Allergy to pimafucin suppositories. Pimafucin - instructions for use, indications and contraindications, reviews

In the treatment of thrush in children, Pimafucin is used. This drug has positive reviews Not only medical workers actively using it in practice, but also grateful parents who used the remedy in the treatment of thrush in their children.

(candidiasis) - infection caused by fungi of the genus Candida. Appears in a child on the mucous membranes oral cavity or genitals. In most cases, the disease affects newborns or children of the first year of life. In rare cases, candidiasis can spread to internal organs.

Pimafucin is a widely used antibiotic that has a detrimental effect on most types of yeast fungi, including Candida. The main source of infection with candidiasis is the mother of the child, since the woman is the carrier of the disease. Candida live in the body all the time, but with reduced immunity, they begin to actively multiply.

The main reasons for the appearance of an ailment with thrush or candida can be:

• Failure to comply with hygiene rules when sterilizing bottles, washing toys, or if the baby's mother does not treat her breasts before feeding;
• During the passage of the newborn through the birth canal;
• If, when examining a child medical staff hand hygiene rules were not observed;
• When the immunity of the body is reduced;
• Dry mucous membranes of the mouth in an infant;
• Restructuring of the hormonal background;
• Violations in the system gastrointestinal tract;
• As a result of taking antibiotics.

Symptoms of thrush or candidal stomatitis:

• The appearance of white plaque in the mouth, which has a sour smell;
• Curd spots on the surface inner sides cheeks, gums, tongue, palate. If you scratch the plaque, then under it there are red inflamed spots, which eventually turn into bleeding sores (with);
• The baby is constantly crying, and when breastfeeding or bottle feeding, he may refuse to eat, because when swallowing, he experiences pain;
• Loss of appetite, regurgitation, vomiting, diarrhea.

Instructions for use

The antifungal drug is available in the following forms:

• Pills;
• Vaginal suppositories;
• Cream or ointment (2%) for external use;
• Drops;
• Suspension.

Cream

Pimafucin cream is used for skin candidiasis, or baby diaper rash. The duration of the course is assigned to each child individually. Even if the symptoms have disappeared, the cream is used for a few more days.

The cream should be used on areas affected by the fungus, such as skin, nails, 2 to 4 times a day.

Treatment of thrush in girls is also carried out with Pimafucin. The cream is applied to the skin of the genital organs several times a day. The ointment should be used with extreme caution in newborns. If the disease has spread to a large area of ​​the skin, then the cream should be smeared with small areas. Do not apply ointment to the entire surface of the baby's skin.

Pills

The peculiarity of taking Pimafucin tablets is that it does not penetrate the gastrointestinal tract. This is an advantage over other antibiotics as they do not cause a huge list of adverse reactions like other drugs. This fact once again confirms the positive reviews about the drug.

Pimafucin tablets are used for candidiasis of the gastrointestinal tract. They act locally, without affecting the gastrointestinal tract.

The shell of the tablet protects against influence gastric juice, which makes it possible to dissolve in the intestines. The dosage depends on the age of the child from 2 to 4 tablets per day, and for children of the first year of life, part of the tablet may be prescribed. In some cases, suppositories or creams may be prescribed along with the drug.

Drops

With candidiasis of the gums, external mucosa of the lips, stomatitis, vulvoginitis local application Pimafucin drops are used. Reviews on the effectiveness of drops are positive character. Drip at least 4 times a day. Treatment takes a week. With stomatitis, drops are most often prescribed.

Candles

Candles are shaped like a torpedo. Pimafucin suppositories are used for vaginal thrush. They contain cetyl alcohol, which causes a burning sensation. Candles dissolve in the body due to a reaction to body temperature. Suppositories should be administered at bedtime. Candles are used from 3 to 6 days. This course is enough to eliminate thrush.

Features of treatment

Treatment of thrush is carried out in two aspects:

• General therapy is aimed at eliminating the conditions conducive to the reproduction of the fungus;
• Medication for the fight against candida.

At the doctor's appointment, it is necessary to discuss such points as the presence of an allergy to certain drugs, whether certain drugs can be used.

During treatment, you need to constantly humidify the air in the room where the child is and spend more time on fresh air which will ensure a speedy recovery. When sick, prescribe proper nutrition, excluding sweets that provoke the spread of the fungus. If the baby spit up, it is necessary to change the method of feeding.

