What does Ranitidine help with? Instructions for use. What is Ranitidine taken for and how does it affect the human body? Terms of sale, recipe in Latin

Why is Ranitidine prescribed by doctors? Before answering the question, you should find out what constitutes this drug, what composition does it have, how should it be taken and in what dosages?

General information

What can Ranitidine be taken for? Such a synthetic drug is one that is capable of significantly reducing the volume gastric juice.

Composition of the drug and its release form

The drug "Ranitidine" is available in the following dosage forms:

• Tablets containing 300 mg and 0.15 g active component(ranitidine hydrochloride form). This medication goes on sale in 100, 30 or 20 pieces in cardboard packaging.
• Solution for injection. This drug is used only when oral administration medication is not possible for some reason. Medicinal solution goes on sale in ampoules of 2 ml.

Pharmacodynamics

Why is Ranitidine so often prescribed by doctors? Such a drug, or rather its active component, quite quickly reduces the volume of gastric juice, the secretion of which is caused by stretching of the main digestive organ. As a rule, this pathological condition occurs due to excessive food load, as well as under the influence of certain biogenic stimulants (histamine, acetylcholine, gastrin, pentagastrin and caffeine) and hormones.

After using the drug "Ranitidine", the patient's protection of the mucous membrane of the main digestive organ is enhanced, and the amount of hydrochloric acid in its juice is noticeably reduced. It should be especially noted that when using this drug, mucus production practically does not change and the enzymatic functions of the liver are not suppressed.

The drug "Ranitidine" promotes the healing and restoration of all damage to the gastric mucosa that is associated with the effects of hydrochloric acid. This effect of the drug is due to an increase in the formation of stomach mucus. According to the instructions, the drug "Ranitidine" in a dose of 0.15 g suppresses the secretion of juice of the main digestive organ for 8-13 hours.

What is Ranitidine prescribed for?

Such medicinal product used for the following deviations:

• ulcer of the duodenum and stomach (especially in the acute stage);
• inflammation of the esophagus, which is caused by the reflux of stomach contents into it (with reflux esophagitis);
• inflammation of the esophagus due to a violation of the integrity of its mucous membrane (with;
• for symptomatic and rapidly developing ulcers of the duodenum and stomach resulting from stress, taking certain medications or certain diseases internal organs;
• stomach ulcers in combination with a benign pancreatic tumor (with Zollinger-Ellison syndrome).

Use for prevention

The drug "Ranitidine" for the stomach is taken not only for treatment, but also for the prevention of the following abnormalities:

• exacerbations of ulcerative and erosive diseases;
• lesions upper sections gastrointestinal organs;
• entry of stomach juice into the respiratory tract when surgical intervention(under anesthesia).

Contraindications for use

Ranitidine stomach tablets should be taken only after consulting a doctor. After all, this drug has some contraindications:

• pregnancy;
• V childhood(up to 14 years old);
• increased sensitivity to the drug;
• lactation period.

Also, the drug "Ranitidine" is prescribed with extreme caution in case of disorders of the excretory function of the kidneys.

Dosage and methods of application

The presented drug is prescribed in one dosage or another depending on the diagnosis:

To prevent stress ulcerations and bleeding, Ranitidine should be used intramuscularly or intravenously at 0.1 or 0.05 g every 7-8 hours.

Side effects

This drug may cause the following: side effects:

• skin rash;
• dizziness;
• thrombocytopenia;
• headache;
• fatigue.

In rare cases, the drug "Ranitidine" provokes hair loss. Also, the presented drug can lead to hallucinations and the development of confusion. With long-term use of large doses, the patient's prolactin levels increase, gynecomastia, leukopenia, impotence, amenorrhea occur, and libido decreases. Sometimes the use of such a drug can lead to the development of hepatitis.

Special instructions

• This drug is prescribed with extreme caution to patients with pronounced violations kidney or liver function.
• Before starting treatment with this drug, you should exclude possible availability malignant disease of the stomach, esophagus or duodenum.
• In case of urgent need to discontinue therapy, the medication is discontinued by gradually reducing the dose.
• Efficiency preventive use of the drug in courses of 50 days in the autumn-spring period is much higher than with its constant use.

Analogues of the product

Analogs of this medication are the drugs “Zantac”, “Rantak”, “Ranisan”, “Acylok”, “Ulran”, “Ulkodin”, “Ranigast” and “Ranidine-Akos”. What are all these remedies taken for? They contain the same active component, and therefore the indications for such drugs are identical.

