Pimafucin during pregnancy: safe treatment of fungal diseases. The use of pimafucin suppositories during pregnancy Effects on the pregnant woman and the fetus
Pimafucin is a modern pharmaceutical product developed for use in obstetrics and gynecology for the treatment of thrush on various stages woman's life, including during pregnancy. Pimafucin during pregnancy is best used in the form of suppositories (candles). This allows you to achieve maximum effect in a minimum period of time.
Consist of the active substance - natamycin, which is recognized as a substance with a low degree of toxicity. This makes it possible to successfully overcome the symptoms of thrush, even during the period of gestation. This effect is achieved due to the fact that the components of the drug are not capable of absorption through the walls of the stomach and intestines. The skin and mucous membranes also do not have sufficient throughput, which would allow the drug to be absorbed inside. Thus, the main effect of the drug is local. Accordingly, the fetus is not affected.
Is pimafucin possible during pregnancy?
There is every reason to say with absolute certainty: yes, pimafucin can be used during pregnancy. This pharmaceutical agent is one of the few agents, the use of which does not have any negative consequences for the body. It can be used without any concerns, both during pregnancy and lactation. The action is purely local in nature, it does not have systemic properties. Accordingly, it cannot affect the fetus. This has been confirmed by numerous studies, both domestic and foreign. In addition, many years of practice of its use confirms its safety.
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ATX code
A07AA03 Natamycin
Active ingredients
Natamycin
Pharmacological group
Antifungals
pharmachologic effect
Fungicidal preparations
Indications for the use of pimafucin during pregnancy
Indications for the use of the drug are cases of bacterial and fungal infection women's reproductive organs, vagina, skin and mucous membranes. Effective against fungi of the genus Candida, respectively, is prescribed for candidiasis of any localization. Treatment of thrush requires the inevitable appointment of pimafucin. It also eliminates various inflammatory diseases. It is recommended for generalized lesions of internal organs, in which the infection spreads uncontrollably. When the infection spreads, the intestines and internal genital organs are affected. In this case, you can not do without pills. In the event of gynecological diseases, the partner also needs treatment and prevention. Used for injury oral cavity, which can be observed with excessively weakened immunity.
From thrush during pregnancy
The onset of pregnancy brings many women serious problem- milkmaid. Pimafucin will help to cope with it. The cause of thrush can be correlated with a decrease in immunity, a restructuring of the microflora due to new conditions for the body. Most experts prescribe pimafucin because it has proven itself to be non-toxic and safe remedy. The embryo is not affected by the drug.
There is no such period of pregnancy when pimafucin would be contraindicated. If symptoms of the disease appear, use immediately. It is important to choose the right dosage and concentration, which only a doctor can do. To do this, you need to look at the analysis. The drug can be used in different form. If the disease is systemic, it is better to resort to pills. Candles will be useful in the local inflammatory process.
With ICI during pregnancy
Isthmic-cervical insufficiency is not a contraindication to the use of pimafucin. It has a therapeutic and prophylactic effect, prevents the risk of infection, which is very important for IC.
With colpitis during pregnancy
Primafucin is active against fungi. It is used in the treatment of colpitis, if it is caused by the action of fungi, dysbacteriosis. It is used in the form of candles. It acts quickly, affects the entire area of inflammation, protects against penetration and further spread of infection, and normalizes the microflora.
Release form
The drug Pimafucin is available in the form of suppositories for intravaginal and rectal administration, tablets for oral administration, ointments and cream for local application to the affected areas.
- Pills
If the disease is prolonged, or difficult to treat, you need to switch to taking pills. In a chronic course, tablets will also have a greater effect. For pregnant women, candles are the best option, but taking pills is also allowed.
Also, tablets are used to prevent the uncontrolled spread of infection, with a severe form of the disease, with systemic lesion internal organs.
- Candles
Candles are the most convenient and affordable form designed for rational treatment during pregnancy. They are effective in local inflammation, because they quickly dissolve, begin to act in a short time. Allow to bypass the gastrointestinal tract, reducing the load on it.
Sometimes it is advisable to use a cream. It has an additional effect, enhances the effect of other forms. It is recommended to use in case of protracted illness, severe form. It can be used for dermatitis, ringworm, other diseases of the skin and nail plates. Provides prevention and treatment
The ointment is used in cases of damage to the reproductive organs, localization of the infectious process on the skin, nails.
Pharmacodynamics
It has an antifungal (antimycotic) effect. Acts directly on microorganisms statically or lytically, depending on the dosage. With a static effect, the drug helps to stop the growth and reproduction of microorganisms, due to which the number of their population decreases and the inflammatory process subsides. With a lytic action, the drug also affects microorganisms, causing a violation of their genetic and metabolic processes resulting in the death of the microorganism. It also helps to reduce the inflammatory process.
The causative agent of thrush in most cases are microorganisms of the genus Candida, which are microscopic yeast-like fungi that are representatives of conditionally pathogenic microflora. That is, they are contained in each healthy body Normally, they form a natural defense. If immunity falls, as well as due to some other factors, an increase in the number of these fungi occurs. If their number significantly exceeds the permissible norm, a disease develops.
Therefore, the action of the drug is directed specifically against them. The required dosage is selected, which will have a lytic or static effect. The dosage should be selected only by a doctor, since a decrease in the number of these fungi in the body below the norm also entails Negative consequences. Natamycin binds irreversibly to cell membranes fungi, the function and structure of which is disturbed, the microorganism dies. Resilience rarely develops.
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Pharmacokinetics
Natamycin, which acts as an active substance, has the ability to irreversibly bind to the cell membranes of the pathogen. This results in the death of the microorganism. It affects not only candida, but also other microorganisms that are sensitive to this ingredient. Habituation is not observed.
Pimafucin has only a local effect. It does not have a toxic effect, does not lead to poisoning, even in case of an overdose.
Use of pimafucin during pregnancy during pregnancy
Pimafucin in pharmacological guides characterized as antifungal drug, which acts against a wide range of microorganisms. It has long been used in the treatment of thrush, andidosis. Its peculiarity lies in the fact that it can be used during pregnancy, due to its high safety and no effect on the embryo. Many expectant mothers note that the drug has a positive effect on them, and consider it the only possible means, saving from the manifestations of thrush.
Doctors are inclined to use this drug due to the lack of teratogenic effects and in connection with the resolution during pregnancy and lactation. In addition, there is no evidence confirming a negative effect on the embryo. Most people prefer to use candles, thanks to which they can quickly achieve the desired effect. Only with their ineffectiveness and the progression of the disease, it is advisable to resort to the use of tablets, or a combination of drugs.
If we analyze the reviews of patients who took the drug, we can note both positive and negative reviews. The positive aspects of pimafucin include: efficiency, rapid achievement of a positive effect, safety. Some women need 1-2 suppositories, while others require several packages for a course of treatment. Many women associate the appearance of thrush with the onset of pregnancy; previously, such cases have not been observed. Apply on different terms pregnancy, but most often the need for the drug occurs in the first months. Women with severe form used suppositories in combination with cream. When the infectious process spreads to internal organs, which was observed extremely rarely, used a tablet form. In especially severe cases, or with a prolonged illness, it was prescribed complex therapy, which included candles and tablets.
Usually one or two courses are enough to fully recover. Relapses are rare. Some women note skin pathologies, which can be easily dealt with with a cream. The effect of the cream is already noticeable after an hour. Candles usually completely eliminate the symptoms of the disease in 6-7 days.