When a child is infected with candidiasis, a white coating, under which red inflamed spots can not only bleed, but also be a hotbed for more dangerous infections. This happens with stomatitis.

If the disease is not treated in time, then it spreads to the throat, and then to the gums and lips, on which cracks form and begin to bleed.

With stomatitis, wounds in the mouth cause the baby such pain that he cannot swallow and refuses to breastfeed. The baby may have a fever. In addition, children experience insomnia and become irritable. The immune system worsens and contributes to the occurrence of allergies, as well as serious illnesses including bronchial asthma.

Analogues and price

Pimafucin is a rather expensive drug and has no analogues in terms of the active substance. The most similar drug in terms of spectrum of action is, which is also used to treat thrush on the skin and in the mouth in babies. You can try cheaper analogues of Cloritmazol or Livarol.

Pimafucin is intended to relieve the symptoms of thrush and prevent the recurrence of her disease. The drug is different quick action. Relief occurs on the second day of treatment.

Pimafucin is available in the form of tablets, suppositories and creams. Preparations different forms release can be combined in one therapeutic course.

A high degree of effectiveness of the drug is provided by the substances that make up its composition. The components not only eliminate the manifestation of thrush, but also have a detrimental effect on the infectious agent.

The drug is safe and approved for use at any stage of pregnancy. In some cases, medication is prescribed for complex treatment both partners.

1. Instructions for use

A detailed scheme for using different forms of release of Pimafucin is described in the instructions. The duration of the course depends on the severity of thrush and the form of the disease. The manufacturer offers information on indications, contraindications, possible side effects and nuances of combining the drug with drugs from other groups for review. Additionally, the manual contains special instructions(This point should be noted if there is serious pathologies or chronic diseases).

pharmachologic effect

Pimafucin - strong antifungal agent from the group of macrolide antibiotics of the polyene series. The active substance of the drug blocks the sterols of the fungal cell membrane, which causes their death. The maximum sensitivity of the drug is manifested in relation to the type Candida mushrooms spp, and the smallest - to dermatophytes. At the moment, the clinical practice of resistance of fungi to natamycin has not been identified.

Natamycin is not absorbed in the gastrointestinal tract, is not absorbed on the skin and mucous membranes. Various dosage forms of Pimafucin provide a successful fight against fungi in all affected areas.

The remedy belongs to those few medicines that are not prohibited for taking to combat thrush in pregnant and lactating women, since they do not have negative impact to the fetus and breast milk.

Indications for use

Pimafucin is used in the presence of the following pathologies:

Mode of application

Depending on the form of release, Pimafucin is used as follows:

1. Tablets (take 1 pc. 4 times a day):

• With nail candidiasis (together with cream) - within 2-3 months;
• With vulvovaginal candidiasis (together with vaginal suppositories in order to sanitize the candidiasis focus in the intestine) - within 10-20 days;
• In the case of intestinal candidiasis (children 1 table. 2 times a day) - within a week;
• With onychomycosis (together with Pimafucin cream) - within 2-3 months.

2. Cream:

• In case of dermacomycosis (including skin or nail lesions), the affected area is lubricated with cream 1-4 times a day. The course of treatment lasts 2-3 weeks;
• When treating candidal lesions in a partner, the drug is applied to the anogenital zone (for fungal intestinal diseases along with taking Pimafucin tablets).

3. Suppositories used in the case of candidal vulvovaginitis, 1 pc. deeply inserting into the vagina at bedtime 1 time per day (introduction to produce in a supine position). The course of treatment is determined individually (usually 3-6 days). Intravaginal administration continues for 2-3 days after the disappearance of external signs.

Suppositories after administration quickly melt from body temperature with the formation of a bulky foamy mass, which improves the distribution of the drug along the walls of the vagina.

When treating with suppositories, interrupt sexual life not necessary. On the onset critical days drug administration is suspended.

After the disappearance of signs of candidiasis, it is not worth immediately refusing to use Pimafucin, since the fungus may not be completely destroyed. Tablets are taken at least 2-3 days. after the symptoms of the disease disappear (burning, itching, the presence of curdled clots).

The most acceptable solution is to consult a doctor who, after prescribing certain tests, will determine the advisability of continuing to take the drug or stopping it.

