Dicloberl side effects. Dicloberl: instructions for use, analogues and reviews, prices in Russian pharmacies

04.11.2019 -

"Dicloberl" is a derivative of phenylacetic acid, which has an anti-inflammatory effect. Diclofenac sodium is active substance, present in this drug. It has anti-edematous, antipyretic and analgesic effects. Given medicine It has various dosage forms; it is also produced in the form of suppositories. Dicloberl candles are not recommended for use by children under 15 years of age.

Use of the drug

You can use Dicloberl suppositories for the following ailments:

inflammation of the musculoskeletal system;
arthritis in all its manifestations;
rheumatism and osteoarthritis;
and Personage-Turner;
for migraine, neuralgia, toothache, radiculitis and ossalgia (if pain exists);
for an infection or cold (if there is a fever);
adnexitis.

Many patients, feeling pain, purchase "Dikloberl" (suppositories). Instructions for use are included inside each package.

Dosage and methods of application

"Dikloberl" suppositories are used no more than several times a day, 50 mg, and if the dosage is 100 mg, then only once a day rectally. When a person feels the first signs of a migraine, this drug should be used immediately. After bowel movements, it is necessary to insert suppositories deep into the anus. The doctor must prescribe correct treatment, which can be long-lasting if there are diseases of a rheumatic nature.

Contraindications

Each pack of Dicloberl contains instructions. Candles have the following contraindications. You cannot use them if:

Available increased sensitivity to the components of the drug.
The person has diseases such as asthma, anemia and the triad.
There are ulcers and erosions in the stomach.
The rectum is injured and there are hemorrhoids.
Children's age is up to 6 years.

Dicloberl suppositories have many contraindications, so they must be used with extreme caution. Pregnant women should not use this drug, as it early stages pregnancy may occur spontaneous miscarriage. In a child, the drug causes the development of heart defects and non-closure of the anterior abdominal wall.

Important points

Elderly people and people who have heart disease and renal failure, as well as those who use diuretics, should use Dicloberl only under the special supervision of a doctor. The condition of the kidneys must be constantly monitored.

Exceeding the dosage this tool may cause:

fainting;
headaches;
bleeding in the gastrointestinal tract;
disorientation;
stomach ache;
nausea.

Dicloberl suppositories 100 and 50 mg are sold in blisters of 5 or 10 suppositories.

Parallel use with other drugs

Doctors allow the combination of Dicloberl (suppositories) with other drugs. The instructions for use, however, state that interaction with certain products can lead to various consequences.

When using the drug "Dicloberl" together with diuretics, the effect of diclofenac on the body is weakened. When they are used together with inhibitors, the body's kidney function is impaired. Probenecid together with this drug slows down the elimination of diclofenac from the human body.

The use of "Dicloberl" in gynecology

Dicloberl suppositories are usually used in gynecology for inflammation of the ovaries. For many girls and women, at the very beginning of menstruation there may be severe pain, which deprive them of their ability to work. These candles are successfully used in this area. Under the influence of internal temperature, suppositories inserted into the vagina quickly dissolve inside and go directly to the diseased organ, which speeds up the healing process. They need to be used every 6 hours.

Usually, inflammation of the ovaries takes quite a long time to treat and can progress to chronic form. This medicine is initial stages disease effectively relieves pain and tension in the inflamed tissues of the female body.

"Dikloberl" suppositories helped many patients to establish normal passage menstrual cycle. Having tried them once, ladies recommend this drug to their friends who have the same gynecological problems.

Instructions

Dicloberl - suppositories that quickly relieve pain and inflammation. The drug has an antipyretic effect and eliminates swelling of the skin.

Dicloberl - suppositories that quickly relieve pain and inflammation.

Pharmacological group

Compound

Rectal suppositories. 1 suppository contains 50 mg of diclofenac and the following additional substances:

starch;
96% alcohol;
hard fat;
propyl gallate.

Torpedo-shaped candles are packed in blisters of 5 pcs. There are 1 or 2 blisters in a cardboard box.

Mechanism of action

Completely depends on the chemical characteristics of the drug.

Pharmacodynamics

NSAIDs have pronounced anti-inflammatory and analgesic effects. In addition, it has the ability to block prostaglandin synthetase.

RECTAL SUPPORT. How to enter correctly?

Nonsteroidal anti-inflammatory drugs

Are painkillers safe?

Effective pain relievers.

Pharmacokinetics

Absorbed quickly into the gastrointestinal tract. Cmax is achieved in 50-60 minutes. The bioavailability of suppositories is comparable to that of oral medication formats. Regular use of the medication does not affect the pharmacokinetic properties of diclofenac. The drug is not subject to accumulation.

T½ - 4-5 hours. The metabolism of diclofenac occurs through meta-, hydroxylation and glucuronidation.

Up to 60% of the medication is excreted along with urine, the rest is excreted through the intestines.

Indications for the use of Dicloberl suppositories

gynecological disorders that are accompanied by pain and/or inflammation (including discomfort during menstruation);
vertebrogenic pain;
pathologies of rheumatic origin (osteoarthritis, arthritis, spondyloarthritis);
acute phase of gout;
chronic headache;
severe inflammatory lesions of the ENT organs.

The underlying disease should be treated with basic therapy medications.

Contraindications

Taking medication is prohibited in the following cases:

congestive heart failure;
previous perforation of the gastrointestinal tract;
intestinal bleeding associated with the use of NSAIDs;
exacerbation of ulcers;
allergy to the composition of the drug;
kidney/liver failure;
pathology of peripheral arterial vessels;
pain treatment after/before coronary artery bypass surgery;
allergy to Aspirin, Ibuprofen;
proctitis;
pregnancy in the 3rd trimester;
inflammatory pathologies of the gastrointestinal tract;
risk of hemostasis failure, bleeding after surgery or hematopoietic disorders;
cardiac ischemia in patients with angina pectoris or those who have had a myocardial infarction.

Method of use and dosage of Dicloberl suppositories

Suppositories must be administered rectally. At the same time, they are placed as deep as possible into the rectum. It is better to do this immediately after defecation.

The initial dosage is from 100 to 150 mg of the drug per day. If symptoms are mild or moderate, as well as during long-term therapy, doses of 75 to 100 mg of medication are used daily.

Migraine begins to be treated with a dosage of 100 mg per day. If necessary, you can introduce an additional suppository. The maximum dose is 150 mg.

For use in gynecology (for dysmenorrhea and other pathologies), doses are prescribed individually.

The average amount is from 50 to 150 mg per day.

For urinary tract disease

In such pathologies, anti-inflammatory non-steroidal drugs in the form of suppositories, they can eliminate swelling of the mucous membranes, minimize the consequences of damage to the epithelial layer and narrow the capillaries. In addition, candles can block pain syndrome. The average dosage is 100 mg/day.

Side effects from the use of Dicloberl suppositories

It is possible that such negative reactions:

hematopoiesis: leukopenia, pancytopenia, thrombocytopenia, anemia;
immune manifestations: vasculitis, urticaria, pneumonia, itching;
mental disorders: spatial disorientation, depressive states, sleep disorders, etc.;
nervous activity: headache, convulsions, fatigue, tremors, hallucinations, stroke, increased fatigue;
genitourinary system: swelling, necrosis of renal tissue, impotence, nephrotic syndrome, proteinuria, swelling;
sense organs: tinnitus, otitis, nerve neuritis eyeball, vision/hearing impairment, vertigo;
digestive system: diarrhea, hepatonecrosis, liver failure, intestinal stenosis, glossitis, colitis, pancreatitis, gastric ulcer, constipation, intestinal bleeding, dyspeptic conditions.