Histamine H2 receptor blocker. Antiulcer drug

Active ingredient

Ranitidine (as hydrochloride)

Release form, composition and packaging

Tablets, coated film-coated light orange in color, round, biconvex.

Excipients: microcrystalline cellulose, corn starch, collidon VA-64, colloidal silicon dioxide, magnesium stearate, hypromellose, ethylcellulose, polyethylene glycol 6000, propylene glycol, sodium lauryl sulfate, titanium dioxide, sunset yellow dye.

10 pcs. - blisters (2) - cardboard boxes.

Pharmacological action

Ranitidine blocks histamine H2 receptors parietal cells gastric mucosa, reduces basal and stimulated secretion of hydrochloric acid caused by irritation of baroreceptors, food load, the action of hormones and biogenic stimulants (gastrin, histamine, pentagastrin). Ranitidine reduces the volume of gastric juice and the content of hydrochloric acid in it, increases the pH of the stomach contents, which leads to a decrease in pepsin activity. After oral administration in therapeutic doses, it does not affect prolactin levels. Inhibits microsomal enzymes.

Duration of action after a single dose is up to 12 hours.

Pharmacokinetics

Rapidly absorbed; food intake does not affect the degree of absorption. When taken orally, the bioavailability of ranitidine is approximately 50%. Cmax is reached 2-3 hours after administration.

Plasma protein binding does not exceed 15%. Slightly metabolized in the liver to form desmethylranitidine and ranitidine S-oxide.

Has a first pass effect through the liver. The rate and degree of elimination depend little on the condition of the liver.

T1/2 after oral administration - 2.5 hours, with CC 20-30 ml/min - 8-9 hours. Excreted mainly in urine (60-70%, unchanged - 35%), a small amount - in feces. Penetrates poorly through the blood-brain barrier. Penetrates through the placenta. Excreted in breast milk (concentration in breast milk in women during lactation is higher than in plasma).

Indications

- treatment and prevention of exacerbations peptic ulcer stomach and duodenum;

Inhibits the metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propracolol, diazepam, lidocaic, phenytoin, theophylline, aminophylline, indirect anticoagulants, glipizide, buformin, metronidazole, calcium antagonists.

Medicines that depress bone marrow, increase the risk of neutropenia.

When used simultaneously with sucralfate in high doses, the absorption of ranitidine may be slowed down, so the break between taking these drugs should be at least 2 hours.

Special instructions

Treatment with ranitidine may mask symptoms associated with gastric carcinoma, so the presence of a cancer-ulcer must be excluded before starting treatment.

Ranitidine, like all H2-histamine blockers, should not be abruptly discontinued (rebound syndrome).

With long-term treatment of weakened patients under stress, bacterial damage to the stomach is possible with subsequent spread of infection.

There is evidence that ranitidine can cause acute attacks of porphyria.

H2-histamine receptor blockers should be taken 2 hours after taking itraconazole or ketoconazole to avoid a significant reduction in their absorption.

May increase glutamate transpeptidase activity.

Could be the reason false positive reaction to test for protein in urine.

H2-histamine receptor blockers can counteract the effect of pentagastrin and histamine on the acid-forming function of the stomach, therefore, within 24 hours preceding the test, the use of H2-histamine receptor blockers is not recommended.

H2-histamine receptor blockers can suppress the skin reaction to histamine, thus leading to false-positive results (before performing diagnostic skin tests to detect allergic reactions). skin reaction immediate type, the use of H2-histamine receptor blockers is recommended to be discontinued).

During treatment you should avoid consuming food, drinks and other medicines which may cause irritation of the gastric mucosa.

Use in pediatrics

Safety and effectiveness of ranitidine in children under 12 years old not installed.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Ranitidine- antiulcer agent, belongs to the group of histamine H2 receptor antagonists. It selectively blocks histamine H2 receptors in the parietal cells of the gastric mucosa and inhibits the secretion of hydrochloric acid. Under the influence Ranitidine The total volume of secretion also decreases, which leads to a decrease in the amount of pepsin in the stomach contents. Antisecretory action Ranitidine creates favorable conditions for healing stomach and duodenal ulcers. Ranitidine increases protective factors in the tissues of the gastroduodenal zone: enhances reparative processes, improves microcirculation, increases the secretion of mucous substances.