Release form, composition

Pimafucin, depending on the form of release, has the following composition:

1. Tablets - round, white color, in an enteric coating, placed in a dark glass bottle, which include:

• The active ingredient is natamycin (100 mg);
• Auxiliary - magnesium stearate, polyvinylpyrrolidone, starch, lactose, talc, gelatin, gum arabic, kaolin, methyl parahydroxybenzoate, titanium dioxide, triacetin, beeswax, cellulose acetate, sugar.

2. White or light yellow cream in tubes of 30 g each, 1 g of which contains:

• The active ingredient is natamycin (20 mg);
• Auxiliary: propylene glycol, diceloleate, cetostearic alcohol, sodium lauryl sulfate, propyl parahydroxybenzoate, cetyl ether.

3. Vaginal suppositories oblong, white or yellow, each containing:

• The active ingredient is natamycin (100 mg);
• Auxiliary - cetyl alcohol, sorbitan trioleate, sodium bicarbonate, polysorbitol 80, adipic acid, solid fat.

Interaction with other drugs

At the moment, there are no facts of the interaction of Pimafucin with other drugs.

2. Side effects

After using Pimafucin, some side effects may occur:

• Signs of allergy in the form of itching and burning, irritation in the genital area after the introduction of the suppository;
• Indigestion, diarrhea;

Overdose

Severe cases of overdose with Pimafucin in medical practice not registered, but doctors do not exclude the risk of adverse symptoms when the dosages of the drug are exceeded. From the side digestive system vomiting may occur or pain different localization. In some cases, an overdose can cause the development hypersensitivity to the medication.

Contraindications

Pimafucin has no contraindications, but before starting use, you should pay attention to the following restrictions:

• Suppositories can be used by girls starting only from the age of 16;
• Tablets for the treatment of candidiasis in newborns are prohibited (there are special suspensions for this).

During pregnancy

3. Special instructions

Influence on the ability to drive vehicles and control mechanisms

The ability to disrupt psychomotor reactions or affect nervous system Pimafucin does not possess.

Pregnancy and lactation

Pimafucin can be taken at any stage of pregnancy. There is no potential harm to the fetus. If you need to take the drug during lactation, additional consultation with your doctor is necessary.

Application in childhood

Pimafucin is used in pediatric practice only on the basis of the testimony of a specialist (the drug has no age restrictions).

For impaired renal function

There are no special instructions in the instructions.

For impaired liver function

There is no need to adjust the course of therapy.

Terms of dispensing from pharmacies

OTC sale.

4. Terms and conditions of storage

The drug in the whole package is stored at up to 25 ° C, avoiding direct sunlight, for 2 years.

Video on the topic: Pimafucin

5. Price

Depending on the location of the pharmacy and its pricing policy, the cost of Pimafucin is as follows:

1. average price in Russia:

• Tablets - 470-525 rubles;
• Cream - 290-315 rubles;
• Suppositories - 277-495 rubles.

2. Average cost in Ukraine:

• Tablets - 139-152 UAH;
• Cream - 81-94 UAH;
• Suppositories - 91-97 UAH.

6. Analogs

The following drugs are analogues of Pimafucin: Nystatin; Alpha normix; Dificlir; Nystamycin; Primafungin.

Both compared drugs are antifungals, freely sold without a prescription. They come in a variety of forms, making them a better choice than other drugs. So, you can seamlessly use candles or creams locally, avoiding possible complications when taking the tablets orally. Doctors recommend these medicines for the following diagnoses:

• various candidiasis,
• fungal diseases of the esophagus and mucous membranes,
• dermatomycosis and a number of others.

It is noteworthy that the use of fluconazole is recommended prophylactically, but not its opponent. This does not mean that one of them is more dangerous. Prevention does not involve the use of medicines just like that, but is intended for patients with diagnoses that are characterized by a weakened immune system. Against its background, fungal diseases often develop. Due to the difference in the main active ingredients, it is important to build a treatment regimen in such a way that microorganisms do not get used to it. If this happens, then the treatment will become not only ineffective, but also dangerous.

The difference in the compositions of Fluconazole and Pimafucin

The active substance of Fluconazole has exactly the same name as the drug itself. It is produced at many domestic and foreign enterprises (for example, Flucostat is a well-known imported drug based on fluconazole). In Pimafucin, produced in Holland, this is natamycin. That's what it sounds like international name medication - natamycin. Is it possible to say that one of them is more efficient? This will not be entirely correct. The use of these drugs varies depending on which substances the causative organisms are more sensitive to. Possible side effects are the same for competitors: diarrhea, nausea, flatulence. However, natamycin, which is part of Pimafucin cream, has an unpleasant feature - it can cause burning and mild skin irritation around the area affected by the fungus.