Overdose

The most common manifestations: headache, intestinal bleeding, diarrhea, irritability, convulsions, liver tissue damage.

Overdose is treated with symptomatic measures.

For prolonged and regular seizures, Diazepam should be used.

Features of application

To minimize the likelihood of negative reactions, therapy should begin with minimal dosages.

Pharmacodynamics of the drug may hide the symptoms of infection. NSAIDs are used cautiously when diabetes mellitus, dyspepsia and cardiac dysfunction in the patient.

During pregnancy and lactation

NSAIDs are prohibited for use in the last months of pregnancy. During lactation and after childbirth, to relieve symptoms and in case of urination problems (including due to fluid retention), it should be used only after the approval of an expert.

Is it possible in childhood

In old age

These patients have an increased risk negative manifestations when using NSAIDs.

For impaired renal function

NSAIDs are prescribed with extreme caution.

For liver dysfunction

In such pathologies, the patient should be carefully monitored by specialists.

Effect on concentration

When taking NSAIDs, there is a risk of decreased motor and mental reactions. Therefore, during the treatment period, you should avoid driving vehicles and other equipment.

Drug interactions

When taken simultaneously with other drugs, negative reactions may occur.

With other drugs

In combination with diuretic medications, the effectiveness of diclofenac is reduced. If you combine the drug with inhibitors, the body’s load on the kidneys increases.

Simultaneous use of NSAIDs with Probenecid inhibits the removal of the active substance from the body.

Alcohol compatibility

Drinking alcohol while being treated with this drug can lead to negative consequences.

Storage conditions and periods

At a temperature of +14°…+24°C, in a dry/dark place. The shelf life does not exceed 3 years.

Conditions for dispensing from pharmacies

To purchase a pharmaceutical product at any pharmacy, you do not need a prescription.

Is it sold without a prescription?

All dosage forms of the drug are dispensed without a medical prescription.

What is the price

Candles cost between 120-200 rubles. depending on the manufacturer and the number of suppositories in the package.

Analogs

If there is no medicine on the market, you can use the following anti-inflammatory drugs with similar effects:

Ketorolac;
Ketalgin;
Dilocaine;
Dicklobrew;
Acefen;
Fanigan;
Slanted;
Ketanov;
Dicloreum.

One ampoule of the drug "Dicloberl" contains 75 mg of diclofenac (active substance). Additional ingredients: benzyl alcohol, sodium hydroxide.

The tablets also contain diclofenac sodium in a volume of 100 mg. Additional components: corn starch, talc, lactose monohydrate.

The suppository contains 50 mg of diclofenac sodium, as well as ethanol and hard fat.

Medicinal properties

"Dicloberl" is a strong decongestant drug. Thanks to its substance - diclofenac, the drug has an analgesic and antipyretic effect.

After intramuscular injection this medicine observed in blood plasma after fifteen minutes. When taking tablets, they are absorbed within three hours.

The medicine is excreted by the kidneys. Most of the drug (more than 75%) is processed by the liver.

Indications for use

"Dicloberl" is prescribed for the following diseases:

Pyogenic arthritis
Spondylosis
Arthrosis
Dysmenorrhea
Constant lower back pain
Spinal fracture
Degenerative diseases of the joints and spine
Dystrophic diseases
Myalgia
Knee injuries
Neuralgia
Osteoarthritis
Tendenitis.

"Dicloberl" is available in the following dosage forms:

Average price from 273 to 310 rubles.

Solution for injections "Dicloberl"

Dosage: in ampoules of 3 mg 75 mg. The cardboard package contains 5 ampoules.

Directions for use

Injections are given intramuscularly. The permissible daily dose is 150 mg. The course of therapy lasts ten days, but if severe conditions The patient's attending physician can extend treatment for another five days. Such injections are administered slowly so as not to damage the muscle tissue.

The average price is from 280 to 300 rubles.

"Dicloberl tablets"

Tablets for oral use. Dosage: 100 mg. 1 blister contains 10 or 20 tablets, coated with a soluble coating

Directions for use

The tablets should be taken once a day after meals. They cannot be chewed. Total duration Treatment should be determined by the attending physician depending on the severity of the patient's illness.

Average price from 210 to 340 rubles.

Suppositories "Dicloberl"

Rectal suppositories 50 mg. In 1 blister there are 5 or 10 candles.

Directions for use

The suppositories are inserted deep into the rectum. The maximum dose per day is 150 mg of diclofenac. Such suppositories should remain in the rectum until completely dissolved and absorbed, so the patient should remain in a supine position for the next two hours after administration of the drug.

Contraindications

"Dicloberl" is contraindicated for the following diseases and conditions:

Chronic form of asthma
Age up to 15
Pregnancy and lactation period
Individual intolerance to the components of the drug
Nasal polyposis
Anemia
Haemorrhoids
Alcoholism
Inflammatory processes of the rectum (if suppositories are used for treatment)
Hepatitis.

During pregnancy and breastfeeding

The use of the drug "Dicloberl" during pregnancy (1st and 2nd trimester) is possible only when the expected benefits to the health of the mother outweigh the likely risks to the fetus. In this case, treatment with this drug should be short-term and in a minimal dose. And it's best to use candles.

In the last months of pregnancy, this drug is contraindicated, as it can negatively affect the development of the child.

Treatment with this drug is contraindicated when breastfeeding.

Precautions

"Dicloberl" is prescribed with caution for dyspepsia, diabetes mellitus, the presence of chronic diseases or heart failure in the patient. Also, people with heart and respiratory diseases should be treated with this drug exclusively under the supervision of a doctor.

Interaction with other drugs

When combined with selective inhibitors or corticosteroids with this drug, the patient increases the risk of internal bleeding.

Concomitant therapy with antidiabetic drugs may provoke the development of hyperglycemia or hypoglycemia.

The interaction of this drug with antihypertensive drugs causes a decrease in their effectiveness.

Side effects

When taking Dicloberl, treatment with suppositories or injections, there is a risk of side effects.

In the digestive system:
- Hepatitis
- Bloating and cramping
- Stomach ulcer
- Melena
- Burning in the anus
- Cirrhosis
- Colitis
- Liver damage
- Constipation - Want to know more? Read the article:
- Taste disturbance and loss of appetite
- Glossitis
- Pancreatitis
Allergic reactions:
- Itchy skin
- Dermatitis
- Swelling of the tongue and larynx
Additional symptoms may include cough, pneumonia, vasculitis, or fluid retention in the body.

Overdose

In case of overdose, the patient may experience body cramps, dizziness, or general confusion. In especially severe cases, internal bleeding may occur.

Conditions and shelf life

The drug must be stored in a dry and dark place, at a temperature not exceeding 25 degrees.
Shelf life: 36 months from the production date indicated on the package.

Analogs

"Dikloberl" has such medicinal analogues and synonyms:

Faran Laboratoris, Greece
Price from 240 to rub.

Main action: antipyretic and analgesic. Prescribed for the treatment of exacerbations of arthrosis, padagra and rheumatism. Composition: one ampoule or capsule contains 75 mg of diclofenac sodium. Release form: solution for intramuscular injections, capsules and suppositories.