There are also negative reviews. For some women, the drug does not work in any way. Perhaps this is due to individual resistance, characteristics of the microflora. Despite the safety of the drug and the fact that it can be safely taken throughout the pregnancy, some doctors prefer to refrain from prescribing it for the first three months. Some women complain about the appearance of relapses, suffer throughout the entire pregnancy, despite taking the drug. They also say that there are candles that are also approved for use during pregnancy, and are more effective. Sometimes there is even an increase in the manifestations of thrush.
Thus, the reviews about the drug are very contradictory. There are both positive and negative ones. This indicates individual sensitivity in the drug, which is quite natural. In each specific situation, the result will be different. In any case, before use, you need to consult a doctor, in no case should you engage in self-medication. And in any case, you need to try: after all, the drug can be effective, and will help to heal forever.
Pimafucin in the first weeks and early stages of pregnancy
If a woman is in the first week of pregnancy, pimafucin can be used. It is at this stage that it is most often prescribed, since in the first weeks the most thrush sulchais are recorded, which is explained by a decrease in immunity. The drug does not disrupt the development of the embryo, does not interfere with the process of implantation.
If signs of thrush are found, you can safely start taking pimafucin. It is non-toxic, does not negative impact to the fruit. The course of treatment is not long. Recovery occurs quickly, relapses are rare.
Pimafucin during pregnancy in the 1st, 2nd, 3rd trimester
Pimafucin is quite safe when used in the first trimester of pregnancy.
From 3 to 6 months, the drug can be used, since it has only a local effect, due to which it acts effectively and quickly.
If there is such a need, the drug can be used from 6 to 9 months. It is a safe, non-toxic drug. But usually the need for it arises at an earlier date. Thrush at 6-9 months is a rare phenomenon, as immunity increases.
Side effects of pimafucin during pregnancy
Side effects may include nausea and diarrhea. These effects pass quickly enough, do not require any additional treatment. At topical application in the form of candles, there may be a feeling of discomfort, burning in the genital area. These symptoms also pass quickly enough without additional intervention.
Discharge and burning sensation after pimafucin during pregnancy
The discharge may intensify due to the fact that the suppository in the vagina melts and flows out. Also, as a result of irritation of the mucosal receptors, additional stimulation of mucus production occurs.
With intravaginal administration of a suppository, or when applying a cream to the external genitalia, irritation of the mucous membrane may occur, resulting in burning and itching. It goes away on its own after a while. Stop treatment is not worth it, no action is needed to take.
Dosage and administration
When conducting systemic therapy, tablets are taken. Dosage - 1 tablet 4 times a day. The duration of treatment is from 7 to 10 days. The dose can be exceeded, since cases of overdose are unknown.
When prescribing candles, they usually prescribe 1 candle daily, or every other day. Depending on the form and severity of the disease, one suppository can be used once a week, or two weeks. One may need 3-4 suppositories per course, others may need several packs.
How often can pimafucin suppositories be used during pregnancy?
The drug is used until the symptoms of the disease can be eliminated. The amount of the drug is individual. Can be used every other day or several times a week. In any case, only the doctor can determine the required dosage, based on the results of the tests.
How to insert pimafucin suppositories during pregnancy?
Pimafucin suppositories are injected deep into the vagina at night. You can use the applicator for the introduction of candles for the introduction. To do this, the candle is placed in a special applicator, inserted into the vagina, released from the applicator, removed. You can buy an applicator at a pharmacy. It ensures the sterility of the introduction and deeper penetration of the agent.
Overdose
Currently, cases of overdose are unknown. Long-term use of the product does not entail any side effects, does not affect either the mucous membranes or the condition of the skin. It does not affect the fetus. No toxic effect occurs even when taken a large number the drug inside, because it is not absorbed through the intestinal mucosa.
Interactions with other drugs
The drug is combined with other drugs, cross-reactions and mutual neutralization does not occur.
Pimafucin and utrogestan during pregnancy
Two drugs are combined with each other, the main thing is to distribute the order and method of their introduction into the body. There are several options: you can use utrogestan intravaginally, and pimafucin - rectally. However, it must be borne in mind that with this method of administration, the effectiveness of pimafucin may decrease and the expected results may not be achieved. Or the duration of treatment will be much longer.
The second option is to take utrozhestan in tablets, administer pimafucin intravaginally. This option is also not without its drawbacks - utrogestan can have a toxic effect on the liver. However, the effectiveness of any drug is not reduced. Utrozhestan has the same effect on the body, both in the vaginal and in the oral route of administration. Its main task is to deliver progesterone to the body.
The third option is to administer both drugs intravaginally, with a break of at least 2 hours. This is the most best option, since the effectiveness of this is not reduced, side effects and drug interaction not happening. At the same time, two drugs should not be administered, you need to take breaks between them.
Storage conditions
The drug should be stored at a temperature not exceeding 25 ° C, in its original packaging. Direct sun rays should not fall.
Shelf life
The drug can be stored for 2 years.
What to do if pimafucin does not help during pregnancy?
The action of the drug is individual. Despite the fact that most women during pregnancy are saved from thrush only with the help of this remedy, for some it may be completely useless. It all depends on the individual characteristics of the organism, in particular, on the sensitivity of the microflora to the active substance. Resistance can develop if a woman has been taking the drug for a long time, or if previously prescribed courses have not been completed.
Treatment with antibacterial and antifungal drugs has its own characteristics. It is necessary to undergo a full course of treatment, even if the symptoms of the disease no longer bother and the body is completely healthy. This is due to the fact that the microorganisms against which the action of the drug is directed can develop resistance over time. The full course is designed to completely kill the pathogen. If you stop using the drug halfway through the course, as soon as the symptoms have disappeared, the microorganisms may not die completely. They survive and, through natural selection, develop further resistance not only to this drug, but to the entire group of these drugs. Since the microorganisms did not die, after a while they can cause the disease again, but the drug will no longer act on them.
Also, if the drug does not work, you need to check the expiration date. Perhaps, the expiration date of its suitability for use has simply expired, and the healing properties have been lost.
Pimafucin analogues during pregnancy
The closest analogue is natamycin. He is - active substance, which is part of pimafucin. In its pure form, it is less effective, since pimafucin contains Excipients. Also in its pure form, natamycin can harm the stomach and intestines. Dysbacteriosis may occur.
clotrimazole
During pregnancy, it is better to use pimafucin, since it is safer and approved for use during childbearing and feeding. Clotrimazole is not recommended to be taken in the 1st trimester of pregnancy and during breastfeeding. An overdose causes severe intoxication, while pimafucin has no side effects with an overdose. In case of an overdose of clotrimazole, in contrast to pimafucin, additional therapy is required.
Livarol
It is better to use pimafucin, because it is more safe. Pimafucin has fewer side effects (in rare cases - diarrhea, nausea, only at the initial stages of administration). When taking Livarol, irritation, severe dizziness and nausea may occur. In addition, the drug may cause severe allergic reactions, respectively, it is contraindicated in people who suffer from allergies. Increases the amount of histamine in the body (which may already be increased during pregnancy). In this case, severe swelling, headaches, dizziness, drowsiness can be observed. The drug is contraindicated in the first trimester.