If the doctor has given the choice to use Fluconazole or Pimafucin, you need to pay attention to excipients. For example, the composition of the latter in the form of tablets includes sucrose, which may be important for some patients. But the cream includes wax based on cetyl ethers, this should be paid attention to those who are prone to allergies. If, nevertheless, some strong reactions or side effects appear, it is simply impossible to change the drug on your own. To cancel one and start another without getting complications, you need to see a doctor.

Advantages and disadvantages

The pros and cons of the compared medicines are mainly determined by how convenient they are to use and how effectively they work. Price does not always play a key role, as it is much more important to get a good result and avoid allergies.

Pimafucin has three forms in which it is produced:

1. tablets for oral administration - 100 mg,
2. vaginal suppositories (candles) - 100 mg,
3. cream for external use - 20 mg / 1g.

His domestic competitor also has three forms of release, they are completely different:

1. capsules for oral administration - 50 or 150 mg (produced by many Russian and Belarusian pharmaceutical sites),
2. suspensions and solutions for intravenous administration(but pharmacies are practically not found).

The form in which the medication is needed is determined by the diagnosed disease and its symptoms. For example, Pimafucin in the form of suppositories and cream is particularly convenient to use for genital candidiasis, both in men and women. Although with "thrush" tablets and suppositories Pimafucin are often prescribed simultaneously.

Fluconazole cannot be used during pregnancy and lactation, Pimafucin has a higher safety profile and has no such restrictions. This can be called the main advantage of the Dutch drug, and the decision Pimafucin or Fluconazole: which is better during pregnancy or HB is definitely in favor of Pimafucin (a consultation with a gynecologist is required, since dosage adjustment may be required).

The domestic analogue has an option for intravenous administration, therefore it is actively used in medical institutions during treatment in a hospital.

Doctors do not recommend using Pimafucin and Fluconazole on their own at the same time. Especially when it comes to oral forms (capsules and tablets) of both drugs. This is due to the fact that they are aimed at the same group of microorganisms using different active substances. The feasibility of using different forms, for example, fluconazole capsules and Pimafucin suppositories, should be discussed with the doctor, since their compatibility may vary individually. Mycobacteria in mild forms fungal disease one antibiotic is enough, other drugs should support therapy, but not aggravate its effect on the body. The use of several drugs at once can only be justified by a severe disease that requires monitoring and monitoring of the state of the liver and kidneys.

While Pimafucin is produced in the Netherlands, the names of different companies can be found on the packaging of its competitor. The countries in which it is produced: Russia, Belarus, Ukraine, Israel, Switzerland, which determines a wide range of prices. Naturally, fluconazole of domestic production is several times cheaper. The difference can be up to several hundred rubles both between different manufacturers and between the drugs themselves.

The drug "Pimafucin" is available in the form vaginal suppositories, tablets and ointments. This is an antifungal agent with a wide range actions. It is intended for the treatment of diseases of the organs of the female reproductive system, which provoke yeast-like fungi. In reviews of Pimafucin tablets for thrush, they are called the number one choice.

The drug demonstrates maximum effectiveness against candidiasis. Therefore, doctors begin therapy for thrush with the appointment of this remedy. The principle of action of the drug is to use pronounced fungicidal properties. Its active substance violates the integrity of pathogenic membranes and destroys microorganisms. The maximum resistance to Pimafucin suppositories, reviews and instructions confirm this, dermatophytes show.

Purpose

Most often, the drug is prescribed for the treatment of skin and mucous membranes affected by fungal infections. various types. Its use is also justified in the treatment of candidiasis. The agent is practically not absorbed from the gastrointestinal tract, from the surface of the skin and mucous membranes. Brief list of indications:

• fungal lesions of the nail plates;
• trichomoniasis;
• inflammation of the vulva;
• vaginitis;
• otomycosis;
• dermatological candidiasis.

oral form

The reviews and instructions for use of the Pimafucin tablets say that the remedy showed excellent results in the treatment and prevention of colonization of the intestines by fungi of the Candida family. Their uncontrolled reproduction provokes long-term use antibiotics, hormonal drugs containing corticosteroids, cytostatics.