Pros

Many forms of release, which makes it possible for different uses drug
Rectal suppositories are approved for treatment (from 2 years)

Cons

Prohibited during pregnancy
Has many side effects.

Pharma, Germany
Price from 230 rub. up to 390 rub.

Main action: anti-inflammatory, analgesic. Release form and composition: gel containing 1% diclofenac. Available in tubes of 50 and 100 g.

Pros

Thanks to external use, the patient can avoid systemic load in the body and deterioration of liver function
The gel is quickly absorbed into the skin and begins to act on soft tissues

Cons

There is a risk of allergic reactions
Contraindicated during pregnancy.

Pharmstandard, Russia, etc.
Price from 30 to 80 rub.

Main action: analgesic, decongestant. Prescribed for arthrosis, arthritis, osteoarthrosis and other diseases of the joints and spine. Release forms: coated tablets, ampoules, gel and ointment.

Pros

Over-the-counter dispensing from a pharmacy
Low cost

Cons

Possible side effects such as increased blood pressure and headaches
The drug is not recommended for treatment during pregnancy, as well as childhood(up to 6 years old).

« »

Novartis Consumer Health, Switzerland
Price from 50 to 450 rub.

Main action: anti-inflammatory and analgesic. Used to treat rheumatism, osteoarthritis, joint injuries, soft tissue swelling and radiculitis. Composition: 100 g of the drug contains 1.30 mg of diclofenac. Release form: gel for topical use, 2%. The tube contains 50 or 100 g of gel.

Pros

Dispensed without a prescription
Rapid anti-inflammatory effect

Cons

Risk of dermatitis and other allergic reactions
The gel is contraindicated for use during pregnancy.

Berlin-Chemie AG, Germany
Price from 330 to 370 rub.

"Dicloberl retard" is available in the form of suppositories and sustained-release capsules. Dispensed by prescription. The active ingredient is diclofenac.

Pros

A small dosage of the active substance in the drug is safe and suitable for long-term use
Has a complex therapeutic effect

Cons

There are often complaints of nausea, vomiting, and diarrhea when taking the drug.
Not for use by children under 15 years of age.

Dicloberl is a non-steroidal drug, its main property is to relieve inflammation in soft tissues. Capable of resisting more than thirty diseases. Very well suited for treatment in complex therapy. It is extremely rarely used for self-treatment.

Various release forms and dosages easily make it possible to choose the most convenient dosage regimen suitable for each specific case. Injections and suppositories are most often used in gynecology. While tablets and capsules are convenient for long-term treatment

Properties

Dicloberl is described as a non-steroidal anti-inflammatory drug. It is a derivative of phenylacetic acid.

Able to work as an active antipyretic agent, providing a timely anti-inflammatory effect.

Well resists inflammatory processes in soft tissues.

It is able to penetrate into various stages of the development of inflammatory processes and acts on them pointwise, preventing the source of inflammation from spreading further.

If inflammatory processes arose after surgical intervention or as a result of injuries, timely administration of Dicloberl will not only help eliminate the pain effect when moving, but will also prevent the formation of surgical swelling.

In case of soft tissue damage, helps reduce sensitivity, helps minimize susceptibility nerve fibers on the damaged area.

Penetrating into the body, Dicloberl begins to actively work to inhibit the proliferation of prostaglandins, which are responsible for the reproduction of foreign bodies in the body. Thanks to this, it is easier for active substances to accumulate their strength in a timely manner to fight the source of inflammation.

Dicloberl is also capable of providing a mild analgesic effect even if the source of pain is not rheumatic in nature.

When consuming pills, the maximum possible concentration in the body occurs no earlier than an hour later and no later than 15 hours. It is metabolized without residue and excreted in the urine no less than 20 hours after the procedure.

After injections, the effectiveness of the drug is slightly lower than that of tablets. But at the same time, the absorption rate is faster, the maximum concentration occurs after 10-20 minutes. Penetrates into the joint fluid without problems. The process of releasing active substances from the body also occurs more actively. 12 hours is enough for the body to get rid of all the products of the drug.

When introducing suppositories, extremely permissible concentration comes within half an hour.

Penetrating into the body, approximately a third of the total volume is metabolized. Once in the intestines, it is eliminated and excreted in the feces. The rest is excreted by the kidneys.

Composition and release form

The main component of Dikloberl is diclofenac sodium. To make it easier to use in treatment, Dicloberl is produced in three varieties. In the form of suppositories, solution for injections and dragees. Each sample is made in its own concentration. Such a variety of forms allows you to choose the most suitable treatment regimen for a given case.

Dikloberl in suppositories is placed only rectally. Available in concentrations of 100 and 50 mg. In addition to the main component, corn starch, ethyl alcohol, solid fat, and propyl gallate are added to their composition.

The injection solution is already ready for use and does not require additional dilution. Each ampoule contains 75 mg sodium. As binding ingredients it contains propylene glycol, injection solution, acetylcesteine, benzyl alcohol, sodium hydroxide.

Each Dikloberl tablet contains 50 mg of diclofenac sodium. As accompanying components it contains magnesium stearate, corn starch, yellow food coloring, simethicone emulsion, talc, glucose monohydrate, titanium dioxide, methacrylic acid.

Dikloberl dragees may also include 100 mg of diclofenac sodium. This dosage has its own name, Dicloberl Retard capsules. Dikloberl Retard as accompanying ingredients includes sucrose, maltose monohydrate, the same corn starch, gelatin, white food coloring and talc. All this allows the pill to better dissolve and be absorbed in the body. Diclofenac Retard, unlike its lightweight companion, is capable of accumulating diclofenac sodium in the body. This is why the results last longer after taking it.

Only the doctor can decide which form of the drug to choose for treatment.

The choice can be influenced not only by age and available concomitant diseases, but also the body’s susceptibility to the components of the drug, as well as the duration and severity of the disease.

Indications for use

It’s not for nothing that this drug has so many design options for the active substance. With a clear understanding of the diagnosis, it is easy to choose the most appropriate form in a particular situation.

Ampoules

Dicloberl injections are most often prescribed for systemic disease joints, especially when it is chronic, with osteoarthritis - the most common type of arthritis, with rheumatoid arthritis, and copes well with pain due to osteochondrosis.

Injections are also often prescribed for colic, both renal and hepatic, and for non-articular rheumatism. Effective against migraine attacks and pain of various etiologies, during the inflammatory process as a result of minor injuries, surgical intervention, after orthopedic or dental procedures.

Capsules

Dicloberl in capsules is often prescribed for injuries of various kinds (sprains, fractures, dislocations), in such conditions the drug can cope well with both painful sensation, and prevent possible inflammation. Dentists often recommend taking a course of capsules after minor dental and orthopedic interventions (tooth extraction). The purpose of the prescription is to relieve pain and prevent inflammation. A course of capsules can also minimize inflammatory processes and relieve pain in various diseases of the musculoskeletal and nervous system spinal column.

Dicloberl in tablets works well with ENT pathologies accompanied by pain and inflammation; in combination with other drugs, it can cope with especially complex forms of these diseases (otitis in acute form, pharyngitis, tonsillitis). Included in complex therapy with systemic joint disease, especially when it is chronic (Bechterew's disease).