Terzhinan
It is better to use pimafucin. First, it is easier to enter. Before the introduction of terzhinan, the tablet is pre-soaked in water. The tablet form is not convenient for insertion into the vagina. Pimafusin suppositories have a more convenient, natural form, do not cause discomfort during administration. Secondly, the duration of the course with terzhinan is much longer - 10-20 days, while pimafucin is treated for 5-7 days. Terzhinan can cause allergic reactions, it is contraindicated in the 1st trimester, as it penetrates the placenta and affects the fetus. It can be used while breastfeeding only in extreme cases.
In addition, terzhinan is more often used in the presence of a secondary inflammatory process, with a combination of thrush with other pathologies, or with a severe form of fungal infection.
Hexicon
During pregnancy and breastfeeding you can use both hexicon and pimafucin. But keep in mind that pimafusin causes allergic reactions and should be used with caution in people who have allergic diseases. Also, taking hexicon may be accompanied by excessive dryness, stickiness of the skin of the face and hands, overdrying of the mucous membranes. There may be a deposit of tartar, plaque. Sometimes taking hexicon is accompanied by a violation of taste. Not compatible with chlorhexidine. If the hexicon has come into contact with a surface previously treated with chlorhexidine, brown spots may form. Also, the drug is incompatible with iodine. It must be taken into account that soap neutralizes the drug, therefore, before applying the drug, it is necessary to completely get rid of even the slightest soap residues on the skin and mucous membranes.
Betadine
With thrush, it is better to use pimafucin, since its main action is directed against the fungus. Betadine has predominantly antibacterial properties. Antifungal activity is in second place. Batidine has a more powerful antiseptic effect. This may have its drawbacks - dry mucous membranes, burn them. Pimafucin during pregnancy is safer, acts gently. Betadine is more often used to treat the skin, postoperative surfaces, trophic ulcers and bedsores. The instructions do not say that the drug is recommended for application to mucous membranes. There is no question of its use during thrush. The drug should not be used in the first trimester, as it may affect the fetus. In addition, it contains iodine, so when long-term use you need to check the function thyroid gland. In newborns whose mothers used betamin, there are congenital disorders of the thyroid gland.
Thrush is a frequent companion of pregnant women. Its immediate cause is yeast fungi of the genus Candida, which are normally present in the vagina in significant amount and do no harm. If, for any reason, immunity decreases (and pregnancy is to some extent an immunodeficiency), these microorganisms begin to multiply intensively, causing clinical picture candidal colpitis, vaginitis or vulvitis.
Information For the treatment of candidiasis (thrush), there are many drugs for local and systemic treatment. During pregnancy, especially in the first trimester, many medicines cannot be used.
One of the drugs that can be used regardless of the duration of pregnancy is Pimafucin. It is available in the form of (candles), tablets and cream. More often in obstetrics and gynecology, it is suppositories that are used, however, with severe vulvitis (inflammation of the vestibule of the vagina and labia), it is more convenient to use cream. Pills inside are rarely used, with severe chronic candidiasis for intestinal sanitation from yeast fungi.
Compound
The composition of Pimafucin includes a substance natamycin. It is an antibiotic of the macrolide group, which has an antifungal effect (kills fungi). Its action is to bind the sterols of the cell wall of the fungus, which leads to its death. Natamycin is effective against most yeasts, especially the Candida genus. Resistance (resistance) to it was not observed.
Additionally Another feature of the drug is that it does not have a systemic effect, since it is not absorbed through the skin and mucous membranes and when taken orally. Therefore, it can be safely used during pregnancy and lactation.
Release form
The drug can be purchased at pharmacies in the form of a cream, vaginal suppositories (candles) and tablets.
Approximate price of the drug
Indications for the use of Pimafucin
Candidal vulvitis, vulvovaginitis.
Contraindications
Individual intolerance to the drug.
Instructions for use Pimafucin
The vaginal suppository is inserted deep into the vagina in the supine position, preferably at night. The duration of treatment is on average 3-6 days. Analogs
Analogues of Pimafucin are:
- Primafungin;
- Natamycin;
- Natamax.
The composition of the drugs can be used during pregnancy and lactation.
Terms and conditions of storage
The drug must be stored in a dry place, out of the reach of children, at a temperature not exceeding 25 Celsius. The shelf life is 4 years.
Pregnancy is a special period in a woman's life when she has to approach the choice of medicines with the highest responsibility and strictly follow the doctor's recommendations. This principle applies to medicines for all diseases, including those that, it would seem, are "traditional" companions of pregnancy. Such common diseases include vaginal candidiasis, or thrush (more details:). For its treatment, there are many various means, however, for pregnant patients, doctors prefer to prescribe the safest of them, namely, pimafucin. Pimafucin is an antifungal antibiotic a wide range action, which has no contraindications for use during pregnancy. In most cases, local therapy with pimafucin in the form of vaginal suppositories is prescribed for pregnant women. The duration of treatment depends on the individual characteristics of the organism and the course of the disease and can range from 3 to 9 days. The drug is injected into the vagina one suppository at night, before going to bed.
What is an indication for the appointment of pimafucin?
During pregnancy, due to hormonal changes in the body of a woman, it immune defense the microflora of the vagina is weakened, the microflora of the vagina changes, and these factors create an opportunity for a fungal infection. Against its background, a woman can develop inflammatory processes such as vaginitis, vulvitis or vulvovaginitis. They affect the skin and mucous membranes of the vulva and vagina, causing itching, burning and discomfort. Like any inflammatory disease, candidal vaginitis, vulvitis and vulvovaginitis adversely affect the course of pregnancy. In cases especially severe complications candidiasis is the cause of thinning and weakening of the membranes of the fetus under the influence of waste products of fungi, which can lead to their premature rupture. In addition, during childbirth, a child can become infected with candidiasis when passing through the birth canal. Therefore, the doctor must, on the one hand, prescribe effective treatment thrush, and on the other hand, choose a drug that will not adversely affect the fetus and the course of pregnancy. Such a drug is pimafucin. His active substance, natamycin, has a local effect on fungal cells, violating the integrity of their membranes and thereby causing the death of microorganisms. At the same time, the drug itself has only a local effect and is not absorbed from the surface of the skin or mucous membrane into the blood, that is, it does not penetrate the uteroplacental barrier.
How is pimafucin therapy carried out?
There are several dosage forms of this drug. Treatment with pimafucin during pregnancy is most often carried out topically. The perinatologist prescribes to a pregnant woman therapy with pimafucin vaginal suppositories containing 100 mg of natamycin. In this case, the suppository is inserted deep into the vagina once a day before bedtime in the supine position. After the introduction of the suppository, it is advisable not to get up for several hours, since under the influence of body heat the suppository quickly dissolves with the formation of a foam that evenly covers all the mucous membranes. If you stand up at this moment, the active substance will quickly flow out of the vagina and medicinal effect will be minimized. In most cases, one treatment course of pimafucin suppositories is enough to cure genital candidiasis.
However, in some cases, the fungal infection proceeds in a generalized manner, that is, in addition to the vagina, it also affects the internal organs. With a generalized candidal lesion of the body, the fungi are located in the walls of the intestine, from where the constant infection of the genital organs occurs. In this case, only one local treatment will be ineffective, so it is combined with systemic therapy, prescribing pimafucin tablets in addition to suppositories. Tablets are sold in packs of 20, each tablet contains 100 mg of natamycin.