The cost of a package of 20 enteric-coated tablets in pharmacies is approximately 600 rubles.

Soft dosage form

The cream is prescribed to patients suffering from candidiasis of the skin and mucous tissues. And also in cases of damage by dermatophytes and other yeast-like fungi. In reviews of the cream "Pimafucin" it is said that the average cost of the drug in Russian pharmacies- 360 rubles. The drug is supplied in metal tubes. Cream weight - 30 g.

suppositories

The main indication for taking suppositories is an infectious and fungal infection of the vulva. They are produced in two configurations. One is designed for short-term treatment of thrush and involves a set of three suppositories packed in a cardboard box. Its price is 300 rubles.

The reviews and instructions for the use of Pimafucin suppositories say that in the treatment of advanced vulvitis and vaginitis of fungal origin, it is advisable to purchase a second set. It consists of six suppositories. The cost of the set is 520 rubles.

Choice of dosage

At inflammatory processes caused by yeast-like fungi in the vulva and vagina, one suppository is prescribed for six days. In some cases, the use of the drug for nine days is allowed. To insert a candle into the vagina as deeply as possible, you need to take horizontal position and relax.

In the reviews on the use of Pimafucin candles, they say that standard scheme prescription is not always effective. In this case, the treatment can be supplemented with an oral form. Take four tablets a day. oral form is responsible for the sanitation of the inner surface of the intestine, which can also serve as a focus of colonization of yeast-like fungi.

The duration of the therapeutic course is ten days. To enhance the effect medical measures, prescribe a mild form of the remedy. In the instructions and reviews of the Pimafucin ointment, they claim that it has proven effective in destroying fungal infections of the skin of the partner's genital organs. The cream is applied one or more times a day.

Balanoposthitis

As part of drug therapy diseases, the use of ointment has become widespread. It lubricates areas of the skin that have been colonized by fungi. The procedure is performed once a day. It is possible to increase the dosage. Instructions and reviews about "Pimafucin" in the form of a cream prove high efficiency drug.

Intestinal tissue damage

Thrush of the excretory system is treated with an oral form of the drug. Adults are advised to take four tablets each day. The duration of treatment is seven days. For children, the dose is halved. They need to take two pills. In reviews of Pimafucin, women give high marks to the results of treatment. They report a lack side effects and good health during the course of therapy.

Mycoses of the skin

With a dermatological lesion, a mild form of the drug is used. The ointment is applied to the affected area of ​​the skin once a day. If necessary, the number of procedures can be increased. In the reviews of women about "Pimafucin" it is mentioned that this remedy has found application in pediatric practice. It is used to treat diaper rash in babies.

Otomycosis

fungal infection ear organs is subject to therapy with natamycin, the main active ingredient of the mild form of Pimafucin. With open access to the affected areas, they are regularly lubricated with ointment. In the instructions and reviews of Pimafucin, it is recommended to pre-clean auricle. A tampon is used to introduce the drug into the middle section. Its surface is abundantly smeared with cream and gently inserted into the ear canal.

The duration of therapy is set individually. You can not stop treatment after the disappearance of the main symptoms. In reviews of the use of "Pimafucin" it is said that the best results are achieved in cases where patients used the ointment for several days after the complete disappearance pathological manifestations underlying disease.

Taking during pregnancy

The remedy is recommended by leading obstetricians and gynecologists for the treatment of thrush during the period of gestation and breastfeeding. The dosage of the drug is indicated by the attending physician. To date, this medication is included in the group of first choice in the treatment of lesions of the mucous membranes and skin with fungal infections in pregnant women and during lactation. Judging by the reviews, every second woman takes Pimafucin in the 1st trimester.

Side effects

Despite the good tolerability of the drug by patients, the doctors recorded the following negative manifestations:

• burning in the vagina and on the skin;
• diarrhea;
• bouts of nausea.

All of the above side effects do not require special treatment and do not lead to discontinuation of the drug. They go away on their own a few days after the start of the therapeutic course.

Contraindications

The main obstacle to treatment may be individual intolerance active component. In this case we are talking about natamycin. Another contraindication, which is indicated in the instructions for use of Pimafucin tablets and in reviews, is porphyria.

Special cases

Uniform distribution of natamycin contained in suppositories over the inner surface of the vagina is ensured by foaming excipients influenced by natural body temperature. In some cases, this drug may be included in the plan complex therapy dermatomycosis of various origins.