Tablets are also prescribed after dental surgery. In gynecology, Dicloberl is often prescribed for inflammatory pathologies, especially if the disease is accompanied by pain. It treats gout well in the acute stage, accelerates the recovery process after injury, especially if there is an inflammatory process in the body. Dicloberl is often included in a complex of drugs for the restoration of spinal lesions for its ability to relieve pain well. Helps tidy up soft tissues after damage from rheumatism.

Dikloberl candles often prescribed for systemic connective tissue disease ( rheumatoid arthritis, including its juvenile form), with systemic joint disease, especially when it is chronic (Bechterew's disease), with spondyloarthritis.

Included in the complex therapy of non-articular rheumatism. Widely used in gynecology for inflammatory pathologies, especially if the disease is accompanied by pain. Dicloberl suppositories work effectively against gout, especially during periods of exacerbation of the disease. It relieves pain well in various diseases of the musculoskeletal and nervous system of the spinal column. Actively works to relieve inflammation and pain after injury or surgery.

A course of Dicloberl is recommended even after minor dental and orthopedic interventions. Can relieve migraines. It works well with ENT pathologies accompanied by pain and inflammation; in combination with other drugs, it can cope with especially complex forms of these diseases (acute otitis media, pharyngitis, tonsillitis).

Most often, Dicloberl is used in combination with other drugs. Thus it gives maximum possible effect from procedures.

Contraindications

Should not be used if there is a stomach or duodenal ulcer. Dicloberl is especially contraindicated when chronic diagnosis or during an exacerbation of this disease.

Minor gastrointestinal bleeding is a good reason to choose something more suitable from analogues.

With oncological diagnoses, it also makes sense to reconsider the choice, in particular if there are tumors of the intestine or rectum.

Dicloberl is contraindicated in all its forms for children under 6 years of age.

Upon reaching this age, in some cases you can take pills, but under close supervision from 15 years of age. special cases it is possible to use candles. From 18 – injections and Dicloberl Retord are allowed.

The presence of chronic kidney and liver diseases is also a good reason to switch to another drug.

Any type of disorder in the maturation of blood cells (hematopoiesis).

Chronic lung diseases, including bronchial asthma.

Ischemia developed against the background of angina pectoris, as well as in the presence of myocardial infarction.

Brain diseases caused by pathological changes cerebral vessels with disruption cerebral circulation, including a stroke that occurred.

It is not advisable to use Dicloberl during pregnancy. In the last trimester it is strictly contraindicated. Studies have proven that the use of this drug increases the risk of cardiovascular defects in the fetus. In the first and second trimesters, Dicloberl can be taken only if the expected benefit from treatment prevails. But for treatment you should drink minimally possible dosage in the shortest possible time.

During breastfeeding, the drug is not directly contraindicated, but one cannot fail to take into account that diclofenac has the ability to pass into milk. With a short course of treatment, this will not entail any consequences. But when long-term use However, it is best to consider stopping breastfeeding.

There is an opinion that Dicloberl reduces female fertility (the ability to get pregnant), so if a woman planning a pregnancy has difficulty conceiving, then it is better to consider replacing Dicloberl with its analogue.

Instructions for use

Dicloberl in ampoules

It should be injected deeply into the gluteal muscle, slowly. One ampoule is equal to the daily requirement. If the situation requires it, it can be increased, but not more than twice. In this case, it is better to take a break of several hours between injections.

Most often, injections are given only in the first few days after the onset of symptoms of the disease, in order to quickly and effectively relieve symptoms. As a last resort, injections continue to be given, but not more than 10 pieces. Further treatment is carried out using another form, for example, suppositories.

The daily intake of Dicloberl should not exceed 150 mg. The optimal daily portion is considered to be 50 mg. If it requires an increase, then the tablets must be taken in several approaches. You need to take the pill during meals, remembering to wash it down with a small portion warm water. As soon as the condition returns to normal, daily intake should be reduced to 50 mg.

In special cases, children over 6 years of age are also prescribed Dicloberl in tablets at a daily dose of 25 mg. You should know that the daily dose should not exceed 2 mg/kg. This formula is used as a starting point when building a treatment regimen.

Dicloberl in capsules

One capsule of Dicloberl Retard per day is enough for successful treatment severe pain. In rare cases, this rate is doubled, bringing it to 200 mg. After the primary effect is achieved, the rate can be gradually reduced. First, up to 150 mg, drinking a capsule and a tablet per day, and then up to one capsule per day. It must be taken into account that such a large dosage, although it is much more successful in combating the disease, is much more more likely to appear side effects. That's why given dosage taken only under the close supervision of the attending physician.

The duration of treatment is adjusted by the doctor.

Dikloberl candles

Dikloberl suppositories are placed in the rectum. If the patient has constipation, it is better to prepare the intestines for the procedure in advance by forcibly emptying the bowels. If these procedures are not carried out, the effect of treatment will be reduced. Typically the daily intake ranges from 50-150 mg. The suppositories need to be administered over several procedures. Subsequently, the consumption rate is reduced to a candle per day. As a rule, treatment lasts no longer than five days.

Overdose

If the instructions attached above are not followed and the daily dosage is not adhered to, an overdose may occur. In what form does it appear?

First of all, dizziness may appear, even fainting. Possible surges in pressure in the direction of increase, increased heart rate. Nausea and vomiting accompanied by diarrhea are possible. Cramps of the limbs, rashes on the skin in the form of red spots, pain in the liver and kidneys is possible. Stomach bleeding may occur.

At the first signs of an overdose, you should rinse your stomach and induce vomiting yourself. If a severe allergic reaction occurs, take a double dose of the antihistamine and call an ambulance.

Side effects

At different situations and depending on the “bouquet” of diseases, the patient may experience adverse reactions:

Pressure deviations may appear. Likely sharp jumps blood pressure upward. There may be pain in the chest area, and tachycardia may also occur.
There may be a decrease in hemoglobin in the blood. The white blood cell count may also drop, against this background the body’s susceptibility to bacterial and fungal diseases increases.
Nausea, vomiting, and the development of gastric ulcers are just some of the disorders that are noted in the gastrointestinal tract.
Possible development depressive state, excitability, headaches.

To minimize such reactions, you need to go through as much full examination before procedures. This will avoid possible problems and will significantly reduce the likely risk of treatment.

Interaction

It is better not to take risks and not to include other non-steroidal anti-inflammatory drugs in parallel use with Dicloberl. This combination is fraught with subsequent stomach ulcers.

Phenytoin, Rifampicin - they speed up the metabolic process and can reduce the effect of treatment.

Diclofenac can almost halve the result of treatment with Kolestyramine and Colestipol.

If one of the drugs cannot be excluded, you should take a break between procedures of a couple of hours.

Diclofenac is also prescribed with caution for diabetes mellitus. There are known situations where, due to taking Dicloberl, the glucose level in the blood changed sharply. Moreover, the readings can increase sharply and, on the contrary, fall below normal.

It is also better to exclude Sulfinpyrazone and Probenecid during treatment with Dicloberl due to their ability to retain diclofenac sodium.

You should also avoid taking medications that weaken the ability of blood to clot and inhibit the formation of blood clots. Since Dicloberl enhances the effect of such drugs.

A parallel course with drugs responsible for lowering blood pressure and diuretics can reduce the effectiveness of taking them. Such combinations should be prescribed extremely carefully, especially among older people. Be extremely careful to ensure that the patient drinks enough water.