In order to avoid recurrences of candidal lesions of the vagina, it is necessary that the woman's partner is also treated. Even if he does not have any symptoms of thrush, the causative agents of this disease can be under the foreskin, on the glans penis and, once on the vaginal mucosa, begin to multiply actively there. Therefore, the partner of a woman who is being treated for candidiasis is advised to conduct topical therapy with pimafucin in the form of a 2% cream. The cream is applied to the skin and mucous membranes once or several times a day. Treatment continues for several days after the disappearance of the symptoms of the lesion in both partners.
At strong weakening Immunity candidiasis sometimes affects the mucous membranes of the oral cavity. In this case, doctors recommend using pimafucin in the form of a 2.5% suspension for topical treatment. However, such a lesion of the oral cavity is rare in adults.
What is the duration of treatment with pimafucin during pregnancy?
The duration of local treatment with suppositories is determined by the intensity of the disease and can range from 3 to 9 days.
With systemic therapy, it is recommended to take 1 tablet of pimafucin 4 times a day for 7-10 days. Pimafucin does not have a teratogenic effect on the fetus, does not penetrate from the intestine into the mother's blood, that is, does not cause any harm to the child, therefore its use is allowed throughout the entire period of pregnancy.
Quite rarely, there is a side effect of the drug when taken orally, which manifests itself in the form of nausea and diarrhea. It does not require discontinuation of treatment and passes by itself after a while. When applied topically, a feeling of discomfort and burning sensation is possible.
An overdose of pimafucin does not cause any toxic damage to the body.
The only contraindication to the appointment of pimafucin is hypersensitivity the patient to the components that make up the drug.
Pimafucin during pregnancy: Reviews
In some cases, treatment with pimafucin may not give a positive effect, but most often this happens when the drug is taken for an insufficiently long time.
Nevertheless, in the vast majority of cases, pimafucin, if not completely destroying the causative agents of a fungal infection, then significantly facilitates its course, eliminating unpleasant and even painful symptoms. Here are the reviews of several women about the treatment with pimafucin:
Ekaterina I've dealt with thrush before pregnancy. But then she took diflucan, which helped her well. In the first weeks of pregnancy, noting the familiar symptoms of thrush, Ekaterina wanted to cure her in the usual way, but before taking the Diflucan tablet, she decided to read the instructions for the drug. Seeing that this drug is contraindicated for use during pregnancy, the woman did not self-medicate, but went to the doctor. She was prescribed a six-day course of pimofucine suppositories. Ekaterina felt relief after the very first day of treatment. After the full course suppositories, the symptoms of thrush did not recur until the 30th week of pregnancy. At this time, the disease relapsed, and Ekaterina was prescribed complex therapy with pills and suppositories of pimafucin. After a week of treatment, the symptoms of thrush disappeared and did not reappear.
Kseniya I first encountered thrush at the 19th week of pregnancy. The itching and burning sensations were very unpleasant. The doctor prescribed a woman pimafucin suppositories for a three-day course. The symptoms of thrush disappeared, but the improvement was short-lived. Two weeks later, Ksenia again came to the doctor with complaints about thrush. This time, she was prescribed pimafucin in suppositories for 6 days, in tablets, 1 piece 4 times a day for a week, and recommendations were given for treating her husband with 2% pimafucin cream. After all the doctor's prescriptions were fulfilled, the thrush no longer bothered Xenia.
Svetlana did not notice any unpleasant symptoms, but at a scheduled appointment in antenatal clinic at 12 weeks' gestation, the perinatologist informed her that Candida fungus was found in a smear in a significant amount, and treatment was needed. Svetlana did not follow the doctor's recommendations, as she was afraid of harming the child with "extra chemistry". After a few weeks, she began to notice abundant curdled discharge who scared her. After visiting a doctor whom she completely trusted, the woman asked for the safest medicine possible. She was recommended topical treatment with pimafucin suppositories for 6 days. This time, Svetlana followed all the doctor's instructions, and the treatment helped her.
Pimafucin during pregnancy is one of the safest drugs, so you should not question the recommendations of a doctor who prescribes a course of pimafucin to a pregnant woman. In the vast majority of cases, this drug will help the expectant mother solve her problems, and most definitely will not cause the slightest harm to the fetus.
Pimafucin instruction
The instruction informs not only about the composition and pharmacological properties of Pimafucin in each of its dosage forms (candles, tablets, cream), but also about other information about Pimafucin that is in demand in the treatment.
Form, composition, packaging
The medicine is produced in three versions: tablets, vaginal suppositories and cream / ointment.
Pimafucin candles
Each Pimafucin candle is placed in a foil strip, where there are only three of them. There may be two or one such strips in a cardboard package.
The active ingredient is natamycin. It is supplemented with the necessary proportions of cetyl alcohol, sodium bicarbonate, adipic acid, polysorbate 80, solid fat, sorbitan trioleate.
Pimafucin tablets
Tablets, called Pifamucin, are round in shape. White. Twenty pieces are sold in tinted glass bottles.
The active substance natamycin is supplemented with kaolin, triacetin, white beeswax, polyvinylpyrrolidone, lactose, titanium dioxide, calcium carbonate, sucrose, potato starch, magnesium stearate, gum arabic, gelatin and methyl parahydroxybenzoate.
Pimafucin cream
Thirty grams of white cream are placed in plastic or aluminum tubes. Color allowed up to light yellow.
The main ingredient, as in other forms of the drug, is natamycin, which is supplemented with propylene glycol, propyl parahydroxybenzoate, cetostearic alcohol, cetyl wax ether, sodium lauryl sulfate, methyl parahydroxybenzoate, decyletate and purified water.
Terms and conditions of storage
The drug Pimafucin, in any form of release, is stored for no more than two years at temperatures up to twenty-five degrees.
Pharmacology
The drug has a fungicidal and antifungal effect, which is due to the binding of styrenes in the cell membrane. Cellular integrity is broken and the microorganism dies.
Pimafucin can have an effect on fungi of a pathogenic and yeast-like species, as well as on dermatophytes.
Pharmacokinetics
The activity of the drug is manifested when used topically. Systemic action the medicine does not show. Absorption through the skin or mucous membranes does not occur. When taking a tablet, its effect is carried out in the intestinal zone, since it has an enteric coating.
Pimafucin indications for use
Each of the varieties of the drug has its own set of indications for the appointment.
Candles Pimafucin indications for use
Pimafucin in the form of a vaginal suppository is recommended for treatment:
- balanoposthitis;
- vaginitis caused by the fungus Candida;
- vulvaginitis;
- vulvitis.
Pimafucin tablets indications
For the use of Pimafucin tablets, the following diagnoses serve as indications:
- diseases of the passage of auditory external fungal etiology;
- acute atrophic or pseudomembranous candidiasis with extreme depletion of the body;
- diseases of the mucous membranes due to a fungal infection;
- vaginitis;
- inflammation in the oral cavity of a fungal nature;
- vulvitis;
- intestinal candidiasis;
- vulvovaginitis;
- the development of ailments against the background of treatment with a cytostatic, antibiotic, corticosteroid.
Pimafucin cream indications
Pimafucin cream is prescribed for:
- with lesions of nails, mucous membranes and skin by a fungus;
- candidiasis skin and nail plates;
- vulvovaginitis;
- otitis media of fungal origin or complicated by candidiasis;
- balanoposthitis;
- dermatomycosis;
- vaginitis.
Contraindications
The use of the drug in any of its forms is not suitable for those patients who suffer from a high degree sensitivity to substances that are part of the drug.
Pimafucin instructions for use
Each of the dosage forms of the drug requires compliance with certain rules of application. After the symptoms of the disease cease to manifest themselves, you should take the medicine for a few more days.