Indications for use

Peptic ulcer of the stomach and duodenum in the acute stage; prevention of exacerbations of peptic ulcer disease; symptomatic ulcers (rapidly developing ulcers of the stomach and duodenum due to stress on the body, taking medications or diseases of other internal organs); erosive esophagitis(inflammation of the esophagus with disruption of the integrity of its mucous membrane) and refluxesophagitis (inflammation of the esophagus caused by the reflux of gastric contents into the esophagus); Zollinger-Ellison syndrome (a combination of stomach ulcers and benign tumor pancreas); prevention of lesions of the upper sections gastrointestinal tract and in postoperative period; prevention of aspiration of gastric juice (entry of gastric juice into the respiratory tract) in patients undergoing surgery under anesthesia.

Directions for use

Doses are set individually. Typically, adults are prescribed 0.15 g 2 times a day (morning and evening) or 0.3 g at bedtime. Duration of treatment is 4-8 weeks. To prevent exacerbations of peptic ulcer, 0.15 g is prescribed before bedtime for up to 12 months with constant endoscopic monitoring (examination of the gastric mucosa with a special tubular optical device intended for visual / vision / examination) every 4 months. For Zollinger-Ellison syndrome, 0.15 g is prescribed 3 times a day; if necessary, the dose can be increased to 0.6-0.9 g per day. To prevent bleeding and stress ulcerations, the drug is administered intravenously or intramuscularly at 0.05-0.1 g every 6-8 hours. Adolescents aged 14 to 18 years are prescribed 0.15 g 2 times a day. Patients with renal failure if the level of creatinine (the end product of nitrogen metabolism) in the blood serum is more than 3.3 mg/100 ml, 0.075 g is prescribed 2 times a day.

Before starting treatment, it is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum. It is not advisable to discontinue the drug abruptly due to the risk of relapse (recurrence) of peptic ulcer disease. Efficiency preventive treatment peptic ulcer disease is higher when taking the drug in courses of 45 days in the spring-autumn period than when taking it continuously. With long-term treatment with the drug in weakened patients under stress, bacterial damage to the stomach is possible with subsequent spread of infection. In cases where the drug is used in combination with antacids (drugs that reduce gastric acidity), the interval between taking antacids and ranitidine should be at least 1-2 hours (antacids may cause malabsorption of ranitidine).

Side effects

Ranitidine is tolerated relatively well, side effects are observed less frequently than with cimetidine. Rarely - headache, dizziness, fatigue, skin rash, thrombocytopenia (decreased number of platelets in the blood), a slight increase in serum creatinine at the beginning of treatment; very rarely - hair loss. In seriously ill patients, confusion and hallucinations (delusions, visions that acquire the character of reality) are possible. Long-term use large doses can lead to an increase in prolactin (pituitary hormone), gynecomastia (enlargement of the mammary glands in men), amenorrhea (cessation of menstruation), impotence (sexual weakness), decreased libido (sex desire), leukopenia (decrease in the level of leukocytes in the blood). Several cases of hepatitis (inflammation of liver tissue) have been described.

Contraindications

Pregnancy, breastfeeding. Increased sensitivity to the drug. Not prescribed for children under 14 years of age. Prescribe the drug with caution to patients with disorders excretory function kidney

Pregnancy

Pregnancy and breastfeeding are contraindications when taking the drug.

Interaction with other drugs

When taken in combination with antacids, a break between taking antacids and Ranitidine should be at least 1-2 hours (antacids may impair the absorption of ranitidine). The drug has virtually no effect on the activity of microsomal liver enzymes.

Release form

Tablets of 0.15 and 0.3 g in packs of 20, 30 or 100 pieces. Solution for injection in ampoules of 2 ml.

And the duodenum compares favorably with its analogues not only due to affordable price, but also a persistent level of popularity that has not declined for several decades. And even despite most claims about their strong negative effect on organs containing histamine receptors, it is still considered the best option in the choice of treatment.

How does the drug work?

Taking the drug leads to blocking of histamine receptors in the thickness of the gastric mucosa, which prevents the excessive release of hydrochloric acid by the parietal cells. It follows that the main indications for the use of Ranitidine are all conditions characterized by increased secretory activity of the stomach.

Scope of application

In therapy these tablets are used in the treatment and prevention of ulcerative lesions of the upper gastrointestinal tract, the treatment of Zollinger-Elisson syndrome (stomach ulcer combined with a pancreatic tumor), reflux esophagitis (inflammation of the esophagus associated with the periodic release of gastric contents into the esophagus) and erosive inflammation of the esophagus.