You should take Dicloberl carefully with potassium-sparing diuretics. With this combination, you need to constantly monitor the level of potassium in the body.

Analogs

Dikloberl has quite a lot of analogues, the most common of them is Diclofenac. It has the same release forms as its brother, plus it is also available in gel form. Which greatly simplifies its use.

Quite often Voltaren and Ketanov are prescribed. Their manufacturers have gone even further; in addition to injections, tablets, capsules, gels and suppositories, they even produce their drugs in the form of a patch.

Also analogues are:

Diclobrew, Ketalgin - are available in the form of tablets and injections.
Dilocaine - has only the form of colas.
Dicloreum also has a fairly wide range of forms. It is sold in pharmacies in the form of injections, gel, suppositories and tablets.
Dicloferol - has only the form of tablets.
Ortofen - also has a wide range of forms and types.
Remetan - available in the same forms as Dicloberl.
Difen, Naklofen, Sanfinac, Tabuk Di, Feloran 25, etc., etc.

In fact, the list can be continued indefinitely. But you should remember, no matter how advertised the drug is, only a doctor can prescribe it and recommend the most effective therapy.

Special instructions

Due to the fact that some of the side effects from taking Dicloberl include dizziness and fatigue, which can cause the inability to concentrate, it is better to avoid driving at this time.

Due to the fact that Dicloberl is an anti-inflammatory drug, it can involuntarily hide the appearance of infectious diseases.

With long-term treatment, a headache may occur; in no case should you try to relieve the pain effect by increasing the dosage.

When mixing alcohol and diclofenac, the effect of the second on the gastrointestinal tract and nervous system. This increases the risk of provoking side effects in these directions. While taking a course of diclofenac, doctors strongly recommend that you stop consuming alcohol-containing products.

1 suppository Dicloberl 50 contains 50 mg diclofenac sodium
The composition of 1 suppository Dicloberl 100 includes 100 mg diclofenac sodium. Additional substances: corn starch, 96% ethanol, propyl gallate, solid fat.

Release form

Torpedo-shaped light yellow candles with a concave base. 5 candles in a blister, 1 or 2 blisters in a cardboard pack.

Pharmacological action

Analgesic, anti-inflammatory, antipyretic effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug has a non-steroidal structure, has a strong analgesic and anti-inflammatory effect, and is also a blocker prostaglandin synthetase.

Pharmacokinetics

Adsorbs quickly and reaches highest concentration in the blood an hour later. The bioavailability of suppositories is comparable to the bioavailability of oral forms of the drug. After repeated doses, pharmacokinetics diclofenac doesn't change. Accumulation of the drug is not observed if the recommended dosages are observed.

Blood protein binding is approximately 99.8%. Easily penetrates into the joint fluid, where its maximum concentration is recorded 3 hours later than in the blood. The half-life of the joint fluid is approximately 4-5 hours. Approximately 2 hours after the onset of maximum concentration in the blood, the content of the active substance in the synovial fluid remains higher than in the blood. This phenomenon is observed within 12 hours.

Metabolized by glucuronidation, hydroxylation and methoxylation with the formation of a number of phenolic derivatives, the vast majority of which form complexes with glucuronic acid. The half-life from the blood is approximately one and a half hours. About 60% of the dose taken is excreted in the urine, the remainder is evacuated through the intestines, with no more than 1% excreted unchanged. diclofenac.

Indications for use

rheumatoid arthritis(including juvenile form), osteoarthritis, ankylosing spondylitis, spondyloarthritis;
vertebrogenic pain syndromes;
rheumatic diseases affecting extra-articular soft tissues;
pain syndromes of post-traumatic and postoperative origin, accompanied by signs of inflammation, after orthopedic and dental interventions;
gynecological disorders accompanied by inflammation and pain;
seizures migraines;
exacerbation gout;
severe diseases of the ENT organs of an inflammatory nature.

The underlying disease must be treated with basic therapy. An increase in temperature in itself is an indication for use. diclofenac is not.

Contraindications

acute ulcer, bleeding or perforation of the intestines or stomach;
allergy on the components of the drug;
increased risk of postoperative bleeding, hemostasis disorders, cerebrovascular bleeding or hematopoietic disorders;
history of bleeding or perforation of the digestive system associated with use anti-inflammatory non-steroidal drugs;
inflammatory bowel diseases;
exacerbation peptic ulcer , ulcerative bleeding, including in the past;
third trimester of pregnancy;
congestive heart failure;
cerebrovascular disorders in persons who have undergone stroke or cases ischemic attacks;
hepatic or renal failure;
peripheral arterial disease;
coronary heart disease in persons who have undergone heart attack or suffering angina pectoris;
pain treatment before and after coronary artery bypass grafting;
proctitis;
allergic reactions on Ibuprofen, Aspirin or others anti-inflammatory nonsteroidal drugs.

Side effects

Hematopoietic reactions: pancytopenia, thrombocytopenia, leukopenia, agranulocytosis, anemia. The first symptoms of these disorders may be pharyngitis, elevated temperature, superficial ulcerations in the mouth, nosebleeds, apathy, skin bleeding.
Immune reactions: skin rash, hives, allergic vasculitis, angioedema, itching, pneumonia.
Mental disorders: depression, disorientation, irritability, insomnia, psychotic disorders, nightmares, other mental disorders.
Reactions from the outside nervous activity: dizziness, headache, agitation, dizziness, drowsiness, paresthesia, sensory disturbances, fatigue, convulsions, memory impairment, tremor, anxiety, hallucinations, taste disorders, aseptic meningitis, confusion, stroke, general malaise.
Reactions from sensory organs: diplopia, blurred vision, neuritis optic nerve, ringing in the ears, vertigo, hearing disorders.
Circulatory reactions: arterial hypotension , heart failure, chest pain, palpitations, vasculitis, arterial hypertension, myocardial infarction.
Respiratory reactions: pneumonitis, asthma.
Digestive reactions: abdominal pain, vomiting, flatulence, nausea, anorexia, gastritis, dyspepsia, diarrhea, bleeding from the digestive organs, stomach ulcer(with possible perforation or bleeding), constipation, disruption of the esophagus, colitis, glossitis, stomatitis, pancreatitis, intestinal stenosis, hepatitis, increasing content transaminases, liver disorders, jaundice, hepatonecrosis, fulminant hepatitis, liver failure.
Skin reactions: manifestations eczema And erythema, hair loss, Lyell's syndrome, Stevens-Johnson syndrome, exfoliative dermatitis, purpura, photosensitivity, itching.
Reactions from the genitourinary area: acute renal failure, edema, proteinuria, hematuria, nephrotic syndrome, interstitial nephritis, impotence, papillary necrosis kidney tissue.
General or local disorders: secretion of mucus mixed with blood, local irritation, painful defecation.

Dicloberl suppositories, instructions for use (Method and dosage)

The instructions for using Dicloberl 50 suppositories and the instructions for Dicloberl 100 suppositories are identical and have no differences.

To reduce the risk of adverse reactions, the lowest possible effective dose should be used for the shortest period of time.

Suppositories are forbidden to be used internally; they are intended only for rectal administration. They should be placed as deep into the rectum as possible after a bowel movement.