Instructions for use of Pimafucin suppositories
The use of suppositories is carried out by insertion into the vagina.
Vulvovaginitis, vulvitis, vaginitis - should be administered 1 pc. / Three to six days / night. The candle is inserted as deep as possible, the patient takes a prone position.
If there is no effect in the treatment, tablets are added to the therapy: 1 pc / 4r / from 10 to 20 days. Men are shown the use of the cream.
The duration of treatment is at the discretion of the doctor.
Pimafucin tablets application
Intestinal candidiasis - for an adult: 1 piece / 4r / day.
for a child: 1 pc / 2r / d
The average duration of the course is seven days.
Pimafucin cream - instructions for use
Application is carried out exclusively externally.
Balanoposthitis, vulvitis, vulvovaginitis - the cream is applied to the affected area of the skin once or several times a day. With a delay in recovery, treatment is supplemented by taking pills and suppositories.
Dermatomycosis, candidiasis of the nail and skin cover - apply the ointment at least 4 times a day.
Mycosis of the external auditory canal - lubricate the affected areas 4 times, followed by the placement of cotton turunda in the ear.
Pimafucin during pregnancy and breastfeeding
Any of the forms of Pimafucin is allowed for use by a pregnant or lactating woman. Thrush can be treated at any stage of pregnancy and while breastfeeding. The safety of the drug and the absence of toxicity, both for the fetus and for the baby, have been established. However, in order to avoid unforeseen situations, it is desirable for this category of patients to use the drug mainly in the form of suppositories or creams.
Pimafucin for babies
Pimafucin candles for babies
This form of the drug for the treatment of infants is not used, since the suppository is administered vaginally.
Pimafucin tablets for babies
children infancy prescribed to receive only part of the pill. The drug is used to treat candidiasis in the intestines. The tablet under the protection of the shell from gastric juice acts precisely in the intestinal zone and, as a rule, does not cause side reactions.
Pimafucin cream for babies
Basically, Pimafucin cream is used for a newborn to treat diaper rash or when vulvitis or skin candidiasis is detected in him. The drug is used by applying to the affected area two to four times a day.
The girl is being treated for thrush by applying a cream to the vulvar area.
Caution should be exercised when treating an infant with this type of drug. With extensive areas of damage, the application should be carried out by dividing them into small areas, since it is forbidden to apply ointment to the entire surface of the baby's skin.
Side effects
For external forms of application of the drug, slight skin irritation, burning sensation is possible.
In tablets, the medicine may initially cause diarrhea or nausea, which resolves on its own and does not require treatment.
Overdose
Cases of overdose were not recorded.
Drug Interactions
There are no descriptions.
Additional instructions
Infection of a chronic or recurrent nature may require treatment with all forms of the drug.
Burning can occur when using suppositories due to the inclusion of cetyl alcohol in their composition. At menstrual bleeding in a woman, treatment using a suppository is interrupted.
Sexual contact during the treatment period is not prohibited. Be sure to use barrier contraceptives and examination, both men and women for subsequent treatment.
Pimafucin is allowed for therapeutic measures in a newborn baby.
Pimafucin analogues
Analogues of the drug Pimafucin tablet form are drugs Alfa-Normiks and Nystatin Health.
Suppositories can be replaced if necessary with Clotrimazole, Livarol, Nystatin suppositories.
Pimafucin price
The cost of any of the forms of the drug must be specified at the pharmacy when buying. Approximately Pimafucin cream can be bought by paying about 190 rubles for a package. Suppositories cost from 275 to 385 rubles, and the tablet form of the drug can be purchased by paying 365 rubles for a pack.
Pimafucin reviews
Reviews of the drug are mostly positive in relation to any of its forms of release. Many report a quick, but in some cases short-lived, therapeutic effect. Some complain about the development of side effects.
Evgenia: Few women today are not familiar with such an ailment as thrush, which develops for many reasons. In my case, the body gave a serious failure after the birth of the baby: sleepless nights, which are fraught with overwork, led to unpleasant symptoms. The doctor prescribed Pimafucin in tablets, explaining that this drug will not harm the baby when breastfeeding, since it is prescribed to infants without fear if it is necessary to treat thrush. I trust my doctor. By following his recommendations, I recovered quickly. Didn't feel any side effects.
Marina: After the thrush turned from mild symptoms into a pronounced ailment, I realized that douching with herbs alone would not be enough and went to the pharmacy. They advised the setting of the Pimafucin suppository. A wonderful tool. Four days and problematic symptoms are gone. I recommend it to anyone who has this problem. Helped me very well.
Veronica: My daughter is only five years old, and already had to visit a gynecologist. The baby began to be disturbed by itching in the genital area, and I decided that it was better to show her to the doctor. The doctor, after a delicate examination, advised to limit the child to sweets and, explaining that thrush caused concern, she advised treatment using Pimafucin cream. The result is good. The drug is not very expensive. The purchase of just one tube saved the child from anxiety.
Similar instructions:
Even in the earliest stages, thrush (candidiasis) can disturb a pregnant woman. Based on the period of pregnancy of a woman, in what form the disease occurs, and how severe it is, drugs are selected for treatment. The safest are Pimafucin suppositories, which are approved for use during the period of bearing a child.
Since hormonal changes occur in the female body during pregnancy, it significantly weakens immune system. As a result, this provokes a change in the microflora of the vagina, in which favorable conditions for the development of fungal infections. In turn, they create an excellent background for the occurrence of a variety of inflammatory processes, among which are:
- vaginitis;
- vulvovaginitis;
- vulvitis.
As a result, the disease affects the mucous membranes of the vagina and external genital organs, even during pregnancy, which can be prevented by using Pimafucin suppositories. At this time, the woman is tormented by itching, discomfort and burning.
White or cheesy mucous discharge begins to appear, accompanied by a sour smell. That is why the disease is called - thrush.
The danger of thrush
Like many other inflammations, candidiasis conditions adversely affect the course of pregnancy. In especially severe cases, candidiasis leads to thinning, weakening of the fetal membrane. The danger is that it may break prematurely.
Also, at the time of passage of the fetus through the birth canal, the baby can become infected with this disease.
The effectiveness of Pimafucin
At such a moment, the doctor is faced with the choice of the maximum effective drug to combat thrush, which would not have a negative impact on the fetus itself and the pregnancy process as a whole. Therefore, Pimafucin suppositories are prescribed, which are the desired drug.
AT this preparation The active ingredient is natamycin. At the local level, it acts on fungal cells by destroying their membranes, which leads to the destruction of pathogens.
The local nature of the effect ensures the absorption of the drug into the blood, and its impermeability through the placental barrier.
The occurrence of side effects
It is worth noting that Pimafucin suppositories have practically no contraindications, including during pregnancy. However, it is worth considering one small exception, namely individual sensitivity to the components that make up the drug. In particular, we are talking about cetyl alcohol. In extremely rare cases, mild irritation or burning may be felt.
It is also worth clarifying that this drug, which contains Pimafucin suppositories, has another equally important advantage: the lack of interaction with others medications, which in turn significantly increases the availability of Pimafucin during the period of bearing a child.
How to use suppositories
During pregnancy, women are prescribed, as a rule, local treatment, recommending Pimafucin suppositories, which contain 100 mg of natamycin in each suppository. The candle in the vagina must be inserted as deep as possible. This procedure should be done just before going to bed. The introduction of a candle is most comfortable to carry out in a supine position. After the drug has been administered, it is necessary to limit movement as much as possible for several hours.