Burning and irritation of the vaginal mucosa, which appear during the use of suppositories, occur due to the addition to the drug. In the composition of the drug, its share is insignificant, but sensitive patients may feel tingling and dryness. This is stated in the reviews of the Pimafucin candles.

If the fungal infection recurs after a certain period of time after the use of suppositories, then the appointment of an oral form of natamycin is recommended. During menstruation, candles are not used, since their effectiveness is minimal. During the course of the therapeutic course, partners are advised to use barrier contraceptives and undergo a thorough examination by specialized specialists.

Women who use suppositories do not need to give up sexual life. The safety of the active substance has been proven. Therefore, natamycin is prescribed for the treatment of newborns. In reviews of Pimafucin candles, young parents mention that pediatricians prescribed this drug to their children.

Storage rules

All forms of the medicinal product must be kept in dry rooms. The recommended air temperature in the warehouse varies between 15-25 °C. The shelf life of the oral and soft form of the medicinal product established by the manufacturer Temmler Italia S.r.L. is four years.

Suppositories should be used after twenty-four months. The instructions and reviews on the use of "Pimafucin" say that when the storage temperature is exceeded, the candles are destroyed. Suppositories foam. Their shape changes.

The composition of the tablets

List of components:

• 100 mg of natamycin;
• 80 mg of potato starch;
• 5 mg PVP;
• 2.5 mg magnesium stearate;
• 66 mg lactose;
• 3 mg gelatin;
• 7 mg gum arabic;
• 30 mg calcium carbonate;
• 14 mg taolin;
• 21 mg talc;
• 18 mg phthalate;
• 122 mg sucrose.

Excipients:

• methyl p-hydroxybenzoate;
• triacetin;
• beeswax.

Composition of vaginal suppositories

Main components:

• 700 mg fat;
• 100 mg natamycin
• 460 mg sorbitol;
• 690 mg cetyl alcohol.

Excipients:

• polysorbate;
• sodium bicarbonate;
• adipic acid.

Soft Form Composition

Main components:

• 20 mg natamycin;
• 100 mg decyloleate;
• 135 mg cetostearyl alcohol;
• 150 mg propylene glycol.

Excipients:

• wax;
• sodium lauryl sulfate.

Patient reviews

In the reviews and instructions for the use of "Pimafucin" it appears that the therapeutic course is generally not associated with the appearance of side effects. The treatment is effective. Patients highlight the following benefits of using this drug:

• proven safety;
• practically complete absence contraindications;
• availability;
• sale without a doctor's prescription;
• an abundance of analogues;
• prompt disposal of thrush;
• the possibility of use during pregnancy and breastfeeding.

Analogues

Preparations that contain natamycin:

• "Primafungin";
• "Pimafukort".

"Primafungin"

"Primafungin" is produced by JSC "Avexima" ( the Russian Federation). Suppositories are packed in a cardboard box of three. The dosage of this drug is fully consistent with the instructions listed in the instructions for use "Pimafucin". Customer reviews confirm this.

One suppository contains 100 mg of natamycin. The drug has almost no effect systemic action on the body. If a pronounced burning sensation occurs during use, you should stop using this remedy and seek medical advice. additional consultation to the attending physician.

"Primafungin" is sold in pharmacies without a prescription. Its price is about 200 rubles. List of indications:

• inflammation of the vulva;
• vaginitis regardless of etiology;
• damage to the skin and mucous membranes by fungi of the Candida family.
• The drug is approved for use during lactation and pregnancy.

"Pimafukort"

This is medicine considered an analogue of "Pimafucin". The reviews and instructions say that it also includes neomycin and hydrocortisone. These components provide a comprehensive therapeutic effect. Produces the drug Italian pharmaceutical company Temmler Italia S.r.L.

According to the manufacturer's description, this remedy has a pronounced anti-inflammatory effect. It perfectly fights fungal infections of the skin and mucous membranes. Used externally. Packed in cardboard boxes. The metal tube contains 15 g of cream.

"Pimafukort" is not complete analogue"Pimafucin", instructions for use, it is mentioned in the reviews, is different. It says that the level of absorption of hydrocortisone through skin without wound lesions is three percent. If the integrity of the epidermis is violated, this value doubles. If there is an infection on the skin, then the degree of absorption reaches 15%.