The initial dose is usually 100-150 mg per day. For mild symptoms, as well as for long-term treatment, using 75-100 mg of the drug per day is sufficient.

Treatment migraines start at a dose of 100 mg when the first signs of an attack develop. If necessary, it is allowed to use a second suppository (another 100 or 50 mg diclofenac) in one day, and also continue treatment in subsequent days, however daily dose should not be higher than 150 mg and divided into 2 or 3 doses.

Dikloberl 100 suppositories in gynecology

During treatment primary dysmenorrhea The dosage is selected individually, as a rule, it is 50-150 mg of the drug per day. The initial dose is usually 50-100 mg per day, but if necessary, it can be increased over 2-3 menstrual cycles to a maximum of 200 mg diclofenac per day. It is recommended to start using the drug after the first pain appears and continue for several days, depending on the degree of easing of symptoms.

Elderly patients

Anti-inflammatory nonsteroidal drugs should be used with caution in this group of people, since they are generally more prone to adverse reactions. Frail elderly patients or patients with low weight should be prescribed the smallest effective doses of Dicloberl.

Overdose

Signs of overdose: nausea, headache, epigastric pain, vomiting, bleeding from the digestive organs, drowsiness, convulsions, dizziness, diarrhea, disorientation, coma, agitation, tinnitus, liver damage, acute renal failure.

Treatment of overdose: symptomatic, cleansing enema (if no more than an hour has passed since the overdose). For frequent or prolonged convulsions, you need to enter Diazepam.

Interaction

When used simultaneously, Dicloberl is able to increase the content lithium in the blood. In such cases, concentration monitoring is recommended. lithium in the blood.

When used together with Digoxin it is possible that the concentration of the latter in the blood may increase. In such cases, concentration monitoring is recommended. Digoxin in the blood.

Concomitant use diclofenac With antihypertensive drugs And diuretics may lead to a weakening of their antihypertensive effect due to inhibition of synthesis angiodilating prostaglandins. Patients should receive adequate amounts of fluids, and regular monitoring of kidney function is also recommended after starting such treatment.

Simultaneous use with Cyclosporine, potassium-sparing diuretics, Trimethoprim or Tacrolimus can increase content potassium in the blood, so the condition of such patients should be monitored more often.

Simultaneous use with anticoagulants may increase the risk of bleeding because diclofenac in large doses can reversibly inhibit platelet adhesion, so such patients should be carefully monitored regularly.

Sharing diclofenac and others or glucocorticosteroids may increase the likelihood of ulcers or gastrointestinal bleeding. That's why simultaneous administration two or more anti-inflammatory nonsteroidal drugs should be avoided.

Simultaneous use anti-inflammatory nonsteroidal drugs And serotonin reuptake blockers increases the risk of bleeding from the digestive organs.

Diclofenac can be prescribed together with oral forms hypoglycemic agents and it doesn't affect them therapeutic effect. But there are some reports of the appearance in these cases hyperglycemia And hypoglycemia, which necessitated dosage adjustment antidiabetic drugs during the reception diclofenac. Therefore, it is recommended to control the content glucose in the blood during combination treatment.

Diclofenac can reduce the rate of excretion Methotrexate, which leads to an increase in the level of the latter in the blood. Diclofenac should be used no earlier than 24 hours before use Methotrexate in order to avoid cases of increasing the concentration of the latter and enhancing its toxic effects.

Joint reception with cyclosporines can enhance their nephrotoxicity, because of this diclofenac should be prescribed in reduced doses.

When using anti-inflammatory nonsteroidal drugs With Tacrolimus the risk of nephrotoxicity may increase.

It is possible that seizures may develop in people who simultaneously use quinolone derivatives and Dicloberl. This phenomenon can be observed in patients with or without a history of seizures. You need to be careful when deciding on the appointment quinolones patients already receiving p anti-inflammatory non-steroidal drugs.

Upon admission Phenytoin along with diclofenac it is necessary to monitor the content of the former in the blood due to a possible increase in its content.

Medicines containing probenecid, slow down excretion diclofenac from the body.

Simultaneous administration cardiac glycosides And anti-inflammatory nonsteroidal drugs may aggravate heart failure, slow down the process glomerular filtration and increase content glycosides in the blood.

Dicloberl should not be used within 9-12 days after the last dose Mifepristone, because diclofenac capable of weakening the effect of the latter.

Caution is recommended when joint use diclofenac with strong CYP2C9 inhibitors, as this may lead to increased concentrations diclofenac in the blood due to inhibition of its metabolism.

Terms of sale

Over the counter.

Storage conditions

Keep away from children. Store in original packaging at room temperature.

Best before date

Special instructions

In order to reduce the risk of adverse reactions, treatment should begin with the minimum effective dose, which should be taken most short course necessary to relieve symptoms.

Avoid taking Dicloberl together with systemic anti-inflammatory nonsteroidal drugs due to possible increased side effects.

Thanks to your pharmacological properties the drug Dicloberl is able to mask signs of infection.

When using all anti-inflammatory nonsteroidal drugs cases of bleeding from the digestive organs, perforation and the formation of ulcers, which can be fatal, have been identified. If in patients receiving diclofenac, such disorders are diagnosed, then its use should be stopped immediately.

Elderly patients have an increased risk of adverse reactions to anti-inflammatory nonsteroidal drugs, especially regarding bleeding and perforation. For this group of patients, as well as for those requiring simultaneous use acetylsalicylic acid , the issue of appointment should be resolved combination therapy using gastroprotective agents (proton pump inhibitors or Misoprostol).

Close medical supervision is necessary when prescribing Dicloberl to patients with liver disease, due to the possible deterioration of their condition.

During long-term treatment with the described drug, constant monitoring of liver function and liver enzyme levels is prescribed. If liver dysfunction persists or worsens, or appears clinical signs, presumably associated with the progression of the disease, the use of Dicloberl should be stopped immediately.

Because during therapy anti-inflammatory non-steroidal drugs an increase in the frequency and severity of edema was recorded; special attention should be paid to persons with arterial hypertension , disorders of the heart or kidneys, in old age, receiving diuretics or nephrotoxic agents, as well as before or after major operations.

In patients with systemic lupus erythematosus or other diseases connective tissue increased risk is possible aseptic meningitis.

Application diclofenac may be associated with an increased likelihood of thrombotic events ( heart attack or stroke).

Patients with peripheral artery disease, coronary disease hearts, congestive heart failure, severe arterial hypertension, cerebrovascular disease It is not recommended to prescribe the drug; in extreme cases, it can be used in a dosage of up to 100 mg per day.

When taking this drug for a long time, it is necessary to carry out regular monitoring blood test.

Patients with bleeding diathesis, impaired hemostasis or hematological disorders taking Dicloberl should be closely monitored.

In patients with chronic obstructive pulmonary disease, asthma, allergic rhinitis, nasal polyps or chronic infections respiratory tract, side effects (attacks) are more likely to occur asthma, Quincke's edema, urticaria) due to reception anti-inflammatory nonsteroidal drugs. This also applies to persons with allergic reactions to other substances, such as itching, rash, hives.

With long-term use painkillers A headache may occur that should not be treated by increasing the dosage of medications.

For patients who experience vertigo, blurred vision, disturbances in nervous activity, drowsiness, fatigue, lethargy, you should not drive a vehicle.