Under the influence of body temperature, Pimafucin suppositories quickly dissolve, forming a kind of foam that evenly covers the mucous membranes of the vagina. If at this moment a woman tries to get up, then the drug with the active active ingredient will quickly leak out, losing all pharmacological properties.
However, to get a more confident effect, you need to use three or four packs of this drug.
During treatment, it is necessary to take into account individual characteristics female body. It is also worth considering that even in large doses, Pimafucin suppositories are not toxic, including during pregnancy.
To prevent relapse
In order to avoid recurrence of lesions of the mucous membranes of the vagina with candidiasis, it is also necessary to treat the woman's partner, despite his complete absence of symptoms of the disease. After all, the causative agents of candidiasis can also be concentrated under the foreskin of the glans penis. Therefore, in case of contact with the mucous membranes of the vagina, they immediately begin to multiply intensively.
For a partner to conduct local therapy with the help of Pimafucin, a cream is applied that contains 2% of the active treatment drug. The composition is applied once a day (if necessary, several times). When the symptoms of the disease disappear in both partners, treatment cannot be completely stopped for a few more days.
Duration of therapy
During pregnancy, the duration of treatment will depend on the degree of the disease itself. Candles Pimafucin can be used from 3 to 9 days. In this case, the main therapy will last at least 5-6 days. At the very beginning of therapy, Pimafucin suppositories can be used 3-4 times.
After the end of the main course, including during pregnancy, it is advisable to take the drug two or three more times. Not often, but there are situations when the use of suppositories did not bring the desired result or, on the contrary, only worsened the patient's condition. In this case, you must definitely contact your doctor. In dominant situations, these conditions can be triggered by a woman's lack of sensitivity to the active substance.
In conclusion, we want to note that Pimafucin suppositories during pregnancy are accessible means not only in composition or effect, but also in price. However, it is worth remembering that the “harmlessness” of this drug does not provide the possibility of self-treatment, especially during childbearing.
During pregnancy, chronic diseases are often exacerbated or diseases appear that have not bothered until that time. The fungus can cause discomfort, as well as affect the well-being of the mother and the health of the unborn baby. Will Pimafucin help in this case and is it safe?
Is Pimafucin harmful during pregnancy
Pimafucin is a topical antibiotic that is indicated for the treatment of fungal diseases of the mucous membranes and skin. According to the instructions, this drug can be used during pregnancy. It is indicated that there are no data on the effect on the fetus. Most often, expectant mothers are prescribed this medicine for thrush, or candidiasis.
Of course, no clinical trials of drugs for pregnant women are carried out, but this drug is considered one of the safest.
Pimafucin can be prescribed by a doctor even for early term pregnancy. In the first trimester fungal diseases women are potentially dangerous for the unborn child: there is a possibility of miscarriage or miscarriage. In II and III trimesters infection is fraught with intrauterine infection of the fetus. Also, during childbirth, the baby can become infected with a fungal disease. Therefore, throughout pregnancy, it is important to listen to your condition and start treatment on time if necessary. However, there is another medical opinion.
Thrush is considered the physiological norm of pregnancy, since increased growth fungus is observed in 80-90% of pregnant women. It is not dangerous for both the pregnant woman and the fetus and newborn.
E.P. Berezovskaya
http://www.komarovskiy.net/faq/beremennost-i-molochnica.html
Composition, action and form of release
The active ingredient in Pimafucin is the antibiotic natamycin. It acts only locally and is not absorbed into the blood. Its content varies depending on the form of release of the drug.
Pimafucin is available in suppositories, tablets and in the form of a cream. When thrush is most often prescribed vaginal suppositories. If the focus of infection is in the intestines, then the doctor can supplement the treatment regimen with taking pills. Cream in similar cases It is used when a fungus affects the external genital organs of a woman and her sexual partner.
Photo gallery: Pimafucin release forms
Pimafucin tablets are intended for oral administration with intestinal candidiasis 
Pimafucin cream has a local antifungal effect on the skin and mucous membranes 
Vaginal suppositories Pimafucin is most often prescribed for thrush
What helps: thrush, colpitis and other indications
In most cases, during pregnancy, vaginal candidiasis is treated with Pimafucin, but the range of application of this local antibiotic is wide, which allows it to be successfully used for other fungal infections. The readings are slightly different for different forms drug release.
Tablets can be prescribed for:
- acute pseudomembranous and atrophic candidiasis;
- otomycosis, external, caused by fungi or complicated by candidiasis;
- skin and nail candidiasis;
- intestinal candidiasis;
- vaginitis (colpitis), vulvitis, vulvovaginitis, balanoposthitis;
- dermatomycosis.
Suppositories are successfully used from:
- vaginitis ();
- vulvitis;
- vulvovaginitis.
The cream can be prescribed in case of:
- vulvitis;
- vulvovaginitis;
- balanoposthitis;
- skin and nail candidiasis;
- otitis externa with candidiasis;
- dermatomycosis.
Despite the safety of the drug, you should not self-medicate. Only a doctor will be able to determine the exact diagnosis and select the appropriate form of medication and an individual treatment regimen.
Instructions for safe use
Features of the use of candles, tablets and cream
According to the instructions, Pimafucin in candles should be used 1 time per day for 3-6 days. The suppository should be administered at night in the supine position. This is necessary so that the medicine released when the candle melts does not leak out.
The drug in tablets is prescribed 4 times a day. The course usually lasts no more than 1 week. Treatment with tablets can be combined with the use of suppositories and creams.
Usually, after the disappearance of unpleasant symptoms, Pimafucin therapy is continued for several more days to prevent a recurrence of the infection.
The final duration of the course of treatment for all forms of the drug is set by the doctor individually, taking into account the patient's condition.
Contraindications and side effects
Among the direct contraindications in the instructions for Pimafucin, only hypersensitivity to natamycin and auxiliary components drug. Local side effects - vaginal irritation and burning sensation - may appear when using Pimafucin in suppositories or in the form of a cream. They are short-term and usually do not require discontinuation of the drug. Tablets have a wider range side effects:
- nausea,
- diarrhea,
Individual reactions associated with intolerance to the components of the drug are possible.
The active substance natamycin does not penetrate the placenta and into the bloodstream that connects the body of the mother and child. Therefore, Pimafucin is considered safe during pregnancy. If any serious by-effect the woman still has it, then treatment should be stopped, since there is a possibility that a similar negative effect can occur in relation to the fetus. For example, if a mother has an allergy, then the baby may be born with a tendency to have the same reaction.
What can replace Pimafucin in different trimesters of pregnancy
It also happens that Pimafucin does not help to cope with fungal diseases that bring severe discomfort. Some women note that after a course of treatment with this drug, discharge and other unpleasant symptoms continue to bother them. In this case, it is necessary to consult a doctor and choose another drug that is safe during pregnancy.