When using "Pimafucort" in the treatment of children, it should be borne in mind that their susceptibility is higher than that of adults. How older child, the lower the absorption rate. There are few side effects. In reviews of Pimafucin and Pimafucort, some patients with sensitive skin insist that they feel a pronounced burning sensation and dryness of the integument on which the ointment was applied. Localized redness was noted. Sometimes women complained of itching.

If you note one of the above actions associated with taking Pimafukort, then we are talking about the manifestation of allergic reactions. In this case, the therapeutic course is canceled, and the drug must be replaced. True, usually these symptoms subside on the third day of using the cream. Similar moments are described by patients in their reviews of Pimafucin.

With prolonged use of the cream in children, a syndrome of suppression of the action of the adrenal cortex is diagnosed. Such a reaction is rare and only in those patients who applied occlusive dressings and applied the agent to large areas of the skin.

Instructions for use

When using "Pimafukort" in the eyelid area, you need to remember about the possibility of increasing intraocular pressure, which can lead to further development cataracts. At therapeutic treatment open wound surfaces, the risk of toxic effects is allowed. The reviews about "Pimafucin", produced in a mild form, talk about the safety of the drug for children.

"Pimafukort" can also be used in pediatrics, but under the supervision of a physician. The list of indications includes all kinds of dermatoses, complications after fungal and bacterial infections. Contraindications include juvenile acne, anogenital itching, allergic reactions to the introduction of vaccination vaccines of an allergic nature. Do not use the cream for ichthyosis, the presence of open wound surfaces, viral diseases epidermis.

"Pimafukort" is prescribed with caution to children under one year old. And in the instructions, reviews of "Pimafucin" confirm this, there is no such restriction. The interaction of "Pimafucort" with other drugs is not described. Cross-type hypersensitivity has been reported when using neomycin with paromomycin, kanamycin, aminoglycosides, gentamicin.

Dosage

Adults and adolescents apply the cream twice a day. The course of treatment should not exceed fourteen days. Pimafukort ointment is the number one choice for the treatment of dermatoses. Occlusive dressings are contraindicated in small children. There were no cases of drug overdose.

Doctors admit the possibility of toxic effects when applying the cream to the surface of the middle ear, provided that the integrity is damaged eardrum. In this case, "Pimafucin" is recommended. User reviews confirm the absence of side effects. To enhance the effect of exposure, other forms of the drug are used.

"Natamycin"

This drug is considered one of the most effective antibiotics aimed at fighting fungal infections. Most often, this remedy is prescribed for the treatment of thrush. In pharmacies, it is represented by suppositories, oral and soft forms. Like Pimafucin tablets, reviews say that Natamycin rarely causes side effects. It is almost non-toxic, therefore it is indicated for the treatment of pregnant women. The number of contraindications is minimal.

Instructions for use

The drug belongs to the group of tetraenes. Its main property is aimed at the destruction of a fungal infection. Nearly all known pathogenic organisms similar origin. Like Pimafucin tablets, reviews of which are advisory in nature, Natamycin is prescribed by a doctor.

The main thing active substance- natamycin. It is obtained by production with an actinomycete. The drug breaks the membrane cells of the pathogenic flora of yeast and similar fungi, dermatomycetes and Trichomonas. Gram-positive cells show resistance to this medication.

"Natamycin" is produced by Russian, European and Asian pharmaceutical companies. The antibiotic is sensitive to sunlight, so it is packaged in a dark opaque container. The active substance natamycin is insoluble in water. It is produced in the form of a powder, which has a yellowish or white color. Soluble in acetic acid, cooled to a minimum possible temperature, and in dimethylformamide.

If necessary, natamycin can be diluted with methyl alcohol. Like the Pimafucin tablets, the instructions and patient reviews confirm this, it does not have a systemic effect on the body. The substance is not absorbed from the gastrointestinal tract and from the surface of the skin. "Natamycin" is not prescribed to patients who suffer from tuberculosis. Avoid the use of the drug for people with individual intolerance medicinal components.

Side effects of "Natamycin"

Doctors note the presence of adverse effects that may be associated with the use of the drug:

• diarrhea varying degrees expressiveness;
• vomit;
• nausea;
• burning;
• dryness.

There are no facts of overdose. Itravaginal suppositories are sold in pharmacies without a prescription. In other cases, pharmacists are asked to present the prescription of the attending physician. The cost of "Natamycin", produced in the form of a cream, is 260 rubles. Candles are sold at a price of 250 rubles. The oral form will cost 470 rubles. It is prescribed not only for women, but also for men.