In surgical practice Ranitidine is prescribed to prevent burns. respiratory tract due to accidental release of gastric juice during general anesthesia or the occurrence of stomach ulcers in the postoperative period.

Even part of the population, far from medicine, knows that Ranitidine helps at sudden attack heartburn. True, here it is used only in cases where for some reason ordinary baking soda is not at hand.

In oncological practice Due to the use of toxic drugs, situations quite often arise in which the activity of almost all parts of the gastrointestinal tract is disrupted with an obligatory increase in the secretion of hydrochloric acid, from which Ranitidine also saves this category of patients.

In some cases, ranitidine is used to stop gastric bleeding, but only in cases where it is caused by additional damage to the organ wall with hydrochloric acid.

Negative qualities

Even when using medication for the above diseases in the dosage recommended by the attending physician, there is a fairly high probability of side effects, associated mainly with the activity of the cardiovascular and central nervous systems. But this deficiency is easily corrected by reducing the dose or using Ranitidine with a lower mg content of active components.

In addition, the drug, even despite the complete absence of teratogenic and carcinogenic effects, confirmed by numerous experiments on animals (it freely penetrates the placental barrier) and in children under 12 years of age (the body is in the process of final formation).

In conclusion, it should be noted that for now, what Ranitidine helps with will only affect the older population or until it is corrected financial situation residents of our country, the popularity of the medicine will not subside, even if there are ultra-modern products with complete absence contraindications or similar negativity.

Found a mistake? Select it and press Ctrl + Enter

Ranitidine is an antiulcer drug that inhibits histamine H2 receptors. Thanks to active substances The medicine manages to achieve a reduction in the secretion of gastric juice by selectively reducing the activity of H2-histamine receptors in the parietal cells of the mucosal membrane.

The drug is distributed in the form of round tablets in a pale orange shell, 10 pieces each. in a box, as well as in the form of injection ampoules.

The active component of the drug is Ranitidine hydrochloride. Additional - lactose, cellulose, sodium starch, magnesium stearite, silicon dioxide.

Why is Ranitidine prescribed?

Important! Numerous patient reviews indicate the effectiveness and safety of the product when used correctly.

Indications for the use of the drug are the following diseases:

• Peptic ulcer disease.
• Ulcer of the mucous membrane of the stomach and duodenum with benign formations(systemic mastocystosis, Zollinger-Ellison syndrome).
• To avoid the appearance of ulcers caused by the use of non-steroidal anti-inflammatory drugs.
• GERD and erosive esophagitis.
• Removal of gastric secretions during surgery.
• Development of bleeding in organs digestive tract.
• Inflammatory processes in the digestive organs.
• Infectious diseases of the digestive system.

Contraindications

It is forbidden to take the drug for children under 12 years of age, for patients who have an individual intolerance to the active component of the drug, as well as its excipients. The drug is contraindicated during pregnancy and lactation.

Ranitidine should be used very carefully in case of renal impairment. liver failure or cirrhosis, with spatial encephalopathy.

Side effects

Against the background of prolonged or improper use of the drug, symptoms may occur. side effects from the neurological condition of the patient, the digestive tract, as well as some other disorders.

From the side of the central nervous system, dizziness, lethargy, drowsiness, irritability, and the appearance of depressive state, hallucinations. Most often, side effects occur in seriously ill and elderly patients.

Arrhythmia, tachycardia, and bradycardia may appear on the part of the heart.

Negative manifestations regarding the digestive tract organs can be in the form of constipation, stool disorders, nausea, vomiting, pain in the stomach and intestines, and dry mouth.

Less common are decreased libido, alopecia, rashes on the body, anaphylaxis, muscle pain, bronchospasm, Quincke's edema.

Special instructions for the use of Ranitidine

Before starting treatment, it is necessary to consider special instructions on the use of the drug. These include:

1. Using the product to treat patients with weakened immune systems can lead to damage to the stomach by pathogenic bacteria and their further spread to internal organs.
2. You cannot abruptly stop taking the drug, since the drug has a “withdrawal syndrome,” which consists of a deterioration in the patient’s condition if the drug is discontinued incorrectly.
3. Sometimes the use of tablets and injections can provoke sharp pain in the abdomen, accompanied by neuralgic disorders (excitement, irritability, depression).
4. When using Ranitidine, drinks containing caffeine, alcohol, carbonated water, and sour juices should be excluded from the patient's diet.
5. When using medications, it is recommended to give up cigarettes. Smoking is a factor that reduces the effectiveness of the drug.
6. The effectiveness and safety of the drug in patients under 12 years of age have not been tested.
7. During treatment with Ranitidine, activities that require high concentration of attention should be avoided.