Table: Pimafucin analogues, clotrimazole and other antibiotics for the treatment of fungal diseases at different stages of pregnancy
| medicinal product | Release form | Active substance | Contraindications | Side effects | |
| Ecofucin | Suppositories vaginal | Natamycin | Hypersensitivity to the components of the drug | - |
|
| Suppositories vaginal | Natamycin | - |
|
||
| Vaginal tablets | It is not recommended to use during pregnancy (especially in the first trimester). |
|
|||
| The issue of prescribing the drug should be decided by the doctor individually. In this case, the use of the applicator is not recommended. | Rarely - a slight burning sensation immediately after the administration of the tablet | ||||
|
Not recommended for use in the first trimester of pregnancy. | allergic reactions | |||
| Pills |
|
|
|||
| Vaginal capsules |
|
Not recommended for use in the first trimester of pregnancy. In the II and III trimesters, the use is possible only as directed by a doctor in cases where the expected benefit to the mother exceeds potential risk for the fetus. |
|
||
Photo gallery: drugs prescribed for pregnant women with fungal infections
Polygynax is not recommended for use in the first trimester of pregnancy. 
According to the manufacturer, Nystatin can be taken during pregnancy 
vaginal tablets Terzhinan can cause mucosal irritation and allergic reactions. 
In the first trimester of pregnancy, clotrimazole is not recommended for use. 
Candide-B6 is not prohibited during pregnancy, but the benefit to the mother and the risk to the fetus should be weighed 
Primafungin is a pharmacological analogue of Pimafucin
Pimafucin tablets during pregnancy are often prescribed to women for the treatment of a common disease - thrush. About what are the indications and contraindications for the use of the drug Pimafucin during pregnancy, we will tell you in our article.
Pregnancy is the most beautiful and long-awaited time in the life of every woman. But very often it is overshadowed by such an unpleasant accompanying disease as thrush (or vaginal candidiasis). And in order to get rid of it, you need to approach this issue with all seriousness. After all, being in interesting position, a woman should be very careful in choosing medicines, choosing not only effective, but, first of all, safe for the fetus.
How does Pimafucin work?
Features of the therapeutic effect of Pimafucin:
- this drug is an antifungal antibiotic broad action, fungi of the Candida family are most sensitive to it;
- natamycin - the main component of the drug - destroys cell walls pathogenic microflora, after which it dies;
- the medicine does not enter the bloodstream, does not cross the utero-placental barrier, including when taking a tablet form, so it does not pose a threat during pregnancy or lactation, and is also safe for treating newborns;
- does not cause allergic reactions;
- used by dermatologists for fungal infections of the skin.
What forms of Pimafucin can be found in pharmacies?
For higher efficiency and a wide spectrum of action, manufacturers produce Pimafucin in different forms, their choice is established by the attending gynecologist situationally, depending on the indications and the severity of the disease:
- Pimafucin suppositories (vaginal suppositories) - the most popular option for pregnant women, since it acts directly on the vaginal mucosa, eliminating the causative agent of vaginal candidiasis;
- Pimafucin tablets are coated, which is resistant to stomach enzymes and dissolves already in the intestine. This form is prescribed for a chronic disease, or if the fungal infection has spread to the lower sections of the abdominal organs, which are not amenable to the action of vaginal suppositories;
- Pimafucin cream during pregnancy is used for local external action, acts on damaged areas of the skin or mucous membrane; can be used by a partner to prevent relapse.
Pimafucin is available in several forms, which allows you to more effectively act on fungi
Indications for use
A little about dairy
Thrush (candidiasis) is one of the most common diseases among women, including pregnant women. It received this name from the pathogen - Candida fungi, an increase in the number of which leads to inflammatory processes of varying severity.
Often, thrush in women occurs against the background of a weakened immune system, intestinal dysbacteriosis, constant stress, and other diseases of the reproductive system.
Approximately every third pregnant woman also faces this problem. unstable hormonal background, additional load on the body weakens the immune system, in addition, the microflora of the vagina changes. All this is the reason that the immunity of a pregnant woman becomes vulnerable, and as a result, a favorable environment is created for the development of diseases such as candidal vulvitis, vaginitis, vulvovaginitis.
Women, including pregnant women, often face thrush
Others possible reasons the occurrence of candidiasis can be such:
- taking antibiotics;
- the presence of pathogenic fungi in the intestine, their reproduction;
- infection from a partner;
- malnutrition;
- use of underwear made of synthetic fabrics.
Thrush is usually manifested by symptoms typical of other sexual diseases. These are light white-yellow discharge from the vagina, often cheesy, with a sour smell. In addition, the skin and mucous membranes of the external and internal genital organs are irritated, resulting in itching, burning, discomfort during intercourse or urination. It is not necessary to have all the symptoms at the same time.
If you notice at least one of the symptoms, such as cheesy discharge, itching, burning, you should contact your gynecologist for an examination.
For pregnant women, the presence of this unpleasant disease in the body is especially undesirable and even dangerous. Like any other inflammatory process, thrush can adversely affect the course of pregnancy. In especially severe cases and complications, vaginal candidiasis can provoke a thinning of the amnion (fetal membrane), which can lead to its rupture ahead of time. There is another danger: the baby can become infected with fungi when passing birth canal at the time of birth.
In this regard, the treatment of thrush in pregnant women or those who plan to become a mother should be carried out under the close supervision of a doctor and only by those medicines that do not harm the health of the woman and the unborn baby.
It should be noted that most women have mushrooms of the Candida family, and in normal quantities with sufficient defense mechanisms they do not manifest themselves in the body and do not require treatment. But at any moment fungal infection can cause a decrease in immunity. Then the woman should contact a specialist for examination and treatment, so as not to transfer the process to the stage of a chronic disease.
This is what Candida looks like
In addition to vaginal candidiasis, there are other indications for the use of Pimafucin. Here are the main ones:
- vaginal candidiasis (colpitis, vulvitis, vulvovaginitis)
- fungal infection of the gastrointestinal tract
- systemic fungal diseases
- fungal diseases of the skin and nails
- ear mycosis
- dermatomycosis, etc.
This drug is taken as prescribed by the attending physician after examination and confirmation of a pathogenic fungal infection (for example, after taking a smear from the vagina).
What are the contraindications to the use of Pimafucin for pregnant women?
The main active ingredient of this drug (natamycin) does not enter the blood system and other tissues, an overdose does not lead to intoxication of the body, so there are no contraindications for taking this drug.
The only thing you should pay attention to is the individual intolerance of the individual components of the drug. Therefore, carefully study the composition of the drug before taking.
How can Pimafucin affect the course of pregnancy?
To make sure that the drug is safe for pregnant and lactating women, carefully read the instructions for it, which clearly states that there is no harmful effect on the fetus. The principle of action of the drug was described above.
I trimester
Usually, in the first trimester, doctors try to limit the intake of drugs by a pregnant woman as much as possible, since the placenta is not yet formed, and all the components in the mother's blood go to the baby. But even in this trimester, the use of Pimafucin is allowed, since it is not absorbed into the blood and has local action. Usually at this time, Pimafucin is used in the form of vaginal suppositories.
II trimester
The second trimester for pregnant women is the most prosperous, because the baby in the womb is already protected by the placenta, future mom gradually gets used to the new state, toxicosis passes. And at this time, doctors are already allowing the reception of more strong drugs for the treatment of various infections. Pimafucin in this trimester also does not pose a threat to the fetus, now it can also be recommended in the form of tablets if treatment with suppositories is not enough.
III trimester
Do not forget that even considering the safety of the therapeutic agent, Pimafucin should be taken strictly according to the doctor's prescription and after the examination.The gynecologist will determine the severity of the disease and the required dosage of the drug. Do not self-medicate, because the signs of thrush that seem at first glance may turn out to be symptoms of a more serious disease, which can only be determined after passing the necessary tests.