Analogs Level 4 ATX code matches:

The most common analogues of Dikloberl are listed below: Almiral, Arguette Rapid, Bioran, Diclofenac, Voltaren, Diclak, Diklobrew, Naklofen, Olfen, Ortofen, Rapten, Feloran, Indomethacin, Ketarolac and others.

The described product is not used in children due to the high concentration of the active substance in it.

With alcohol

When alcohol and Dicloberl are consumed together, undesirable reactions to the gastrointestinal tract or nervous system intensify.

During pregnancy and lactation

In the first two trimesters of pregnancy, Dicloberl is allowed to be prescribed only under strict indications and under medical supervision, and the duration of therapy should be as short as possible. In the last trimester of pregnancy, the use of the drug is prohibited due to the risk of inhibition of uterine contractility and early closure of the ductus arteriosus.

Diclofenac is able to pass into milk during breastfeeding, so the drug should not be used during lactation to avoid negative effects on the baby.

Dicloberl can also negatively affect fertility in women, so it is not recommended for use by women planning pregnancy.

Reviews for Dicloberl

In general, patients positively characterize the analgesic effect of the drug in the treatment of moderate pain. The described form of release (suppositories) is more preferable for stomach diseases. Reviews of Dikloberl suppositories in gynecology are also quite good, but due to the high ability to cause side effects in this area of medicine they are more often used selective blockers cyclooxygenase-2. From negative aspects remedies mainly indicate frequent side effects from the digestive system. Cases of ineffectiveness are rare.

Dicloberl price, where to buy

The price of Dikloberl 50 No. 10 candles in Russia is 260-360 rubles, and Dikloberl 100 No. 10 is 400-560 rubles.

In Ukraine, the price of the specified head start for the production of suppositories with a dosage of 50 mg is 75-83 hryvnia, and for suppositories with a dosage of 100 mg – 95-105 hryvnia.

Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

Pharmacy24

Dicloberl tablets 50 mg No. 50 Berlin-Chemie (Germany)

Dicloberl RetardBerlin-Chemie/Menarini Group (Germany)

DikloberlMenarirni Manufacturing (Italy)

Suppositories dikloberl 100 mg No. 10 Berlin-Chemie (Germany)

PaniPharmacy

Supp. dikloberl 100 mg No. 10Berlin-Chemie

BIOSPHERE

Dicloberl 75 mg/3 ml No. 5 solution d/in.amp.Berlin-Chemie (Germany)

Dicloberl 100 mg No. 20 caps.retardBerlin-Chemie (Germany)

PLEASE NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Dicloberl, be sure to consult with your doctor.

Pregnancy is a wonderful period when a woman prepares to become a mother. All her organs and systems undergo the necessary changes that contribute to the long nine-month gestation of the child. However, at the same time there is a decrease immune defense, which can lead to the development of inflammatory processes of various etiologies.

In this case, a pain syndrome arises, the high intensity of which forces the pregnant woman to look for ways to alleviate it.

After consultation with a gynecologist, certain medications may be prescribed, including non-steroidal anti-inflammatory drugs. This group of medications includes Dicloberl, which is most often used in the form of suppositories in pregnant women.

Mechanism of action

The action of Dikloberl 100 candles occurs in three directions. On the one hand, the activity of the inflammatory process is suppressed, on the other hand, the intensity of pain decreases. The third direction is reducing body temperature.

This complex action on the human body is achieved by inhibiting the synthesis of prostaglandins - biologically active substances formed in the body and taking part in almost all processes, including pathological ones.

Indications for use

According to the instructions for use, the use of Dicloberl 100 suppositories is limited to inflammatory processes of various nature in the musculoskeletal system. A more detailed list of indications is as follows:

acute and chronic diseases of the joints of rheumatic and non-rheumatic etiology;

attacks of gout;
inflammatory processes in cartilage tissue against the background of degenerative changes;
pain syndrome associated with mechanical damage;
condition after surgery, accompanied by pain.

Contraindications for use

Instructions for use of Dicloberl 100 suppositories contain standard contraindications inherent in all non-steroidal anti-inflammatory drugs. These include:

third trimester of pregnancy;
individual intolerance to diclofenac or excipients;
stomach ulcer or duodenum;
bleeding from the veins of the digestive tract;
diseases of the hematopoietic organs.

Adverse reactions

The use of Dikloberl 100 suppositories can cause adverse reactions on the part of many internal organs. This is mainly due to the pharmacodynamics of diclofenac. It acts on the synthesis of various prostaglandins, including physiological ones. The instructions for use describe the following adverse reactions:

Organs gastrointestinal tract. Dyspeptic symptoms, changes in the nature of bowel movements, and minor bleeding that can lead to anemia are often observed. With long-term use of Dicloberl 100 suppositories, ulcerative defects of the gastric mucosa may occur due to a decrease in the concentration of protective factors against hydrochloric acid. This is fraught with abundant internal bleeding and organ perforations. Suppositories can cause discomfort during bowel movements.
Nervous system. The most common side effect of using Dicloberl 100 suppositories is headache. There may also be sudden changes in mood, general well-being worsens, and in rare cases, clouding of consciousness is possible.
Skin. While taking Dicloberl 100 suppositories, rashes and itching of the skin were sometimes observed.
Hematopoietic organs. In some patients, the hematopoietic function may be inhibited, which is accompanied by anemia, the development of fungal infections of the mucous membranes, and a decrease in the body's resistance.

In addition to the above adverse reactions, diclofenac may have a negative effect on the fetus. It has been proven that this chemical substance can provoke early occlusion of the ductus arteriosus, which is necessary for free circulation of blood from the system pulmonary artery into the vessels of the aorta.

When it closes prematurely, the right parts of the unborn child’s heart muscle are overloaded, the immature structures of which are not able to compensate for this condition. This can cause the death of the baby.

In a pregnant woman, the use of drugs that block prostaglandin synthesis may cause weakness labor activity, which leads to post-maturity of the fetus.

Application diagram

The duration of use of Dicloberl 100 suppositories depends on the intensity of the inflammatory process and is determined individually in each specific case. The daily dosage varies from 50 to 150 mg of diclofenac and is divided into several doses. For convenience, you can use Dicloberl with a lower content of active ingredient. Suppositories must be administered rectally, preferably after physiological functions.

The drug should be used during pregnancy only in case of urgent need. Before use, you need to consult a gynecologist who will select the minimum therapeutic dosage. The doctor always takes into account the ratio of risk to the fetus - benefit to the mother.

Advantages and disadvantages of candles

The first mention of candles dosage form, found in domestic pharmacopoeias back in the 16th century. Since then, the technology for manufacturing suppositories has been constantly improved, which has made it possible to maximize their advantages and almost completely eliminate their disadvantages.

The benefits of candles include:

Admission medicinal substance directly into the general bloodstream, bypassing the destructive effect gastric juice and transformation of drugs in liver cells.
The onset of action of the drug is comparable to that for intravenous administration.
Practically complete absence allergic side reactions.
Possibility of introducing a drug with poor taste properties.
Can be used in patients with swallowing disorders.
Not accompanied by pronounced unpleasant sensations, unlike injectable medications.
Does not require additional tools for insertion.

The disadvantages include the short shelf life of suppositories with hydrophilic bases and some inconvenience when using the suppository.

The drug Dicloberl - active substance Diclofenac is an NSAID wide range. Available in different forms, suppositories are often used in gynecological practice.