After achieving the required therapeutic effect, treatment should be continued for another 1-3 weeks to consolidate the results.

Ranitidine cannot be combined with certain medications.

Methods of application

Depending on the disease and the age of the patient, the medication and its dose differ. You should take the pills after diagnosis, as prescribed by a specialist.
Renitidine is taken in prescribed doses without chewing, with water.

Treatment of ulcers and gastritis

For the treatment of acute peptic ulcers and gastritis, the drug is prescribed at a dose of 150 mg. twice during the day. According to a doctor's prescription, the dose can be a single dose of 300 mg in the evening before bed.

The course of treatment is at least a month; therapy can be carried out either in combination with other medications or as an independent remedy.

For the preventive treatment of diseases of the gastrointestinal tract, Ranitidine is taken in doses prescribed by a gastroenterologist.

Treatment of esophageal diseases

Due to dysfunction of the alimentary sphincter, the walls of the esophagus are irritated by stomach acid. This happens due to insufficient compression of the ring, which ensures the closure of the entrance to the stomach.

The release of hydrochloric acid provokes damage to the esophagus, irritation of its walls, the appearance of ulcers and an inflammatory process.

Treatment of diseases associated with inflammatory process, is carried out according to the same scheme as therapy for peptic ulcer disease (300 mg over 24 hours). In particularly severe cases of the disease, the dosage can be changed by the attending physician to 600 mg.

Use for Zollinger-Ellison syndrome

The dosage of the medicine should be determined by a specialist, taking into account the severity of the pathology, as well as individual characteristics patient. Daily dose Ranitidine is from 3 to 6 g of the drug.

If side effects from the liver occur, the dose of the drug can be adjusted by the attending physician.

Drug interactions

Procainamide and ranitidine should also not be used at the same time. Ranitidine helps to slow down the excretion of Procainamide by the kidneys, which greatly increases its concentration in the blood.

Analogs

To means having similar action and composition include the following medications:

1. Gastrodicin– used for the treatment of peptic ulcers, as a prophylaxis for disorders of the digestive system. Prescribed to patients suffering from gastritis chronic form, increased formation of gastric juice.
2. Gistak– used to treat gastric ulcers caused by taking non-steroidal anti-inflammatory drugs, when functional dyspepsia, chronic gastritis, causing high production of hydrochloric acid. And also for GERD and other pathologies of the digestive system.
3. Rentak– refers to medications used for the treatment of peptic ulcers, GERD, chronic gastritis with increased formation of gastric juice.
4. Famosan– widely used for stomach ulcers, for the treatment and prevention of recurrence of ulcerative pathology, for Zollinger-Ellison syndrome, and gastrointestinal erosions.
5. Ulfamid– prescribed for peptic ulcers of the duodenum and stomach, for ulcers caused by prolonged or improper use of non-steroidal anti-inflammatory drugs. Ulfamide is indicated for patients with acute gastritis, not ulcerative dyspepsia.
6. Ulran– treatment and prevention of peptic ulcer of the duodenum and stomach, therapy of gastroesophageal reflux. Ulran is prescribed for the treatment of pathologies associated with excessive formation of gastric juice. In tandem with others medications used to treat ulcers caused by Helicobacter pylori.
7. Umetak– an antiulcer medicine used for the treatment and prevention of ulcers, in acute gastritis, which provokes excessive secretion of hydrochloric acid in the stomach, as well as for the treatment of diseases such as esophagitis, ulcers due to Helicobacter pylori. IN the latter case the product is used in complex therapy along with antibiotics.

Storage conditions

The drug should be kept protected from direct contact sun rays place, at a temperature not exceeding 25 degrees Celsius, away from humid conditions and children.

The shelf life from the date of production, subject to the recommended conditions, is 3 years. After this time, it is strictly prohibited to use the medicine.

The price of Ranitidine should be checked at the pharmacy. The cost of the product depends on the manufacturer, release form and the number of blisters in the package.

Ranitidine is a powerful remedy for the treatment of ulcers, gastritis and other gastrointestinal disorders, providing lasting results in many diseases of the digestive system. Proper use medications in accordance with the doctor’s prescription will help get rid of the disease and prevent relapse.