids, amiodarone, methotrexate and ketoconazole.

Use in allopathy

Echinacea preparations are recommended for functional immunodeficiency associated with chronic inflammatory diseases, exposure to ionizing ultraviolet radiation, chemotherapy drugs, and long-term antibiotic therapy.
"Echinacea purpurea" and angustifolia are used internally for infectious and septic diseases, externally for carbuncles, abscesses, infected wounds, burns I-III degrees and severe bedsores.
Echinacea preparations are recommended for the treatment and prevention of acute respiratory viral infections.

Application in homeopathy

Echinacea angustifolia and purpurea are used in homeopathy.
It is believed that their homeopathic pathogenesis is practically the same.

Echinacea is included in various complex drugs, used as nonspecific immunostimulants for the treatment and prevention of mainly acute respiratory viral infections.

In classical (Hahnemannian) homeopathy, Echinacea is used to treat purulent inflammatory processes, sepsis, erysipelas, snake bites and other animals.

* to effectively maintain the immune status of the body;
* for the prevention of colds and flu, reducing their duration;
* as an adjuvant for chronic inflammatory diseases (rheumatism, polyarthritis, prostatitis, gynecological disorders), exposure to radiation, taking chemotherapy drugs, long-term antibiotic therapy;
* to inhibit the growth and reproduction of streptococcus, staphylococcus, E. coli, influenza viruses, herpes, stomatitis.

Contraindications:
Individual intolerance to components; if pregnant or breastfeeding, consult a doctor.

Duration of use: 2-3 weeks for adults, 2-3 pcs. 3 times a day during meals, with plenty of water.

Production: Parapharm LLC, Penza

Shelf life: 2 years.

Information about "Echinacea purpurea" was borrowed from the company Parapharm LLC.

Buy "Echinacea P" tab. No. 100 in the store -->

Film-coated tablets Secrets of Longevity Echinacea P has immunomodulatory and anti-inflammatory effects. Echinacea P tablets increase the body's resistance to various infections(bacterial, viral, fungal). This is an excellent immunostimulant. In addition, the drug in tablets stimulates phagocytosis and has an anti-inflammatory effect. Increases the concentration of corticosteroids in the blood, the number of interleukin and leukocytes. Echinacea's ability to stimulate protective functions body, thereby having a beneficial effect on it when various pathologies associated with decreased immunity. These drugs differ in their antiviral and antibacterial effects. Echinacea inhibits the reproduction and growth of staphylococci, streptococci, herpes and influenza viruses, and E. coli.

Release form

Pills

Compound

Contraindicated during pregnancy and breastfeeding.

Indications

An increase in nonspecific body defense factors in uncomplicated acute infectious diseases and with a predisposition to frequent colds, in order to stimulate the immune system in patients with uncomplicated acute infectious diseases(as an auxiliary treatment), prevention of acute respiratory viral infections and influenza, as an auxiliary medicine with long-term antibiotic therapy of chronic infectious diseases.

Precautions

1 month 2-4 pcs. 3 times a day during meals for adults and children over 12 years of age.

Use during pregnancy and breastfeeding

Contraindicated in case of individual intolerance to the components, pregnancy and breastfeeding.