What side effects can be from taking "Pimafucin" in pregnant women?
As a rule, this drug is well tolerated by pregnant women. Sometimes when taking suppositories and creams, irritation, burning, redness may occur at the site of action of the drug. Tablets can affect the increase in toxicosis, cause nausea and indigestion. But usually these manifestations do not last long and go away on their own in 2-3 days.
The main contraindication when taking Pimafucin is individual intolerance or allergy to the accompanying components of the drug. Therefore, if you feel any other reactions not described above, stop taking the drug and consult your doctor.
If you follow the instructions and listen to the instructions of the attending physician, the thrush will pass quickly and without consequences.
How long should I take Pimafucin?
The dosage of the drug, the form and duration of administration is calculated by the attending physician based on the severity of the disease.
Usually, treatment with vaginal suppositories lasts from 3 to 9 days, with tablets - 7-10 days. It all depends on the performance and well-being of the woman.
One course of medication is often enough to get rid of this unpleasant disease. Sometimes the doctor may recommend taking the drug for another 2-3 days after the symptoms disappear to “fix” the effect.
During pregnancy, chronic diseases are often exacerbated or diseases appear that have not bothered until that time. The fungus can cause discomfort, as well as affect the well-being of the mother and the health of the unborn baby. Will Pimafucin help in this case and is it safe?
Is Pimafucin harmful during pregnancy
Pimafucin is a topical antibiotic that is indicated for the treatment of fungal diseases of the mucous membranes and skin. According to the instructions, this drug can be used during pregnancy. It is indicated that there are no data on the effect on the fetus. Most often, expectant mothers are prescribed this medicine for thrush, or candidiasis.
Of course, no clinical trials of drugs for pregnant women are carried out, but this drug is considered one of the safest.
Pimafucin can be prescribed by a doctor even in early pregnancy. In the first trimester, fungal diseases of a woman are potentially dangerous for the unborn child: there is a possibility of miscarriage or missed pregnancy. In the II and III trimesters, the infection is fraught with intrauterine infection of the fetus. Also, during childbirth, the baby can become infected with a fungal disease. Therefore, throughout pregnancy, it is important to listen to your condition and start treatment on time if necessary. However, there is another medical opinion.
Thrush is considered the physiological norm of pregnancy, since increased growth of the fungus is observed in 80-90% of pregnant women. It is not dangerous for both the pregnant woman and the fetus and newborn.
E.P. Berezovskaya
http://www.komarovskiy.net/faq/beremennost-i-molochnica.html
Composition, action and form of release
The active ingredient in Pimafucin is the antibiotic natamycin. It acts only locally and is not absorbed into the blood. Its content varies depending on the form of release of the drug.
Pimafucin is available in suppositories, tablets and in the form of a cream. With thrush, vaginal suppositories are most often prescribed. If the focus of infection is in the intestines, then the doctor can supplement the treatment regimen with taking pills. The cream in such cases is used when the fungus affects the external genital organs of a woman and her sexual partner.
Photo gallery: Pimafucin release forms
Pimafucin tablets are intended for oral administration with intestinal candidiasis 
Pimafucin cream has a local antifungal effect on the skin and mucous membranes 
Pimafucin vaginal suppositories are most often prescribed for thrush
What helps: thrush, colpitis and other indications
In most cases, during pregnancy, vaginal candidiasis is treated with Pimafucin, but the range of application of this local antibiotic is wide, which allows it to be successfully used for other fungal infections. Indications are slightly different for different forms of release of the drug.
Tablets can be prescribed for:
- acute pseudomembranous and atrophic candidiasis;
- otomycosis, external, caused by fungi or complicated by candidiasis;
- skin and nail candidiasis;
- intestinal candidiasis;
- vaginitis (colpitis), vulvitis, vulvovaginitis, balanoposthitis;
- dermatomycosis.
Suppositories are successfully used from:
- vaginitis ();
- vulvitis;
- vulvovaginitis.
The cream can be prescribed in case of:
- vulvitis;
- vulvovaginitis;
- balanoposthitis;
- skin and nail candidiasis;
- otitis externa with candidiasis;
- dermatomycosis.
Despite the safety of the drug, you should not self-medicate. Only a doctor will be able to determine the exact diagnosis and select the appropriate form of medication and an individual treatment regimen.
Instructions for safe use
Features of the use of candles, tablets and cream
According to the instructions, Pimafucin in candles should be used 1 time per day for 3-6 days. The suppository should be administered at night in the supine position. This is necessary so that the medicine released when the candle melts does not leak out.
The drug in tablets is prescribed 4 times a day. The course usually lasts no more than 1 week. Treatment with tablets can be combined with the use of suppositories and creams.
Usually, after the disappearance of unpleasant symptoms, Pimafucin therapy is continued for several more days to prevent a recurrence of the infection.
The final duration of the course of treatment for all forms of the drug is set by the doctor individually, taking into account the patient's condition.
Contraindications and side effects
Among the direct contraindications in the instructions for Pimafucin, only hypersensitivity to natamycin and auxiliary components of the drug was noted. Local side effects - vaginal irritation and burning sensation - may appear when using Pimafucin in suppositories or in the form of a cream. They are short-term and usually do not require discontinuation of the drug. Tablets have a wider list of side effects:
- nausea,
- diarrhea,
Individual reactions associated with intolerance to the components of the drug are possible.
The active substance natamycin does not penetrate the placenta and into the bloodstream that connects the body of the mother and child. Therefore, Pimafucin is considered safe during pregnancy. If any serious side effect still occurs in a woman, then treatment should be stopped, since there is a possibility that a similar negative effect can happen to the fetus. For example, if a mother has an allergy, then the baby may be born with a tendency to have the same reaction.
What can replace Pimafucin in different trimesters of pregnancy
It also happens that Pimafucin does not help to cope with fungal diseases that bring severe discomfort. Some women note that after a course of treatment with this drug, discharge and other unpleasant symptoms continue to bother them. In this case, it is necessary to consult a doctor and choose another drug that is safe during pregnancy.
Table: Pimafucin analogues, clotrimazole and other antibiotics for the treatment of fungal diseases at different stages of pregnancy
| medicinal product | Release form | Active substance | Contraindications | Side effects | |
| Ecofucin | Suppositories vaginal | Natamycin | Hypersensitivity to the components of the drug | - |
|
| Suppositories vaginal | Natamycin | - |
|
||
| Vaginal tablets | It is not recommended to use during pregnancy (especially in the first trimester). |
|
|||
| The issue of prescribing the drug should be decided by the doctor individually. In this case, the use of the applicator is not recommended. | Rarely - a slight burning sensation immediately after the administration of the tablet | ||||
| Not recommended for use in the first trimester of pregnancy. | allergic reactions | |||
| Pills |
|
|
|||
| Vaginal capsules |
| Not recommended for use in the first trimester of pregnancy. In the II and III trimesters, the use is possible only as directed by a doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus. |
|
||
Photo gallery: drugs prescribed for pregnant women with fungal infections
Polygynax is not recommended for use in the first trimester of pregnancy. 
According to the manufacturer, Nystatin can be taken during pregnancy 
Terzhinan vaginal tablets can cause mucosal irritation and allergic reactions. 
In the first trimester of pregnancy, clotrimazole is not recommended for use. Candide-B6 is not prohibited during pregnancy, but the benefit to the mother and the risk to the fetus should be weighed 
Primafungin is a pharmacological analogue of Pimafucin