Dicloberl 100 suppositories are used as an analgesic, antipyretic and anti-inflammatory agent. It has a number of contraindications; in special cases it is necessary to decide what is the priority.

Effect of the drug Dicloberl 100

Medical professionals value those drugs that work on three fronts:

relieve pain;
reduce fever;
remove inflammation.

This class of drugs includes Diclofenac, an effective non-steroidal anti-inflammatory drug; Dicloberl 100 suppositories are based on it.

Wide range of applications for these medicinal suppositories, they are used for the following purposes:

sciatica treatment;
eliminating pain in the spine during pregnancy;
treatment of cystitis;
relieving inflammation of the hip joints;
relief of gynecological inflammations.

The drug acts quickly, relieves the most sharp pains in a short time, the antitumor effect of the drug has been proven. A product with a smaller composition of the main active NSAID (50 mg) is perceived a little softer; Dicloberl 100 suppositories work faster, they:

relieve severe pain;
relieve swelling;
treat inflammation.

Dissolving very quickly, the medicine penetrates the mucous membrane with lightning speed and reaches the source of inflammation in the shortest possible time. Taking tablets of an identical drug acts an order of magnitude slower.

When are Dicloberl 100 suppositories used in gynecology?

Most often, gynecologists prescribe suppositories to those patients who complain of severe pain during the first days of the menstrual cycle. Sometimes one application is enough to relieve spasms, inflammation and nagging pain. Reviews of women who use suppositories often call the drug a salvation from severe pain in the lower abdomen.

Dicloberl 100 is prescribed to patients in case of gynecological and other health problems, in particular:

for primary dysmenorrhea - to reduce blood loss;
to eliminate Adnexitis;
in the treatment of inflammation of the ovaries (appendages);
from the threat of spontaneous miscarriage;
inflammatory processes in the vagina and uterus of various etiologies;
inflammation of other pelvic organs;
V postoperative period to relieve inflammation, which prevents the formation of adhesions.

Young women increasingly began to use Diclofenac in the form of suppositories. Reviews about them are somewhat contradictory. Some praise him for quick help, others complain about side effects.

How does the active substance act in a woman’s body?

Using Diclaberl 100, women relieve inflammatory processes due to the main component – Diclofenac. The active substance contained in suppositories reduces the amount of prostaglandins in the body, the main culprits of pain, swelling, and fever in humans.

Instructions for use of suppositories strongly limit the time of use of the drug. Without a doctor’s advice, it’s 3 or 4 days. But usually they are used for no more than 3 days, to minimize side effects from use.

If inflammatory processes occur during pregnancy or breastfeeding, then you should be aware of the complete ban on the use of Dicloberl 100 in such cases.

Dikloberl – rectal suppositories, injected into the rectum while lying in bed, after defecation, as deep as possible. A cleansing enema before inserting the suppository is also indicated.

After complete dissolution, a burning sensation may occur. Daily dose should not exceed 100 mg. You can use a more gentle dosage of 25, 50, 75 mg twice a day if the burning sensation in the anus continues.

The dosage and duration of the course are determined by the attending physician and depend on the severity of the disease. Can be applied within a day maximum dose– 150 mg. These are three candles of 50, 2 pcs. 75 or 1 suppository of 100 mg of active diclofenac sodium.

At rectal use maximum plasma concentration occurs after half an hour. It is excreted through the kidneys and with bile in the form of metabolites. Bioavailability is 50%. The connection with blood proteins is close to 99%. A third of the substance is excreted from feces, the rest - kidneys.

Contraindications to the use of Decloburn suppository

If a woman has hypersensitivity to NSAIDs, has hematopoietic disorders, exacerbation of intestinal colitis, ulcerative processes of the duodenum or stomach, has had aspirin-induced asthma, or is pregnant, the drug is contraindicated.

Children should not use medicine before the age of 16.

There are not many contraindications for NSAID suppositories, but specialist advice is required due to the large number of side effects when using the drug.

Common consequences of long-term use of NSAIDs include:

disorders of the central nervous system;
skin allergic reactions;
liver damage;
defecation disorder;
pancreatitis;
bloody stool and vomiting.

Therefore, Dicloberl suppositories are used for a short time. Reviews from patients indicate the effectiveness of the drug if used for a short time.

"Dicloberl" is a derivative of phenylacetic acid, which has an anti-inflammatory effect. Diclofenac sodium is the active substance present in this medicine. It has anti-edematous, antipyretic and analgesic effects. This drug has various dosage forms; it is also produced in the form of suppositories. Dicloberl candles are not recommended for use by children under 15 years of age.

Use of the drug

You can use Dicloberl suppositories for the following ailments:

inflammation of the musculoskeletal system;
arthritis in all its manifestations;
rheumatism and osteoarthritis;
Ankylosing spondylitis and Personage-Turner disease;
for migraine, neuralgia, toothache, radiculitis and ossalgia (if pain exists);
for an infection or cold (if there is a fever);
adnexitis.

Many patients, feeling pain, purchase “Dicloberl” (suppositories). Instructions for use are included inside each package.

Dosage and methods of application

Dicloberl suppositories are used no more than several times a day, 50 mg, and if the dosage is 100 mg, then only once a day rectally. When a person feels the first signs of a migraine, this drug should be used immediately. After bowel movements, it is necessary to insert suppositories deep into the anus. The doctor must prescribe the correct treatment, which can be long-term if there are rheumatic diseases.

Contraindications

Each pack of Dicloberl contains instructions. Candles have the following contraindications. You cannot use them if:

There is hypersensitivity to the components of the drug.
The person has diseases such as asthma, anemia and the triad.
Poor blood clotting.
There are ulcers and erosions in the stomach.
The rectum is injured and there are hemorrhoids.
Children's age is up to 6 years.

Dicloberl suppositories have many contraindications, so they must be used with extreme caution. Pregnant women should not use this drug, as spontaneous miscarriage may occur in the early stages of pregnancy. In a child, the drug causes the development of heart defects and non-closure of the anterior abdominal wall.

Important points

Elderly people and people who have heart and kidney failure, as well as those who use diuretics, should use Dicloberl only under the special supervision of a physician. The condition of the kidneys must be constantly monitored.

Exceeding the dosage of this drug may cause:

fainting;
headaches;
bleeding in the gastrointestinal tract;
disorientation;
stomach ache;
nausea.

Dicloberl suppositories 100 and 50 mg are sold in blisters of 5 or 10 suppositories.

Parallel use with other drugs

Doctors allow the combination of Dicloberl (suppositories) with other drugs. The instructions for use, however, state that interaction with certain products can lead to various consequences.

The use of "Dicloberl" in gynecology

Dicloberl suppositories in gynecology are usually used for painful periods and inflammation of the ovaries. Many girls and women at the very beginning of menstruation may experience severe pain that makes them unable to work. These candles are successfully used in this area. Under the influence of internal temperature, suppositories inserted into the vagina quickly dissolve inside and go directly to the diseased organ, which speeds up the healing process. They need to be used every 6 hours.

Typically, ovarian inflammation takes quite a long time to be treated and can become chronic. In the initial stages of the disease, this medicine effectively relieves pain and tension in the inflamed tissues of the female body.

Dicloberl suppositories have helped many patients achieve normal menstrual cycles. Having tried them once, ladies recommend this drug to their friends who have the same gynecological problems.