Treatment of thrush

modern medicine has a wide range of products intended for the treatment of fungal infections. In addition to analogues of "Pimafucin", pharmacological companies offer preparations based on fluconazole:

• "Flucostat";
• "Fluconazole-Teva";
• "Fluconazole-OBL";
• "Fluconazole-Stada";
• "Diflucan";
• "Mycosist";
• "Diflazon".

This active ingredient is also contained by "Vagisept" and "Safocid".

"Flucostat"

The capsules are produced by the Russian pharmaceutical company Pharmstandard. Minimum packing - 1 piece. Available in packs of two and seven capsules. The minimum cost is 200 rubles. For seven capsules they ask for 360 rubles. The main component of the drug is fluconazole. Its weight in the composition of the Flucostat capsules is 50 mg. Excipients:

• sodium lauryl sulfate;
• lactose;
• refined corn starch;
• magnesium stearate;
• aerosil;
• gelatin;
• food coloring;
• acetic acid;
• titanium dioxide.

Side effects of Flucostat

While taking the medication, patients may experience the following: pathological conditions:

• headache in different localization;
• convulsions;
• dizziness;
• nausea;
• leukopenia;
• trembling of the ventricles of the heart;
• thrombocytopenia;
• agranulocytosis;
• skin rash;
• anaphylactic shock;
• alopecia;
• erythema;
• necrolysis;
• violation of the urinary system.

Basic information about Flucostat

The drug is sold in pharmacies without a prescription. It is prescribed for the treatment of cryptococcosis and candidiasis. Also used for prevention bacterial infection in patients with AIDS. The tool has a lot of contraindications:

• kidney failure;
• hepatic dysfunction;
• combined reception with homeopathic preparations;
• alcohol addiction;
• organic disease remedies;
• pathological changes electrolyte balance.

"Fluconazole"

This drug is produced by many international and Russian pharmaceutical companies. Estimated price is 280 rubles. It contains 50 mg of fluconazole. The active substance is excreted in a volume of 80%. The drug is sold in pharmacy network upon presentation of a prescription.

Indications:

• cryptococcal meningitis;
• mycosis of the epidermis;
• candidiasis of various origins.

Contraindications:

• children under 16;
• individual intolerance;
• lactation;
• taking cisapride;
• lactase deficiency;
• the use of terfenadine;
• congenital heart disorders.

"Diflucan"

This drug is produced by the world famous French company Pfizer. This is also an effective antifungal agent, which is aimed at treating thrush. The main component is fluconazole. Packages may contain 12, 7 or 4 capsules.

"Mikosist"

The medicine is sold in cardboard packs. They contain 4 capsules. The manufacturer is the Russian branch of the Gedeon Richter concern. Estimated cost - 730 rubles. The composition of the drug contains 150 mg active substance. It is released according to the prescription of the attending physician.

Indications:

• cryptococcosis;
• candidiasis;
• fungal infections.
• Contraindications:
• lactation;
• the use of astemizole;
• lactose deficiency.

"Diflazon"

This prescription drug produced by Vector-Pharm LLC, which is based in Slovenia. Produced in glass bottles with a capacity of 100 ml. The recommended storage temperature is 20°C. Effective antifungal drug intended for infusion. Used as excipients water solution sodium chloride.

Side effects:

• headache;
• convulsions;
• neutropenia;
• violations of cardiac activity;
• swelling of the face;
• skin rash;
• necrolysis.

"Vagisept"

The drug contains fluconazole and metronidazole. The medicine is produced in Russia by Firn-M. The drug is dispensed by prescription. Estimated cost is 350 rubles. The carton box contains ten vaginal suppositories.

"Safocide"

A package of 12 tablets of the drug is sold at a price of 1681 rubles. Producer - JSC "Nizhpharm" (Russia). There are Indian counterparts. In addition to fluconazole, the drug contains the antibiotic azithromycin, secnidazole.

Since "Safocide" is a set individual tablets, then the set of ingredients of each is different.

Indications:

• various infections genitourinary system;
• trichomoniasis;
• urethritis;
• cervicitis;
• gonorrhea;
• vaginosis of bacterial origin;
• cystitis;
• inflammation of the tissues of the vulva;
• vaginitis.